The Experts below are selected from a list of 4464 Experts worldwide ranked by ideXlab platform
D. Bogod - One of the best experts on this subject based on the ideXlab platform.
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Cerebral haemodynamics in pregnancy and pre‐eclampsia as assessed by Transcranial Doppler Ultrasonography
British journal of anaesthesia, 2002Co-Authors: R. W. Sherman, Ravi Mahajan, R. A. Bowie, M. M.e. Henfrey, D. BogodAbstract:Background Altered cerebral circulation, as reported during normal pregnancy, and in patients with pre-eclampsia, can be associated with changes in cerebral vascular reactivity and/or cerebral autoregulation. The aim of our study was to perform a comparative assessment of cerebral haemodynamics, including vascular reactivity and autoregulation, in pre-eclamptic patients, healthy pregnant women, and healthy non-pregnant women. Methods Thirty patients with pre-eclampsia were recruited. Age- and height-matched healthy pregnant (n=30) and non-pregnant control (n=30) groups were also recruited. Monitoring included Transcranial Doppler Ultrasonography, end-tidal carbon dioxide and non-invasive arterial pressure measurement. Cerebral autoregulation was assessed by performing the transient hyperaemic response (THR) test. The cerebrovascular reactivity to carbon dioxide (CRCO2) was assessed by measuring middle cerebral artery blood flow velocity (MCAFV) after induced changes in end-tidal carbon dioxide. Estimated cerebral perfusion pressure (eCPP) and critical closing pressure (CrCP) were calculated using established formulae. Statistical analysis included ANOVA with Tukey's pairwise comparisons. Results Mean arterial pressure (MAP) was increased in pre-eclampsia (P Conclusions Healthy pregnancy increases eCPP, presumably by decreasing CrCP. In pre-eclampsia, eCPP is maintained at the same level as in healthy pregnancy despite an increased MAP. Pre-eclampsia has no significant effect on cerebral autoregulation or CRCO2.
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cerebral haemodynamics in pregnancy and pre eclampsia as assessed by Transcranial Doppler Ultrasonography
BJA: British Journal of Anaesthesia, 2002Co-Authors: R. W. Sherman, R. P. Mahajan, R. A. Bowie, M. M.e. Henfrey, D. BogodAbstract:Background Altered cerebral circulation, as reported during normal pregnancy, and in patients with pre-eclampsia, can be associated with changes in cerebral vascular reactivity and/or cerebral autoregulation. The aim of our study was to perform a comparative assessment of cerebral haemodynamics, including vascular reactivity and autoregulation, in pre-eclamptic patients, healthy pregnant women, and healthy non-pregnant women. Methods Thirty patients with pre-eclampsia were recruited. Age- and height-matched healthy pregnant (n=30) and non-pregnant control (n=30) groups were also recruited. Monitoring included Transcranial Doppler Ultrasonography, end-tidal carbon dioxide and non-invasive arterial pressure measurement. Cerebral autoregulation was assessed by performing the transient hyperaemic response (THR) test. The cerebrovascular reactivity to carbon dioxide (CRCO2) was assessed by measuring middle cerebral artery blood flow velocity (MCAFV) after induced changes in end-tidal carbon dioxide. Estimated cerebral perfusion pressure (eCPP) and critical closing pressure (CrCP) were calculated using established formulae. Statistical analysis included ANOVA with Tukey's pairwise comparisons. Results Mean arterial pressure (MAP) was increased in pre-eclampsia (P Conclusions Healthy pregnancy increases eCPP, presumably by decreasing CrCP. In pre-eclampsia, eCPP is maintained at the same level as in healthy pregnancy despite an increased MAP. Pre-eclampsia has no significant effect on cerebral autoregulation or CRCO2.
M Bitzani - One of the best experts on this subject based on the ideXlab platform.
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The use of Transcranial Doppler Ultrasonography in early outcome prediction of patients with subarachnoid hemorrhage
Critical Care, 2005Co-Authors: A Lavrentieva, B Soulountzi, B Boutsas, A Lampanari, A Mitka, M BitzaniAbstract:Transcranial Doppler Ultrasonography (TCD) is a well-established technique for detection of cerebral vasospasm in patients with subarachnoid hemorrhage (SAH). The aim of our study is to investigate whether there is a relationship between TCD findings during the first 3 days after admission and the neurological outcome of patients.
