The Experts below are selected from a list of 90 Experts worldwide ranked by ideXlab platform

Jean-françois Brunet - One of the best experts on this subject based on the ideXlab platform.

  • Specification of the Central Noradrenergic Phenotype by the Homeobox Gene Phox2b
    Molecular and cellular neurosciences, 2000
    Co-Authors: Alexandre Pattyn, Christo Goridis, Jean-françois Brunet
    Abstract:

    The closely related homeobox genes Phox2a and Phox2b are expressed in all central and peripheral noradrenergic neurons. Our previous results have shown that Phox2a controls the differentiation of the main noradrenergic center of the brain, the locus coeruleus, but leaves unaffected the other noradrenergic centers. Here, we report that Phox2b has a wider and overlapping role, in that it is required for the differentiation of all noradrenergic centers in the brain, including the locus coeruleus. Together with the previously reported lack of dopamine-b-hydroxylase and tyrosine hydroxylase expression in the peripheral nervous system of Phox2b knock-out embryos, our present findings make Phox2b a master regulator of all central and peripheral noradrenergic differentiation. We discuss the nonredundancy of Phox2 genes and their complex partnership with the bHLH Transcription Factor Mash1, which is also required for the differentiation of most noradrenergic cell types.

  • the homeobox gene phox2b is essential for the development of autonomic neural crest derivatives
    Nature, 1999
    Co-Authors: Alexandre Pattyn, Christo Goridis, Xavier Morin, Harold Cremer, Jean-françois Brunet
    Abstract:

    The sympathetic, parasympathetic and enteric ganglia are the main components of the peripheral autonomic nervous system1, and are all derived from the neural crest2. The Factors needed for these structures to develop include the Transcription Factor Mash1 (refs 3,4,5), the glial-derived neurotrophic Factor GNDF (refs 6,7,8) and its receptor subunits9,10,11,12, and the neuregulin signalling system13, each of which is essential for the differentiation and survival of subsets of autonomic neurons. Here we show that all autonomic ganglia fail to form properly and degenerate in mice lacking the homeodomain Transcription Factor Phox2b, as do the three cranial sensory ganglia that are part of the autonomic reflex circuits. In the anlagen of the enteric nervous system and the sympathetic ganglia, Phox2b is needed for the expression of the GDNF-receptor subunit Ret and for maintaining Mash1 expression. Mutant ganglionic anlagen also fail to switch on the genes that encode two enzymes needed for the biosynthesis of the neurotransmitter noradrenaline, dopamine-β-hydroxylase and tyrosine hydroxylase, demonstrating that Phox2b regulates the noradrenergic phenotype in vertebrates.

  • the homeobox gene phox2b is essential for the development of autonomic neural crest derivatives
    Nature, 1999
    Co-Authors: Alexandre Pattyn, Christo Goridis, Xavier Morin, Harold Cremer, Jean-françois Brunet
    Abstract:

    The sympathetic, parasympathetic and enteric ganglia are the main components of the peripheral autonomic nervous system, and are all derived from the neural crest. The Factors needed for these structures to develop include the Transcription Factor Mash1, the glial-derived neurotrophic Factor GNDF and its receptor subunits, and the neuregulin signalling system, each of which is essential for the differentiation and survival of subsets of autonomic neurons. Here we show that all autonomic ganglia fail to form properly and degenerate in mice lacking the homeodomain Transcription Factor Phox2b, as do the three cranial sensory ganglia that are part of the autonomic reflex circuits. In the anlagen of the enteric nervous system and the sympathetic ganglia, Phox2b is needed for the expression of the GDNF-receptor subunit Ret and for maintaining Mash1 expression. Mutant ganglionic anlagen also fail to switch on the genes that encode two enzymes needed for the biosynthesis of the neurotransmitter noradrenaline, dopamine-beta-hydroxylase and tyrosine hydroxylase, demonstrating that Phox2b regulates the noradrenergic phenotype in vertebrates.

Alexandre Pattyn - One of the best experts on this subject based on the ideXlab platform.

