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Kazuyoshi Hashizume - One of the best experts on this subject based on the ideXlab platform.

  • newly identified interferon tau responsive hes family bhlh Transcription Factor 4 and cytidine uridine monophosphate kinase 2 genes in peripheral blood granulocytes during early pregnancy in cows
    Domestic Animal Endocrinology, 2019
    Co-Authors: M Kikuchi, Keiichiro Kizaki, S Shigeno, Noriyuki Toji, Toshina Ishigurooonuma, Katsuo Koshi, Toru Takahashi, Kazuyoshi Hashizume
    Abstract:

    Abstract In cattle, interferon-stimulated genes (ISGs) such as ISG15, MX1, MX2, and OAS1 are known as classic ISGs that are highly involved in the implantation process. Various molecules play a crucial role in the mechanisms underlying ISG effects. Although microarray analyses have highlighted the expression of various molecules during the implantation period, these molecules remain incompletely characterized. In the present study, various specifically expressed genes were selected and their characteristics were examined. The microarray data from peripheral blood leucocytes derived from artificially inseminated cows and granulocytes obtained from embryo-transferred cows, respectively, were used to identify new ISG candidates. Seven common genes, including ISG15 and OAS1, were confirmed, but only four of the five genes were amplified by reverse Transcription quantitative polymerase chain reaction. Additionally, three expressed sequence tags (ESTs) exhibited significantly greater expression in granulocytes from pregnant cows than that observed in bred non-pregnant cows, and the expression in granulocytes increased after IFNT stimulation. Sequence alignment revealed similar sequences within two ESTs on the Hairy and enhancer of split (Hes) family basic helix-loop-helix (BHLH) Transcription Factor 4 (HES4) gene. An additional EST was identified as cytidine/uridine monophosphate kinase 2 (CMPK2). In silico analysis facilitated the identification of Transcription Factor-binding sequences, including an interferon-stimulated response element and interferon regulatory Factor-binding sites, within the promoter region of HES4 and CMPK2. These genes may function as new ISGs in the context of implantation and may participate in the coordination of the feto-maternal interface in cows.

  • newly identified interferon tau responsive hes family bhlh Transcription Factor 4 and cytidine uridine monophosphate kinase 2 genes in peripheral blood granulocytes during early pregnancy in cows
    Domestic Animal Endocrinology, 2019
    Co-Authors: M Kikuchi, Keiichiro Kizaki, S Shigeno, Noriyuki Toji, Toshina Ishigurooonuma, Katsuo Koshi, Toru Takahashi, Kazuyoshi Hashizume
    Abstract:

    Abstract In cattle, interferon-stimulated genes (ISGs) such as ISG15, MX1, MX2, and OAS1 are known as classic ISGs that are highly involved in the implantation process. Various molecules play a crucial role in the mechanisms underlying ISG effects. Although microarray analyses have highlighted the expression of various molecules during the implantation period, these molecules remain incompletely characterized. In the present study, various specifically expressed genes were selected and their characteristics were examined. The microarray data from peripheral blood leukocytes derived from artificially inseminated cows and granulocytes obtained from embryo-transferred cows, respectively, were used to identify new ISG candidates. Seven common genes, including ISG15 and OAS1, were confirmed, but only 4 of the 5 genes were amplified by reverse Transcription quantitative polymerase chain reaction. In addition, 3 expressed sequence tags (ESTs) exhibited significantly greater expression in granulocytes from pregnant cows than that observed in bred nonpregnant cows, and the expression in granulocytes increased after interferon-tau stimulation. Sequence alignment revealed similar sequences within 2 ESTs on the Hairy and enhancer of split (Hes) family basic helix-loop-helix Transcription Factor 4 (HES4) gene. An additional EST was identified as cytidine/uridine monophosphate kinase 2 (CMPK2). In silico analysis facilitated the identification of Transcription Factor–binding sequences, including an interferon-stimulated response element and interferon regulatory Factor-binding sites, within the promoter region of HES4 and CMPK2. These genes may function as new ISGs in the context of implantation and may participate in the coordination of the feto-maternal interface in cows.

