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Paolo Aureli - One of the best experts on this subject based on the ideXlab platform.
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intestinal Toxemia botulism in italy 1984 2005
European Journal of Clinical Microbiology & Infectious Diseases, 2007Co-Authors: Lucia Fenicia, Fabrizio Anniballi, Paolo AureliAbstract:Botulism in humans is caused by botulinum neurotoxins, produced in most cases by Clostridium botulinum, although other Clostridia species are implicated as well. Of the five forms of botulism in humans, three are referred to as "infective": wound botulism, infant botulism, and adult intestinal botulism; the latter two forms are also referred to as "intestinal Toxemia botulism" because the organism colonizes the lumen of the intestinal tract and produces botulinum neurotoxin in vivo. Twenty-three cases of infant botulism and three cases of adult intestinal botulism occurred in Italy between 1984 and 2005. Microbiological analyses of clinical, environmental, and food samples and analysis of clinical and epidemiological data revealed two main characteristics of intestinal Toxemia botulism in Italy that are not common in cases in other countries: the isolation of a strain of C. butyricum that produced botulinum neurotoxin type E in 6 of 26 cases, including two cases of adult intestinal Toxemia botulism, and the onset of botulism in these cases with concomitant severe gastrointestinal symptomatology. This report summarizes the microbiological, clinical, and epidemiological data of all cases of intestinal Toxemia botulism that have occurred in Italy in the period 1984-2005.
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a case of infant botulism due to neurotoxigenic clostridium butyricum type e associated with clostridium difficile colitis
European Journal of Clinical Microbiology & Infectious Diseases, 2002Co-Authors: Lucia Fenicia, Fabrizio Anniballi, L Da Dalt, Giovanna Franciosa, Stefania Zanconato, Paolo AureliAbstract:Reported here is the sixth case of intestinal Toxemia botulism caused by Clostridium butyricum type E in Italy since 1984. In this case, the patient was concomitantly affected with colitis due to Clostridium difficile toxin. A review of previously reported cases revealed that some of these patients may also have had intestinal Toxemia botulism associated with Clostridium difficile colitis, based on the reported symptoms. Given that this association has been shown to exist not only in Italy but also in the USA, it is recommended that individuals with intestinal botulism and symptoms of colitis undergo testing for Clostridium difficile and its toxins in fecal samples.
Fabrizio Anniballi - One of the best experts on this subject based on the ideXlab platform.
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Adult Intestinal Toxemia Botulism.
Toxins, 2020Co-Authors: Richard A. Harris, Fabrizio Anniballi, John W. AustinAbstract:Intoxication with botulinum neurotoxin can occur through various routes. Foodborne botulism results after consumption of food in which botulinum neurotoxin-producing clostridia (i.e., Clostridium botulinum or strains of Clostridium butyricum type E or Clostridium baratii type F) have replicated and produced botulinum neurotoxin. Infection of a wound with C. botulinum and in situ production of botulinum neurotoxin leads to wound botulism. Colonization of the intestine by neurotoxigenic clostridia, with consequent production of botulinum toxin in the intestine, leads to intestinal Toxemia botulism. When this occurs in an infant, it is referred to as infant botulism, whereas in adults or children over 1 year of age, it is intestinal colonization botulism. Predisposing factors for intestinal colonization in children or adults include previous bowel or gastric surgery, anatomical bowel abnormalities, Crohn’s disease, inflammatory bowel disease, antimicrobial therapy, or foodborne botulism. Intestinal colonization botulism is confirmed by detection of botulinum toxin in serum and/or stool, or isolation of neurotoxigenic clostridia from the stool, without finding a toxic food. Shedding of neurotoxigenic clostridia in the stool may occur for a period of several weeks. Adult intestinal botulism occurs as isolated cases, and may go undiagnosed, contributing to the low reported incidence of this rare disease.
