Tissue Perfusion

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Stokes, Simo M. - One of the best experts on this subject based on the ideXlab platform.

  • Lamellar energy metabolism and Perfusion in the euglycaemic hyperinsulinaemic clamp model of equine laminitis
    'Wiley', 2020
    Co-Authors: Stokes, Simo M., Ertin, Francois R., Stefanovski Darko, Elknap, James K., Medina‐torres, Carlos E., Pollitt, Christophe C., Eps, Andrew W.
    Abstract:

    Hyperinsulinaemia is associated with the development of endocrinopathic laminitis; however, the mechanisms remain unclear.Evaluate the effects of hyperinsulinaemia on lamellar energy metabolism and Perfusion during laminitis development.In vivo experiment.Eight Standardbred horses were instrumented with a microdialysis probe in the lamellae of a forelimb. A 24\ua0hours baseline period (BASELINE) was followed by 48\ua0hours of a continuous euglycaemic hyperinsulinaemic clamp (EHC) from 24 to 72\ua0hours (CLAMP). Microdialysate was collected every 6\ua0hours and analysed for glucose, lactate and pyruvate concentrations and lactate-to-pyruvate ratio (L:P). Microdialysis urea clearance was used to estimate lamellar Tissue Perfusion. Archived microdialysis samples from six identically instrumented Standardbred horses served as controls (CON). Variables were compared over time and between EHC and CON horses using a mixed-effects linear regression model.Glucose concentration decreased during the CLAMP period in CON and EHC horses (P\ua0\ua0.9). Lactate concentration increased during the CLAMP period in CON and EHC horses (P\ua

  • The effect of continuous digital hypothermia on lamellar energy metabolism and Perfusion during laminitis development in two experimental models
    'Wiley', 2020
    Co-Authors: Stokes, Simo M., Stefanovski Darko, Elknap, James K., Pollitt, Christophe C., Erti Francois-rene, Poulse Lea, Medina-torres, Carlos E., Van Eps, Andrew W.
    Abstract:

    Background: Continuous digital hypothermia (CDH) prevents lamellar failure in the euglycaemic hyperinsulinaemic clamp (EHC) and oligofructose (OF) laminitis models, but the mechanisms remain unclear. Objectives: To evaluate the effects of CDH on lamellar energy metabolism and Perfusion in healthy horses and during EHC and OF laminitis models. Study design: In vivo experiment. Methods: Archived samples were used from Standardbred geldings that received no treatment (CON) (n\ua0=\ua08) or underwent EHC (n\ua0=\ua08) or OF (n\ua0=\ua06) laminitis models. Both forelimbs were instrumented with a lamellar microdialysis system, and one forelimb was cooled (CDH) with the other maintained at ambient temperature (AMB). Microdialysate was collected every 6\ua0hours and analysed for glucose, lactate and pyruvate concentrations and lactate to pyruvate ratio (L:P). Microdialysis urea clearance was used to estimate lamellar Tissue Perfusion. Data were analysed using a mixed-effects linear regression model. Results: Glucose did not change in CDH limbs relative to AMB in CON (P\ua0=.3), EHC (P\ua0=.3) or OF (P\ua0=.6) groups. There was a decrease in lactate (P\ua

Murphy L. - One of the best experts on this subject based on the ideXlab platform.

  • Patient-Specific Monitoring and Trend Analysis of Model-Based Markers of Fluid Responsiveness in Sepsis: A Proof-of-Concept Animal Study
    2020
    Co-Authors: Murphy L., Davidso S., Chase J. G., Knopp J. L., Zhou T., Desaive Thomas
    Abstract:

