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A Cusano - One of the best experts on this subject based on the ideXlab platform.
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giant sensitivity of long period gratings in Transition Mode near the dispersion turning point an integrated design approach
Optics Letters, 2012Co-Authors: P Pilla, Michele Giordano, C Trono, Francesco Baldini, Francesco Chiavaioli, A CusanoAbstract:We report an original design approach based on the modal dispersion curves for the development of long period gratings in Transition Mode near the dispersion turning point exhibiting ultrahigh refractive index sensitivity. The theoretical Model predicting a giant sensitivity of 9900 nm per refractive index unit in a watery environment was experimentally validated with a result of approximately 9100 nm per refractive index unit around an ambient index of 1.3469. This result places thin film coated LPGs as an alternative to other fiber-based technologies for high-performance chemical and biological sensing applications.
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Transition Mode long period grating biosensor with functional multilayer coatings
Optics Express, 2011Co-Authors: P Pilla, Anna Borriello, Viera Malachovska, A Buosciolo, A Cutolo, Luigi Ambrosio, M Giordano, A CusanoAbstract:We report our latest research results concerning the development of a platform for label-free biosensing based on overlayered Long Period Gratings (LPGs) working in Transition Mode. The main novelty of this work lies in a multilayer design that allows to decouple the problem of an efficient surface functionalization from that of the tuning in Transition region of the cladding Modes. An innovative solvent/nonsolvent strategy for the dip-coating technique was developed in order to deposit on the LPG multiple layers of transparent polymers. In particular, a primary coating of atactic polystyrene was used as high refractive index layer to tune the working point of the device in the so-called Transition region. In this way, state-of-the-art-competitive sensitivity to surrounding medium refractive index changes was achieved. An extremely thin secondary functional layer of poly(methyl methacrylate-co-methacrylic acid) was deposited onto the primary coating by means of an original identification of selective solvents. This approach allowed to obtain desired functional groups (carboxyls) on the surface of the device for a stable covalent attachment of bioreceptors and minimal perturbation of the optical design. Standard 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / N-hydrosuccinimide (EDC / NHS) coupling chemistry was used to link streptavidin on the surface of the coated LPG. Highly sensitive real-time monitoring of multiple affinity assays between streptavidin and biotinylated bovine serum albumin was performed by following the shift of the LPGs attenuation bands.
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self assembling and coordination of water nano layers on polymeric coated long period gratings as promising tool for cation detection
Proceedings of SPIE the International Society for Optical Engineering, 2010Co-Authors: Foglia P Manzillo, P Pilla, Stefania Campopiano, Anna Borriello, Michele Giordano, A CusanoAbstract:In this work, polymeric coated Long Period Gratings (LPGs) working in Transition Mode have been used to monitor the coordination and self assembling of water nano layers providing new scenarios in chemical sensing applications. In particular, nano-scale layers of syndiotactic and atactic polystyrene (sPS and aPS) have been deposited by dip - coating onto LPGs to tune the devices at the Transition point. Experimental results demonstrate the polymers capability to orient water molecules in proximity of their surfaces. The sPS and aPS interactions with water have been compared. Moreover, the high sensitivity of the coated LPGs was used to monitor the effect of disorder induced by different cations depending on their size and electrical charge. Experimental results show for the first time that, thanks to the water - polymer interaction, sPS coated LPGs could be successfully employed as high sensitivity cation sensors.
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long period grating working in Transition Mode as promising technological platform for label free biosensing
Optics Express, 2009Co-Authors: P Pilla, Foglia P Manzillo, Stefania Campopiano, Viera Malachovska, A Buosciolo, A Cutolo, Luigi Ambrosio, M Giordano, A CusanoAbstract:We present the development of a platform for label-free biosensing based on overlayered Long Period Gratings (LPGs) working in Transition Mode. Nano-scale layers of Polystyrene (PS) with different thicknesses were deposited onto the same LPG to test the performances of the device in different working points of its modified sensitivity characteristic. Adsorption dynamic of biotinylated bovine serum albumin (BBSA) onto the PS overlays was on-line monitored as well as a subsequent streptavidin (SA) binding dynamic on the biotinylated sites of the protein ad-layer. Experimental results show that overlayered LPGs are among the most sensitive refractive index transducers to be employed in label-free biochemical detection and that wide margins of further optimization exist.
P Pilla - One of the best experts on this subject based on the ideXlab platform.
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giant sensitivity of long period gratings in Transition Mode near the dispersion turning point an integrated design approach
Optics Letters, 2012Co-Authors: P Pilla, Michele Giordano, C Trono, Francesco Baldini, Francesco Chiavaioli, A CusanoAbstract:We report an original design approach based on the modal dispersion curves for the development of long period gratings in Transition Mode near the dispersion turning point exhibiting ultrahigh refractive index sensitivity. The theoretical Model predicting a giant sensitivity of 9900 nm per refractive index unit in a watery environment was experimentally validated with a result of approximately 9100 nm per refractive index unit around an ambient index of 1.3469. This result places thin film coated LPGs as an alternative to other fiber-based technologies for high-performance chemical and biological sensing applications.
