The Experts below are selected from a list of 111 Experts worldwide ranked by ideXlab platform

Julia Rodriguez - One of the best experts on this subject based on the ideXlab platform.

  • Allergic urticaria from Tonic Water
    Allergy, 2002
    Co-Authors: Rosendo Bugarín González, Rosa Merchán, Jesus F Crespo, Julia Rodriguez
    Abstract:

    . WE evaluated a 50-year-old male who was admitted to the emergency room because of generalized pruritus and urticarial lesions on his abdomen, arms, and face, as well as mild periorbital edema. He had no past medical history of chronic medical conditions. He denied a history of previous episodes of urticaria triggered by heat, cold, pressure, exercise, sunlight, emotional stress, medications, foods or food additives. The patient reported having had a half of a glass of Tonic Water 30–40 min before the onset of symptoms. In the emergency room, the patient was treated with intramuscular epinephrine injections (0.3 mg), methylprednisolone sodium succinate (60 mg), and dexchlorpheniramine (5 mg). His urticarial lesions disappeared within 8 h. After obtaining informed consent, we investigated the patient and 10 healthy, non-atopic control subjects. We conducted skin prick tests for the same brand of Tonic Water at 1:10 dilution and quinine sulfate at 3 mg/ml. The response was evaluated 20 min later. A positive reaction was observed with Tonic Water (wheal: 435 mm in diameter; flare: 8312 mm) and with quinine sulfate (wheal: 535 mm; flare 9311 mm). The 10 control subjects had no skin test response to Tonic Water and quinine sulfate. The patient underwent an open oral challenge with increasing doses of the same brand of Tonic Water. Fifteen minutes after a 60 ml dose (5.4 mg of quinine hydrochloride) the patient developed pruritic wheals on his trunk and arms. The suspicion of quinine as the causative agent prompted us to perform a double-blind placebo-controlled food challenge with quinine. Increasing doses of quinine sulfate or placebo (dextrose) were administered in opaque capsules at 30-min intervals. The verum and placebo were randomly given on two separate days with an interval of 48 h. The patient reacted with generalized pruritic wheals to a cumulative dose of 9 mg of quinine sulfate. Quinine-related hypersensitivity manifestations have been reported to include thrombocytopenia and hemolytic uremic syndrome (1), lupus-like syndrome (2), photosensitivity (3), cutaneous vasculitis (4), and anaphylactic shock (5). In our patient, the results of oral challenges established a definite causal relationship between quinine and urticaria. Furthermore, the positive results of skin testing suggest that urticaria resulted from an IgE-dependent hypersensitivity mechanism. Tonic Water is widely consumed worldwide and may be an unrecognized cause of urticaria. The concentration of quinine in commercial beverages should be considered as a potential cause of acute IgE-mediated urticaria and angioedema.

Michael B West - One of the best experts on this subject based on the ideXlab platform.

  • quinine and the abcs of long qt a patient s misfortune with arthritis alcoholic beverages and cramps
    Journal of General Internal Medicine, 2016
    Co-Authors: Elyce T Sheehan, Jarrod D Frizzell, Jude Gabaldon, Michael B West
    Abstract:

    A 91-year-old woman presented to the emergency department by ambulance after her family found her minimally responsive. Telemetry monitoring demonstrated episodes of non-sustained polymorphic ventricular tachycardia (PMVT) associated with significantly prolonged repolarization. Her medical history revealed that she was taking quinine or a derivative in three different forms: hydroxychloroquine, quinine sulfate (for leg cramps), and her gin mixed with Tonic Water (containing quinine). The present case is illustrative of classic etiologies and findings of acquired long QT syndrome, and serves as an important reminder for providers to take a complete medication history, including use of duplicative and alternative medicines and type of alcohol consumption.

Rosendo Bugarín González - One of the best experts on this subject based on the ideXlab platform.

  • Allergic urticaria from Tonic Water
    Allergy, 2002
    Co-Authors: Rosendo Bugarín González, Rosa Merchán, Jesus F Crespo, Julia Rodriguez
    Abstract:

    . WE evaluated a 50-year-old male who was admitted to the emergency room because of generalized pruritus and urticarial lesions on his abdomen, arms, and face, as well as mild periorbital edema. He had no past medical history of chronic medical conditions. He denied a history of previous episodes of urticaria triggered by heat, cold, pressure, exercise, sunlight, emotional stress, medications, foods or food additives. The patient reported having had a half of a glass of Tonic Water 30–40 min before the onset of symptoms. In the emergency room, the patient was treated with intramuscular epinephrine injections (0.3 mg), methylprednisolone sodium succinate (60 mg), and dexchlorpheniramine (5 mg). His urticarial lesions disappeared within 8 h. After obtaining informed consent, we investigated the patient and 10 healthy, non-atopic control subjects. We conducted skin prick tests for the same brand of Tonic Water at 1:10 dilution and quinine sulfate at 3 mg/ml. The response was evaluated 20 min later. A positive reaction was observed with Tonic Water (wheal: 435 mm in diameter; flare: 8312 mm) and with quinine sulfate (wheal: 535 mm; flare 9311 mm). The 10 control subjects had no skin test response to Tonic Water and quinine sulfate. The patient underwent an open oral challenge with increasing doses of the same brand of Tonic Water. Fifteen minutes after a 60 ml dose (5.4 mg of quinine hydrochloride) the patient developed pruritic wheals on his trunk and arms. The suspicion of quinine as the causative agent prompted us to perform a double-blind placebo-controlled food challenge with quinine. Increasing doses of quinine sulfate or placebo (dextrose) were administered in opaque capsules at 30-min intervals. The verum and placebo were randomly given on two separate days with an interval of 48 h. The patient reacted with generalized pruritic wheals to a cumulative dose of 9 mg of quinine sulfate. Quinine-related hypersensitivity manifestations have been reported to include thrombocytopenia and hemolytic uremic syndrome (1), lupus-like syndrome (2), photosensitivity (3), cutaneous vasculitis (4), and anaphylactic shock (5). In our patient, the results of oral challenges established a definite causal relationship between quinine and urticaria. Furthermore, the positive results of skin testing suggest that urticaria resulted from an IgE-dependent hypersensitivity mechanism. Tonic Water is widely consumed worldwide and may be an unrecognized cause of urticaria. The concentration of quinine in commercial beverages should be considered as a potential cause of acute IgE-mediated urticaria and angioedema.

Pedro Callol - One of the best experts on this subject based on the ideXlab platform.

Claudimir Lucio Do Lago - One of the best experts on this subject based on the ideXlab platform.

  • monoalkyl carbonates in carbonated alcoholic beverages
    Food Chemistry, 2012
    Co-Authors: Marcelo Rabello Rossi, Denis Tadeu Rajh Vidal, Claudimir Lucio Do Lago
    Abstract:

    Abstract The presence of monoethyl carbonate (MEC) in beer and sparkling wine is demonstrated for the first time, as well as the formation of this species in drinks prepared with a distilled beverage and a carbonated soft drink. A capillary electrophoresis (CE) equipment with two capacitively coupled contactless conductivity detector (C4D) was used to identify and quantify this species. The concentrations of MEC in samples of lager beer and rum and cola drink were, respectively, 1.2 and 4.1 mmol/l, which agree with the levels of ethanol and CO2 available in these products. Previous results about the kinetics of the reaction suggest that only a small amount of MEC should be formed after the ingredients of a drink are mixed. However, in all three cases (whisky and club soda; rum with cola; gin and Tonic Water), MEC was quickly formed, which was attributed to the low pH of the drinks.