The Experts below are selected from a list of 10197 Experts worldwide ranked by ideXlab platform
Chengzhong Xing - One of the best experts on this subject based on the ideXlab platform.
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is the seventh edition of the uicc ajcc TNM Staging System reasonable for patients with tumor deposits in colorectal cancer
Annals of Surgery, 2012Co-Authors: Linlin Tong, Zhe Sun, Zhenning Wang, Peng Gao, Yongxi Song, Chengzhong XingAbstract:Objective To assess the rationality of the seventh edition of TNM Staging System on tumor deposits (TDs) and propose a novel subclassification. Summary background data The TDs had been debated for many years. The seventh edition of TNM Staging System proposed a "pN1c" concept. However, the value of the modification is still debated. Methods A total of 1541 patients with colorectal cancer were reviewed. Overall survival rates were compared between patients without LNM but TD (+), and those who were TD (-). The TDs were stratified into the "any T + any N" category. Two-step multivariate analysis was performed to identify significant prognostic factors. Univariate analysis was used to determine whether a correlation existed between the number of TDs and prognosis. Results There was a significant prognostic difference between patients without LNM or TDs compared with those with positive TDs. Only in T3N2bM0 there was a significant prognostic difference between LNM (+), TD (+) patients and TD (-) patients. The seventh edition of TNM Staging System was substituted by the novel TNM Staging System in 2-step multivariate analysis. Only in T3N1cM0 there was a significant prognostic difference between patients with only 1 TD and those with more than 1 TD. Conclusion The seventh edition of TNM Staging System on TDs satisfactorily predicts patients' outcome for those without LNM. Patients who categorized as T3N2bM0TD (+) and T4N2bM0TD (-/+) should be reclassified as stage IV. Number of TDs was not an independent prognostic parameter in the TNM Staging System.
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Is the seventh edition of the UICC/AJCC TNM Staging System reasonable for patients with tumor deposits in colorectal cancer?
Annals of surgery, 2012Co-Authors: Linlin Tong, Zhe Sun, Zhenning Wang, Peng Gao, Yongxi Song, Chengzhong XingAbstract:Objective To assess the rationality of the seventh edition of TNM Staging System on tumor deposits (TDs) and propose a novel subclassification. Summary background data The TDs had been debated for many years. The seventh edition of TNM Staging System proposed a "pN1c" concept. However, the value of the modification is still debated. Methods A total of 1541 patients with colorectal cancer were reviewed. Overall survival rates were compared between patients without LNM but TD (+), and those who were TD (-). The TDs were stratified into the "any T + any N" category. Two-step multivariate analysis was performed to identify significant prognostic factors. Univariate analysis was used to determine whether a correlation existed between the number of TDs and prognosis. Results There was a significant prognostic difference between patients without LNM or TDs compared with those with positive TDs. Only in T3N2bM0 there was a significant prognostic difference between LNM (+), TD (+) patients and TD (-) patients. The seventh edition of TNM Staging System was substituted by the novel TNM Staging System in 2-step multivariate analysis. Only in T3N1cM0 there was a significant prognostic difference between patients with only 1 TD and those with more than 1 TD. Conclusion The seventh edition of TNM Staging System on TDs satisfactorily predicts patients' outcome for those without LNM. Patients who categorized as T3N2bM0TD (+) and T4N2bM0TD (-/+) should be reclassified as stage IV. Number of TDs was not an independent prognostic parameter in the TNM Staging System.
Zhenning Wang - One of the best experts on this subject based on the ideXlab platform.
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Assessment of the 8th edition of TNM Staging System for gastric cancer: the results from the SEER and a single-institution database.