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Transition Mode long period grating biosensor with functional multilayer coatings
Optics Express, 2011Co-Authors: P Pilla, Anna Borriello, Viera Malachovska, A Buosciolo, A Cutolo, Luigi Ambrosio, M Giordano, A CusanoAbstract:We report our latest research results concerning the development of a platform for label-free biosensing based on overlayered Long Period Gratings (LPGs) working in Transition Mode. The main novelty of this work lies in a multilayer design that allows to decouple the problem of an efficient surface functionalization from that of the tuning in Transition region of the cladding Modes. An innovative solvent/nonsolvent strategy for the dip-coating technique was developed in order to deposit on the LPG multiple layers of transparent polymers. In particular, a primary coating of atactic polystyrene was used as high refractive index layer to tune the working point of the device in the so-called Transition region. In this way, state-of-the-art-competitive sensitivity to surrounding medium refractive index changes was achieved. An extremely thin secondary functional layer of poly(methyl methacrylate-co-methacrylic acid) was deposited onto the primary coating by means of an original identification of selective solvents. This approach allowed to obtain desired functional groups (carboxyls) on the surface of the device for a stable covalent attachment of bioreceptors and minimal perturbation of the optical design. Standard 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / N-hydrosuccinimide (EDC / NHS) coupling chemistry was used to link streptavidin on the surface of the coated LPG. Highly sensitive real-time monitoring of multiple affinity assays between streptavidin and biotinylated bovine serum albumin was performed by following the shift of the LPGs attenuation bands.
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self assembling and coordination of water nano layers on polymeric coated long period gratings as promising tool for cation detection
Proceedings of SPIE the International Society for Optical Engineering, 2010Co-Authors: Foglia P Manzillo, P Pilla, Stefania Campopiano, Anna Borriello, Michele Giordano, A CusanoAbstract:In this work, polymeric coated Long Period Gratings (LPGs) working in Transition Mode have been used to monitor the coordination and self assembling of water nano layers providing new scenarios in chemical sensing applications. In particular, nano-scale layers of syndiotactic and atactic polystyrene (sPS and aPS) have been deposited by dip - coating onto LPGs to tune the devices at the Transition point. Experimental results demonstrate the polymers capability to orient water molecules in proximity of their surfaces. The sPS and aPS interactions with water have been compared. Moreover, the high sensitivity of the coated LPGs was used to monitor the effect of disorder induced by different cations depending on their size and electrical charge. Experimental results show for the first time that, thanks to the water - polymer interaction, sPS coated LPGs could be successfully employed as high sensitivity cation sensors.
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long period grating working in Transition Mode as promising technological platform for label free biosensing
Optics Express, 2009Co-Authors: P Pilla, Foglia P Manzillo, Stefania Campopiano, Viera Malachovska, A Buosciolo, A Cutolo, Luigi Ambrosio, M Giordano, A CusanoAbstract:We present the development of a platform for label-free biosensing based on overlayered Long Period Gratings (LPGs) working in Transition Mode. Nano-scale layers of Polystyrene (PS) with different thicknesses were deposited onto the same LPG to test the performances of the device in different working points of its modified sensitivity characteristic. Adsorption dynamic of biotinylated bovine serum albumin (BBSA) onto the PS overlays was on-line monitored as well as a subsequent streptavidin (SA) binding dynamic on the biotinylated sites of the protein ad-layer. Experimental results show that overlayered LPGs are among the most sensitive refractive index transducers to be employed in label-free biochemical detection and that wide margins of further optimization exist.
Somnath Bandyopadhyay - One of the best experts on this subject based on the ideXlab platform.
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design fabrication and characterisation of silica titania thin film coated over coupled long period fibre gratings towards bio sensing applications
Sensors and Actuators B-chemical, 2017Co-Authors: Palas Biswas, C Trono, Francesco Baldini, Francesco Chiavaioli, Sunirmal Jana, Nandini Basumallick, A Giannetti, Sara Tombelli, Aparajita Mallick, Somnath BandyopadhyayAbstract:Abstract In this paper we report on the application of over coupled long period fibre gratings (OCLPFGs) for detecting small changes in the surrounding refractive index (SRI). In addition, the optimization of a high RI (HRI) overlay deposited over the fibre for the adhesion of biological species is described. In this study, we utilised a sol-gel-based silica-titania thin film as HRI material deposited on the grating portion using the simple and versatile dip-coating (DC) technique. The OCLPFG-based sensor has been manufactured in such a way that the resonant band retains good visibility (close to the maximum coupling condition) in the transmission spectrum even after high thermal sintering of the coating material. Three different batches of OCLPFGs were produced using different withdrawal speeds and sol viscosities. By carefully tuning both the overlay thickness during the DC process and the RI of the sol-gel material during its preparation, it was possible to bring the sensor into the so-called Transition Mode working region, and thus maximize the sensing performance in terms of SRI changes. All devices were characterized as optical refractometers in the RI range of interest for a bio-sensing application (from 1.33 to 1.34) and, after a suitable bio-functionalisation process, one of them was used to implement a classical receptor-analyte biosensor.
