The Experts below are selected from a list of 23883 Experts worldwide ranked by ideXlab platform
Anthony Atala - One of the best experts on this subject based on the ideXlab platform.
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carbon nanotube applications for Tissue Engineering
Biomaterials, 2007Co-Authors: Benjamin S Harrison, Anthony AtalaAbstract:As the field of Tissue Engineering advances, new tools for better monitoring and evaluating of engineered Tissues along with new bioMaterials to direct Tissue growth are needed. Carbon nanotubes may be an important Tissue Engineering Material for improved tracking of cells, sensing of microenvironments, delivering of transfection agents, and scaffolding for incorporating with the host's body. Using carbon nanotubes for optical, magnetic resonance and radiotracer contrast agents would provide better means of evaluating Tissue formation. In addition, monitoring and altering intra and intercellular processes would be useful for design of better engineered Tissues. Carbon nanotubes can also be incorporated into scaffolds providing structural reinforcement as well as imparting novel properties such as electrical conductivity into the scaffolds may aid in directing cell growth. Potential cytotoxic effects associated with carbon nanotubes may be mitigated by chemically functionalizing the surface. Overall, carbon nanotubes may play an integral role as unique bioMaterial for creating and monitoring engineered Tissue.
Fan Zhang - One of the best experts on this subject based on the ideXlab platform.
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a novel high mechanical property plga composite matrix loaded with nanodiamond phospholipid compound for bone Tissue Engineering
ACS Applied Materials & Interfaces, 2016Co-Authors: Fan Zhang, Qingxin Song, Xuan Huang, Kun Wang, Yixing Tang, Canglong Hou, Hongxing ShenAbstract:A potential bone Tissue Engineering Material was produced from a biodegradable polymer, poly(lactic-co-glycolic acid) (PLGA), loaded with nanodiamond phospholipid compound (NDPC) via physical mixing. On the basis of hydrophobic effects and physical absorption, we modified the original hydrophilic surface of the nanodiamond (NDs) with phospholipids to be amphipathic, forming a typical core-shell structure. The ND-phospholipid weight ratio was optimized to generate sample NDPC50 (i.e., ND-phospholipid weight ratio of 100:50), and NDPC50 was able to be dispersed in a PLGA matrix at up to 20 wt %. Compared to a pure PLGA matrix, the introduction of 10 wt % of NDPC (i.e., sample NDPC50-PF10) resulted in a significant improvement in the Material's mechanical and surface properties, including a decrease in the water contact angle from 80 to 55°, an approximately 100% increase in the Young's modulus, and an approximate 550% increase in hardness, thus closely resembling that of human cortical bone. As a novel matrix supporting human osteoblast (hFOB1.19) growth, NDPC50-PFs with different amounts of NDPC50 demonstrated no negative effects on cell proliferation and osteogenic differentiation. Furthermore, we focused on the behaviors of NDPC-PFs implanted into mice for 8 weeks and found that NDPC-PFs induced acceptable immune response and can reduce the rapid biodegradation of PLGA matrix. Our results represent the first in vivo research on ND (or NDPC) as nanofillers in a polymer matrix for bone Tissue Engineering. The high mechanical properties, good in vitro and in vivo biocompatibility, and increased mineralization capability suggest that biodegradable PLGA composite matrices loaded with NDPC may potentially be useful for a variety of biomedical applications, especially bone Tissue Engineering.
Benjamin S Harrison - One of the best experts on this subject based on the ideXlab platform.
