The Experts below are selected from a list of 49701 Experts worldwide ranked by ideXlab platform
Akira Miyauchi - One of the best experts on this subject based on the ideXlab platform.
-
Comparison of thyroglobulin and thyroid peroxidase antibodies measured by five different kits in autoimmune thyroid diseases.
Endocrine Journal, 2017Co-Authors: Eijun Nishihara, Hirotoshi Nakamura, Nobuyuki Amino, Takumi Kudo, Shuji Fukata, Mitsushige Nishikawa, Akira MiyauchiAbstract:: It is generally believed that the detection of thyroid peroxidase antibodies (TPOAb) is superior to that of thyroglobulin antibodies (TgAb) for the diagnosis of Hashimoto's Thyroiditis. However, limited data are available on the comparison of TgAb and TPOAb prevalence as a diagnostic measurement for Hashimoto's Thyroiditis using sensitive immunoassays. We herein used five different current immunoassay kits (A-E) to compare the prevalence of TgAb and TPOAb in Hashimoto's Thyroiditis (n = 70), Graves' disease (n = 70), painless Thyroiditis (n = 50), and healthy control subjects (n = 100). In patients with Hashimoto's Thyroiditis, positive TgAb was significantly more frequent than positive TPOAb in kits A-D (mean ± SD of the four kits: 98.6 ± 1.7 vs 81.4 ± 2.0%). In patients with Graves' disease, TgAb prevalence was almost equivalent to that of TPOAb in five kits. Patients with painless Thyroiditis exhibited positive TgAb significantly more frequently than positive TPOAb in kits A-D (73.5 ± 4.1 vs 33.0 ± 3.4%). The prevalence of TgAb alone was significantly higher than that of TPOAb alone in both Hashimoto's Thyroiditis and painless Thyroiditis in kits A-D. In kit E, TgAb and TPOAb prevalence did not differ significantly for any disease, and TgAb distribution was different from other kits. In conclusion, the prevalence of TgAb was higher than that of TPOAb in patients with Hashimoto's Thyroiditis and painless Thyroiditis using commercially available kits. We suggest that TgAb immunoassay is the first choice of screening test for thyroid autoimmune abnormalities in Japan.
-
distinct histopathological features of hashimoto s Thyroiditis with respect to igg4 related disease
Modern Pathology, 2012Co-Authors: Gengyin Zhou, Yanhua Bai, Zhiyan Liu, Takashi Ozaki, Emiko Taniguchi, Kennichi Kakudo, Eijun Nishihara, Fumio Matsuzuka, Akira MiyauchiAbstract:A form of Hashimoto’s Thyroiditis with lymphoplasmacytic sclerosing changes and increased numbers of IgG4-positive plasma cells has recently been reported in the literature. These histopathological features suggest that this subtype of Hashimoto’s Thyroiditis may be closely related to IgG4-related disease. Therefore, this unique form of IgG4-related Hashimoto’s Thyroiditis, which is referred to as IgG4 Thyroiditis, has its own clinical, serological, and sonographic features that are distinct from those associated with non-IgG4 Thyroiditis. IgG4 Thyroiditis shares similarities with the well-known fibrous variant of Hashimoto’s Thyroiditis; however, the detailed histopathological features of IgG4 Thyroiditis have not been well established. Based on immunostaining results, 105 patients with Hashimoto’s Thyroiditis were divided into an IgG4 Thyroiditis group (n=28) and a non-IgG4 Thyroiditis group (n=77). As in our previous reports, IgG4 Thyroiditis was associated with a patient population of a younger age, a lower female-to-male ratio, rapid progression, higher levels of thyroid autoantibodies, subclinical hypothyroidism, and diffuse sonographic echogenicity. Histopathologically, this group revealed severe lymphoplasmacytic infiltration, dense stromal fibrosis, marked follicular cell degeneration, numerous micro-follicles, and notable giant cell/histiocyte infiltration. Importantly, the IgG4-related group did not completely overlap with fibrous variant of Hashimoto’s Thyroiditis. Four cases (14%) in the IgG4 Thyroiditis group presented only mild fibrosis in the stroma, whereas 29 cases (38%) in the non-IgG4 Thyroiditis group met the diagnostic criteria for fibrous variant of Hashimoto’s Thyroiditis. Furthermore, we observed three patterns of stromal fibrosis in Hashimoto’s Thyroiditis: interfollicular fibrosis, interlobular fibrosis, and scar fibrosis. The IgG4 Thyroiditis group was significantly associated with the presence of predominant interfollicular fibrosis. In conclusion, IgG4 Hashimoto’s Thyroiditis presents histopathological features quite distinct from its non-IgG4 counterpart.
