The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform
Vazquez Alexei - One of the best experts on this subject based on the ideXlab platform.
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Amino acid dependent formaldehyde metabolism in mammals
'Organisation for Economic Co-Operation and Development (OECD)', 2020Co-Authors: Pietzke Matthias, Burgos-barragan Guillermo, Wit Niek, Tait-mulder Jacqueline, Sumpton David, Mackay, Gillian M., Patel, Ketan J., Vazquez AlexeiAbstract:Abstract: Aldehyde dehydrogenase class 3, encoded by ADH5 in humans, catalyzes the glutathione dependent detoxification of formaldehyde. Here we show that ADH5 deficient cells turn over formaldehyde using alternative pathways starting from the reaction of formaldehyde with free amino acids. When mammalian cells are exposed to formaldehyde, the levels of the reaction products of formaldehyde with the amino acids cysteine and histidine - Timonacic and spinacine - are increased. These reactions take place spontaneously and the formation of Timonacic is reversible. The levels of Timonacic are higher in the plasma of Adh5−/− mice relative to controls and they are further increased upon administration of methanol. We conclude that mammals possess pathways of cysteine and histidine dependent formaldehyde metabolism and that Timonacic is a formaldehyde reservoir
Pietzke Matthias - One of the best experts on this subject based on the ideXlab platform.
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Amino acid dependent formaldehyde metabolism in mammals
'Organisation for Economic Co-Operation and Development (OECD)', 2020Co-Authors: Pietzke Matthias, Burgos-barragan Guillermo, Wit Niek, Tait-mulder Jacqueline, Sumpton David, Mackay, Gillian M., Patel, Ketan J., Vazquez AlexeiAbstract:Abstract: Aldehyde dehydrogenase class 3, encoded by ADH5 in humans, catalyzes the glutathione dependent detoxification of formaldehyde. Here we show that ADH5 deficient cells turn over formaldehyde using alternative pathways starting from the reaction of formaldehyde with free amino acids. When mammalian cells are exposed to formaldehyde, the levels of the reaction products of formaldehyde with the amino acids cysteine and histidine - Timonacic and spinacine - are increased. These reactions take place spontaneously and the formation of Timonacic is reversible. The levels of Timonacic are higher in the plasma of Adh5−/− mice relative to controls and they are further increased upon administration of methanol. We conclude that mammals possess pathways of cysteine and histidine dependent formaldehyde metabolism and that Timonacic is a formaldehyde reservoir
Burgos-barragan Guillermo - One of the best experts on this subject based on the ideXlab platform.
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Amino acid dependent formaldehyde metabolism in mammals
'Organisation for Economic Co-Operation and Development (OECD)', 2020Co-Authors: Pietzke Matthias, Burgos-barragan Guillermo, Wit Niek, Tait-mulder Jacqueline, Sumpton David, Mackay, Gillian M., Patel, Ketan J., Vazquez AlexeiAbstract:Abstract: Aldehyde dehydrogenase class 3, encoded by ADH5 in humans, catalyzes the glutathione dependent detoxification of formaldehyde. Here we show that ADH5 deficient cells turn over formaldehyde using alternative pathways starting from the reaction of formaldehyde with free amino acids. When mammalian cells are exposed to formaldehyde, the levels of the reaction products of formaldehyde with the amino acids cysteine and histidine - Timonacic and spinacine - are increased. These reactions take place spontaneously and the formation of Timonacic is reversible. The levels of Timonacic are higher in the plasma of Adh5−/− mice relative to controls and they are further increased upon administration of methanol. We conclude that mammals possess pathways of cysteine and histidine dependent formaldehyde metabolism and that Timonacic is a formaldehyde reservoir
Wit Niek - One of the best experts on this subject based on the ideXlab platform.
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Amino acid dependent formaldehyde metabolism in mammals
'Organisation for Economic Co-Operation and Development (OECD)', 2020Co-Authors: Pietzke Matthias, Burgos-barragan Guillermo, Wit Niek, Tait-mulder Jacqueline, Sumpton David, Mackay, Gillian M., Patel, Ketan J., Vazquez AlexeiAbstract:Abstract: Aldehyde dehydrogenase class 3, encoded by ADH5 in humans, catalyzes the glutathione dependent detoxification of formaldehyde. Here we show that ADH5 deficient cells turn over formaldehyde using alternative pathways starting from the reaction of formaldehyde with free amino acids. When mammalian cells are exposed to formaldehyde, the levels of the reaction products of formaldehyde with the amino acids cysteine and histidine - Timonacic and spinacine - are increased. These reactions take place spontaneously and the formation of Timonacic is reversible. The levels of Timonacic are higher in the plasma of Adh5−/− mice relative to controls and they are further increased upon administration of methanol. We conclude that mammals possess pathways of cysteine and histidine dependent formaldehyde metabolism and that Timonacic is a formaldehyde reservoir
Tait-mulder Jacqueline - One of the best experts on this subject based on the ideXlab platform.
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Amino acid dependent formaldehyde metabolism in mammals
'Organisation for Economic Co-Operation and Development (OECD)', 2020Co-Authors: Pietzke Matthias, Burgos-barragan Guillermo, Wit Niek, Tait-mulder Jacqueline, Sumpton David, Mackay, Gillian M., Patel, Ketan J., Vazquez AlexeiAbstract:Abstract: Aldehyde dehydrogenase class 3, encoded by ADH5 in humans, catalyzes the glutathione dependent detoxification of formaldehyde. Here we show that ADH5 deficient cells turn over formaldehyde using alternative pathways starting from the reaction of formaldehyde with free amino acids. When mammalian cells are exposed to formaldehyde, the levels of the reaction products of formaldehyde with the amino acids cysteine and histidine - Timonacic and spinacine - are increased. These reactions take place spontaneously and the formation of Timonacic is reversible. The levels of Timonacic are higher in the plasma of Adh5−/− mice relative to controls and they are further increased upon administration of methanol. We conclude that mammals possess pathways of cysteine and histidine dependent formaldehyde metabolism and that Timonacic is a formaldehyde reservoir