Future oncology (London England), 2018Co-Authors: Bochao Zhao, Zhenning Wang, Jingting Zhang, Jiale Zhang, Rui Luo, Baojun HuangAbstract:Aim To investigate whether the 8th edition of Tumor, Node, Metastasis (TNM) Staging could properly evaluate the prognosis of gastric cancer patients. Methods The prognostic performance between the 7th and 8th edition of TNM Staging was compared and clinicopathologic features were analyzed. Results The stage shifts in the 8th edition Staging resulted in the increased numbers of stage IIIA patients and decreased numbers of stage IIB, stage IIIB and stage IIIC patients. Compared with the previous edition, the 8th edition of TNM Staging provided a better prognostic stratification for stage III patients. However, whether it is reasonable to incorporate T4aN2, T4aN3a and T4bN3b into stage IIIA, stage IIIB and stage IIIC respectively, which still need further validation. Conclusion Despite the obvious superiority, several deficiencies may still exist in the new edition Staging. To better provide prognostic information and therapeutic guidance for gastric cancer patients, the TNM Staging System should be further improved in the future.
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The present issues and the trend of the TNM Staging System
2015Co-Authors: Zhenning WangAbstract:As the study on the colorectal cancer develops, the TNM Staging System has been adjusted in every edition.The author discussed several issues in the 7th edition and made some prospects on the coming 8th TNM classification edition on the the hotspots of research fields in recent years. Key words: Colorectal neoplasms; Neoplasm Staging
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Which is a more accurate predictor in colorectal survival analysis? Nine data mining algorithms vs. the TNM Staging System.
PloS one, 2012Co-Authors: Peng Gao, Zhenning Wang, Linlin Tong, Yongxi Song, Xin Zhou, Zhenyu YueAbstract:Objective Over the past decades, many studies have used data mining technology to predict the 5-year survival rate of colorectal cancer, but there have been few reports that compared multiple data mining algorithms to the TNM classification of malignant tumors (TNM) Staging System using a dataset in which the training and testing data were from different sources. Here we compared nine data mining algorithms to the TNM Staging System for colorectal survival analysis.
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is the seventh edition of the uicc ajcc TNM Staging System reasonable for patients with tumor deposits in colorectal cancer
Annals of Surgery, 2012Co-Authors: Linlin Tong, Zhe Sun, Zhenning Wang, Peng Gao, Yongxi Song, Chengzhong XingAbstract:Objective To assess the rationality of the seventh edition of TNM Staging System on tumor deposits (TDs) and propose a novel subclassification. Summary background data The TDs had been debated for many years. The seventh edition of TNM Staging System proposed a "pN1c" concept. However, the value of the modification is still debated. Methods A total of 1541 patients with colorectal cancer were reviewed. Overall survival rates were compared between patients without LNM but TD (+), and those who were TD (-). The TDs were stratified into the "any T + any N" category. Two-step multivariate analysis was performed to identify significant prognostic factors. Univariate analysis was used to determine whether a correlation existed between the number of TDs and prognosis. Results There was a significant prognostic difference between patients without LNM or TDs compared with those with positive TDs. Only in T3N2bM0 there was a significant prognostic difference between LNM (+), TD (+) patients and TD (-) patients. The seventh edition of TNM Staging System was substituted by the novel TNM Staging System in 2-step multivariate analysis. Only in T3N1cM0 there was a significant prognostic difference between patients with only 1 TD and those with more than 1 TD. Conclusion The seventh edition of TNM Staging System on TDs satisfactorily predicts patients' outcome for those without LNM. Patients who categorized as T3N2bM0TD (+) and T4N2bM0TD (-/+) should be reclassified as stage IV. Number of TDs was not an independent prognostic parameter in the TNM Staging System.
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evaluation of the seventh edition of american joint committee on cancer TNM Staging System for gastric cancer results from a chinese monoinstitutional study
Annals of Surgical Oncology, 2012Co-Authors: Zhe Sun, Zhenning Wang, Zhi Zhu, Baojun Huang, Guolian ZhuAbstract:Background To investigate the validity of the 7th edition of American Joint Committee on Cancer (AJCC) TNM Staging System for gastric cancer with special attention paid to pT2/pT3, pN1/pN2, and pN3a/pN3b category.
