The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform
Richard J. Gibbons - One of the best experts on this subject based on the ideXlab platform.
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LOCALIZATION OF A PUTATIVE Transcriptional Regulator (ATRX) AT PERICENTROMERIC HETEROCHROMATIN AND THE SHORT ARMS OF ACROCENTRIC CHROMOSOMES
Proceedings of the National Academy of Sciences of the United States of America, 1999Co-Authors: T. L. Mcdowell, Wendy A. Bickmore, Richard J. Gibbons, Heidi G. Sutherland, Delia O'rourke, Ana Pombo, H. Turley, K. Gatter, David J. Picketts, Veronica J. BuckleAbstract:ATRX is a member of the SNF2 family of helicase/ATPases that is thought to regulate gene expression via an effect on chromatin structure and/or function. Mutations in the hATRX gene cause severe syndromal mental retardation associated with α-thalassemia. Using indirect immunofluorescence and confocal microscopy we have shown that ATRX protein is associated with pericentromeric heterochromatin during interphase and mitosis. By coimmunofluorescence, ATRX localizes with a mouse homologue of the Drosophila heterochromatic protein HP1 in vivo, consistent with a previous two-hybrid screen identifying this interaction. From the analysis of a trap assay for nuclear proteins, we have shown that the localization of ATRX to heterochromatin is encoded by its N-terminal region, which contains a conserved plant homeodomain-like finger and a coiled-coil domain. In addition to its association with heterochromatin, at metaphase ATRX clearly binds to the short arms of human acrocentric chromosomes, where the arrays of ribosomal DNA are located. The unexpected association of a putative Transcriptional Regulator with highly repetitive DNA provides a potential explanation for the variability in phenotype of patients with identical mutations in the ATRX gene.
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mutations in Transcriptional Regulator ATRX establish the functional significance of a phd like domain
Nature Genetics, 1997Co-Authors: Richard J. Gibbons, David J. Picketts, Satvinder Bachoo, Salim Aftimos, Bernhard Asenbauer, Joann Bergoffen, Susan A Berry, Niklas Dahl, Alan Fryer, Kim KepplerAbstract:Mutations in Transcriptional Regulator ATRX establish the functional significance of a PHD-like domain.
David J. Picketts - One of the best experts on this subject based on the ideXlab platform.
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LOCALIZATION OF A PUTATIVE Transcriptional Regulator (ATRX) AT PERICENTROMERIC HETEROCHROMATIN AND THE SHORT ARMS OF ACROCENTRIC CHROMOSOMES
Proceedings of the National Academy of Sciences of the United States of America, 1999Co-Authors: T. L. Mcdowell, Wendy A. Bickmore, Richard J. Gibbons, Heidi G. Sutherland, Delia O'rourke, Ana Pombo, H. Turley, K. Gatter, David J. Picketts, Veronica J. BuckleAbstract:ATRX is a member of the SNF2 family of helicase/ATPases that is thought to regulate gene expression via an effect on chromatin structure and/or function. Mutations in the hATRX gene cause severe syndromal mental retardation associated with α-thalassemia. Using indirect immunofluorescence and confocal microscopy we have shown that ATRX protein is associated with pericentromeric heterochromatin during interphase and mitosis. By coimmunofluorescence, ATRX localizes with a mouse homologue of the Drosophila heterochromatic protein HP1 in vivo, consistent with a previous two-hybrid screen identifying this interaction. From the analysis of a trap assay for nuclear proteins, we have shown that the localization of ATRX to heterochromatin is encoded by its N-terminal region, which contains a conserved plant homeodomain-like finger and a coiled-coil domain. In addition to its association with heterochromatin, at metaphase ATRX clearly binds to the short arms of human acrocentric chromosomes, where the arrays of ribosomal DNA are located. The unexpected association of a putative Transcriptional Regulator with highly repetitive DNA provides a potential explanation for the variability in phenotype of patients with identical mutations in the ATRX gene.
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mutations in Transcriptional Regulator ATRX establish the functional significance of a phd like domain
Nature Genetics, 1997Co-Authors: Richard J. Gibbons, David J. Picketts, Satvinder Bachoo, Salim Aftimos, Bernhard Asenbauer, Joann Bergoffen, Susan A Berry, Niklas Dahl, Alan Fryer, Kim KepplerAbstract:Mutations in Transcriptional Regulator ATRX establish the functional significance of a PHD-like domain.
