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George Wadih - One of the best experts on this subject based on the ideXlab platform.
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Thyroglossal Duct carcinoma a rational approach to management
Laryngoscope, 1998Co-Authors: Thomas L Kennedy, Mark Whitaker, George WadihAbstract:Objective: To discuss the authors' experience with Thyroglossal Duct carcinoma and present a rational approach to the management of this entity. Study Design and Methods: A retrospective review of the cytopathology and pathology records of all patients with the diagnosis of a Thyroglossal Duct remnant from 1965 to 1997 was performed. Results: Three cases of papillary Thyroglossal Duct carcinoma were identified, with one suspected squamous cell carcinoma by needle aspiration. The papillary carcinomas are discussed in detail to illustrate the difficulty encountered in managing the thyroid gland in the setting of a Thyroglossal Duct carcinoma. Fine-needle aspiration proved effective in making the diagnosis preoperatively. Conclusions: The authors recommend that a Thyroglossal Duct cyst with a microscopic focus of papillary carcinoma, without cyst wall invasion, be managed with a Sistrunk procedure. Treatment of all other Thyroglossal Duct papillary carcinomas should include removal of all thyroid tissue followed by radioactive iodine treatment.
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Thyroglossal Duct carcinoma: a rational approach to management.
The Laryngoscope, 1998Co-Authors: T L Kennedy, M Whitaker, George WadihAbstract:To discuss the authors' experience with Thyroglossal Duct carcinoma and present a rational approach to the management of this entity. A retrospective review of the cytopathology and pathology records of all patients with the diagnosis of a Thyroglossal Duct remnant from 1965 to 1997 was performed. Three cases of papillary Thyroglossal Duct carcinoma were identified, with one suspected squamous cell carcinoma by needle aspiration. The papillary carcinomas are discussed in detail to illustrate the difficulty encountered in managing the thyroid gland in the setting of a Thyroglossal Duct carcinoma. Fine-needle aspiration proved effective in making the diagnosis preoperatively. The authors recommend that a Thyroglossal Duct cyst with a microscopic focus of papillary carcinoma, without cyst wall invasion, be managed with a Sistrunk procedure. Treatment of all other Thyroglossal Duct papillary carcinomas should include removal of all thyroid tissue followed by radioactive iodine treatment.
Mark Whitaker - One of the best experts on this subject based on the ideXlab platform.
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the ct appearance of Thyroglossal Duct carcinoma
American Journal of Neuroradiology, 2000Co-Authors: Barton F Branstetter, Jane L Weissman, Thomas L Kennedy, Mark WhitakerAbstract:BACKGROUND AND PURPOSE: Thyroid carcinoma arising in a Thyroglossal Duct cyst may be clinically indistinguishable from a benign Thyroglossal Duct cyst. The preoperative diagnosis of carcinoma, however, can have important implications for surgical planning and postoperative treatment. Our purpose was to describe the CT appearance of Thyroglossal Duct carcinoma and identify the features that distinguish Thyroglossal Duct carcinoma from benign Thyroglossal Duct cysts. METHODS: Retrospective review of the medical records from the University of Pittsburgh Medical Center and Geisinger Medical Center (Danville, Pennsylvania) identified six patients with papillary thyroid carcinoma within the Thyroglossal Duct who had undergone preoperative CT examinations of the neck. There were two women and four men. Their ages ranged from 14 to 59 years. Three patients underwent contrast-enhanced CT of the neck, and three underwent unenhanced CT. All CT examinations consisted of 3- to 5-mm-thick contiguous axial sections. RESULTS: Each patient had an anterior neck mass with a cystic component. Two of the masses had dense or enhancing mural nodules, two had irregular calcification throughout the mass, and two had dense or enhancing mural nodules with additional foci of calcification. One patient had cervical lymphadenopathy. CONCLUSION: Carcinoma should be considered in Thyroglossal Duct cysts that have a mural nodule or calcification or both.
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Thyroglossal Duct carcinoma a rational approach to management
Laryngoscope, 1998Co-Authors: Thomas L Kennedy, Mark Whitaker, George WadihAbstract:Objective: To discuss the authors' experience with Thyroglossal Duct carcinoma and present a rational approach to the management of this entity. Study Design and Methods: A retrospective review of the cytopathology and pathology records of all patients with the diagnosis of a Thyroglossal Duct remnant from 1965 to 1997 was performed. Results: Three cases of papillary Thyroglossal Duct carcinoma were identified, with one suspected squamous cell carcinoma by needle aspiration. The papillary carcinomas are discussed in detail to illustrate the difficulty encountered in managing the thyroid gland in the setting of a Thyroglossal Duct carcinoma. Fine-needle aspiration proved effective in making the diagnosis preoperatively. Conclusions: The authors recommend that a Thyroglossal Duct cyst with a microscopic focus of papillary carcinoma, without cyst wall invasion, be managed with a Sistrunk procedure. Treatment of all other Thyroglossal Duct papillary carcinomas should include removal of all thyroid tissue followed by radioactive iodine treatment.
Thomas L Kennedy - One of the best experts on this subject based on the ideXlab platform.