  • Specification of the Central Noradrenergic Phenotype by the Homeobox Gene Phox2b
    Molecular and cellular neurosciences, 2000
    Co-Authors: Alexandre Pattyn, Christo Goridis, Jean-françois Brunet
    Abstract:

    The closely related homeobox genes Phox2a and Phox2b are expressed in all central and peripheral noradrenergic neurons. Our previous results have shown that Phox2a controls the differentiation of the main noradrenergic center of the brain, the locus coeruleus, but leaves unaffected the other noradrenergic centers. Here, we report that Phox2b has a wider and overlapping role, in that it is required for the differentiation of all noradrenergic centers in the brain, including the locus coeruleus. Together with the previously reported lack of dopamine-b-hydroxylase and tyrosine hydroxylase expression in the peripheral nervous system of Phox2b knock-out embryos, our present findings make Phox2b a master regulator of all central and peripheral noradrenergic differentiation. We discuss the nonredundancy of Phox2 genes and their complex partnership with the bHLH Transcription Factor Mash1, which is also required for the differentiation of most noradrenergic cell types.

  • the homeobox gene phox2b is essential for the development of autonomic neural crest derivatives
    Nature, 1999
    Co-Authors: Alexandre Pattyn, Christo Goridis, Xavier Morin, Harold Cremer, Jean-françois Brunet
    Abstract:

    The sympathetic, parasympathetic and enteric ganglia are the main components of the peripheral autonomic nervous system1, and are all derived from the neural crest2. The Factors needed for these structures to develop include the Transcription Factor Mash1 (refs 3,4,5), the glial-derived neurotrophic Factor GNDF (refs 6,7,8) and its receptor subunits9,10,11,12, and the neuregulin signalling system13, each of which is essential for the differentiation and survival of subsets of autonomic neurons. Here we show that all autonomic ganglia fail to form properly and degenerate in mice lacking the homeodomain Transcription Factor Phox2b, as do the three cranial sensory ganglia that are part of the autonomic reflex circuits. In the anlagen of the enteric nervous system and the sympathetic ganglia, Phox2b is needed for the expression of the GDNF-receptor subunit Ret and for maintaining Mash1 expression. Mutant ganglionic anlagen also fail to switch on the genes that encode two enzymes needed for the biosynthesis of the neurotransmitter noradrenaline, dopamine-β-hydroxylase and tyrosine hydroxylase, demonstrating that Phox2b regulates the noradrenergic phenotype in vertebrates.

  • the homeobox gene phox2b is essential for the development of autonomic neural crest derivatives
    Nature, 1999
    Co-Authors: Alexandre Pattyn, Christo Goridis, Xavier Morin, Harold Cremer, Jean-françois Brunet
    Abstract:

    The sympathetic, parasympathetic and enteric ganglia are the main components of the peripheral autonomic nervous system, and are all derived from the neural crest. The Factors needed for these structures to develop include the Transcription Factor Mash1, the glial-derived neurotrophic Factor GNDF and its receptor subunits, and the neuregulin signalling system, each of which is essential for the differentiation and survival of subsets of autonomic neurons. Here we show that all autonomic ganglia fail to form properly and degenerate in mice lacking the homeodomain Transcription Factor Phox2b, as do the three cranial sensory ganglia that are part of the autonomic reflex circuits. In the anlagen of the enteric nervous system and the sympathetic ganglia, Phox2b is needed for the expression of the GDNF-receptor subunit Ret and for maintaining Mash1 expression. Mutant ganglionic anlagen also fail to switch on the genes that encode two enzymes needed for the biosynthesis of the neurotransmitter noradrenaline, dopamine-beta-hydroxylase and tyrosine hydroxylase, demonstrating that Phox2b regulates the noradrenergic phenotype in vertebrates.

Christo Goridis - One of the best experts on this subject based on the ideXlab platform.

  • Specification of the Central Noradrenergic Phenotype by the Homeobox Gene Phox2b
    Molecular and cellular neurosciences, 2000
    Co-Authors: Alexandre Pattyn, Christo Goridis, Jean-françois Brunet
    Abstract:

    The closely related homeobox genes Phox2a and Phox2b are expressed in all central and peripheral noradrenergic neurons. Our previous results have shown that Phox2a controls the differentiation of the main noradrenergic center of the brain, the locus coeruleus, but leaves unaffected the other noradrenergic centers. Here, we report that Phox2b has a wider and overlapping role, in that it is required for the differentiation of all noradrenergic centers in the brain, including the locus coeruleus. Together with the previously reported lack of dopamine-b-hydroxylase and tyrosine hydroxylase expression in the peripheral nervous system of Phox2b knock-out embryos, our present findings make Phox2b a master regulator of all central and peripheral noradrenergic differentiation. We discuss the nonredundancy of Phox2 genes and their complex partnership with the bHLH Transcription Factor Mash1, which is also required for the differentiation of most noradrenergic cell types.

