The Experts below are selected from a list of 30702 Experts worldwide ranked by ideXlab platform
Yimin Zou - One of the best experts on this subject based on the ideXlab platform.
-
Wnt–Ryk signalling mediates medial–lateral retinotectal Topographic Mapping
Nature, 2006Co-Authors: Adam M. Schmitt, Jun Shi, Alex M. Wolf, Leslie A. King, Yimin ZouAbstract:Computational modelling has suggested that at least two counteracting forces are required for establishing Topographic maps. Ephrin-family proteins are required for both anterior-posterior and medial-lateral Topographic Mapping, but the opposing forces have not been well characterized. Wnt-family proteins are recently discovered axon guidance cues. We find that Wnt3 is expressed in a medial-lateral decreasing gradient in chick optic tectum and mouse superior colliculus. Retinal ganglion cell (RGC) axons from different dorsal-ventral positions showed graded and biphasic response to Wnt3 in a concentration-dependent manner. Wnt3 repulsion is mediated by Ryk, expressed in a ventral-to-dorsal decreasing gradient, whereas attraction of dorsal axons at lower Wnt3 concentrations is mediated by Frizzled(s). Overexpression of Wnt3 in the lateral tectum repelled the termination zones of dorsal RGC axons in vivo. Expression of a dominant-negative Ryk in dorsal RGC axons caused a medial shift of the termination zones, promoting medially directed interstitial branches and eliminating laterally directed branches. Therefore, a classical morphogen, Wnt3, acting as an axon guidance molecule, plays a role in retinotectal Mapping along the medial-lateral axis, counterbalancing the medial-directed EphrinB1-EphB activity.
-
wnt ryk signalling mediates medial lateral retinotectal Topographic Mapping
Nature, 2006Co-Authors: Adam M. Schmitt, Jun Shi, Alex M. Wolf, Leslie A. King, Yimin ZouAbstract:Computational modelling has suggested that at least two counteracting forces are required for establishing Topographic maps. Ephrin-family proteins are required for both anterior-posterior and medial-lateral Topographic Mapping, but the opposing forces have not been well characterized. Wnt-family proteins are recently discovered axon guidance cues. We find that Wnt3 is expressed in a medial-lateral decreasing gradient in chick optic tectum and mouse superior colliculus. Retinal ganglion cell (RGC) axons from different dorsal-ventral positions showed graded and biphasic response to Wnt3 in a concentration-dependent manner. Wnt3 repulsion is mediated by Ryk, expressed in a ventral-to-dorsal decreasing gradient, whereas attraction of dorsal axons at lower Wnt3 concentrations is mediated by Frizzled(s). Overexpression of Wnt3 in the lateral tectum repelled the termination zones of dorsal RGC axons in vivo. Expression of a dominant-negative Ryk in dorsal RGC axons caused a medial shift of the termination zones, promoting medially directed interstitial branches and eliminating laterally directed branches. Therefore, a classical morphogen, Wnt3, acting as an axon guidance molecule, plays a role in retinotectal Mapping along the medial-lateral axis, counterbalancing the medial-directed EphrinB1-EphB activity.
Adam M. Schmitt - One of the best experts on this subject based on the ideXlab platform.
-
Wnt–Ryk signalling mediates medial–lateral retinotectal Topographic Mapping
Nature, 2006Co-Authors: Adam M. Schmitt, Jun Shi, Alex M. Wolf, Leslie A. King, Yimin ZouAbstract:Computational modelling has suggested that at least two counteracting forces are required for establishing Topographic maps. Ephrin-family proteins are required for both anterior-posterior and medial-lateral Topographic Mapping, but the opposing forces have not been well characterized. Wnt-family proteins are recently discovered axon guidance cues. We find that Wnt3 is expressed in a medial-lateral decreasing gradient in chick optic tectum and mouse superior colliculus. Retinal ganglion cell (RGC) axons from different dorsal-ventral positions showed graded and biphasic response to Wnt3 in a concentration-dependent manner. Wnt3 repulsion is mediated by Ryk, expressed in a ventral-to-dorsal decreasing gradient, whereas attraction of dorsal axons at lower Wnt3 concentrations is mediated by Frizzled(s). Overexpression of Wnt3 in the lateral tectum repelled the termination zones of dorsal RGC axons in vivo. Expression of a dominant-negative Ryk in dorsal RGC axons caused a medial shift of the termination zones, promoting medially directed interstitial branches and eliminating laterally directed branches. Therefore, a classical morphogen, Wnt3, acting as an axon guidance molecule, plays a role in retinotectal Mapping along the medial-lateral axis, counterbalancing the medial-directed EphrinB1-EphB activity.