M Kikuchi - One of the best experts on this subject based on the ideXlab platform.

  • newly identified interferon tau responsive hes family bhlh Transcription Factor 4 and cytidine uridine monophosphate kinase 2 genes in peripheral blood granulocytes during early pregnancy in cows
    Domestic Animal Endocrinology, 2019
    Co-Authors: M Kikuchi, Keiichiro Kizaki, S Shigeno, Noriyuki Toji, Toshina Ishigurooonuma, Katsuo Koshi, Toru Takahashi, Kazuyoshi Hashizume
    Abstract:

    Abstract In cattle, interferon-stimulated genes (ISGs) such as ISG15, MX1, MX2, and OAS1 are known as classic ISGs that are highly involved in the implantation process. Various molecules play a crucial role in the mechanisms underlying ISG effects. Although microarray analyses have highlighted the expression of various molecules during the implantation period, these molecules remain incompletely characterized. In the present study, various specifically expressed genes were selected and their characteristics were examined. The microarray data from peripheral blood leucocytes derived from artificially inseminated cows and granulocytes obtained from embryo-transferred cows, respectively, were used to identify new ISG candidates. Seven common genes, including ISG15 and OAS1, were confirmed, but only four of the five genes were amplified by reverse Transcription quantitative polymerase chain reaction. Additionally, three expressed sequence tags (ESTs) exhibited significantly greater expression in granulocytes from pregnant cows than that observed in bred non-pregnant cows, and the expression in granulocytes increased after IFNT stimulation. Sequence alignment revealed similar sequences within two ESTs on the Hairy and enhancer of split (Hes) family basic helix-loop-helix (BHLH) Transcription Factor 4 (HES4) gene. An additional EST was identified as cytidine/uridine monophosphate kinase 2 (CMPK2). In silico analysis facilitated the identification of Transcription Factor-binding sequences, including an interferon-stimulated response element and interferon regulatory Factor-binding sites, within the promoter region of HES4 and CMPK2. These genes may function as new ISGs in the context of implantation and may participate in the coordination of the feto-maternal interface in cows.

  • newly identified interferon tau responsive hes family bhlh Transcription Factor 4 and cytidine uridine monophosphate kinase 2 genes in peripheral blood granulocytes during early pregnancy in cows
    Domestic Animal Endocrinology, 2019
    Co-Authors: M Kikuchi, Keiichiro Kizaki, S Shigeno, Noriyuki Toji, Toshina Ishigurooonuma, Katsuo Koshi, Toru Takahashi, Kazuyoshi Hashizume
    Abstract:

    Abstract In cattle, interferon-stimulated genes (ISGs) such as ISG15, MX1, MX2, and OAS1 are known as classic ISGs that are highly involved in the implantation process. Various molecules play a crucial role in the mechanisms underlying ISG effects. Although microarray analyses have highlighted the expression of various molecules during the implantation period, these molecules remain incompletely characterized. In the present study, various specifically expressed genes were selected and their characteristics were examined. The microarray data from peripheral blood leukocytes derived from artificially inseminated cows and granulocytes obtained from embryo-transferred cows, respectively, were used to identify new ISG candidates. Seven common genes, including ISG15 and OAS1, were confirmed, but only 4 of the 5 genes were amplified by reverse Transcription quantitative polymerase chain reaction. In addition, 3 expressed sequence tags (ESTs) exhibited significantly greater expression in granulocytes from pregnant cows than that observed in bred nonpregnant cows, and the expression in granulocytes increased after interferon-tau stimulation. Sequence alignment revealed similar sequences within 2 ESTs on the Hairy and enhancer of split (Hes) family basic helix-loop-helix Transcription Factor 4 (HES4) gene. An additional EST was identified as cytidine/uridine monophosphate kinase 2 (CMPK2). In silico analysis facilitated the identification of Transcription Factor–binding sequences, including an interferon-stimulated response element and interferon regulatory Factor-binding sites, within the promoter region of HES4 and CMPK2. These genes may function as new ISGs in the context of implantation and may participate in the coordination of the feto-maternal interface in cows.