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carbon nanotube applications for Tissue Engineering
Biomaterials, 2007Co-Authors: Benjamin S Harrison, Anthony AtalaAbstract:As the field of Tissue Engineering advances, new tools for better monitoring and evaluating of engineered Tissues along with new bioMaterials to direct Tissue growth are needed. Carbon nanotubes may be an important Tissue Engineering Material for improved tracking of cells, sensing of microenvironments, delivering of transfection agents, and scaffolding for incorporating with the host's body. Using carbon nanotubes for optical, magnetic resonance and radiotracer contrast agents would provide better means of evaluating Tissue formation. In addition, monitoring and altering intra and intercellular processes would be useful for design of better engineered Tissues. Carbon nanotubes can also be incorporated into scaffolds providing structural reinforcement as well as imparting novel properties such as electrical conductivity into the scaffolds may aid in directing cell growth. Potential cytotoxic effects associated with carbon nanotubes may be mitigated by chemically functionalizing the surface. Overall, carbon nanotubes may play an integral role as unique bioMaterial for creating and monitoring engineered Tissue.
Oh Hyeong Kwon - One of the best experts on this subject based on the ideXlab platform.
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a composite of hydroxyapatite with electrospun biodegradable nanofibers as a Tissue Engineering Material
Journal of Bioscience and Bioengineering, 2005Co-Authors: Yoshihiro Ito, Hirokazu Hasuda, Masanobu Kamitakahara, Chikara Ohtsuki, Masao Tanihara, Innkyu Kang, Oh Hyeong KwonAbstract:Biodegradable and biocompatible poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), a copolymer of microbial polyester, was fabricated as a nanofibrous film by electrospinning and composited with hydroxyapatite (HAp) by soaking in simulated body fluid. Compared with a PHBV cast (flat) film, the electrospun PHBV nanofibrous film was hydrophobic. However, after HAp deposition, both of the surfaces were extremely hydrophilic. The degradation rate of HAp/PHBV nanofibrous films in the presence of polyhydroxybutyrate depolymerase was very fast. Nanofiber formation increased the specific surface area and HAp enhanced the invasion of enzyme into the film by increasing surface hydrophilicity. The surface of the nanofibrous film showed enhanced cell adhesion over that of the flat film, although cell adhesion was not significantly affected by the combination with HAp.
Hongxing Shen - One of the best experts on this subject based on the ideXlab platform.
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a novel high mechanical property plga composite matrix loaded with nanodiamond phospholipid compound for bone Tissue Engineering
ACS Applied Materials & Interfaces, 2016Co-Authors: Fan Zhang, Qingxin Song, Xuan Huang, Kun Wang, Yixing Tang, Canglong Hou, Hongxing ShenAbstract:A potential bone Tissue Engineering Material was produced from a biodegradable polymer, poly(lactic-co-glycolic acid) (PLGA), loaded with nanodiamond phospholipid compound (NDPC) via physical mixing. On the basis of hydrophobic effects and physical absorption, we modified the original hydrophilic surface of the nanodiamond (NDs) with phospholipids to be amphipathic, forming a typical core-shell structure. The ND-phospholipid weight ratio was optimized to generate sample NDPC50 (i.e., ND-phospholipid weight ratio of 100:50), and NDPC50 was able to be dispersed in a PLGA matrix at up to 20 wt %. Compared to a pure PLGA matrix, the introduction of 10 wt % of NDPC (i.e., sample NDPC50-PF10) resulted in a significant improvement in the Material's mechanical and surface properties, including a decrease in the water contact angle from 80 to 55°, an approximately 100% increase in the Young's modulus, and an approximate 550% increase in hardness, thus closely resembling that of human cortical bone. As a novel matrix supporting human osteoblast (hFOB1.19) growth, NDPC50-PFs with different amounts of NDPC50 demonstrated no negative effects on cell proliferation and osteogenic differentiation. Furthermore, we focused on the behaviors of NDPC-PFs implanted into mice for 8 weeks and found that NDPC-PFs induced acceptable immune response and can reduce the rapid biodegradation of PLGA matrix. Our results represent the first in vivo research on ND (or NDPC) as nanofillers in a polymer matrix for bone Tissue Engineering. The high mechanical properties, good in vitro and in vivo biocompatibility, and increased mineralization capability suggest that biodegradable PLGA composite matrices loaded with NDPC may potentially be useful for a variety of biomedical applications, especially bone Tissue Engineering.