Francesco Baldini - One of the best experts on this subject based on the ideXlab platform.
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design fabrication and characterisation of silica titania thin film coated over coupled long period fibre gratings towards bio sensing applications
Sensors and Actuators B-chemical, 2017Co-Authors: Palas Biswas, C Trono, Francesco Baldini, Francesco Chiavaioli, Sunirmal Jana, Nandini Basumallick, A Giannetti, Sara Tombelli, Aparajita Mallick, Somnath BandyopadhyayAbstract:Abstract In this paper we report on the application of over coupled long period fibre gratings (OCLPFGs) for detecting small changes in the surrounding refractive index (SRI). In addition, the optimization of a high RI (HRI) overlay deposited over the fibre for the adhesion of biological species is described. In this study, we utilised a sol-gel-based silica-titania thin film as HRI material deposited on the grating portion using the simple and versatile dip-coating (DC) technique. The OCLPFG-based sensor has been manufactured in such a way that the resonant band retains good visibility (close to the maximum coupling condition) in the transmission spectrum even after high thermal sintering of the coating material. Three different batches of OCLPFGs were produced using different withdrawal speeds and sol viscosities. By carefully tuning both the overlay thickness during the DC process and the RI of the sol-gel material during its preparation, it was possible to bring the sensor into the so-called Transition Mode working region, and thus maximize the sensing performance in terms of SRI changes. All devices were characterized as optical refractometers in the RI range of interest for a bio-sensing application (from 1.33 to 1.34) and, after a suitable bio-functionalisation process, one of them was used to implement a classical receptor-analyte biosensor.
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giant sensitivity of long period gratings in Transition Mode near the dispersion turning point an integrated design approach
Optics Letters, 2012Co-Authors: P Pilla, Michele Giordano, C Trono, Francesco Baldini, Francesco Chiavaioli, A CusanoAbstract:We report an original design approach based on the modal dispersion curves for the development of long period gratings in Transition Mode near the dispersion turning point exhibiting ultrahigh refractive index sensitivity. The theoretical Model predicting a giant sensitivity of 9900 nm per refractive index unit in a watery environment was experimentally validated with a result of approximately 9100 nm per refractive index unit around an ambient index of 1.3469. This result places thin film coated LPGs as an alternative to other fiber-based technologies for high-performance chemical and biological sensing applications.
Francesco Chiavaioli - One of the best experts on this subject based on the ideXlab platform.
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design fabrication and characterisation of silica titania thin film coated over coupled long period fibre gratings towards bio sensing applications
Sensors and Actuators B-chemical, 2017Co-Authors: Palas Biswas, C Trono, Francesco Baldini, Francesco Chiavaioli, Sunirmal Jana, Nandini Basumallick, A Giannetti, Sara Tombelli, Aparajita Mallick, Somnath BandyopadhyayAbstract:Abstract In this paper we report on the application of over coupled long period fibre gratings (OCLPFGs) for detecting small changes in the surrounding refractive index (SRI). In addition, the optimization of a high RI (HRI) overlay deposited over the fibre for the adhesion of biological species is described. In this study, we utilised a sol-gel-based silica-titania thin film as HRI material deposited on the grating portion using the simple and versatile dip-coating (DC) technique. The OCLPFG-based sensor has been manufactured in such a way that the resonant band retains good visibility (close to the maximum coupling condition) in the transmission spectrum even after high thermal sintering of the coating material. Three different batches of OCLPFGs were produced using different withdrawal speeds and sol viscosities. By carefully tuning both the overlay thickness during the DC process and the RI of the sol-gel material during its preparation, it was possible to bring the sensor into the so-called Transition Mode working region, and thus maximize the sensing performance in terms of SRI changes. All devices were characterized as optical refractometers in the RI range of interest for a bio-sensing application (from 1.33 to 1.34) and, after a suitable bio-functionalisation process, one of them was used to implement a classical receptor-analyte biosensor.
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giant sensitivity of long period gratings in Transition Mode near the dispersion turning point an integrated design approach
Optics Letters, 2012Co-Authors: P Pilla, Michele Giordano, C Trono, Francesco Baldini, Francesco Chiavaioli, A CusanoAbstract:We report an original design approach based on the modal dispersion curves for the development of long period gratings in Transition Mode near the dispersion turning point exhibiting ultrahigh refractive index sensitivity. The theoretical Model predicting a giant sensitivity of 9900 nm per refractive index unit in a watery environment was experimentally validated with a result of approximately 9100 nm per refractive index unit around an ambient index of 1.3469. This result places thin film coated LPGs as an alternative to other fiber-based technologies for high-performance chemical and biological sensing applications.