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intestinal Toxemia botulism in italy 1984 2005
European Journal of Clinical Microbiology & Infectious Diseases, 2007Co-Authors: Lucia Fenicia, Fabrizio Anniballi, Paolo AureliAbstract:Botulism in humans is caused by botulinum neurotoxins, produced in most cases by Clostridium botulinum, although other Clostridia species are implicated as well. Of the five forms of botulism in humans, three are referred to as "infective": wound botulism, infant botulism, and adult intestinal botulism; the latter two forms are also referred to as "intestinal Toxemia botulism" because the organism colonizes the lumen of the intestinal tract and produces botulinum neurotoxin in vivo. Twenty-three cases of infant botulism and three cases of adult intestinal botulism occurred in Italy between 1984 and 2005. Microbiological analyses of clinical, environmental, and food samples and analysis of clinical and epidemiological data revealed two main characteristics of intestinal Toxemia botulism in Italy that are not common in cases in other countries: the isolation of a strain of C. butyricum that produced botulinum neurotoxin type E in 6 of 26 cases, including two cases of adult intestinal Toxemia botulism, and the onset of botulism in these cases with concomitant severe gastrointestinal symptomatology. This report summarizes the microbiological, clinical, and epidemiological data of all cases of intestinal Toxemia botulism that have occurred in Italy in the period 1984-2005.
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a case of infant botulism due to neurotoxigenic clostridium butyricum type e associated with clostridium difficile colitis
European Journal of Clinical Microbiology & Infectious Diseases, 2002Co-Authors: Lucia Fenicia, Fabrizio Anniballi, L Da Dalt, Giovanna Franciosa, Stefania Zanconato, Paolo AureliAbstract:Reported here is the sixth case of intestinal Toxemia botulism caused by Clostridium butyricum type E in Italy since 1984. In this case, the patient was concomitantly affected with colitis due to Clostridium difficile toxin. A review of previously reported cases revealed that some of these patients may also have had intestinal Toxemia botulism associated with Clostridium difficile colitis, based on the reported symptoms. Given that this association has been shown to exist not only in Italy but also in the USA, it is recommended that individuals with intestinal botulism and symptoms of colitis undergo testing for Clostridium difficile and its toxins in fecal samples.
Lucia Fenicia - One of the best experts on this subject based on the ideXlab platform.
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intestinal Toxemia botulism in italy 1984 2005
European Journal of Clinical Microbiology & Infectious Diseases, 2007Co-Authors: Lucia Fenicia, Fabrizio Anniballi, Paolo AureliAbstract:Botulism in humans is caused by botulinum neurotoxins, produced in most cases by Clostridium botulinum, although other Clostridia species are implicated as well. Of the five forms of botulism in humans, three are referred to as "infective": wound botulism, infant botulism, and adult intestinal botulism; the latter two forms are also referred to as "intestinal Toxemia botulism" because the organism colonizes the lumen of the intestinal tract and produces botulinum neurotoxin in vivo. Twenty-three cases of infant botulism and three cases of adult intestinal botulism occurred in Italy between 1984 and 2005. Microbiological analyses of clinical, environmental, and food samples and analysis of clinical and epidemiological data revealed two main characteristics of intestinal Toxemia botulism in Italy that are not common in cases in other countries: the isolation of a strain of C. butyricum that produced botulinum neurotoxin type E in 6 of 26 cases, including two cases of adult intestinal Toxemia botulism, and the onset of botulism in these cases with concomitant severe gastrointestinal symptomatology. This report summarizes the microbiological, clinical, and epidemiological data of all cases of intestinal Toxemia botulism that have occurred in Italy in the period 1984-2005.
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a case of infant botulism due to neurotoxigenic clostridium butyricum type e associated with clostridium difficile colitis
European Journal of Clinical Microbiology & Infectious Diseases, 2002Co-Authors: Lucia Fenicia, Fabrizio Anniballi, L Da Dalt, Giovanna Franciosa, Stefania Zanconato, Paolo AureliAbstract:Reported here is the sixth case of intestinal Toxemia botulism caused by Clostridium butyricum type E in Italy since 1984. In this case, the patient was concomitantly affected with colitis due to Clostridium difficile toxin. A review of previously reported cases revealed that some of these patients may also have had intestinal Toxemia botulism associated with Clostridium difficile colitis, based on the reported symptoms. Given that this association has been shown to exist not only in Italy but also in the USA, it is recommended that individuals with intestinal botulism and symptoms of colitis undergo testing for Clostridium difficile and its toxins in fecal samples.