  • the homeobox gene phox2b is essential for the development of autonomic neural crest derivatives
    Nature, 1999
    Co-Authors: Alexandre Pattyn, Christo Goridis, Xavier Morin, Harold Cremer, Jean-françois Brunet
    Abstract:

    The sympathetic, parasympathetic and enteric ganglia are the main components of the peripheral autonomic nervous system1, and are all derived from the neural crest2. The Factors needed for these structures to develop include the Transcription Factor Mash1 (refs 3,4,5), the glial-derived neurotrophic Factor GNDF (refs 6,7,8) and its receptor subunits9,10,11,12, and the neuregulin signalling system13, each of which is essential for the differentiation and survival of subsets of autonomic neurons. Here we show that all autonomic ganglia fail to form properly and degenerate in mice lacking the homeodomain Transcription Factor Phox2b, as do the three cranial sensory ganglia that are part of the autonomic reflex circuits. In the anlagen of the enteric nervous system and the sympathetic ganglia, Phox2b is needed for the expression of the GDNF-receptor subunit Ret and for maintaining Mash1 expression. Mutant ganglionic anlagen also fail to switch on the genes that encode two enzymes needed for the biosynthesis of the neurotransmitter noradrenaline, dopamine-β-hydroxylase and tyrosine hydroxylase, demonstrating that Phox2b regulates the noradrenergic phenotype in vertebrates.

  • the homeobox gene phox2b is essential for the development of autonomic neural crest derivatives
    Nature, 1999
    Co-Authors: Alexandre Pattyn, Christo Goridis, Xavier Morin, Harold Cremer, Jean-françois Brunet
    Abstract:

    The sympathetic, parasympathetic and enteric ganglia are the main components of the peripheral autonomic nervous system, and are all derived from the neural crest. The Factors needed for these structures to develop include the Transcription Factor Mash1, the glial-derived neurotrophic Factor GNDF and its receptor subunits, and the neuregulin signalling system, each of which is essential for the differentiation and survival of subsets of autonomic neurons. Here we show that all autonomic ganglia fail to form properly and degenerate in mice lacking the homeodomain Transcription Factor Phox2b, as do the three cranial sensory ganglia that are part of the autonomic reflex circuits. In the anlagen of the enteric nervous system and the sympathetic ganglia, Phox2b is needed for the expression of the GDNF-receptor subunit Ret and for maintaining Mash1 expression. Mutant ganglionic anlagen also fail to switch on the genes that encode two enzymes needed for the biosynthesis of the neurotransmitter noradrenaline, dopamine-beta-hydroxylase and tyrosine hydroxylase, demonstrating that Phox2b regulates the noradrenergic phenotype in vertebrates.

Xavier Morin - One of the best experts on this subject based on the ideXlab platform.

  • the homeobox gene phox2b is essential for the development of autonomic neural crest derivatives
    Nature, 1999
    Co-Authors: Alexandre Pattyn, Christo Goridis, Xavier Morin, Harold Cremer, Jean-françois Brunet
    Abstract:

    The sympathetic, parasympathetic and enteric ganglia are the main components of the peripheral autonomic nervous system1, and are all derived from the neural crest2. The Factors needed for these structures to develop include the Transcription Factor Mash1 (refs 3,4,5), the glial-derived neurotrophic Factor GNDF (refs 6,7,8) and its receptor subunits9,10,11,12, and the neuregulin signalling system13, each of which is essential for the differentiation and survival of subsets of autonomic neurons. Here we show that all autonomic ganglia fail to form properly and degenerate in mice lacking the homeodomain Transcription Factor Phox2b, as do the three cranial sensory ganglia that are part of the autonomic reflex circuits. In the anlagen of the enteric nervous system and the sympathetic ganglia, Phox2b is needed for the expression of the GDNF-receptor subunit Ret and for maintaining Mash1 expression. Mutant ganglionic anlagen also fail to switch on the genes that encode two enzymes needed for the biosynthesis of the neurotransmitter noradrenaline, dopamine-β-hydroxylase and tyrosine hydroxylase, demonstrating that Phox2b regulates the noradrenergic phenotype in vertebrates.

