The Experts below are selected from a list of 111 Experts worldwide ranked by ideXlab platform
Abba J. Kastin - One of the best experts on this subject based on the ideXlab platform.
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Lack of Effect of Steroids on Thyrotropin-Releasing Hormone (TRH) Mediated Thyrotropin (TSH) Release in Man
Neuroendocrinology, 1Co-Authors: Paul D. Woolf, David Gonzalez-barcena, Don S. Schalch, Louyse A. Lee, J.p. Arzac, A.v. Schally, Abba J. KastinAbstract:Plasma Thyrotropin levels were measured after the acute i.v. administration of 400 µg of synthetic Thyrotropin-releasing hormone (TRH) in 6 patients with Addison’s disease, 2 patients with thrombo-cyt
Thomas Gudermann - One of the best experts on this subject based on the ideXlab platform.
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Congenital Hypothyroidism Caused by Mutations in the Thyrotropin-Receptor Gene
The New England journal of medicine, 1997Co-Authors: Heiki Biebermann, Annette Grüters, Torsten Schöneberg, Thomas GudermannAbstract:To the Editor: The causes of congenital hypothyroidism are poorly understood. Recently, two different missense mutations in the extracellular domain of the Thyrotropin receptor were identified in three siblings who had elevated serum Thyrotropin concentrations but were euthyroid and had thyroid glands of normal size.1 We describe a patient with congenital hypothyroidism and thyroid hypoplasia due to two loss-of-function mutations in exon 10 of the Thyrotropin-receptor gene. At birth the patient, the firstborn infant of nonconsanguineous parents, had a blood Thyrotropin concentration of 89 mU per liter. Reexamination revealed a serum Thyrotropin concentration of 82 mU per liter (normal,
Robin J Leach - One of the best experts on this subject based on the ideXlab platform.
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Thyrotropin (TSH) Response to Thyrotropin Releasing Hormone (TRH) in Children with 18q-Syndrome † 434
Pediatric Research, 1998Co-Authors: Daniel E Hale, Jannine D Cody, Rebecca L Schaub, Celia I Kaye, Robin J LeachAbstract:Thyrotropin (TSH) Response to Thyrotropin Releasing Hormone (TRH) in Children with 18q-Syndrome † 434
Paul D. Woolf - One of the best experts on this subject based on the ideXlab platform.
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Lack of Effect of Steroids on Thyrotropin-Releasing Hormone (TRH) Mediated Thyrotropin (TSH) Release in Man
Neuroendocrinology, 1Co-Authors: Paul D. Woolf, David Gonzalez-barcena, Don S. Schalch, Louyse A. Lee, J.p. Arzac, A.v. Schally, Abba J. KastinAbstract:Plasma Thyrotropin levels were measured after the acute i.v. administration of 400 µg of synthetic Thyrotropin-releasing hormone (TRH) in 6 patients with Addison’s disease, 2 patients with thrombo-cyt
Gilbert Vassart - One of the best experts on this subject based on the ideXlab platform.
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Functional Characteristics of a Variant Thyrotropin Receptor
European journal of biochemistry, 1996Co-Authors: Massimo Tonacchera, Filomena Cetani, Sabine Costagliola, Jacqueline Van Sande, Samuel Refetoff, Gilbert VassartAbstract:A claim has been made that a variant of the human Thyrotropin receptor in which Pro52 is replaced by Thr ([Thr52]Thyrotropin receptor) is associated with autoimmune thyroid diseases and displays increased responsiveness to Thyrotropin. We have analysed the functional characteristics of this variant receptor. Equivalent numbers of of the wild type and of the variant Thyrotropin receptor, measured both by 125I-Thyrotropin binding and by flow cytofluorimetry, were transiently expressed in COS-7 cells. Under these conditions, the two receptors showed the same degree of constitutive activity for the cAMP pathway, the same affinity for bovine Thyrotropin, and a virtually identical responsiveness to bovine Thyrotropin for activation of both the cAMP and inositol-phosphate regulatory pathways. Our results show that the [Thr52]Thyrotropin receptor variant of the human Thyrotropin receptor, which is present in the 12% of the population, does not affect receptor function and represents most likely a simple polymorphism.
