The Experts below are selected from a list of 1854 Experts worldwide ranked by ideXlab platform
Henri A. Bergoënd - One of the best experts on this subject based on the ideXlab platform.
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Tiopronin-induced lichenoid eruption
Journal of the American Academy of Dermatology, 1994Co-Authors: Eric Piérard, Emmanuel Delaporte, René-marc Flipo, Valérie Duneton-bitbol, Yves Dejobert, Frédéric Piette, Henri A. BergoëndAbstract:Sulfhydryl drugs such as D-penicillamine or captopril have many side effects, notably cutaneous eruptions. 1-3Tiopronin (Thiola.Acadione) is a sulfhydryl drug that is prescribed primarily for the treatment of cystinuria. It was recently proposed for the treatment of rheumatoid arthritis. Its efficacy is comparable to D-penicillamine. Among the side effects of Tiopronin, cutaneous reactions are the most common and occur in 10% to 32% of patients." These reactions include pruritus, stomatitis," pemphigus6 maculopapular exanthems, erythemamultiforme, andeczematous eruptions.3 Lichenoid eruptions caused by Tiopronin appear to be rare. In Japan, where this drug has been prescribed for more than 15 years, eight cases have been reported.' To our knowledge this is the first documented French case.
Shengtai He - One of the best experts on this subject based on the ideXlab platform.
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size dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells multicellular spheroids and tumors in vivo
ACS Nano, 2012Co-Authors: Keyang Huang, Juan Liu, Shuaidong Huo, Anil Kumar, Tuo Wei, Xu Zhang, Shubin Jin, Yaling Gan, Paul C Wang, Shengtai HeAbstract:This work demonstrated that ultrasmall gold nanoparticles (AuNPs) smaller than 10 nm display unique advantages over nanoparticles larger than 10 nm in terms of localization to, and penetration of, breast cancer cells, multicellular tumor spheroids, and tumors in mice. Au@Tiopronin nanoparticles that have tunable sizes from 2 to 15 nm with identical surface coatings of Tiopronin and charge were successfully prepared. For monolayer cells, the smaller the Au@Tiopronin NPs, the more AuNPs found in each cell. In addition, the accumulation of Au NPs in the ex vivo tumor model was size-dependent: smaller AuNPs were able to penetrate deeply into tumor spheroids, whereas 15 nm nanoparticles were not. Owing to their ultrasmall nanostructure, 2 and 6 nm nanoparticles showed high levels of accumulation in tumor tissue in mice after a single intravenous injection. Surprisingly, both 2 and 6 nm Au@Tiopronin nanoparticles were distributed throughout the cytoplasm and nucleus of cancer cells in vitro and in vivo, whereas...
Keyang Huang - One of the best experts on this subject based on the ideXlab platform.
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size dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells multicellular spheroids and tumors in vivo
ACS Nano, 2012Co-Authors: Keyang Huang, Juan Liu, Shuaidong Huo, Anil Kumar, Tuo Wei, Xu Zhang, Shubin Jin, Yaling Gan, Paul C Wang, Shengtai HeAbstract:This work demonstrated that ultrasmall gold nanoparticles (AuNPs) smaller than 10 nm display unique advantages over nanoparticles larger than 10 nm in terms of localization to, and penetration of, breast cancer cells, multicellular tumor spheroids, and tumors in mice. Au@Tiopronin nanoparticles that have tunable sizes from 2 to 15 nm with identical surface coatings of Tiopronin and charge were successfully prepared. For monolayer cells, the smaller the Au@Tiopronin NPs, the more AuNPs found in each cell. In addition, the accumulation of Au NPs in the ex vivo tumor model was size-dependent: smaller AuNPs were able to penetrate deeply into tumor spheroids, whereas 15 nm nanoparticles were not. Owing to their ultrasmall nanostructure, 2 and 6 nm nanoparticles showed high levels of accumulation in tumor tissue in mice after a single intravenous injection. Surprisingly, both 2 and 6 nm Au@Tiopronin nanoparticles were distributed throughout the cytoplasm and nucleus of cancer cells in vitro and in vivo, whereas...