-
wnt ryk signalling mediates medial lateral retinotectal Topographic Mapping
Nature, 2006Co-Authors: Adam M. Schmitt, Jun Shi, Alex M. Wolf, Leslie A. King, Yimin ZouAbstract:Computational modelling has suggested that at least two counteracting forces are required for establishing Topographic maps. Ephrin-family proteins are required for both anterior-posterior and medial-lateral Topographic Mapping, but the opposing forces have not been well characterized. Wnt-family proteins are recently discovered axon guidance cues. We find that Wnt3 is expressed in a medial-lateral decreasing gradient in chick optic tectum and mouse superior colliculus. Retinal ganglion cell (RGC) axons from different dorsal-ventral positions showed graded and biphasic response to Wnt3 in a concentration-dependent manner. Wnt3 repulsion is mediated by Ryk, expressed in a ventral-to-dorsal decreasing gradient, whereas attraction of dorsal axons at lower Wnt3 concentrations is mediated by Frizzled(s). Overexpression of Wnt3 in the lateral tectum repelled the termination zones of dorsal RGC axons in vivo. Expression of a dominant-negative Ryk in dorsal RGC axons caused a medial shift of the termination zones, promoting medially directed interstitial branches and eliminating laterally directed branches. Therefore, a classical morphogen, Wnt3, acting as an axon guidance molecule, plays a role in retinotectal Mapping along the medial-lateral axis, counterbalancing the medial-directed EphrinB1-EphB activity.
Carol A. Mason - One of the best experts on this subject based on the ideXlab platform.
-
It's All in the Assay: A New Model for Retinotectal Topographic Mapping
Neuron, 2004Co-Authors: Pierre Godement, Carol A. MasonAbstract:Ephrin-As have been implicated as Topographic Mapping labels in the retinotectal system, but the underlying molecular mechanisms for their activities in this context remain somewhat mysterious. Hansen et al. (this issue of Neuron) developed an assay that reveals new mechanisms for ephrins in Topographic Mapping and suggest a model whereby retinal axons grow and terminate in the tectum via a balance of growth promotion and repulsion, with the balance point depending on retinal position and concentration of ephrin-As.
Leslie A. King - One of the best experts on this subject based on the ideXlab platform.
-
Wnt–Ryk signalling mediates medial–lateral retinotectal Topographic Mapping
Nature, 2006Co-Authors: Adam M. Schmitt, Jun Shi, Alex M. Wolf, Leslie A. King, Yimin ZouAbstract:Computational modelling has suggested that at least two counteracting forces are required for establishing Topographic maps. Ephrin-family proteins are required for both anterior-posterior and medial-lateral Topographic Mapping, but the opposing forces have not been well characterized. Wnt-family proteins are recently discovered axon guidance cues. We find that Wnt3 is expressed in a medial-lateral decreasing gradient in chick optic tectum and mouse superior colliculus. Retinal ganglion cell (RGC) axons from different dorsal-ventral positions showed graded and biphasic response to Wnt3 in a concentration-dependent manner. Wnt3 repulsion is mediated by Ryk, expressed in a ventral-to-dorsal decreasing gradient, whereas attraction of dorsal axons at lower Wnt3 concentrations is mediated by Frizzled(s). Overexpression of Wnt3 in the lateral tectum repelled the termination zones of dorsal RGC axons in vivo. Expression of a dominant-negative Ryk in dorsal RGC axons caused a medial shift of the termination zones, promoting medially directed interstitial branches and eliminating laterally directed branches. Therefore, a classical morphogen, Wnt3, acting as an axon guidance molecule, plays a role in retinotectal Mapping along the medial-lateral axis, counterbalancing the medial-directed EphrinB1-EphB activity.
