The Experts below are selected from a list of 33 Experts worldwide ranked by ideXlab platform

Timothy John Tranbarger - One of the best experts on this subject based on the ideXlab platform.

  • pluripotent versus Totipotent plant Stem Cells dependence versus autonomy
    Trends in Plant Science, 2007
    Co-Authors: Jean-luc Verdeil, Laurence Alemanno, Nicolas Niemenak, Timothy John Tranbarger
    Abstract:

    Little is known of the mechanisms that induce the dedifferentiation of a single somatic Cell into a Totipotent embryogenic Cell that can either be regenerated or develop into an embryo and subsequently an entire plant. In this Opinion article, we examine the Cellular, physiological and molecular similarities and differences between different plant Stem Cell types. We propose to extend the plant Stem Cell concept to include single embryogenic Cells as a Totipotent Stem Cell based on their capacity to regenerate or develop into an embryo under certain conditions. Our survey suggests that differences in chromatin structure might ensure that meriStem-localized Stem Cells have supervised freedom and are pluripotent, and that embryogenic Stem Cells are unsupervised, autonomous and, hence, freely Totipotent.

Jean-luc Verdeil - One of the best experts on this subject based on the ideXlab platform.

  • pluripotent versus Totipotent plant Stem Cells dependence versus autonomy
    Trends in Plant Science, 2007
    Co-Authors: Jean-luc Verdeil, Laurence Alemanno, Nicolas Niemenak, Timothy John Tranbarger
    Abstract:

    Little is known of the mechanisms that induce the dedifferentiation of a single somatic Cell into a Totipotent embryogenic Cell that can either be regenerated or develop into an embryo and subsequently an entire plant. In this Opinion article, we examine the Cellular, physiological and molecular similarities and differences between different plant Stem Cell types. We propose to extend the plant Stem Cell concept to include single embryogenic Cells as a Totipotent Stem Cell based on their capacity to regenerate or develop into an embryo under certain conditions. Our survey suggests that differences in chromatin structure might ensure that meriStem-localized Stem Cells have supervised freedom and are pluripotent, and that embryogenic Stem Cells are unsupervised, autonomous and, hence, freely Totipotent.

Laurence Alemanno - One of the best experts on this subject based on the ideXlab platform.

  • pluripotent versus Totipotent plant Stem Cells dependence versus autonomy
    Trends in Plant Science, 2007
    Co-Authors: Jean-luc Verdeil, Laurence Alemanno, Nicolas Niemenak, Timothy John Tranbarger
    Abstract:

    Little is known of the mechanisms that induce the dedifferentiation of a single somatic Cell into a Totipotent embryogenic Cell that can either be regenerated or develop into an embryo and subsequently an entire plant. In this Opinion article, we examine the Cellular, physiological and molecular similarities and differences between different plant Stem Cell types. We propose to extend the plant Stem Cell concept to include single embryogenic Cells as a Totipotent Stem Cell based on their capacity to regenerate or develop into an embryo under certain conditions. Our survey suggests that differences in chromatin structure might ensure that meriStem-localized Stem Cells have supervised freedom and are pluripotent, and that embryogenic Stem Cells are unsupervised, autonomous and, hence, freely Totipotent.

Nicolas Niemenak - One of the best experts on this subject based on the ideXlab platform.

  • pluripotent versus Totipotent plant Stem Cells dependence versus autonomy
    Trends in Plant Science, 2007
    Co-Authors: Jean-luc Verdeil, Laurence Alemanno, Nicolas Niemenak, Timothy John Tranbarger
    Abstract:

    Little is known of the mechanisms that induce the dedifferentiation of a single somatic Cell into a Totipotent embryogenic Cell that can either be regenerated or develop into an embryo and subsequently an entire plant. In this Opinion article, we examine the Cellular, physiological and molecular similarities and differences between different plant Stem Cell types. We propose to extend the plant Stem Cell concept to include single embryogenic Cells as a Totipotent Stem Cell based on their capacity to regenerate or develop into an embryo under certain conditions. Our survey suggests that differences in chromatin structure might ensure that meriStem-localized Stem Cells have supervised freedom and are pluripotent, and that embryogenic Stem Cells are unsupervised, autonomous and, hence, freely Totipotent.

Gerard Marguerie - One of the best experts on this subject based on the ideXlab platform.

  • suppression of erythro megakaryocytopoiesis and the induction of reversible thrombocytopenia in mice transgenic for the thymidine kinase gene targeted by the platelet glycoprotein alpha iib promoter
    Journal of Experimental Medicine, 1995
    Co-Authors: Tronikle D Roux, Valerie Roullot, Annie Schweitzer, Rolande Berthier, Gerard Marguerie
    Abstract:

    The mechanisms that regulate the commitment of a Totipotent Stem Cell to the megakaryocytic lineage are largely unknown. Using a molecular approach to the study of megakaryocytopoiesis and platelet production, mice in which thrombocytopoiesis could be controlled were produced by targeting the expression of the herpes simplex virus thymidine kinase toxigene to megakaryocytes using the regulatory region of the gene encoding the alpha subunit of the platelet integrin alpha IIb beta 3. The programmed eradication of the megakaryocytic lineage was induced by treating transgenic mice bearing the hybrid construct (alpha IIbtk) with the antiherpetic drug ganciclovir (GCV). After 10 d of treatment, the platelet number was reduced by > 94.6%. After discontinuing GCV, the bone marrow was repopulated with megakaryocytes and the platelet count was restored within 7 d. Prolonged GCV treatment induced erythropenia in the transgenic mice. Assays of myeloid progenitor Cells in vitro demonstrated that the transgene was expressed in early erythro-megakaryocytic progenitor Cells. The reversibility and facility of this syStem provides a powerful model to determine both the critical events in megakaryocytic and erythroid lineage development and for evaluating the precise role that platelets play in the pathogenesis of a number of vascular occlusive disorders.