    Total stressed blood volume (SBVT) and arterial elastance (Ea) are two potentially important, clinically applicable metrics for guiding treatment in patients with altered hemodynamic states. Defined as the total pressure generating blood in the circulation, SBVT is a potential direct measurement of Tissue Perfusion, a critical component in treatment of sepsis. Ea is closely related to arterial tone thus provides insight into cardiac efficiency. However, it is not clinically feasible or ethical to measure SBVT in patients, so a three chambered cardiovascular system model using measured left ventricle pressure and volume, aortic pressure and central venous pressure is implemented to identify SBVT and Ea from clinical data. SBVT and Ea are identified from clinical data from six (6) pigs, who have undergone clinical procedures aimed at simulating septic shock and subsequent treatment, to identify clinically relevant changes. A novel, validated trend analysis method is used to adjudge clinically significant changes in state in the real-time Ea and SBVT traces. Results matched hypothesised increases in SBVT during fluid therapy, with a mean change of + 21% during initial therapy, and hypothesised decreases during endotoxin induced sepsis, with a mean change of − 29%. Ea displayed the hypothesised reciprocal behaviour with a mean changes of − 12 and + 30% during initial therapy and endotoxin induced sepsis, respectively. The overall results validate the efficacy of SBVT in tracking changes in hemodynamic state in septic shock and fluid therapy. © 2019, Biomedical Engineering Society.Peer reviewe

  • Patient-Specific Monitoring and Trend Analysis of Model-Based Markers of Fluid Responsiveness in Sepsis: A Proof-of-Concept Animal Study
    Springer Science and Business Media LLC, 2020
    Co-Authors: Murphy L., Davidso S., Zhou T., Desaive T
    Abstract:

    © 2019, Biomedical Engineering Society. Total stressed blood volume (SBVT) and arterial elastance (Ea) are two potentially important, clinically applicable metrics for guiding treatment in patients with altered hemodynamic states. Defined as the total pressure generating blood in the circulation, SBVT is a potential direct measurement of Tissue Perfusion, a critical component in treatment of sepsis. Ea is closely related to arterial tone thus provides insight into cardiac efficiency. However, it is not clinically feasible or ethical to measure SBVT in patients, so a three chambered cardiovascular system model using measured left ventricle pressure and volume, aortic pressure and central venous pressure is implemented to identify SBVT and Ea from clinical data. SBVT and Ea are identified from clinical data from six (6) pigs, who have undergone clinical procedures aimed at simulating septic shock and subsequent treatment, to identify clinically relevant changes. A novel, validated trend analysis method is used to adjudge clinically significant changes in state in the real-time Ea and SBVT traces. Results matched hypothesised increases in SBVT during fluid therapy, with a mean change of + 21% during initial therapy, and hypothesised decreases during endotoxin induced sepsis, with a mean change of − 29%. Ea displayed the hypothesised reciprocal behaviour with a mean changes of − 12 and + 30% during initial therapy and endotoxin induced sepsis, respectively. The overall results validate the efficacy of SBVT in tracking changes in hemodynamic state in septic shock and fluid therapy

Stefanovski Darko - One of the best experts on this subject based on the ideXlab platform.

  • Lamellar energy metabolism and Perfusion in the euglycaemic hyperinsulinaemic clamp model of equine laminitis
    'Wiley', 2020
    Co-Authors: Stokes, Simo M., Ertin, Francois R., Stefanovski Darko, Elknap, James K., Medina‐torres, Carlos E., Pollitt, Christophe C., Eps, Andrew W.
    Abstract:

    Hyperinsulinaemia is associated with the development of endocrinopathic laminitis; however, the mechanisms remain unclear.Evaluate the effects of hyperinsulinaemia on lamellar energy metabolism and Perfusion during laminitis development.In vivo experiment.Eight Standardbred horses were instrumented with a microdialysis probe in the lamellae of a forelimb. A 24\ua0hours baseline period (BASELINE) was followed by 48\ua0hours of a continuous euglycaemic hyperinsulinaemic clamp (EHC) from 24 to 72\ua0hours (CLAMP). Microdialysate was collected every 6\ua0hours and analysed for glucose, lactate and pyruvate concentrations and lactate-to-pyruvate ratio (L:P). Microdialysis urea clearance was used to estimate lamellar Tissue Perfusion. Archived microdialysis samples from six identically instrumented Standardbred horses served as controls (CON). Variables were compared over time and between EHC and CON horses using a mixed-effects linear regression model.Glucose concentration decreased during the CLAMP period in CON and EHC horses (P\ua0\ua0.9). Lactate concentration increased during the CLAMP period in CON and EHC horses (P\ua