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Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo
2012Co-Authors: Keyang Huang, Juan Liu, Shuaidong Huo, Anil Kumar, Tuo Wei, Xu Zhang, Shubin Jin, Yaling Gan, Paul C WangAbstract:This work demonstrated that ultrasmall gold nanoparticles (AuNPs) smaller than 10 nm display unique advantages over nanoparticles larger than 10 nm in terms of localization to, and penetration of, breast cancer cells, multicellular tumor spheroids, and tumors in mice. Au@Tiopronin nanoparticles that have tunable sizes from 2 to 15 nm with identical surface coatings of Tiopronin and charge were successfully prepared. For monolayer cells, the smaller the Au@Tiopronin NPs, the more AuNPs found in each cell. In addition, the accumulation of Au NPs in the ex vivo tumor model was size-dependent: smaller AuNPs were able to penetrate deeply into tumor spheroids, whereas 15 nm nanoparticles were not. Owing to their ultrasmall nanostructure, 2 and 6 nm nanoparticles showed high levels of accumulation in tumor tissue in mice after a single intravenous injection. Surprisingly, both 2 and 6 nm Au@Tiopronin nanoparticles were distributed throughout the cytoplasm and nucleus of cancer cells in vitro and in vivo, whereas 15 nm Au@Tiopronin nanoparticles were found only in the cytoplasm, where they formed aggregates. The ex vivo multicellular spheroid proved to be a good model to simulate in vivo tumor tissue and evaluate nanoparticle penetration behavior. This work gives important insights into the design and functionalization of nanoparticles to achieve high levels of accumulation in tumors
Eric Piérard - One of the best experts on this subject based on the ideXlab platform.
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Tiopronin-induced lichenoid eruption
Journal of the American Academy of Dermatology, 1994Co-Authors: Eric Piérard, Emmanuel Delaporte, René-marc Flipo, Valérie Duneton-bitbol, Yves Dejobert, Frédéric Piette, Henri A. BergoëndAbstract:Sulfhydryl drugs such as D-penicillamine or captopril have many side effects, notably cutaneous eruptions. 1-3Tiopronin (Thiola.Acadione) is a sulfhydryl drug that is prescribed primarily for the treatment of cystinuria. It was recently proposed for the treatment of rheumatoid arthritis. Its efficacy is comparable to D-penicillamine. Among the side effects of Tiopronin, cutaneous reactions are the most common and occur in 10% to 32% of patients." These reactions include pruritus, stomatitis," pemphigus6 maculopapular exanthems, erythemamultiforme, andeczematous eruptions.3 Lichenoid eruptions caused by Tiopronin appear to be rare. In Japan, where this drug has been prescribed for more than 15 years, eight cases have been reported.' To our knowledge this is the first documented French case.
Paul C Wang - One of the best experts on this subject based on the ideXlab platform.
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size dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells multicellular spheroids and tumors in vivo
ACS Nano, 2012Co-Authors: Keyang Huang, Juan Liu, Shuaidong Huo, Anil Kumar, Tuo Wei, Xu Zhang, Shubin Jin, Yaling Gan, Paul C Wang, Shengtai HeAbstract:This work demonstrated that ultrasmall gold nanoparticles (AuNPs) smaller than 10 nm display unique advantages over nanoparticles larger than 10 nm in terms of localization to, and penetration of, breast cancer cells, multicellular tumor spheroids, and tumors in mice. Au@Tiopronin nanoparticles that have tunable sizes from 2 to 15 nm with identical surface coatings of Tiopronin and charge were successfully prepared. For monolayer cells, the smaller the Au@Tiopronin NPs, the more AuNPs found in each cell. In addition, the accumulation of Au NPs in the ex vivo tumor model was size-dependent: smaller AuNPs were able to penetrate deeply into tumor spheroids, whereas 15 nm nanoparticles were not. Owing to their ultrasmall nanostructure, 2 and 6 nm nanoparticles showed high levels of accumulation in tumor tissue in mice after a single intravenous injection. Surprisingly, both 2 and 6 nm Au@Tiopronin nanoparticles were distributed throughout the cytoplasm and nucleus of cancer cells in vitro and in vivo, whereas...
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Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo
2012Co-Authors: Keyang Huang, Juan Liu, Shuaidong Huo, Anil Kumar, Tuo Wei, Xu Zhang, Shubin Jin, Yaling Gan, Paul C WangAbstract:This work demonstrated that ultrasmall gold nanoparticles (AuNPs) smaller than 10 nm display unique advantages over nanoparticles larger than 10 nm in terms of localization to, and penetration of, breast cancer cells, multicellular tumor spheroids, and tumors in mice. Au@Tiopronin nanoparticles that have tunable sizes from 2 to 15 nm with identical surface coatings of Tiopronin and charge were successfully prepared. For monolayer cells, the smaller the Au@Tiopronin NPs, the more AuNPs found in each cell. In addition, the accumulation of Au NPs in the ex vivo tumor model was size-dependent: smaller AuNPs were able to penetrate deeply into tumor spheroids, whereas 15 nm nanoparticles were not. Owing to their ultrasmall nanostructure, 2 and 6 nm nanoparticles showed high levels of accumulation in tumor tissue in mice after a single intravenous injection. Surprisingly, both 2 and 6 nm Au@Tiopronin nanoparticles were distributed throughout the cytoplasm and nucleus of cancer cells in vitro and in vivo, whereas 15 nm Au@Tiopronin nanoparticles were found only in the cytoplasm, where they formed aggregates. The ex vivo multicellular spheroid proved to be a good model to simulate in vivo tumor tissue and evaluate nanoparticle penetration behavior. This work gives important insights into the design and functionalization of nanoparticles to achieve high levels of accumulation in tumors
