The Experts below are selected from a list of 192 Experts worldwide ranked by ideXlab platform
Wayne L Chandler - One of the best experts on this subject based on the ideXlab platform.
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discordant partial Thromboplastin Time ptt vs anti xa heparin activity
American Journal of Clinical Pathology, 2019Co-Authors: Jenna Khan, Wayne L ChandlerAbstract:Objectives To determine the relationship between baseline variations in the partial Thromboplastin Time (PTT) and the discordance between the PTT and anti-Xa heparin activity (anti-Xa) during heparin therapy. Methods The baseline PTT on heparin was determined using automated heparin neutralization with protamine (prPTT). The prPTT was used to calculate a baseline-corrected PTT on heparin to reduce discordance with anti-Xa measurements. Results The prPTT removed up to 1 U/mL of heparin, returning baseline values for normal, factor-deficient, and lupus inhibitor plasmas. A prolonged prPTT was seen in 97 (53%) of 182 samples from heparinized patients. The heparinized PTT was discordant compared with anti-Xa in 64 (35%) of 182 samples and 43 (67%) of 64 discordant samples, and 46% of concordant samples showed a prolonged prPTT. A baseline-corrected PTT reduced discordance with anti-Xa measurements by 64%. Conclusions PTT/anti-Xa discordance due to baseline PTT prolongation could be reduced using a baseline-corrected PTT.
Paul R J Ames - One of the best experts on this subject based on the ideXlab platform.
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prolonged activated partial Thromboplastin Time difficulties in discriminating coexistent factor viii inhibitor and lupus anticoagulant
Clinical and Applied Thrombosis-Hemostasis, 2015Co-Authors: Paul R J Ames, Maria Graf, Jeremy Archer, N Scarpato, Luigi IannacconeAbstract:To review the diagnostic difficulties of a prolonged activated partial Thromboplastin Time (aPTT) when 2 inhibitors with opposite clinical presentations coexist, we searched MEDLINE from January 19...
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Sequential thrombosis and bleeding in a woman with a prolonged activated partial Thromboplastin Time
Thrombosis Journal, 2011Co-Authors: Akpan Spencer, Michael I Pearce, Paul R J AmesAbstract:Simultaneous or sequential haemorrhage and thrombosis in the presence of a prolonged activated partial Thromboplastin Time (aPTT) is a rare occurrence: we describe the case a 37 year old lady who developed post-delivery deep vein thrombosis treated with low molecular heparin and warfarin followed a week later by extensive bruising over legs and forearms, a significant drop in haemoglobin and a very prolonged aPTT. Further tests revealed an acquired factor VIII inhibitor at 35 Bethesda Units. We discuss the clinical and laboratory implications and provide a literature review of simultaneous thrombophilia and haemophilia in the presence of a prolonged aPTT.
Paul F. Lindholm - One of the best experts on this subject based on the ideXlab platform.
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Mixing Studies in Patients With Prolonged Activated Partial Thromboplastin Time or Prothrombin Time
Anesthesia and analgesia, 2019Co-Authors: Honorio T. Benzon, Meghan Park, Robert J. Mccarthy, Mark C. Kendall, Paul F. LindholmAbstract:BACKGROUND:Patients presenting for surgery may have isolated or combined prolonged activated partial Thromboplastin Time (aPTT) and/or prothrombin Time (PT). In patients not receiving anticoagulants or with no identifiable cause for abnormal clot formation, a mixing study is performed. The index of
Jana N Gausman - One of the best experts on this subject based on the ideXlab platform.
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activated partial Thromboplastin Time monitoring of unfractionated heparin therapy issues and recommendations
Seminars in Thrombosis and Hemostasis, 2016Co-Authors: Richard A Marlar, Bernadette Clement, Jana N GausmanAbstract:When administering unfractionated heparin (UFH), therapeutic levels of anticoagulation must be achieved rapidly and maintained consistently in the therapeutic range. The basic assays for monitoring UFH therapy are the activated partial Thromboplastin Time (APTT) and/or the chromogenic antifactor Xa or antithrombin assays. For many laboratories, the APTT is the preferred standard of practice; however, the APTT is a surrogate marker that only estimates the heparin concentration. Many factors, including patient variation, reagents of the APTT, UFH composition, and concentration can influence the APTT result. This article reviews various methods to determine the heparin therapeutic range and presents recommendations for the laboratory to establish an APTT heparin therapeutic range for all sizes of hospitals.
C A Hart - One of the best experts on this subject based on the ideXlab platform.
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Diagnostic efficacy of activated partial Thromboplastin Time waveform and procalcitonin analysis in pediatric meningococcal sepsis.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Car, 2011Co-Authors: Fauzia Paize, Colin Downey, F A I Riordan, A P J Thomson, Enitan D. Carrol, Christopher M. Parry, Gerwyn Green, Peter J. Diggle, Paul Newland, C A HartAbstract:Objective:A biphasic activated partial Thromboplastin Time waveform predicts sepsis and disseminated intravascular coagulation in adults. This has not been previously investigated in children. Our aim is to ascertain whether there are changes in the activated partial Thromboplastin Time waveform in
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ACTIVATED PARTIAL Thromboplastin Time WAVEFORM ANALYSIS IN CHILDHOOD MENINGOCOCCAL DISEASE
Archives of Disease in Childhood, 2008Co-Authors: Fauzia Paize, C Powel, Colin Downey, F A I Riordan, A P J Thomson, Enitan D. Carrol, C A HartAbstract:Objective A biphasic waveform pattern in coagulation assays has been shown to correlate with the onset of disseminated intravascular coagulation in adult patients. The aim of this study was to ascertain whether abnormal activated partial Thromboplastin Time (aPTT) waveforms are present in children with meningococcal septicaemia. Method Biphasic profiles occur when light transmission decreases before clot formation. To quantitate, light transmission at Time 0 is set at 100% and the value at 18 s (TL18) is the index of the abnormality. aPTT waveform analysis was carried out on plasma samples from 56 children: 22 with confirmed meningococcal disease (MCD); 14 with a presumed viral illness inducing a non-blanching rash and 20 healthy children attending for routine surgery. Results There was a significant difference in aPTT waveform between children with MCD, those with a viral illness (Mann–Whitney U, p Conclusion These findings demonstrate that the aPTT waveform is abnormal in severe meningococcal sepsis in children when compared with viral illness and controls. aPTT waveform analysis may be a useful tool for the diagnosis of sepsis in children.