Keiichiro Kizaki - One of the best experts on this subject based on the ideXlab platform.

  • newly identified interferon tau responsive hes family bhlh Transcription Factor 4 and cytidine uridine monophosphate kinase 2 genes in peripheral blood granulocytes during early pregnancy in cows
    Domestic Animal Endocrinology, 2019
    Co-Authors: M Kikuchi, Keiichiro Kizaki, S Shigeno, Noriyuki Toji, Toshina Ishigurooonuma, Katsuo Koshi, Toru Takahashi, Kazuyoshi Hashizume
    Abstract:

    Abstract In cattle, interferon-stimulated genes (ISGs) such as ISG15, MX1, MX2, and OAS1 are known as classic ISGs that are highly involved in the implantation process. Various molecules play a crucial role in the mechanisms underlying ISG effects. Although microarray analyses have highlighted the expression of various molecules during the implantation period, these molecules remain incompletely characterized. In the present study, various specifically expressed genes were selected and their characteristics were examined. The microarray data from peripheral blood leucocytes derived from artificially inseminated cows and granulocytes obtained from embryo-transferred cows, respectively, were used to identify new ISG candidates. Seven common genes, including ISG15 and OAS1, were confirmed, but only four of the five genes were amplified by reverse Transcription quantitative polymerase chain reaction. Additionally, three expressed sequence tags (ESTs) exhibited significantly greater expression in granulocytes from pregnant cows than that observed in bred non-pregnant cows, and the expression in granulocytes increased after IFNT stimulation. Sequence alignment revealed similar sequences within two ESTs on the Hairy and enhancer of split (Hes) family basic helix-loop-helix (BHLH) Transcription Factor 4 (HES4) gene. An additional EST was identified as cytidine/uridine monophosphate kinase 2 (CMPK2). In silico analysis facilitated the identification of Transcription Factor-binding sequences, including an interferon-stimulated response element and interferon regulatory Factor-binding sites, within the promoter region of HES4 and CMPK2. These genes may function as new ISGs in the context of implantation and may participate in the coordination of the feto-maternal interface in cows.

  • newly identified interferon tau responsive hes family bhlh Transcription Factor 4 and cytidine uridine monophosphate kinase 2 genes in peripheral blood granulocytes during early pregnancy in cows
    Domestic Animal Endocrinology, 2019
    Co-Authors: M Kikuchi, Keiichiro Kizaki, S Shigeno, Noriyuki Toji, Toshina Ishigurooonuma, Katsuo Koshi, Toru Takahashi, Kazuyoshi Hashizume
    Abstract:

    Abstract In cattle, interferon-stimulated genes (ISGs) such as ISG15, MX1, MX2, and OAS1 are known as classic ISGs that are highly involved in the implantation process. Various molecules play a crucial role in the mechanisms underlying ISG effects. Although microarray analyses have highlighted the expression of various molecules during the implantation period, these molecules remain incompletely characterized. In the present study, various specifically expressed genes were selected and their characteristics were examined. The microarray data from peripheral blood leukocytes derived from artificially inseminated cows and granulocytes obtained from embryo-transferred cows, respectively, were used to identify new ISG candidates. Seven common genes, including ISG15 and OAS1, were confirmed, but only 4 of the 5 genes were amplified by reverse Transcription quantitative polymerase chain reaction. In addition, 3 expressed sequence tags (ESTs) exhibited significantly greater expression in granulocytes from pregnant cows than that observed in bred nonpregnant cows, and the expression in granulocytes increased after interferon-tau stimulation. Sequence alignment revealed similar sequences within 2 ESTs on the Hairy and enhancer of split (Hes) family basic helix-loop-helix Transcription Factor 4 (HES4) gene. An additional EST was identified as cytidine/uridine monophosphate kinase 2 (CMPK2). In silico analysis facilitated the identification of Transcription Factor–binding sequences, including an interferon-stimulated response element and interferon regulatory Factor-binding sites, within the promoter region of HES4 and CMPK2. These genes may function as new ISGs in the context of implantation and may participate in the coordination of the feto-maternal interface in cows.