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the ct appearance of Thyroglossal Duct carcinoma
American Journal of Neuroradiology, 2000Co-Authors: Barton F Branstetter, Jane L Weissman, Thomas L Kennedy, Mark WhitakerAbstract:BACKGROUND AND PURPOSE: Thyroid carcinoma arising in a Thyroglossal Duct cyst may be clinically indistinguishable from a benign Thyroglossal Duct cyst. The preoperative diagnosis of carcinoma, however, can have important implications for surgical planning and postoperative treatment. Our purpose was to describe the CT appearance of Thyroglossal Duct carcinoma and identify the features that distinguish Thyroglossal Duct carcinoma from benign Thyroglossal Duct cysts. METHODS: Retrospective review of the medical records from the University of Pittsburgh Medical Center and Geisinger Medical Center (Danville, Pennsylvania) identified six patients with papillary thyroid carcinoma within the Thyroglossal Duct who had undergone preoperative CT examinations of the neck. There were two women and four men. Their ages ranged from 14 to 59 years. Three patients underwent contrast-enhanced CT of the neck, and three underwent unenhanced CT. All CT examinations consisted of 3- to 5-mm-thick contiguous axial sections. RESULTS: Each patient had an anterior neck mass with a cystic component. Two of the masses had dense or enhancing mural nodules, two had irregular calcification throughout the mass, and two had dense or enhancing mural nodules with additional foci of calcification. One patient had cervical lymphadenopathy. CONCLUSION: Carcinoma should be considered in Thyroglossal Duct cysts that have a mural nodule or calcification or both.
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Thyroglossal Duct carcinoma a rational approach to management
Laryngoscope, 1998Co-Authors: Thomas L Kennedy, Mark Whitaker, George WadihAbstract:Objective: To discuss the authors' experience with Thyroglossal Duct carcinoma and present a rational approach to the management of this entity. Study Design and Methods: A retrospective review of the cytopathology and pathology records of all patients with the diagnosis of a Thyroglossal Duct remnant from 1965 to 1997 was performed. Results: Three cases of papillary Thyroglossal Duct carcinoma were identified, with one suspected squamous cell carcinoma by needle aspiration. The papillary carcinomas are discussed in detail to illustrate the difficulty encountered in managing the thyroid gland in the setting of a Thyroglossal Duct carcinoma. Fine-needle aspiration proved effective in making the diagnosis preoperatively. Conclusions: The authors recommend that a Thyroglossal Duct cyst with a microscopic focus of papillary carcinoma, without cyst wall invasion, be managed with a Sistrunk procedure. Treatment of all other Thyroglossal Duct papillary carcinomas should include removal of all thyroid tissue followed by radioactive iodine treatment.
Majid Assadi - One of the best experts on this subject based on the ideXlab platform.
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invasive Thyroglossal Duct cyst papillary carcinoma a case report
Journal of Medical Case Reports, 2009Co-Authors: Leila Aghaghazvini, Habib Mazaher, Hashem Sharifian, Shirin Aghaghazvini, Majid AssadiAbstract:IntroDuction A Thyroglossal Duct cyst is the most common congenital anomaly of the thyroid gland and midline masses in childhood (70% abnormality in childhood, 7% in adult). Carcinomas arising from a Thyroglossal Duct cyst are rare (only 1% of Thyroglossal Duct cyst cases) and characterized by relatively non-aggressive behavior and rare lymphatic spread. They are also diagnosed mostly during the third and fourth decades of life. About 85% to 92% of all Thyroglossal Duct cyst carcinomas are papillary carcinomas.
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primary papillary carcinoma in a Thyroglossal Duct cyst
Hellenic Journal of Nuclear Medicine, 2006Co-Authors: Majid Kazemi, Majid Assadi, Ahmad Ali Kazemi, Leila Agha GhazviniAbstract:Thyroglossal Duct cysts are the most common congenital anomalies in thyroid development, which in less than 1% of cases are malignant. In most cases the diagnosis is made postoperatively. Up to now, a few cases have been reported which had been papillary carcinoma. Controversies exist concerning its nature and treatment. We present a 30 years old woman with papillary carcinoma of Thyroglossal Duct cyst, identified in pathologic study after sistrunk procedure. In our case there was neither invasion to adjacent tissue nor lymph node involvement. No further procedure was performed. After 2 years of followup, the patient was asymptomatic and there was no evidence of recurrence. Based on otolaryngologic refrences, we recommend sistrunk procedure and long term follow up for management of Thyroglossal Duct cyst with papillary carcinomas without marginal invasion and node metastasis.
Ric H Harnsberger - One of the best experts on this subject based on the ideXlab platform.
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the ct and mr imaging features of carcinoma arising in Thyroglossal Duct remnants
American Journal of Neuroradiology, 2000Co-Authors: Christine M Glastonbury, Christian H Davidson, Jeffrey R Haller, Ric H HarnsbergerAbstract:BACKGROUND AND PURPOSE: Carcinoma arising in Thyroglossal Duct remnants is a well-described entity in the pathology and surgery literature, but it has little recognition in the radiology literature. Preoperative diagnosis may alter surgical management, although this diagnosis is rarely made. This study was undertaken to determine the radiologic features that might differentiate carcinoma from benign Thyroglossal Duct cysts. METHODS: Twenty-one cases of nonpediatric Thyroglossal Duct anomalies imaged at our institution during a 15-year period were reviewed retrospectively. The images were assessed for lesion wall thickness, enhancement, soft-tissue component, calcification, and loculation of the cystic component. Three additional cases of Thyroglossal Duct carcinoma obtained from outside institutions were reviewed for these features also. RESULTS: Six cases of Thyroglossal Duct carcinoma were reviewed. All cases of carcinoma had solid soft-tissue elements visible on CT scans or MR images, compared with three of 18 cases of benign Thyroglossal Duct cysts. The malignant component was seen as a small peripherally based mass in relation to a cyst, a solid mass in the expected course of the Thyroglossal Duct, or a complex invasive mass also in the midline of the neck. CT only revealed calcification in cases of carcinoma, within either the primary carcinoma mass or a metastatic node. CONCLUSION: Thyroglossal Duct carcinoma should be suspected in an adult patient in the presence of a solid nodule or invasive features in association with a Thyroglossal Duct lesion visible on CT scans or MR images. The presence of calcification, which is seen best on CT scans, may be a specific marker for carcinoma.