-
wnt ryk signalling mediates medial lateral retinotectal Topographic Mapping
Nature, 2006Co-Authors: Adam M. Schmitt, Jun Shi, Alex M. Wolf, Leslie A. King, Yimin ZouAbstract:Computational modelling has suggested that at least two counteracting forces are required for establishing Topographic maps. Ephrin-family proteins are required for both anterior-posterior and medial-lateral Topographic Mapping, but the opposing forces have not been well characterized. Wnt-family proteins are recently discovered axon guidance cues. We find that Wnt3 is expressed in a medial-lateral decreasing gradient in chick optic tectum and mouse superior colliculus. Retinal ganglion cell (RGC) axons from different dorsal-ventral positions showed graded and biphasic response to Wnt3 in a concentration-dependent manner. Wnt3 repulsion is mediated by Ryk, expressed in a ventral-to-dorsal decreasing gradient, whereas attraction of dorsal axons at lower Wnt3 concentrations is mediated by Frizzled(s). Overexpression of Wnt3 in the lateral tectum repelled the termination zones of dorsal RGC axons in vivo. Expression of a dominant-negative Ryk in dorsal RGC axons caused a medial shift of the termination zones, promoting medially directed interstitial branches and eliminating laterally directed branches. Therefore, a classical morphogen, Wnt3, acting as an axon guidance molecule, plays a role in retinotectal Mapping along the medial-lateral axis, counterbalancing the medial-directed EphrinB1-EphB activity.
Jun Shi - One of the best experts on this subject based on the ideXlab platform.
-
Wnt–Ryk signalling mediates medial–lateral retinotectal Topographic Mapping
Nature, 2006Co-Authors: Adam M. Schmitt, Jun Shi, Alex M. Wolf, Leslie A. King, Yimin ZouAbstract:Computational modelling has suggested that at least two counteracting forces are required for establishing Topographic maps. Ephrin-family proteins are required for both anterior-posterior and medial-lateral Topographic Mapping, but the opposing forces have not been well characterized. Wnt-family proteins are recently discovered axon guidance cues. We find that Wnt3 is expressed in a medial-lateral decreasing gradient in chick optic tectum and mouse superior colliculus. Retinal ganglion cell (RGC) axons from different dorsal-ventral positions showed graded and biphasic response to Wnt3 in a concentration-dependent manner. Wnt3 repulsion is mediated by Ryk, expressed in a ventral-to-dorsal decreasing gradient, whereas attraction of dorsal axons at lower Wnt3 concentrations is mediated by Frizzled(s). Overexpression of Wnt3 in the lateral tectum repelled the termination zones of dorsal RGC axons in vivo. Expression of a dominant-negative Ryk in dorsal RGC axons caused a medial shift of the termination zones, promoting medially directed interstitial branches and eliminating laterally directed branches. Therefore, a classical morphogen, Wnt3, acting as an axon guidance molecule, plays a role in retinotectal Mapping along the medial-lateral axis, counterbalancing the medial-directed EphrinB1-EphB activity.
-
wnt ryk signalling mediates medial lateral retinotectal Topographic Mapping
Nature, 2006Co-Authors: Adam M. Schmitt, Jun Shi, Alex M. Wolf, Leslie A. King, Yimin ZouAbstract:Computational modelling has suggested that at least two counteracting forces are required for establishing Topographic maps. Ephrin-family proteins are required for both anterior-posterior and medial-lateral Topographic Mapping, but the opposing forces have not been well characterized. Wnt-family proteins are recently discovered axon guidance cues. We find that Wnt3 is expressed in a medial-lateral decreasing gradient in chick optic tectum and mouse superior colliculus. Retinal ganglion cell (RGC) axons from different dorsal-ventral positions showed graded and biphasic response to Wnt3 in a concentration-dependent manner. Wnt3 repulsion is mediated by Ryk, expressed in a ventral-to-dorsal decreasing gradient, whereas attraction of dorsal axons at lower Wnt3 concentrations is mediated by Frizzled(s). Overexpression of Wnt3 in the lateral tectum repelled the termination zones of dorsal RGC axons in vivo. Expression of a dominant-negative Ryk in dorsal RGC axons caused a medial shift of the termination zones, promoting medially directed interstitial branches and eliminating laterally directed branches. Therefore, a classical morphogen, Wnt3, acting as an axon guidance molecule, plays a role in retinotectal Mapping along the medial-lateral axis, counterbalancing the medial-directed EphrinB1-EphB activity.