S Shigeno - One of the best experts on this subject based on the ideXlab platform.

  • newly identified interferon tau responsive hes family bhlh Transcription Factor 4 and cytidine uridine monophosphate kinase 2 genes in peripheral blood granulocytes during early pregnancy in cows
    Domestic Animal Endocrinology, 2019
    Co-Authors: M Kikuchi, Keiichiro Kizaki, S Shigeno, Noriyuki Toji, Toshina Ishigurooonuma, Katsuo Koshi, Toru Takahashi, Kazuyoshi Hashizume
    Abstract:

    Abstract In cattle, interferon-stimulated genes (ISGs) such as ISG15, MX1, MX2, and OAS1 are known as classic ISGs that are highly involved in the implantation process. Various molecules play a crucial role in the mechanisms underlying ISG effects. Although microarray analyses have highlighted the expression of various molecules during the implantation period, these molecules remain incompletely characterized. In the present study, various specifically expressed genes were selected and their characteristics were examined. The microarray data from peripheral blood leucocytes derived from artificially inseminated cows and granulocytes obtained from embryo-transferred cows, respectively, were used to identify new ISG candidates. Seven common genes, including ISG15 and OAS1, were confirmed, but only four of the five genes were amplified by reverse Transcription quantitative polymerase chain reaction. Additionally, three expressed sequence tags (ESTs) exhibited significantly greater expression in granulocytes from pregnant cows than that observed in bred non-pregnant cows, and the expression in granulocytes increased after IFNT stimulation. Sequence alignment revealed similar sequences within two ESTs on the Hairy and enhancer of split (Hes) family basic helix-loop-helix (BHLH) Transcription Factor 4 (HES4) gene. An additional EST was identified as cytidine/uridine monophosphate kinase 2 (CMPK2). In silico analysis facilitated the identification of Transcription Factor-binding sequences, including an interferon-stimulated response element and interferon regulatory Factor-binding sites, within the promoter region of HES4 and CMPK2. These genes may function as new ISGs in the context of implantation and may participate in the coordination of the feto-maternal interface in cows.

  • newly identified interferon tau responsive hes family bhlh Transcription Factor 4 and cytidine uridine monophosphate kinase 2 genes in peripheral blood granulocytes during early pregnancy in cows
    Domestic Animal Endocrinology, 2019
    Co-Authors: M Kikuchi, Keiichiro Kizaki, S Shigeno, Noriyuki Toji, Toshina Ishigurooonuma, Katsuo Koshi, Toru Takahashi, Kazuyoshi Hashizume
    Abstract:

    Abstract In cattle, interferon-stimulated genes (ISGs) such as ISG15, MX1, MX2, and OAS1 are known as classic ISGs that are highly involved in the implantation process. Various molecules play a crucial role in the mechanisms underlying ISG effects. Although microarray analyses have highlighted the expression of various molecules during the implantation period, these molecules remain incompletely characterized. In the present study, various specifically expressed genes were selected and their characteristics were examined. The microarray data from peripheral blood leukocytes derived from artificially inseminated cows and granulocytes obtained from embryo-transferred cows, respectively, were used to identify new ISG candidates. Seven common genes, including ISG15 and OAS1, were confirmed, but only 4 of the 5 genes were amplified by reverse Transcription quantitative polymerase chain reaction. In addition, 3 expressed sequence tags (ESTs) exhibited significantly greater expression in granulocytes from pregnant cows than that observed in bred nonpregnant cows, and the expression in granulocytes increased after interferon-tau stimulation. Sequence alignment revealed similar sequences within 2 ESTs on the Hairy and enhancer of split (Hes) family basic helix-loop-helix Transcription Factor 4 (HES4) gene. An additional EST was identified as cytidine/uridine monophosphate kinase 2 (CMPK2). In silico analysis facilitated the identification of Transcription Factor–binding sequences, including an interferon-stimulated response element and interferon regulatory Factor-binding sites, within the promoter region of HES4 and CMPK2. These genes may function as new ISGs in the context of implantation and may participate in the coordination of the feto-maternal interface in cows.