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Comparison of biochemical markers and Transcranial Doppler Ultrasonography findings as early predictors of outcome in patients with traumatic brain injury: preliminary report
Critical Care, 2005Co-Authors: I Rodini, A Lavrentieva, B Soulountzi, C Fitili, M Karvouniaris, M BitzaniAbstract:Early brain ischemia after traumatic brain injury (TBI) is predictive of pure outcome. We investigated the time course of biochemical markers of brain damage: serum neuron-specific enolase (NSE) and protein S-100 (Pr S-100) during the first 5 days after the ICU admission. Brain hemodynamics were synchronously assessed using Transcranial Doppler Ultrasonography (TCD). Each patient was examined with TCD, and the maximum, mean, and the end diastolic velocities and pulsatility index (PI) were evaluated.
R. W. Sherman - One of the best experts on this subject based on the ideXlab platform.
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Cerebral haemodynamics in pregnancy and pre‐eclampsia as assessed by Transcranial Doppler Ultrasonography
British journal of anaesthesia, 2002Co-Authors: R. W. Sherman, Ravi Mahajan, R. A. Bowie, M. M.e. Henfrey, D. BogodAbstract:Background Altered cerebral circulation, as reported during normal pregnancy, and in patients with pre-eclampsia, can be associated with changes in cerebral vascular reactivity and/or cerebral autoregulation. The aim of our study was to perform a comparative assessment of cerebral haemodynamics, including vascular reactivity and autoregulation, in pre-eclamptic patients, healthy pregnant women, and healthy non-pregnant women. Methods Thirty patients with pre-eclampsia were recruited. Age- and height-matched healthy pregnant (n=30) and non-pregnant control (n=30) groups were also recruited. Monitoring included Transcranial Doppler Ultrasonography, end-tidal carbon dioxide and non-invasive arterial pressure measurement. Cerebral autoregulation was assessed by performing the transient hyperaemic response (THR) test. The cerebrovascular reactivity to carbon dioxide (CRCO2) was assessed by measuring middle cerebral artery blood flow velocity (MCAFV) after induced changes in end-tidal carbon dioxide. Estimated cerebral perfusion pressure (eCPP) and critical closing pressure (CrCP) were calculated using established formulae. Statistical analysis included ANOVA with Tukey's pairwise comparisons. Results Mean arterial pressure (MAP) was increased in pre-eclampsia (P Conclusions Healthy pregnancy increases eCPP, presumably by decreasing CrCP. In pre-eclampsia, eCPP is maintained at the same level as in healthy pregnancy despite an increased MAP. Pre-eclampsia has no significant effect on cerebral autoregulation or CRCO2.
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cerebral haemodynamics in pregnancy and pre eclampsia as assessed by Transcranial Doppler Ultrasonography
BJA: British Journal of Anaesthesia, 2002Co-Authors: R. W. Sherman, R. P. Mahajan, R. A. Bowie, M. M.e. Henfrey, D. BogodAbstract:Background Altered cerebral circulation, as reported during normal pregnancy, and in patients with pre-eclampsia, can be associated with changes in cerebral vascular reactivity and/or cerebral autoregulation. The aim of our study was to perform a comparative assessment of cerebral haemodynamics, including vascular reactivity and autoregulation, in pre-eclamptic patients, healthy pregnant women, and healthy non-pregnant women. Methods Thirty patients with pre-eclampsia were recruited. Age- and height-matched healthy pregnant (n=30) and non-pregnant control (n=30) groups were also recruited. Monitoring included Transcranial Doppler Ultrasonography, end-tidal carbon dioxide and non-invasive arterial pressure measurement. Cerebral autoregulation was assessed by performing the transient hyperaemic response (THR) test. The cerebrovascular reactivity to carbon dioxide (CRCO2) was assessed by measuring middle cerebral artery blood flow velocity (MCAFV) after induced changes in end-tidal carbon dioxide. Estimated cerebral perfusion pressure (eCPP) and critical closing pressure (CrCP) were calculated using established formulae. Statistical analysis included ANOVA with Tukey's pairwise comparisons. Results Mean arterial pressure (MAP) was increased in pre-eclampsia (P Conclusions Healthy pregnancy increases eCPP, presumably by decreasing CrCP. In pre-eclampsia, eCPP is maintained at the same level as in healthy pregnancy despite an increased MAP. Pre-eclampsia has no significant effect on cerebral autoregulation or CRCO2.
Vijay K. Sharma - One of the best experts on this subject based on the ideXlab platform.
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Role of Transcranial Doppler Ultrasonography in cerebrovascular disease.