  • The effect of continuous digital hypothermia on lamellar energy metabolism and Perfusion during laminitis development in two experimental models
    'Wiley', 2020
    Co-Authors: Stokes, Simo M., Stefanovski Darko, Elknap, James K., Pollitt, Christophe C., Erti Francois-rene, Poulse Lea, Medina-torres, Carlos E., Van Eps, Andrew W.
    Abstract:

    Background: Continuous digital hypothermia (CDH) prevents lamellar failure in the euglycaemic hyperinsulinaemic clamp (EHC) and oligofructose (OF) laminitis models, but the mechanisms remain unclear. Objectives: To evaluate the effects of CDH on lamellar energy metabolism and Perfusion in healthy horses and during EHC and OF laminitis models. Study design: In vivo experiment. Methods: Archived samples were used from Standardbred geldings that received no treatment (CON) (n\ua0=\ua08) or underwent EHC (n\ua0=\ua08) or OF (n\ua0=\ua06) laminitis models. Both forelimbs were instrumented with a lamellar microdialysis system, and one forelimb was cooled (CDH) with the other maintained at ambient temperature (AMB). Microdialysate was collected every 6\ua0hours and analysed for glucose, lactate and pyruvate concentrations and lactate to pyruvate ratio (L:P). Microdialysis urea clearance was used to estimate lamellar Tissue Perfusion. Data were analysed using a mixed-effects linear regression model. Results: Glucose did not change in CDH limbs relative to AMB in CON (P\ua0=.3), EHC (P\ua0=.3) or OF (P\ua0=.6) groups. There was a decrease in lactate (P\ua

Pollitt, Christophe C. - One of the best experts on this subject based on the ideXlab platform.

  • Lamellar energy metabolism and Perfusion in the euglycaemic hyperinsulinaemic clamp model of equine laminitis
    'Wiley', 2020
    Co-Authors: Stokes, Simo M., Ertin, Francois R., Stefanovski Darko, Elknap, James K., Medina‐torres, Carlos E., Pollitt, Christophe C., Eps, Andrew W.
    Abstract:

    Hyperinsulinaemia is associated with the development of endocrinopathic laminitis; however, the mechanisms remain unclear.Evaluate the effects of hyperinsulinaemia on lamellar energy metabolism and Perfusion during laminitis development.In vivo experiment.Eight Standardbred horses were instrumented with a microdialysis probe in the lamellae of a forelimb. A 24\ua0hours baseline period (BASELINE) was followed by 48\ua0hours of a continuous euglycaemic hyperinsulinaemic clamp (EHC) from 24 to 72\ua0hours (CLAMP). Microdialysate was collected every 6\ua0hours and analysed for glucose, lactate and pyruvate concentrations and lactate-to-pyruvate ratio (L:P). Microdialysis urea clearance was used to estimate lamellar Tissue Perfusion. Archived microdialysis samples from six identically instrumented Standardbred horses served as controls (CON). Variables were compared over time and between EHC and CON horses using a mixed-effects linear regression model.Glucose concentration decreased during the CLAMP period in CON and EHC horses (P\ua0\ua0.9). Lactate concentration increased during the CLAMP period in CON and EHC horses (P\ua

  • The effect of continuous digital hypothermia on lamellar energy metabolism and Perfusion during laminitis development in two experimental models
    'Wiley', 2020
    Co-Authors: Stokes, Simo M., Stefanovski Darko, Elknap, James K., Pollitt, Christophe C., Erti Francois-rene, Poulse Lea, Medina-torres, Carlos E., Van Eps, Andrew W.
    Abstract:

    Background: Continuous digital hypothermia (CDH) prevents lamellar failure in the euglycaemic hyperinsulinaemic clamp (EHC) and oligofructose (OF) laminitis models, but the mechanisms remain unclear. Objectives: To evaluate the effects of CDH on lamellar energy metabolism and Perfusion in healthy horses and during EHC and OF laminitis models. Study design: In vivo experiment. Methods: Archived samples were used from Standardbred geldings that received no treatment (CON) (n\ua0=\ua08) or underwent EHC (n\ua0=\ua08) or OF (n\ua0=\ua06) laminitis models. Both forelimbs were instrumented with a lamellar microdialysis system, and one forelimb was cooled (CDH) with the other maintained at ambient temperature (AMB). Microdialysate was collected every 6\ua0hours and analysed for glucose, lactate and pyruvate concentrations and lactate to pyruvate ratio (L:P). Microdialysis urea clearance was used to estimate lamellar Tissue Perfusion. Data were analysed using a mixed-effects linear regression model. Results: Glucose did not change in CDH limbs relative to AMB in CON (P\ua0=.3), EHC (P\ua0=.3) or OF (P\ua0=.6) groups. There was a decrease in lactate (P\ua

Elknap, James K. - One of the best experts on this subject based on the ideXlab platform.

  • Lamellar energy metabolism and Perfusion in the euglycaemic hyperinsulinaemic clamp model of equine laminitis
    'Wiley', 2020
    Co-Authors: Stokes, Simo M., Ertin, Francois R., Stefanovski Darko, Elknap, James K., Medina‐torres, Carlos E., Pollitt, Christophe C., Eps, Andrew W.
    Abstract:

    Hyperinsulinaemia is associated with the development of endocrinopathic laminitis; however, the mechanisms remain unclear.Evaluate the effects of hyperinsulinaemia on lamellar energy metabolism and Perfusion during laminitis development.In vivo experiment.Eight Standardbred horses were instrumented with a microdialysis probe in the lamellae of a forelimb. A 24\ua0hours baseline period (BASELINE) was followed by 48\ua0hours of a continuous euglycaemic hyperinsulinaemic clamp (EHC) from 24 to 72\ua0hours (CLAMP). Microdialysate was collected every 6\ua0hours and analysed for glucose, lactate and pyruvate concentrations and lactate-to-pyruvate ratio (L:P). Microdialysis urea clearance was used to estimate lamellar Tissue Perfusion. Archived microdialysis samples from six identically instrumented Standardbred horses served as controls (CON). Variables were compared over time and between EHC and CON horses using a mixed-effects linear regression model.Glucose concentration decreased during the CLAMP period in CON and EHC horses (P\ua0\ua0.9). Lactate concentration increased during the CLAMP period in CON and EHC horses (P\ua

  • The effect of continuous digital hypothermia on lamellar energy metabolism and Perfusion during laminitis development in two experimental models
    'Wiley', 2020
    Co-Authors: Stokes, Simo M., Stefanovski Darko, Elknap, James K., Pollitt, Christophe C., Erti Francois-rene, Poulse Lea, Medina-torres, Carlos E., Van Eps, Andrew W.
    Abstract:

    Background: Continuous digital hypothermia (CDH) prevents lamellar failure in the euglycaemic hyperinsulinaemic clamp (EHC) and oligofructose (OF) laminitis models, but the mechanisms remain unclear. Objectives: To evaluate the effects of CDH on lamellar energy metabolism and Perfusion in healthy horses and during EHC and OF laminitis models. Study design: In vivo experiment. Methods: Archived samples were used from Standardbred geldings that received no treatment (CON) (n\ua0=\ua08) or underwent EHC (n\ua0=\ua08) or OF (n\ua0=\ua06) laminitis models. Both forelimbs were instrumented with a lamellar microdialysis system, and one forelimb was cooled (CDH) with the other maintained at ambient temperature (AMB). Microdialysate was collected every 6\ua0hours and analysed for glucose, lactate and pyruvate concentrations and lactate to pyruvate ratio (L:P). Microdialysis urea clearance was used to estimate lamellar Tissue Perfusion. Data were analysed using a mixed-effects linear regression model. Results: Glucose did not change in CDH limbs relative to AMB in CON (P\ua0=.3), EHC (P\ua0=.3) or OF (P\ua0=.6) groups. There was a decrease in lactate (P\ua

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