-
What should autoimmune Thyroiditis be considered for
World Journal of Endocrine Surgery, 2012Co-Authors: Shoichi Kikuchi, Fumio Matsuzuka, Akira Miyauchi, Tsukasa Aihara, Chiaki Yasui, Hidenori Yanagi, Masao Mitsunobu, Naoki Yamanaka, Ayako Kakuno, Amit AgarwalAbstract:Hashimoto‘s Thyroiditis is an autoimmune disease that usually requires medical treatment but sometimes benefits from surgical treatment. The reasons why patients with Hashimoto‘s Thyroiditis requires thyroidectomy are (a) malignant lymphoma (b) repeated acute exacerbation of Thyroiditis and (c) concern of coexisting thyroid neoplasm from Hashimoto’s Thyroiditis. We present three patients with Hashimoto‘s Thyroiditis, a 69-year-old woman with MALT lymphoma, a 53-year-old woman with repeated episodes of neckpain and a 67-year-old woman with a coexistent benign thyroid nodule. These three patients with Hashimoto’s Thyroiditis received surgical treatment and had an excellent outcome and document that some patients with Hashimoto’s Thyroiditis warrant surgical treatment.
-
quantitative measurement of thyroid blood flow for differentiation of painless Thyroiditis from graves disease
Clinical Endocrinology, 2007Co-Authors: Hisashi Ota, Nobuyuki Amino, Shuji Fukata, Shinji Morita, Kaoru Kobayashi, Sumihisa Kubota, Naohisa Kamiyama, Akira MiyauchiAbstract:Summary Objective Differentiation between destruction-induced thyrotoxicosis and Graves’ thyrotoxicosis is important for selection of proper therapy. It is, however, often difficult to make this distinction without measurement of radioactive iodine uptake. We investigated the possibility that assessment of thyroid blood flow would allow differentiation between the two entities. Patients and measurements One hundred and fourteen untreated patients with thyrotoxicosis (56 Graves’ disease, 28 painless Thyroiditis, 30 subacute Thyroiditis) and 25 normal controls were examined. Serum levels of freeT4 (FT4), freeT3 (FT3) and TSH were measured by chemiluminescent immunoassay, and anti-TSH receptor antibodies (TSH-binding inhibitory immunoglobulin, TBII) were measured by enzyme-linked immunosorbent assay. Thyroid volume and blood flow (TBF) were measured quantitatively by ultrasonography. Results TBF was significantly higher in Graves’ disease (mean ± 1SD: 14·9 ± 6·4%, P < 0·0001) than in painless Thyroiditis (0·8 ± 0·5%), subacute Thyroiditis (0·9 ± 0·7%) and in normal controls (0·8 ± 0·5%). All patients with Graves’ disease had TBF values of more than 4% and all patients with painless Thyroiditis and subacute Thyroiditis had TBF values less than 4%. TBF values significantly correlated with values of radioactive iodine uptake (RAIU) either at 3 h (r = 0·492, P < 0·01) or 24 h (r = 0·762, P < 0·001) within the Graves’ disease and painless Thyroiditis groups. There was no relationship between TBF values and thyroid volumes or values of TBII in the Graves’ disease group. All patients with Graves’ disease had positive TBII of 15% or more. Three of 28 patients with painless Thyroiditis and one of 30 patients with subacute Thyroiditis had positive TBII. Conclusion TBF was quantitatively measured by power Doppler ultrasonography and was more effective than TBII for differentiation between destruction-induced thyrotoxicosis (painless or subacute Thyroiditis) and Graves’ thyrotoxicosis. TBF values of less than 4% in untreated thyrotoxic patients are laboratory signals of destruction-induced thyrotoxicosis and if these are determined, the radioactive iodine uptake test can be omitted for differential diagnosis of these two types of thyrotoxicosis.
