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Ali A. Al-shawaf - One of the best experts on this subject based on the ideXlab platform.

  • Innervation of the rat Thymus Gland
    Brain behavior and immunity, 1991
    Co-Authors: Marion D. Kendall, Ali A. Al-shawaf
    Abstract:

    Abstract Current views from different laboratories on the innervation of the Thymus Gland are reviewed with particular reference to the rat. Noradrenergic nerve profiles of the sympathetic nervous system have been demonstrated in the subcapsular cortex, at the corticomedullary junction and in the cortex itself, and extremely sparsely in the medulla. By following β-adrenergic receptor development in postnatal rats, it has been shown that there is a marked increase in density and morphological organization of the receptor in the medulla with the maturation of thymocyte function (monitored by measuring the proliferation response to concanavalin A) and a sexual dimorphism during the ontogeny of the receptor. Chemical sympathectomy of adult rats with 6-hydroxydopamine (6-OHDA) or guanethidine resulted in a loss of Thymus weight, decreased cellularity, and increased apoptosis but a rise in the numbers of proliferating cells in the cortex. By contrast, proliferation of peripheral T cells was reduced after the use of 6-OHDA. Chemical sympathectomy also demonstrated that there were at least three nerve nets in the Gland: noradrenergic neural profiles that were destroyed with both 6-OHDA and guanethidine, vasoactive intestinal polypeptide (VIP)-positive profiles that persisted, and AChE- and CGRP-positive profiles and cells that also persisted but had a different distribution to VIP-positive fibers. Some functional correlates of thymic innervation are discussed although the subject now needs to be further researched.

Marion D. Kendall - One of the best experts on this subject based on the ideXlab platform.

  • Innervation of the rat Thymus Gland
    Brain behavior and immunity, 1991
    Co-Authors: Marion D. Kendall, Ali A. Al-shawaf
    Abstract:

    Abstract Current views from different laboratories on the innervation of the Thymus Gland are reviewed with particular reference to the rat. Noradrenergic nerve profiles of the sympathetic nervous system have been demonstrated in the subcapsular cortex, at the corticomedullary junction and in the cortex itself, and extremely sparsely in the medulla. By following β-adrenergic receptor development in postnatal rats, it has been shown that there is a marked increase in density and morphological organization of the receptor in the medulla with the maturation of thymocyte function (monitored by measuring the proliferation response to concanavalin A) and a sexual dimorphism during the ontogeny of the receptor. Chemical sympathectomy of adult rats with 6-hydroxydopamine (6-OHDA) or guanethidine resulted in a loss of Thymus weight, decreased cellularity, and increased apoptosis but a rise in the numbers of proliferating cells in the cortex. By contrast, proliferation of peripheral T cells was reduced after the use of 6-OHDA. Chemical sympathectomy also demonstrated that there were at least three nerve nets in the Gland: noradrenergic neural profiles that were destroyed with both 6-OHDA and guanethidine, vasoactive intestinal polypeptide (VIP)-positive profiles that persisted, and AChE- and CGRP-positive profiles and cells that also persisted but had a different distribution to VIP-positive fibers. Some functional correlates of thymic innervation are discussed although the subject now needs to be further researched.

Takehiko Fujisawa - One of the best experts on this subject based on the ideXlab platform.

  • Papillary carcinoma of the Thymus Gland.
    The Annals of thoracic surgery, 2005
    Co-Authors: Mitsuru Yoshino, Kenzo Hiroshima, Shinichiro Motohashi, Kiyoshi Shibuya, Akira Iyoda, Yasuo Sekine, Takehiko Fujisawa
    Abstract:

    In 1999, the World Health Organization introduced a new classification of a rare thymic cancer called papillary adenocarcinoma of the Thymus Gland. In this study we report on a case of papillary thymic carcinoma in a 29-year-old woman. Histologically, the tumor consisted of a papillary component admixed with a solid component, a component that is commonly found in type A thymoma.

Mitsuru Yoshino - One of the best experts on this subject based on the ideXlab platform.

  • Papillary carcinoma of the Thymus Gland.
    The Annals of thoracic surgery, 2005
    Co-Authors: Mitsuru Yoshino, Kenzo Hiroshima, Shinichiro Motohashi, Kiyoshi Shibuya, Akira Iyoda, Yasuo Sekine, Takehiko Fujisawa
    Abstract:

    In 1999, the World Health Organization introduced a new classification of a rare thymic cancer called papillary adenocarcinoma of the Thymus Gland. In this study we report on a case of papillary thymic carcinoma in a 29-year-old woman. Histologically, the tumor consisted of a papillary component admixed with a solid component, a component that is commonly found in type A thymoma.

Masaharu Tsuchiya - One of the best experts on this subject based on the ideXlab platform.

  • Sulfhydryl blocker‐induced colitis in the rat: Immunological changes in Thymus Gland and colonic mucosa
    Journal of gastroenterology and hepatology, 1994
    Co-Authors: Hidekazu Suzuki, Toshifumi Hibi, Masaya Oda, Yasuo Hosoda, Mikiji Mori, Soichirou Miura, Shin Tanaka, Mamoru Watanabe, Masaharu Tsuchiya
    Abstract:

    The study was designed to examine the changes of Thymus in sulfhydryl blocker-induced colitis. We used N-ethylmaleimide (NEM) as sulfhydryl blockers. Fasted male Sprague-Dawley rats were given 3% NEM in 1% methyl cellulose into the colon. N-ethylmaleimide treatment caused severe diarrhoea with bleeding for the first 7 days. At autopsy, adhesions, colon dilatation, and single or multiple erosions and ulcers were observed. Time-course studies revealed that the lesions were most extensive and severe 3 or 7 days after the administration of NEM. Histological examination of colon on the 3rd day after NEM treatment demonstrated mucosal erosion, oedema and extensive infiltration of neutrophils. The mucosal lesions extended into the submucosa and muscle on the 7th day after NEM treatment. Immunohistochemical studies showed that T cells and macrophages were markedly increased in the lamina propria of colonic mucosa. After 3 weeks, the infiltration of chronic inflammatory cells was observed and regeneration of the mucosa was noticed. The Thymus Gland was significantly decreased in weight and size on the 3rd day after NEM treatment, but the weight loss of Thymus Gland was regained in 3 weeks. Transient atrophy of Thymus Gland was noticed in this colitis model. The phenotypes of thymocytes were not influenced by NEM treatment. It is concluded that the Thymus abnormalities in human ulcerative colitis are not induced in this animal model and that other chronic models are necessary for the elucidation of the immunological abnormalities, including Thymus abnormalities.