The Experts below are selected from a list of 1593 Experts worldwide ranked by ideXlab platform
Changfa Wang - One of the best experts on this subject based on the ideXlab platform.
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voltammetric sensor for Tinidazole based on poly carmine film modified electrode and its application
Dyes and Pigments, 2007Co-Authors: Chenghang Wang, Fang Wang, Changfa WangAbstract:Abstract A poly(carmine) film modified glassy carbon electrode (GCE) was fabricated and the electrochemical behaviors of Tinidazole were investigated by electrochemical methods at this modified electrode. A well-defined reduction peak is observed at 0.606 V. Compared with that at a bare GCE, the reduction peak potential of Tinidazole shifts negatively and the reduction peak current increases significantly at the modified electrode. The influences of some parameters on the reduction of Tinidazole were examined and a simple and sensitive electroanalytical method was developed for the determination of Tinidazole. The reduction peak current is proportional to the concentration of Tinidazole from 1 × 10 −7 to 5 × 10 −5 M. The detection limit is about 5.0 × 10 −8 M for 90 s accumulation at a constant potential of 0 V. Based on the experimental data a possible mechanism is proposed and discussed. The proposed method was applied to determine Tinidazole in drugs and the result was satisfying.
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voltammetric sensor for Tinidazole based on poly carmine film modified electrode and its application
Journal of Pharmaceutical and Biomedical Analysis, 2006Co-Authors: Chenghang Wang, Fang Wang, Changfa WangAbstract:Abstract A poly(carmine) film-modified glassy carbon electrode (GCE) was fabricated and the electrochemical behavior of Tinidazole at the modified electrode was investigated by electrochemical methods. A well-defined reduction peak was observed at 0.61 V and was applied for the determination of Tinidazole. Compared with that at a bare GCE, the reduction peak potential of Tinidazole shifted negatively and the reduction peak current increased significantly. The influences of some parameters on the reduction of Tinidazole were also examined. Based on the experimental data, a possible mechanism was proposed for the electrochemical reaction of Tinidazole at the modified electrode. It was found that the reduction peak current was proportional to the concentration of Tinidazole in the range from 1.0 × 10 −7 to 5.0 × 10 −5 mol L −1 . The detection limit was about 1.0 × 10 −8 mol L −1 after accumulation 90 s at a constant potential of 0.0 V. The proposed method was applied to determine Tinidazole in drugs and the result was satisfied.
Chenghang Wang - One of the best experts on this subject based on the ideXlab platform.
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voltammetric sensor for Tinidazole based on poly carmine film modified electrode and its application
Dyes and Pigments, 2007Co-Authors: Chenghang Wang, Fang Wang, Changfa WangAbstract:Abstract A poly(carmine) film modified glassy carbon electrode (GCE) was fabricated and the electrochemical behaviors of Tinidazole were investigated by electrochemical methods at this modified electrode. A well-defined reduction peak is observed at 0.606 V. Compared with that at a bare GCE, the reduction peak potential of Tinidazole shifts negatively and the reduction peak current increases significantly at the modified electrode. The influences of some parameters on the reduction of Tinidazole were examined and a simple and sensitive electroanalytical method was developed for the determination of Tinidazole. The reduction peak current is proportional to the concentration of Tinidazole from 1 × 10 −7 to 5 × 10 −5 M. The detection limit is about 5.0 × 10 −8 M for 90 s accumulation at a constant potential of 0 V. Based on the experimental data a possible mechanism is proposed and discussed. The proposed method was applied to determine Tinidazole in drugs and the result was satisfying.
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voltammetric sensor for Tinidazole based on poly carmine film modified electrode and its application
Journal of Pharmaceutical and Biomedical Analysis, 2006Co-Authors: Chenghang Wang, Fang Wang, Changfa WangAbstract:Abstract A poly(carmine) film-modified glassy carbon electrode (GCE) was fabricated and the electrochemical behavior of Tinidazole at the modified electrode was investigated by electrochemical methods. A well-defined reduction peak was observed at 0.61 V and was applied for the determination of Tinidazole. Compared with that at a bare GCE, the reduction peak potential of Tinidazole shifted negatively and the reduction peak current increased significantly. The influences of some parameters on the reduction of Tinidazole were also examined. Based on the experimental data, a possible mechanism was proposed for the electrochemical reaction of Tinidazole at the modified electrode. It was found that the reduction peak current was proportional to the concentration of Tinidazole in the range from 1.0 × 10 −7 to 5.0 × 10 −5 mol L −1 . The detection limit was about 1.0 × 10 −8 mol L −1 after accumulation 90 s at a constant potential of 0.0 V. The proposed method was applied to determine Tinidazole in drugs and the result was satisfied.
Jack D. Sobel - One of the best experts on this subject based on the ideXlab platform.