Jared D. Taylor - One of the best experts on this subject based on the ideXlab platform.
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characterization of short and long term morbidity and mortality of goat kids born to does with pregnancy Toxemia
Journal of Veterinary Internal Medicine, 2021Co-Authors: Leslie F. Weaver, Melanie J. Boileau, Lyndi L. Gilliam, Jared D. TaylorAbstract:BACKGROUND Pregnancy Toxemia is a common metabolic disease of periparturient small ruminants. Information on its effects on metabolism and perinatal adaptation of newborn lambs and kids is lacking. OBJECTIVES Evaluate differences in morbidity, mortality, and common biochemical and hematologic variables between pregnancy Toxemia kids (PT) and control kids (CON). ANIMALS Sixteen kids born to does being treated at the hospital for pregnancy Toxemia (blood beta-hydroxybutyrate concentration [BHB] > 1.2 mmol/L) and 12 kids from healthy dams (dam BHB < 1.2 mmol/L) that kidded at the hospital. METHODS In this cohort study, serial measurements of blood L-lactate, glucose, and BHB concentrations, arterial blood gases, hematocrit, total protein concentrations, nonesterified fatty acids (NEFAs) concentrations, and body weight were compared between groups over the first 72 hours of life. Long-term follow-up was performed after 3 months. RESULTS Pregnancy Toxemia kids were more likely to require tube feeding at 0 and 12 hours (relative risk 7.7 [1.13, 52.45] and 2.8 [1.39, 5.65]). Pregnancy Toxemia kids were more acidemic (7.26 ± 0.069 vs 7.34 ± 0.079, P = .003) and hyperlactatemic (8.17 ± 2.57 vs 5.48 ± 2.71, P = .003) at birth than CON kids. Control kids were 1.1 [1.01, 1.77] times more likely to survive to discharge and 2.2 [1.15, 4.20] times more likely to survive to 3 months than PT kids. CONCLUSIONS AND CLINICAL IMPORTANCE Pregnancy Toxemia kids had higher short- and long-term mortality and were more likely to require perinatal intervention. Weight loss in the first few days could be a useful predictor of nonsurvival.
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Evaluation of prognostic indicators for goats with pregnancy Toxemia.
Journal of the American Veterinary Medical Association, 2019Co-Authors: Katharine M. Simpson, Jared D. Taylor, Robert N. StreeterAbstract:Objective To evaluate potential prognostic indicators for does with pregnancy Toxemia (PT) and their offspring. DESIGN Retrospective cohort study. ANIMALS 56 does. PROCEDURES Medical records were s...
John W. Austin - One of the best experts on this subject based on the ideXlab platform.
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Adult Intestinal Toxemia Botulism.
Toxins, 2020Co-Authors: Richard A. Harris, Fabrizio Anniballi, John W. AustinAbstract:Intoxication with botulinum neurotoxin can occur through various routes. Foodborne botulism results after consumption of food in which botulinum neurotoxin-producing clostridia (i.e., Clostridium botulinum or strains of Clostridium butyricum type E or Clostridium baratii type F) have replicated and produced botulinum neurotoxin. Infection of a wound with C. botulinum and in situ production of botulinum neurotoxin leads to wound botulism. Colonization of the intestine by neurotoxigenic clostridia, with consequent production of botulinum toxin in the intestine, leads to intestinal Toxemia botulism. When this occurs in an infant, it is referred to as infant botulism, whereas in adults or children over 1 year of age, it is intestinal colonization botulism. Predisposing factors for intestinal colonization in children or adults include previous bowel or gastric surgery, anatomical bowel abnormalities, Crohn’s disease, inflammatory bowel disease, antimicrobial therapy, or foodborne botulism. Intestinal colonization botulism is confirmed by detection of botulinum toxin in serum and/or stool, or isolation of neurotoxigenic clostridia from the stool, without finding a toxic food. Shedding of neurotoxigenic clostridia in the stool may occur for a period of several weeks. Adult intestinal botulism occurs as isolated cases, and may go undiagnosed, contributing to the low reported incidence of this rare disease.