Kim Keppler - One of the best experts on this subject based on the ideXlab platform.
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mutations in Transcriptional Regulator ATRX establish the functional significance of a phd like domain
Nature Genetics, 1997Co-Authors: Richard J. Gibbons, David J. Picketts, Satvinder Bachoo, Salim Aftimos, Bernhard Asenbauer, Joann Bergoffen, Susan A Berry, Niklas Dahl, Alan Fryer, Kim KepplerAbstract:Mutations in Transcriptional Regulator ATRX establish the functional significance of a PHD-like domain.
Veronica J. Buckle - One of the best experts on this subject based on the ideXlab platform.
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LOCALIZATION OF A PUTATIVE Transcriptional Regulator (ATRX) AT PERICENTROMERIC HETEROCHROMATIN AND THE SHORT ARMS OF ACROCENTRIC CHROMOSOMES
Proceedings of the National Academy of Sciences of the United States of America, 1999Co-Authors: T. L. Mcdowell, Wendy A. Bickmore, Richard J. Gibbons, Heidi G. Sutherland, Delia O'rourke, Ana Pombo, H. Turley, K. Gatter, David J. Picketts, Veronica J. BuckleAbstract:ATRX is a member of the SNF2 family of helicase/ATPases that is thought to regulate gene expression via an effect on chromatin structure and/or function. Mutations in the hATRX gene cause severe syndromal mental retardation associated with α-thalassemia. Using indirect immunofluorescence and confocal microscopy we have shown that ATRX protein is associated with pericentromeric heterochromatin during interphase and mitosis. By coimmunofluorescence, ATRX localizes with a mouse homologue of the Drosophila heterochromatic protein HP1 in vivo, consistent with a previous two-hybrid screen identifying this interaction. From the analysis of a trap assay for nuclear proteins, we have shown that the localization of ATRX to heterochromatin is encoded by its N-terminal region, which contains a conserved plant homeodomain-like finger and a coiled-coil domain. In addition to its association with heterochromatin, at metaphase ATRX clearly binds to the short arms of human acrocentric chromosomes, where the arrays of ribosomal DNA are located. The unexpected association of a putative Transcriptional Regulator with highly repetitive DNA provides a potential explanation for the variability in phenotype of patients with identical mutations in the ATRX gene.
T. L. Mcdowell - One of the best experts on this subject based on the ideXlab platform.
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LOCALIZATION OF A PUTATIVE Transcriptional Regulator (ATRX) AT PERICENTROMERIC HETEROCHROMATIN AND THE SHORT ARMS OF ACROCENTRIC CHROMOSOMES
Proceedings of the National Academy of Sciences of the United States of America, 1999Co-Authors: T. L. Mcdowell, Wendy A. Bickmore, Richard J. Gibbons, Heidi G. Sutherland, Delia O'rourke, Ana Pombo, H. Turley, K. Gatter, David J. Picketts, Veronica J. BuckleAbstract:ATRX is a member of the SNF2 family of helicase/ATPases that is thought to regulate gene expression via an effect on chromatin structure and/or function. Mutations in the hATRX gene cause severe syndromal mental retardation associated with α-thalassemia. Using indirect immunofluorescence and confocal microscopy we have shown that ATRX protein is associated with pericentromeric heterochromatin during interphase and mitosis. By coimmunofluorescence, ATRX localizes with a mouse homologue of the Drosophila heterochromatic protein HP1 in vivo, consistent with a previous two-hybrid screen identifying this interaction. From the analysis of a trap assay for nuclear proteins, we have shown that the localization of ATRX to heterochromatin is encoded by its N-terminal region, which contains a conserved plant homeodomain-like finger and a coiled-coil domain. In addition to its association with heterochromatin, at metaphase ATRX clearly binds to the short arms of human acrocentric chromosomes, where the arrays of ribosomal DNA are located. The unexpected association of a putative Transcriptional Regulator with highly repetitive DNA provides a potential explanation for the variability in phenotype of patients with identical mutations in the ATRX gene.