Noriyuki Toji - One of the best experts on this subject based on the ideXlab platform.

  • newly identified interferon tau responsive hes family bhlh Transcription Factor 4 and cytidine uridine monophosphate kinase 2 genes in peripheral blood granulocytes during early pregnancy in cows
    Domestic Animal Endocrinology, 2019
    Co-Authors: M Kikuchi, Keiichiro Kizaki, S Shigeno, Noriyuki Toji, Toshina Ishigurooonuma, Katsuo Koshi, Toru Takahashi, Kazuyoshi Hashizume
    Abstract:

    Abstract In cattle, interferon-stimulated genes (ISGs) such as ISG15, MX1, MX2, and OAS1 are known as classic ISGs that are highly involved in the implantation process. Various molecules play a crucial role in the mechanisms underlying ISG effects. Although microarray analyses have highlighted the expression of various molecules during the implantation period, these molecules remain incompletely characterized. In the present study, various specifically expressed genes were selected and their characteristics were examined. The microarray data from peripheral blood leucocytes derived from artificially inseminated cows and granulocytes obtained from embryo-transferred cows, respectively, were used to identify new ISG candidates. Seven common genes, including ISG15 and OAS1, were confirmed, but only four of the five genes were amplified by reverse Transcription quantitative polymerase chain reaction. Additionally, three expressed sequence tags (ESTs) exhibited significantly greater expression in granulocytes from pregnant cows than that observed in bred non-pregnant cows, and the expression in granulocytes increased after IFNT stimulation. Sequence alignment revealed similar sequences within two ESTs on the Hairy and enhancer of split (Hes) family basic helix-loop-helix (BHLH) Transcription Factor 4 (HES4) gene. An additional EST was identified as cytidine/uridine monophosphate kinase 2 (CMPK2). In silico analysis facilitated the identification of Transcription Factor-binding sequences, including an interferon-stimulated response element and interferon regulatory Factor-binding sites, within the promoter region of HES4 and CMPK2. These genes may function as new ISGs in the context of implantation and may participate in the coordination of the feto-maternal interface in cows.

  • newly identified interferon tau responsive hes family bhlh Transcription Factor 4 and cytidine uridine monophosphate kinase 2 genes in peripheral blood granulocytes during early pregnancy in cows
    Domestic Animal Endocrinology, 2019
    Co-Authors: M Kikuchi, Keiichiro Kizaki, S Shigeno, Noriyuki Toji, Toshina Ishigurooonuma, Katsuo Koshi, Toru Takahashi, Kazuyoshi Hashizume
    Abstract:

    Abstract In cattle, interferon-stimulated genes (ISGs) such as ISG15, MX1, MX2, and OAS1 are known as classic ISGs that are highly involved in the implantation process. Various molecules play a crucial role in the mechanisms underlying ISG effects. Although microarray analyses have highlighted the expression of various molecules during the implantation period, these molecules remain incompletely characterized. In the present study, various specifically expressed genes were selected and their characteristics were examined. The microarray data from peripheral blood leukocytes derived from artificially inseminated cows and granulocytes obtained from embryo-transferred cows, respectively, were used to identify new ISG candidates. Seven common genes, including ISG15 and OAS1, were confirmed, but only 4 of the 5 genes were amplified by reverse Transcription quantitative polymerase chain reaction. In addition, 3 expressed sequence tags (ESTs) exhibited significantly greater expression in granulocytes from pregnant cows than that observed in bred nonpregnant cows, and the expression in granulocytes increased after interferon-tau stimulation. Sequence alignment revealed similar sequences within 2 ESTs on the Hairy and enhancer of split (Hes) family basic helix-loop-helix Transcription Factor 4 (HES4) gene. An additional EST was identified as cytidine/uridine monophosphate kinase 2 (CMPK2). In silico analysis facilitated the identification of Transcription Factor–binding sequences, including an interferon-stimulated response element and interferon regulatory Factor-binding sites, within the promoter region of HES4 and CMPK2. These genes may function as new ISGs in the context of implantation and may participate in the coordination of the feto-maternal interface in cows.