The Experts below are selected from a list of 1179 Experts worldwide ranked by ideXlab platform
Karen Smet - One of the best experts on this subject based on the ideXlab platform.
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the urinary metabolic profile of diethylene glycol methyl ether and triethylene glycol methyl ether in sprague dawley rats and the role of the metabolite methoxyacetic acid in their toxicity
Regulatory Toxicology and Pharmacology, 2020Co-Authors: Jeffrey R Kelsey, Nicole H P Cnubben, J J P Bogaards, Rene B H Braakman, Leo L P Van Stee, Karen SmetAbstract:Abstract Ethylene glycol ethers are a well-known series of solvents and hydraulic fluids derived from the reaction of ethylene oxide and monoalcohols. Use of methanol as the alcohol results in a series of mono, di and triethylene glycol methyl ethers. The first in the series, monoethylene glycol methyl ether (EGME or 2-methoxyethanol) is well characterised and metabolises in vivo to methoxyacetic acid (MAA), a known reproductive Toxicant. Metabolism data is not available for the di and triethylene glycol ethers (DEGME and TEGME respectively). This study evaluated the Metabolism of these two substances in male rats following single oral gavage doses of 500, 1000 and 2000 mg/kg for DEGME and 1000 mg/kg for TEGME. As for EGME, the dominant metabolite of each was the acid metabolite derived by oxidation of the terminal hydroxyl group. Elimination of these metabolites was rapid, with half-lives
Jeffrey R Kelsey - One of the best experts on this subject based on the ideXlab platform.
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the urinary metabolic profile of diethylene glycol methyl ether and triethylene glycol methyl ether in sprague dawley rats and the role of the metabolite methoxyacetic acid in their toxicity
Regulatory Toxicology and Pharmacology, 2020Co-Authors: Jeffrey R Kelsey, Nicole H P Cnubben, J J P Bogaards, Rene B H Braakman, Leo L P Van Stee, Karen SmetAbstract:Abstract Ethylene glycol ethers are a well-known series of solvents and hydraulic fluids derived from the reaction of ethylene oxide and monoalcohols. Use of methanol as the alcohol results in a series of mono, di and triethylene glycol methyl ethers. The first in the series, monoethylene glycol methyl ether (EGME or 2-methoxyethanol) is well characterised and metabolises in vivo to methoxyacetic acid (MAA), a known reproductive Toxicant. Metabolism data is not available for the di and triethylene glycol ethers (DEGME and TEGME respectively). This study evaluated the Metabolism of these two substances in male rats following single oral gavage doses of 500, 1000 and 2000 mg/kg for DEGME and 1000 mg/kg for TEGME. As for EGME, the dominant metabolite of each was the acid metabolite derived by oxidation of the terminal hydroxyl group. Elimination of these metabolites was rapid, with half-lives
Leo L P Van Stee - One of the best experts on this subject based on the ideXlab platform.
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the urinary metabolic profile of diethylene glycol methyl ether and triethylene glycol methyl ether in sprague dawley rats and the role of the metabolite methoxyacetic acid in their toxicity
Regulatory Toxicology and Pharmacology, 2020Co-Authors: Jeffrey R Kelsey, Nicole H P Cnubben, J J P Bogaards, Rene B H Braakman, Leo L P Van Stee, Karen SmetAbstract:Abstract Ethylene glycol ethers are a well-known series of solvents and hydraulic fluids derived from the reaction of ethylene oxide and monoalcohols. Use of methanol as the alcohol results in a series of mono, di and triethylene glycol methyl ethers. The first in the series, monoethylene glycol methyl ether (EGME or 2-methoxyethanol) is well characterised and metabolises in vivo to methoxyacetic acid (MAA), a known reproductive Toxicant. Metabolism data is not available for the di and triethylene glycol ethers (DEGME and TEGME respectively). This study evaluated the Metabolism of these two substances in male rats following single oral gavage doses of 500, 1000 and 2000 mg/kg for DEGME and 1000 mg/kg for TEGME. As for EGME, the dominant metabolite of each was the acid metabolite derived by oxidation of the terminal hydroxyl group. Elimination of these metabolites was rapid, with half-lives
J J P Bogaards - One of the best experts on this subject based on the ideXlab platform.
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the urinary metabolic profile of diethylene glycol methyl ether and triethylene glycol methyl ether in sprague dawley rats and the role of the metabolite methoxyacetic acid in their toxicity
Regulatory Toxicology and Pharmacology, 2020Co-Authors: Jeffrey R Kelsey, Nicole H P Cnubben, J J P Bogaards, Rene B H Braakman, Leo L P Van Stee, Karen SmetAbstract:Abstract Ethylene glycol ethers are a well-known series of solvents and hydraulic fluids derived from the reaction of ethylene oxide and monoalcohols. Use of methanol as the alcohol results in a series of mono, di and triethylene glycol methyl ethers. The first in the series, monoethylene glycol methyl ether (EGME or 2-methoxyethanol) is well characterised and metabolises in vivo to methoxyacetic acid (MAA), a known reproductive Toxicant. Metabolism data is not available for the di and triethylene glycol ethers (DEGME and TEGME respectively). This study evaluated the Metabolism of these two substances in male rats following single oral gavage doses of 500, 1000 and 2000 mg/kg for DEGME and 1000 mg/kg for TEGME. As for EGME, the dominant metabolite of each was the acid metabolite derived by oxidation of the terminal hydroxyl group. Elimination of these metabolites was rapid, with half-lives
Rene B H Braakman - One of the best experts on this subject based on the ideXlab platform.
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the urinary metabolic profile of diethylene glycol methyl ether and triethylene glycol methyl ether in sprague dawley rats and the role of the metabolite methoxyacetic acid in their toxicity
Regulatory Toxicology and Pharmacology, 2020Co-Authors: Jeffrey R Kelsey, Nicole H P Cnubben, J J P Bogaards, Rene B H Braakman, Leo L P Van Stee, Karen SmetAbstract:Abstract Ethylene glycol ethers are a well-known series of solvents and hydraulic fluids derived from the reaction of ethylene oxide and monoalcohols. Use of methanol as the alcohol results in a series of mono, di and triethylene glycol methyl ethers. The first in the series, monoethylene glycol methyl ether (EGME or 2-methoxyethanol) is well characterised and metabolises in vivo to methoxyacetic acid (MAA), a known reproductive Toxicant. Metabolism data is not available for the di and triethylene glycol ethers (DEGME and TEGME respectively). This study evaluated the Metabolism of these two substances in male rats following single oral gavage doses of 500, 1000 and 2000 mg/kg for DEGME and 1000 mg/kg for TEGME. As for EGME, the dominant metabolite of each was the acid metabolite derived by oxidation of the terminal hydroxyl group. Elimination of these metabolites was rapid, with half-lives