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guidelines for the treatment of bacterial vaginosis focus on Tinidazole
Therapeutics and Clinical Risk Management, 2009Co-Authors: Laura J Dickey, Michael D Nailor, Jack D. SobelAbstract:Bacterial vaginosis (BV) is a complex vaginal infection most commonly associated with women of child-bearing age. Risk factors for BV are numerous. There are currently multiple clinical and laboratory tests for diagnosis of BV, including the most commonly used diagnostic methods: Amsel’s criteria or Nugent’s Gram stain scale. The mainstay of BV therapy is metronidazole, but Tinidazole as well as a few other agents have also been used successfully. Tinidazole is the second nitroimidazole antiprotozoal agent and a structural derivative of metronidazole. With a favorable pharmacokinetic profile and reduced side effects, Tinidazole is an alternative agent for BV treatment. There are minimal head-to-head comparative data to establish Tinidazole’s superiority to metronidazole or other therapeutic agents. Available data suggest Tinidazole has a role in special populations particularly for refractory or relapsing BV.
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Guidelines for the treatment of bacterial vaginosis: focus on Tinidazole
Dove Medical Press, 2009Co-Authors: Laura J Dickey, Michael D Nailor, Jack D. SobelAbstract:Laura J Dickey1, Michael D Nailor2,3, Jack D Sobel41Department of Pharmacy Services, Detroit Receiving Hospital, Detroit, MI, USA; 2University of Connecticut, School of Pharmacy, Storrs, CT, USA; 3Hartford Hospital, Department of Pharmacy, Hartford, CT, USA; 4Wayne State University, School of Medicine, Detroit, MI, USAAbstract: Bacterial vaginosis (BV) is a complex vaginal infection most commonly associated with women of child-bearing age. Risk factors for BV are numerous. There are currently multiple clinical and laboratory tests for diagnosis of BV, including the most commonly used diagnostic methods: Amsel’s criteria or Nugent’s Gram stain scale. The mainstay of BV therapy is metronidazole, but Tinidazole as well as a few other agents have also been used successfully. Tinidazole is the second nitroimidazole antiprotozoal agent and a structural derivative of metronidazole. With a favorable pharmacokinetic profile and reduced side effects, Tinidazole is an alternative agent for BV treatment. There are minimal head-to-head comparative data to establish Tinidazole’s superiority to metronidazole or other therapeutic agents. Available data suggest Tinidazole has a role in special populations particularly for refractory or relapsing BV.Keywords: bacterial vaginosis, vaginosis, Tinidazole, Gardnerell
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Tinidazole for bacterial vaginosis
Expert Review of Anti-infective Therapy, 2007Co-Authors: Michael D Nailor, Jack D. SobelAbstract:Tinidazole has been used for bacterial vaginosis (BV) outside the USA for almost four decades. Tinidazole has recently been resurrected and FDA approved for trichomoniasis and BV in the USA and is being restudied as an alternative to metronidazole for BV. In vitro antimicrobial activity and pharmacokinetics studies indicate that when compared directly with metronidazole, Tinidazole has minor but possibly relevant antimicrobial as well as pharmacokinetic advantages. Clinical comparisons have been infrequent, although the limited head-to-head studies indicate minimal therapeutic advantage with Tinidazole. Perhaps the more relevant differences relate to the enhanced tolerance and reduced toxicity of Tinidazole. Currently, studies are still ongoing directly comparing the clinical efficacy of metronidazole and Tinidazole. These studies should establish the role of Tinidazole in the treatment of BV; however, cure rates are unlikely to be significantly different.
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Tinidazole for the treatment of vaginal infections
Expert Opinion on Investigational Drugs, 2007Co-Authors: Michael D Nailor, Jack D. SobelAbstract:Tinidazole has been used for vaginal infection worldwide but not in the US for > 40 years. Recently, Tinidazole has been re-introduced and approved by the FDA for trichomoniasis and restudied as an alternative to metronidazole for bacterial vaginosis. In vitro antimicrobial activity and pharmacokinetics studies indicate that Tinidazole has minor but possibly relevant antimicrobial as well as pharmacokinetic advantages when compared directly with metronidazole. Clinical comparison has been infrequent although the limited head-to-head studies indicate minimal therapeutic advantage with Tinidazole. Perhaps the more relevant differences relate to the enhanced tolerance and reduced toxicity of Tinidazole. Ongoing, as yet incomplete, studies directly comparing the clinical efficacy of metronidazole and Tinidazole for bacterial vaginosis should clarify the status of Tinidazole; however, cure rates are unlikely to be significantly different. Although uncommon, high-level trichomonal metronidazole resistance can be reliably cured by using Tinidazole, which is an invaluable advantage.
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Tinidazole Therapy for Metronidazole-Resistant Vaginal Trichomoniasis
Clinical Infectious Diseases, 2001Co-Authors: Jack D. Sobel, P. Nyirjesy, William J. BrownAbstract:Treatment of patients with metronidazole-refractory vaginal trichomoniasis constitutes a major therapeutic challenge, and treatment options are extremely limited. Although the majority of patients infected with trichomonads, who demonstrate reduced in vitro susceptibility to metronidazole, respond to high-dose but poorly tolerated regimens of metronidazole, clinical failure is by no means uncommon. We report a cure rate of 22 (92%) of 24 patients with refractory trichomoniasis treated with high doses of oral and vaginal Tinidazole. This series included 15 cases with increased in vitro minimal lethal concentration values of metronidazole. Tinidazole, despite the high doses used, was extremely well tolerated, with few side effects. Topical paromomycin was effective in 7 (58%) of 12 patients treated, but frequent local vulvovaginal adverse reactions precluded extensive use. Widespread reports of metronidazole resistance and limited treatment options emphasize the need for additional trichomonacidal agents.