Linlin Tong - One of the best experts on this subject based on the ideXlab platform.
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Which is a more accurate predictor in colorectal survival analysis? Nine data mining algorithms vs. the TNM Staging System.
PloS one, 2012Co-Authors: Peng Gao, Zhenning Wang, Linlin Tong, Yongxi Song, Xin Zhou, Zhenyu YueAbstract:Objective Over the past decades, many studies have used data mining technology to predict the 5-year survival rate of colorectal cancer, but there have been few reports that compared multiple data mining algorithms to the TNM classification of malignant tumors (TNM) Staging System using a dataset in which the training and testing data were from different sources. Here we compared nine data mining algorithms to the TNM Staging System for colorectal survival analysis.
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is the seventh edition of the uicc ajcc TNM Staging System reasonable for patients with tumor deposits in colorectal cancer
Annals of Surgery, 2012Co-Authors: Linlin Tong, Zhe Sun, Zhenning Wang, Peng Gao, Yongxi Song, Chengzhong XingAbstract:Objective To assess the rationality of the seventh edition of TNM Staging System on tumor deposits (TDs) and propose a novel subclassification. Summary background data The TDs had been debated for many years. The seventh edition of TNM Staging System proposed a "pN1c" concept. However, the value of the modification is still debated. Methods A total of 1541 patients with colorectal cancer were reviewed. Overall survival rates were compared between patients without LNM but TD (+), and those who were TD (-). The TDs were stratified into the "any T + any N" category. Two-step multivariate analysis was performed to identify significant prognostic factors. Univariate analysis was used to determine whether a correlation existed between the number of TDs and prognosis. Results There was a significant prognostic difference between patients without LNM or TDs compared with those with positive TDs. Only in T3N2bM0 there was a significant prognostic difference between LNM (+), TD (+) patients and TD (-) patients. The seventh edition of TNM Staging System was substituted by the novel TNM Staging System in 2-step multivariate analysis. Only in T3N1cM0 there was a significant prognostic difference between patients with only 1 TD and those with more than 1 TD. Conclusion The seventh edition of TNM Staging System on TDs satisfactorily predicts patients' outcome for those without LNM. Patients who categorized as T3N2bM0TD (+) and T4N2bM0TD (-/+) should be reclassified as stage IV. Number of TDs was not an independent prognostic parameter in the TNM Staging System.
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Is the seventh edition of the UICC/AJCC TNM Staging System reasonable for patients with tumor deposits in colorectal cancer?
Annals of surgery, 2012Co-Authors: Linlin Tong, Zhe Sun, Zhenning Wang, Peng Gao, Yongxi Song, Chengzhong XingAbstract:Objective To assess the rationality of the seventh edition of TNM Staging System on tumor deposits (TDs) and propose a novel subclassification. Summary background data The TDs had been debated for many years. The seventh edition of TNM Staging System proposed a "pN1c" concept. However, the value of the modification is still debated. Methods A total of 1541 patients with colorectal cancer were reviewed. Overall survival rates were compared between patients without LNM but TD (+), and those who were TD (-). The TDs were stratified into the "any T + any N" category. Two-step multivariate analysis was performed to identify significant prognostic factors. Univariate analysis was used to determine whether a correlation existed between the number of TDs and prognosis. Results There was a significant prognostic difference between patients without LNM or TDs compared with those with positive TDs. Only in T3N2bM0 there was a significant prognostic difference between LNM (+), TD (+) patients and TD (-) patients. The seventh edition of TNM Staging System was substituted by the novel TNM Staging System in 2-step multivariate analysis. Only in T3N1cM0 there was a significant prognostic difference between patients with only 1 TD and those with more than 1 TD. Conclusion The seventh edition of TNM Staging System on TDs satisfactorily predicts patients' outcome for those without LNM. Patients who categorized as T3N2bM0TD (+) and T4N2bM0TD (-/+) should be reclassified as stage IV. Number of TDs was not an independent prognostic parameter in the TNM Staging System.