Recent patents on CNS drug discovery, 2010Co-Authors: Leonard L.l. Yeo, Vijay K. SharmaAbstract:Abstract Transcranial Doppler Ultrasonography (TCD) is the only non-invasive examination that provides a reliable evaluation of intracranial blood flow patterns in real-time, adding physiological information to the anatomical information obtained from other neuroimaging modalities. TCD is relatively cheap, can be performed bedside, and allows monitoring both in acute emergency settings as well as for prolonged periods with a high temporal resolution making it ideal for studying dynamic cerebrovascular responses. Extended applications of Transcranial Doppler in enhancing intravenous thrombolysis in acute stroke, emboli monitoring, right-to-left shunt detection and vasomotor reactivity provide important information about the pathophysiology of cerebrovascular ischemia. In acute cerebral ischemia, TCD is capable of providing rapid information about the hemodynamic status of the cerebral circulation, monitoring recanalization in real-time with a potential for enhancing tissue plasminogen activator (TPA) induced thrombolysis. Advanced applications of TCD make it an important and valuable tool for evaluating stroke mechanisms, plan and monitor treatment and determine prognosis. TCD has an established clinical value in the diagnostic workup of stroke patients and is suggested as essential components of a comprehensive stroke center. We have reviewed various recent patents in addition to the diagnostic, therapeutic, as well as, prognostic applications of TCD in patients with cerebrovascular disease.
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Role of Transcranial Doppler Ultrasonography in evaluation of patients with cerebrovascular disease
Current Neurology and Neuroscience Reports, 2007Co-Authors: Vijay K. Sharma, Georgios Tsivgoulis, Annabelle Y. Lao, Andrei V. AlexandrovAbstract:Transcranial Doppler Ultrasonography (TCD) is the only noninvasive examination method that enables the reliable evaluation of blood flow from the basal intracerebral vessels, adding physiologic information to the anatomic images. TCD is relatively inexpensive, can be performed at bedside, and allows monitoring in acute emergency settings and for prolonged periods with a high temporal resolution, making it ideal for studying dynamic cerebrovascular responses. In acute stroke, TCD is capable of providing rapid information about the hemodynamic status of the cerebral circulation and monitoring recanalization in real-time, with a potential for enhancing tissue plasminogen activator-induced thrombolysis. Extended applications such as emboli monitoring, right-to-left shunt detection, and vasomotor reactivity make TCD an important and valuable tool for evaluating stroke mechanisms, planning and monitoring treatment, and determining prognosis.
Andrei V. Alexandrov - One of the best experts on this subject based on the ideXlab platform.
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Advances in Transcranial Doppler Ultrasonography.
Current neurology and neuroscience reports, 2008Co-Authors: Georgios Tsivgoulis, Andrei V. Alexandrov, Michael A. SloanAbstract:Transcranial Doppler Ultrasonography (TCD) is the only noninvasive real-time neuroimaging modality for the evaluation of characteristics of blood flow in basal intracerebral vessels that adds physiologic information to structural imaging. TCD has been rapidly evolving from a simple noninvasive diagnostic tool to an imaging modality with a broad spectrum of clinical applications. In acute stroke, TCD can provide rapid information about vascular stenosis and occlusion, the hemodynamic status of the cerebral circulation, and real-time monitoring of recanalization. Extended applications such as vasomotor reactivity testing, emboli monitoring, and right-to-left shunt detection help clinicians ascertain stroke mechanisms at the bedside, plan and monitor treatment, and determine prognosis. In the neurointensive care unit, TCD is useful for detecting increased intracranial pressure and confirming cerebral circulatory arrest. TCD is of established value for screening children with sickle cell disease and detecting and monitoring vasospasm after spontaneous subarachnoid hemorrhage.
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Role of Transcranial Doppler Ultrasonography in evaluation of patients with cerebrovascular disease
Current Neurology and Neuroscience Reports, 2007Co-Authors: Vijay K. Sharma, Georgios Tsivgoulis, Annabelle Y. Lao, Andrei V. AlexandrovAbstract:Transcranial Doppler Ultrasonography (TCD) is the only noninvasive examination method that enables the reliable evaluation of blood flow from the basal intracerebral vessels, adding physiologic information to the anatomic images. TCD is relatively inexpensive, can be performed at bedside, and allows monitoring in acute emergency settings and for prolonged periods with a high temporal resolution, making it ideal for studying dynamic cerebrovascular responses. In acute stroke, TCD is capable of providing rapid information about the hemodynamic status of the cerebral circulation and monitoring recanalization in real-time, with a potential for enhancing tissue plasminogen activator-induced thrombolysis. Extended applications such as emboli monitoring, right-to-left shunt detection, and vasomotor reactivity make TCD an important and valuable tool for evaluating stroke mechanisms, planning and monitoring treatment, and determining prognosis.