The Experts below are selected from a list of 1515 Experts worldwide ranked by ideXlab platform
L. Garner - One of the best experts on this subject based on the ideXlab platform.
-
Endocrine Toxicity of Drinking Water Disinfectants. 11. Inhibition of Hepatic 5 ’-Thyroxine Deiodinase by
2016Co-Authors: Halogenated Nutrients, Jeno P. Bercz, L. GarnerAbstract:Administration of drinking water treated with chlorine-based disinfectants was shown in prior studies to interfere with thyroid function of laboratory animals. One possible mechanism is that intraalimentary redox interactions between chlorine oxides and organic and inorganic contents of the gastrointestinal tract cause formation of iodinated and chlorinated nutrients. Several halogenated organic molecules generated by this route were shown to vary in their in vivo dehalogenation and clearance. In seeking clues to the etiology of the thyroid effect, the influence of several iodinated and chlorinated amino and fatty acid isomers on 5’-deiodination of Thyroxine (T,) to triiodothyronine (T,) was studied using rat liver homogenates in this study. Several of the compounds tested inhibited conversion of T, to T,, with effective concentration comparable to the known inhibitor of the type I 5’4hyroxine Deiodinase (5’-TDI). Unexpectedly, iodinated isomers of histidine, and chlorotyrosine appeared to activate rather than decrease T, formation. Effective molar concentrations indicated that even if all of the chlorine dose ingested via drinking water would be converted into such halogenated analogs, their levels in body fluids would be too small to cause clinically detectable thyroid changes
Juan M. Guerrero - One of the best experts on this subject based on the ideXlab platform.
-
continuous light exposure modifies the nocturnal increase in rat thymus type ii Thyroxine 5 Deiodinase
Cellular and Molecular Life Sciences, 1997Co-Authors: Mohammed Soutto, Patrocinio Molinero, Juan M. GuerreroAbstract:In the present study we show that thymus type II Thyroxine Deiodinase activity exhibits a nyctohemeral profile, with basal values during the day and high values at night. This rhythmic character is dependent on neuroadrenergic input since exposure to continuous light at night completely abolished the nocturnal rise of the enzyme activity. However, treatment with isoproterenol under light exposure at night restored it.
Halogenated Nutrients - One of the best experts on this subject based on the ideXlab platform.
-
Endocrine Toxicity of Drinking Water Disinfectants. 11. Inhibition of Hepatic 5 ’-Thyroxine Deiodinase by
2016Co-Authors: Halogenated Nutrients, Jeno P. Bercz, L. GarnerAbstract:Administration of drinking water treated with chlorine-based disinfectants was shown in prior studies to interfere with thyroid function of laboratory animals. One possible mechanism is that intraalimentary redox interactions between chlorine oxides and organic and inorganic contents of the gastrointestinal tract cause formation of iodinated and chlorinated nutrients. Several halogenated organic molecules generated by this route were shown to vary in their in vivo dehalogenation and clearance. In seeking clues to the etiology of the thyroid effect, the influence of several iodinated and chlorinated amino and fatty acid isomers on 5’-deiodination of Thyroxine (T,) to triiodothyronine (T,) was studied using rat liver homogenates in this study. Several of the compounds tested inhibited conversion of T, to T,, with effective concentration comparable to the known inhibitor of the type I 5’4hyroxine Deiodinase (5’-TDI). Unexpectedly, iodinated isomers of histidine, and chlorotyrosine appeared to activate rather than decrease T, formation. Effective molar concentrations indicated that even if all of the chlorine dose ingested via drinking water would be converted into such halogenated analogs, their levels in body fluids would be too small to cause clinically detectable thyroid changes
Ronald M Lechan - One of the best experts on this subject based on the ideXlab platform.
-
regional distribution of type 2 Thyroxine Deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone
Endocrinology, 1997Co-Authors: Sungwoo Kim, Domenico Salvatore, Tibor Bartha, Gabor Legradi, Reed P Larsen, Ronald M LechanAbstract:To identify the specific locations of type 2 Deiodinase (D2) messenger RNA (mRNA) in the hypothalamus and pituitary gland and determine its regulation by thyroid hormone, we performed in situ hybridization histochemistry, Northern analysis, and quantitative RT-PCR in euthyroid, hypothyroid, and hyperthyroid rats. By in situ hybridization histochemistry, silver grains were concentrated over ependymal cells lining the floor and infralateral walls of the third ventricle extending from the rostral tip of the median eminence (ME) to the infundibular recess, surrounding blood vessels in the arcuate nucleus (ARC), and in the ME adjacent to the portal vessels and overlying the tuberoinfundibular sulci. Silver grains also accumulated over distinct cells in the midportion of the anterior pituitary. In hypothyroid animals, an increase in signal intensity was observed in the caudal hypothalamus, and a marked increase in the number of positive cells occurred in the anterior pituitary. Microdissection of the hypothalam...
Mohammed Soutto - One of the best experts on this subject based on the ideXlab platform.
-
continuous light exposure modifies the nocturnal increase in rat thymus type ii Thyroxine 5 Deiodinase
Cellular and Molecular Life Sciences, 1997Co-Authors: Mohammed Soutto, Patrocinio Molinero, Juan M. GuerreroAbstract:In the present study we show that thymus type II Thyroxine Deiodinase activity exhibits a nyctohemeral profile, with basal values during the day and high values at night. This rhythmic character is dependent on neuroadrenergic input since exposure to continuous light at night completely abolished the nocturnal rise of the enzyme activity. However, treatment with isoproterenol under light exposure at night restored it.