  • the homeobox gene phox2b is essential for the development of autonomic neural crest derivatives
    Nature, 1999
    Co-Authors: Alexandre Pattyn, Christo Goridis, Xavier Morin, Harold Cremer, Jean-françois Brunet
    Abstract:

    The sympathetic, parasympathetic and enteric ganglia are the main components of the peripheral autonomic nervous system, and are all derived from the neural crest. The Factors needed for these structures to develop include the Transcription Factor Mash1, the glial-derived neurotrophic Factor GNDF and its receptor subunits, and the neuregulin signalling system, each of which is essential for the differentiation and survival of subsets of autonomic neurons. Here we show that all autonomic ganglia fail to form properly and degenerate in mice lacking the homeodomain Transcription Factor Phox2b, as do the three cranial sensory ganglia that are part of the autonomic reflex circuits. In the anlagen of the enteric nervous system and the sympathetic ganglia, Phox2b is needed for the expression of the GDNF-receptor subunit Ret and for maintaining Mash1 expression. Mutant ganglionic anlagen also fail to switch on the genes that encode two enzymes needed for the biosynthesis of the neurotransmitter noradrenaline, dopamine-beta-hydroxylase and tyrosine hydroxylase, demonstrating that Phox2b regulates the noradrenergic phenotype in vertebrates.

Harold Cremer - One of the best experts on this subject based on the ideXlab platform.

  • the homeobox gene phox2b is essential for the development of autonomic neural crest derivatives
    Nature, 1999
    Co-Authors: Alexandre Pattyn, Christo Goridis, Xavier Morin, Harold Cremer, Jean-françois Brunet
    Abstract:

    The sympathetic, parasympathetic and enteric ganglia are the main components of the peripheral autonomic nervous system1, and are all derived from the neural crest2. The Factors needed for these structures to develop include the Transcription Factor Mash1 (refs 3,4,5), the glial-derived neurotrophic Factor GNDF (refs 6,7,8) and its receptor subunits9,10,11,12, and the neuregulin signalling system13, each of which is essential for the differentiation and survival of subsets of autonomic neurons. Here we show that all autonomic ganglia fail to form properly and degenerate in mice lacking the homeodomain Transcription Factor Phox2b, as do the three cranial sensory ganglia that are part of the autonomic reflex circuits. In the anlagen of the enteric nervous system and the sympathetic ganglia, Phox2b is needed for the expression of the GDNF-receptor subunit Ret and for maintaining Mash1 expression. Mutant ganglionic anlagen also fail to switch on the genes that encode two enzymes needed for the biosynthesis of the neurotransmitter noradrenaline, dopamine-β-hydroxylase and tyrosine hydroxylase, demonstrating that Phox2b regulates the noradrenergic phenotype in vertebrates.

  • the homeobox gene phox2b is essential for the development of autonomic neural crest derivatives
    Nature, 1999
    Co-Authors: Alexandre Pattyn, Christo Goridis, Xavier Morin, Harold Cremer, Jean-françois Brunet
    Abstract:

    The sympathetic, parasympathetic and enteric ganglia are the main components of the peripheral autonomic nervous system, and are all derived from the neural crest. The Factors needed for these structures to develop include the Transcription Factor Mash1, the glial-derived neurotrophic Factor GNDF and its receptor subunits, and the neuregulin signalling system, each of which is essential for the differentiation and survival of subsets of autonomic neurons. Here we show that all autonomic ganglia fail to form properly and degenerate in mice lacking the homeodomain Transcription Factor Phox2b, as do the three cranial sensory ganglia that are part of the autonomic reflex circuits. In the anlagen of the enteric nervous system and the sympathetic ganglia, Phox2b is needed for the expression of the GDNF-receptor subunit Ret and for maintaining Mash1 expression. Mutant ganglionic anlagen also fail to switch on the genes that encode two enzymes needed for the biosynthesis of the neurotransmitter noradrenaline, dopamine-beta-hydroxylase and tyrosine hydroxylase, demonstrating that Phox2b regulates the noradrenergic phenotype in vertebrates.