Arie Berghout - One of the best experts on this subject based on the ideXlab platform.
-
postpartum Thyroiditis and autoimmune Thyroiditis in women of childbearing age recent insights and consequences for antenatal and postnatal care
Endocrine Reviews, 2001Co-Authors: Alex F Muller, H A Drexhage, Arie BerghoutAbstract:Postpartum Thyroiditis is a syndrome of transient or permanent thyroid dysfunction occurring in the first year after delivery and based on an autoimmune inflammation of the thyroid. The prevalence ranges from 5-7%. We discuss the role of antibodies (especially thyroid peroxidase antibodies), complement, activated T cells, and apoptosis in the outbreak of postpartum Thyroiditis. Postpartum Thyroiditis is conceptualized as an acute phase of autoimmune thyroid destruction in the context of an existing and ongoing process of thyroid autosensitization. From pregnancy an enhanced state of immune tolerance ensues. A rebound reaction to this pregnancy-associated immune suppression after delivery explains the aggravation of autoimmune syndromes in the puerperal period, e.g., the occurrence of clinically overt postpartum Thyroiditis. Low thyroid reserve due to autoimmune Thyroiditis is increasingly recognized as a serious health problem. 1) Thyroid autoimmunity increases the probability of spontaneous fetal loss. 2) Thyroid failure due to autoimmune Thyroiditis-often mild and subclinical-can lead to permanent and significant impairment in neuropsychological performance of the offspring. 3) Evidence is emerging that as women age subclinical hypothyroidism-as a sequel of postpartum Thyroiditis-predisposes them to cardiovascular disease. Hence, postpartum Thyroiditis is no longer considered a mild and transient disorder. Screening is considered.
Kennichi Kakudo - One of the best experts on this subject based on the ideXlab platform.
-
distinct histopathological features of hashimoto s Thyroiditis with respect to igg4 related disease
Modern Pathology, 2012Co-Authors: Gengyin Zhou, Yanhua Bai, Zhiyan Liu, Takashi Ozaki, Emiko Taniguchi, Kennichi Kakudo, Eijun Nishihara, Fumio Matsuzuka, Akira MiyauchiAbstract:A form of Hashimoto’s Thyroiditis with lymphoplasmacytic sclerosing changes and increased numbers of IgG4-positive plasma cells has recently been reported in the literature. These histopathological features suggest that this subtype of Hashimoto’s Thyroiditis may be closely related to IgG4-related disease. Therefore, this unique form of IgG4-related Hashimoto’s Thyroiditis, which is referred to as IgG4 Thyroiditis, has its own clinical, serological, and sonographic features that are distinct from those associated with non-IgG4 Thyroiditis. IgG4 Thyroiditis shares similarities with the well-known fibrous variant of Hashimoto’s Thyroiditis; however, the detailed histopathological features of IgG4 Thyroiditis have not been well established. Based on immunostaining results, 105 patients with Hashimoto’s Thyroiditis were divided into an IgG4 Thyroiditis group (n=28) and a non-IgG4 Thyroiditis group (n=77). As in our previous reports, IgG4 Thyroiditis was associated with a patient population of a younger age, a lower female-to-male ratio, rapid progression, higher levels of thyroid autoantibodies, subclinical hypothyroidism, and diffuse sonographic echogenicity. Histopathologically, this group revealed severe lymphoplasmacytic infiltration, dense stromal fibrosis, marked follicular cell degeneration, numerous micro-follicles, and notable giant cell/histiocyte infiltration. Importantly, the IgG4-related group did not completely overlap with fibrous variant of Hashimoto’s Thyroiditis. Four cases (14%) in the IgG4 Thyroiditis group presented only mild fibrosis in the stroma, whereas 29 cases (38%) in the non-IgG4 Thyroiditis group met the diagnostic criteria for fibrous variant of Hashimoto’s Thyroiditis. Furthermore, we observed three patterns of stromal fibrosis in Hashimoto’s Thyroiditis: interfollicular fibrosis, interlobular fibrosis, and scar fibrosis. The IgG4 Thyroiditis group was significantly associated with the presence of predominant interfollicular fibrosis. In conclusion, IgG4 Hashimoto’s Thyroiditis presents histopathological features quite distinct from its non-IgG4 counterpart.