Zhe Sun - One of the best experts on this subject based on the ideXlab platform.
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is the seventh edition of the uicc ajcc TNM Staging System reasonable for patients with tumor deposits in colorectal cancer
Annals of Surgery, 2012Co-Authors: Linlin Tong, Zhe Sun, Zhenning Wang, Peng Gao, Yongxi Song, Chengzhong XingAbstract:Objective To assess the rationality of the seventh edition of TNM Staging System on tumor deposits (TDs) and propose a novel subclassification. Summary background data The TDs had been debated for many years. The seventh edition of TNM Staging System proposed a "pN1c" concept. However, the value of the modification is still debated. Methods A total of 1541 patients with colorectal cancer were reviewed. Overall survival rates were compared between patients without LNM but TD (+), and those who were TD (-). The TDs were stratified into the "any T + any N" category. Two-step multivariate analysis was performed to identify significant prognostic factors. Univariate analysis was used to determine whether a correlation existed between the number of TDs and prognosis. Results There was a significant prognostic difference between patients without LNM or TDs compared with those with positive TDs. Only in T3N2bM0 there was a significant prognostic difference between LNM (+), TD (+) patients and TD (-) patients. The seventh edition of TNM Staging System was substituted by the novel TNM Staging System in 2-step multivariate analysis. Only in T3N1cM0 there was a significant prognostic difference between patients with only 1 TD and those with more than 1 TD. Conclusion The seventh edition of TNM Staging System on TDs satisfactorily predicts patients' outcome for those without LNM. Patients who categorized as T3N2bM0TD (+) and T4N2bM0TD (-/+) should be reclassified as stage IV. Number of TDs was not an independent prognostic parameter in the TNM Staging System.
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evaluation of the seventh edition of american joint committee on cancer TNM Staging System for gastric cancer results from a chinese monoinstitutional study
Annals of Surgical Oncology, 2012Co-Authors: Zhe Sun, Zhenning Wang, Zhi Zhu, Baojun Huang, Guolian ZhuAbstract:Background To investigate the validity of the 7th edition of American Joint Committee on Cancer (AJCC) TNM Staging System for gastric cancer with special attention paid to pT2/pT3, pN1/pN2, and pN3a/pN3b category.
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Is the seventh edition of the UICC/AJCC TNM Staging System reasonable for patients with tumor deposits in colorectal cancer?
Annals of surgery, 2012Co-Authors: Linlin Tong, Zhe Sun, Zhenning Wang, Peng Gao, Yongxi Song, Chengzhong XingAbstract:Objective To assess the rationality of the seventh edition of TNM Staging System on tumor deposits (TDs) and propose a novel subclassification. Summary background data The TDs had been debated for many years. The seventh edition of TNM Staging System proposed a "pN1c" concept. However, the value of the modification is still debated. Methods A total of 1541 patients with colorectal cancer were reviewed. Overall survival rates were compared between patients without LNM but TD (+), and those who were TD (-). The TDs were stratified into the "any T + any N" category. Two-step multivariate analysis was performed to identify significant prognostic factors. Univariate analysis was used to determine whether a correlation existed between the number of TDs and prognosis. Results There was a significant prognostic difference between patients without LNM or TDs compared with those with positive TDs. Only in T3N2bM0 there was a significant prognostic difference between LNM (+), TD (+) patients and TD (-) patients. The seventh edition of TNM Staging System was substituted by the novel TNM Staging System in 2-step multivariate analysis. Only in T3N1cM0 there was a significant prognostic difference between patients with only 1 TD and those with more than 1 TD. Conclusion The seventh edition of TNM Staging System on TDs satisfactorily predicts patients' outcome for those without LNM. Patients who categorized as T3N2bM0TD (+) and T4N2bM0TD (-/+) should be reclassified as stage IV. Number of TDs was not an independent prognostic parameter in the TNM Staging System.