W. Evan Secor - One of the best experts on this subject based on the ideXlab platform.
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In Vitro Metronidazole and Tinidazole Activities against Metronidazole- Resistant Strains of Trichomonas vaginalis
Antimicrobial agents and chemotherapy, 2003Co-Authors: Andrea L. Crowell, Kolby Sanders-lewis, W. Evan SecorAbstract:The in vitro activities of Tinidazole and metronidazole against Trichomonas vaginalis isolates clinically resistant to metronidazole were compared. Minimal lethal concentrations (MLCs) of Tinidazole were significantly lower than MLCs of metronidazole. Increased metronidazole resistance correlated with increased Tinidazole resistance. These data support a role for Tinidazole in the treatment of trichomoniasis.
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in vitro effect of Tinidazole and furazolidone on metronidazole resistant trichomonas vaginalis
Antimicrobial Agents and Chemotherapy, 1996Co-Authors: E M Narcisi, W. Evan SecorAbstract:Trichomonas vaginalis is a common sexually transmitted protozoan parasite. Although often considered simply a nuisance infection, T. vaginalis has been implicated in premature rupture of placental membranes and increases in the risk of acquiring human immunodeficiency virus. Metronidazole, a 5-nitroimidazole, is currently the drug of choice to treat T. vaginalis infection. Because some patients have severe reactions to metronidazole and others are infected with metronidazole-resistant T. vaginalis, we were prompted to investigate alternative therapies. Tinidazole, another 5-nitroimidazole used in other countries to treat T. vaginalis infections, and furazolidone, a nitrofuran presently used to treat giardiasis and infections with some anaerobic enteric bacteria, were investigated for effectiveness against 9 metronidazole-susceptible and 12 metronidazole-resistant T. vaginalis patient isolates. The in vitro aerobic and anaerobic minimum lethal concentrations (MLC) and the time for drug efficacy were determined. Tinidazole killed the metronidazole-susceptible isolates at a low MLC but was effective against only 4 of the 12 metronidazole-resistant isolates. In contrast, furazolidone was effective at a low MLC for all isolates. When Tinidazole was effective, it required > 6 h to kill trichomonads. However, furazolidone killed both metronidazole-susceptible and resistant trichomonads within 2 to 3 h of exposure. These data suggest that furazolidone may be a good candidate for treating metronidazole-resistant trichomoniasis and that further investigation of this drug is warranted.
Fang Wang - One of the best experts on this subject based on the ideXlab platform.
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voltammetric sensor for Tinidazole based on poly carmine film modified electrode and its application
Dyes and Pigments, 2007Co-Authors: Chenghang Wang, Fang Wang, Changfa WangAbstract:Abstract A poly(carmine) film modified glassy carbon electrode (GCE) was fabricated and the electrochemical behaviors of Tinidazole were investigated by electrochemical methods at this modified electrode. A well-defined reduction peak is observed at 0.606 V. Compared with that at a bare GCE, the reduction peak potential of Tinidazole shifts negatively and the reduction peak current increases significantly at the modified electrode. The influences of some parameters on the reduction of Tinidazole were examined and a simple and sensitive electroanalytical method was developed for the determination of Tinidazole. The reduction peak current is proportional to the concentration of Tinidazole from 1 × 10 −7 to 5 × 10 −5 M. The detection limit is about 5.0 × 10 −8 M for 90 s accumulation at a constant potential of 0 V. Based on the experimental data a possible mechanism is proposed and discussed. The proposed method was applied to determine Tinidazole in drugs and the result was satisfying.
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voltammetric sensor for Tinidazole based on poly carmine film modified electrode and its application
Journal of Pharmaceutical and Biomedical Analysis, 2006Co-Authors: Chenghang Wang, Fang Wang, Changfa WangAbstract:Abstract A poly(carmine) film-modified glassy carbon electrode (GCE) was fabricated and the electrochemical behavior of Tinidazole at the modified electrode was investigated by electrochemical methods. A well-defined reduction peak was observed at 0.61 V and was applied for the determination of Tinidazole. Compared with that at a bare GCE, the reduction peak potential of Tinidazole shifted negatively and the reduction peak current increased significantly. The influences of some parameters on the reduction of Tinidazole were also examined. Based on the experimental data, a possible mechanism was proposed for the electrochemical reaction of Tinidazole at the modified electrode. It was found that the reduction peak current was proportional to the concentration of Tinidazole in the range from 1.0 × 10 −7 to 5.0 × 10 −5 mol L −1 . The detection limit was about 1.0 × 10 −8 mol L −1 after accumulation 90 s at a constant potential of 0.0 V. The proposed method was applied to determine Tinidazole in drugs and the result was satisfied.