-
immunohistochemistry of igg4 can help subclassify hashimoto s autoimmune Thyroiditis
Pathology International, 2009Co-Authors: Yanhua Bai, Zhiyan Liu, Takashi Ozaki, Emiko Taniguchi, Ichiro Mori, Koji Nagayama, Hirotoshi Nakamura, Kennichi KakudoAbstract:IgG4-related sclerosing disease has been recently recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis and diffuse lymphoplasmacytic infiltration by many IgG4-positive plasma cells. Similar histopathological features have often been noted in the fibrous variant of Hashimoto's autoimmune Thyroiditis, but thyroid gland involvement has been only briefly mentioned with regard to IgG4, and no immunohistochemistry for IgG4 has been reported in Hashimoto's autoimmune Thyroiditis. Herein, the purpose of the present study was to investigate the infiltration of IgG- and IgG4-positive plasma cells on immunohistochemistry for a panel of Thyroiditis samples (Hashimoto's autoimmune Thyroiditis, n= 13; subacute Thyroiditis, n= 2; lymphocytic Thyroiditis, n= 2). Cases of Hashimoto's Thyroiditis could be classified into two groups based on immunostaining of IgG4: IgG4 Thyroiditis (IgG4-related, IgG4-positive plasma cell-rich Thyroiditis) and non-IgG4 Thyroiditis (non-IgG4-related, IgG4-positive plasma cell-poor Thyroiditis). IgG4 Thyroiditis presents with severe lymphoplasmacytic infiltration, dense fibrosis, marked follicular cell degeneration, oxyphilic change and lymphoid follicle formation, while non-IgG4 Thyroiditis presents with relatively mild or absent histopathological characteristics. In conclusion, immunostaining of IgG4 can help subclassify Hashimoto's Thyroiditis; and IgG4 Thyroiditis may have a close relationship with IgG4-related sclerosing disease.
Marcus Kremer - One of the best experts on this subject based on the ideXlab platform.
-
A small subgroup of Hashimoto’s Thyroiditis is associated with IgG4-related disease
Virchows Archiv, 2016Co-Authors: Friedrich Jokisch, Irene Kleinlein, Bernhard Haller, Tanja Seehaus, Heinrich Fuerst, Marcus KremerAbstract:IgG4-related disease is a newly identified syndrome characterized by high serum IgG4 levels and increased IgG4-positive plasma cells in involved organs. The incidence of IgG4-related Thyroiditis in the Caucasian population of Europe is unknown. We investigated formalin-fixed thyroid gland samples of 216 patients (191 Hashimoto’s Thyroiditis, 5 Riedel’s Thyroiditis, and 20 goiters, as controls), morphologically, and immunohistochemically. Cases were divided into two groups: IgG4-related Hashimoto’s Thyroiditis (24 cases) together with Riedel Thyroiditis (1 case) and 171 non-IgG4-related Thyroiditis. Compared to the non-IgG4-related cases, IgG4-related Thyroiditis showed a higher IgG4/IgG ratio (0.6 vs. 0.1, p
Aysenur Cila - One of the best experts on this subject based on the ideXlab platform.
-
riedel s Thyroiditis in multifocal fibrosclerosis ct and mr imaging findings
American Journal of Neuroradiology, 2000Co-Authors: Ali Ozgen, Aysenur CilaAbstract:Summary: Riedel’s Thyroiditis is a rare disorder of unknown etiology and may be seen isolated or as a part of multifocal fibrosclerosis. It is important to distinguish Riedel’s Thyroiditis from thyroid carcinoma. Reports about imaging features of Riedel’s Thyroiditis are limited in the radiologic literature. We describe herein CT and MR imaging features of Riedel’s Thyroiditis in a case of multifocal fibrosclerosis with previously unreported radiologic observations.