Peng Gao - One of the best experts on this subject based on the ideXlab platform.
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Which is a more accurate predictor in colorectal survival analysis? Nine data mining algorithms vs. the TNM Staging System.
PloS one, 2012Co-Authors: Peng Gao, Zhenning Wang, Linlin Tong, Yongxi Song, Xin Zhou, Zhenyu YueAbstract:Objective Over the past decades, many studies have used data mining technology to predict the 5-year survival rate of colorectal cancer, but there have been few reports that compared multiple data mining algorithms to the TNM classification of malignant tumors (TNM) Staging System using a dataset in which the training and testing data were from different sources. Here we compared nine data mining algorithms to the TNM Staging System for colorectal survival analysis.
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is the seventh edition of the uicc ajcc TNM Staging System reasonable for patients with tumor deposits in colorectal cancer
Annals of Surgery, 2012Co-Authors: Linlin Tong, Zhe Sun, Zhenning Wang, Peng Gao, Yongxi Song, Chengzhong XingAbstract:Objective To assess the rationality of the seventh edition of TNM Staging System on tumor deposits (TDs) and propose a novel subclassification. Summary background data The TDs had been debated for many years. The seventh edition of TNM Staging System proposed a "pN1c" concept. However, the value of the modification is still debated. Methods A total of 1541 patients with colorectal cancer were reviewed. Overall survival rates were compared between patients without LNM but TD (+), and those who were TD (-). The TDs were stratified into the "any T + any N" category. Two-step multivariate analysis was performed to identify significant prognostic factors. Univariate analysis was used to determine whether a correlation existed between the number of TDs and prognosis. Results There was a significant prognostic difference between patients without LNM or TDs compared with those with positive TDs. Only in T3N2bM0 there was a significant prognostic difference between LNM (+), TD (+) patients and TD (-) patients. The seventh edition of TNM Staging System was substituted by the novel TNM Staging System in 2-step multivariate analysis. Only in T3N1cM0 there was a significant prognostic difference between patients with only 1 TD and those with more than 1 TD. Conclusion The seventh edition of TNM Staging System on TDs satisfactorily predicts patients' outcome for those without LNM. Patients who categorized as T3N2bM0TD (+) and T4N2bM0TD (-/+) should be reclassified as stage IV. Number of TDs was not an independent prognostic parameter in the TNM Staging System.
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Is the seventh edition of the UICC/AJCC TNM Staging System reasonable for patients with tumor deposits in colorectal cancer?
Annals of surgery, 2012Co-Authors: Linlin Tong, Zhe Sun, Zhenning Wang, Peng Gao, Yongxi Song, Chengzhong XingAbstract:Objective To assess the rationality of the seventh edition of TNM Staging System on tumor deposits (TDs) and propose a novel subclassification. Summary background data The TDs had been debated for many years. The seventh edition of TNM Staging System proposed a "pN1c" concept. However, the value of the modification is still debated. Methods A total of 1541 patients with colorectal cancer were reviewed. Overall survival rates were compared between patients without LNM but TD (+), and those who were TD (-). The TDs were stratified into the "any T + any N" category. Two-step multivariate analysis was performed to identify significant prognostic factors. Univariate analysis was used to determine whether a correlation existed between the number of TDs and prognosis. Results There was a significant prognostic difference between patients without LNM or TDs compared with those with positive TDs. Only in T3N2bM0 there was a significant prognostic difference between LNM (+), TD (+) patients and TD (-) patients. The seventh edition of TNM Staging System was substituted by the novel TNM Staging System in 2-step multivariate analysis. Only in T3N1cM0 there was a significant prognostic difference between patients with only 1 TD and those with more than 1 TD. Conclusion The seventh edition of TNM Staging System on TDs satisfactorily predicts patients' outcome for those without LNM. Patients who categorized as T3N2bM0TD (+) and T4N2bM0TD (-/+) should be reclassified as stage IV. Number of TDs was not an independent prognostic parameter in the TNM Staging System.
