The Experts below are selected from a list of 43557 Experts worldwide ranked by ideXlab platform
Marieke Vossen - One of the best experts on this subject based on the ideXlab platform.
-
on the ethics of facial Transplantation Research
American Journal of Bioethics, 2004Co-Authors: Osborne P. Wiggins, Michael R Cunningham, Claudio Maldonado, Marieke Vossen, Cedric Francois, Gustavo Perezabadia, Federico V Grossi, Serge A. Martinez, John H Barker, Joseph C. BanisAbstract:Transplantation continues to push the frontiers of medicine into domains that summon forth troublesome ethical questions. Looming on the frontier today is human facial Transplantation. We develop criteria that, we maintain, must be satisfied in order to ethically undertake this as-yet-untried transplant procedure. We draw on the criteria advanced by Dr. Francis Moore in the late 1980s for introducing innovative procedures in transplant surgery. In addition to these we also insist that human face Transplantation must meet all the ethical requirements usually applied to health care Research. We summarize the achievements of transplant surgery to date, focusing in particular on the safety and efficacy of immunosuppressive medications. We also emphasize the importance of risk/benefit assessments that take into account the physical, aesthetic, psychological, and social dimensions of facial disfiguration, reconstruction, and Transplantation. Finally, we maintain that the time has come to move facial transplanta...
-
response to selected commentaries on the ajob target article on the ethics of facial Transplantation Research
American Journal of Bioethics, 2004Co-Authors: Joseph C. Banis, Michael R Cunningham, Claudio Maldonado, Cedric Francois, Gustavo Perezabadia, Federico V Grossi, Serge A. Martinez, John H Barker, Allen Furr, Marieke VossenAbstract:Main Response Topics • Introduction • Open display and public evaluation • Publicity versus patient privacy • Facial tissue donation • Validity of Louisville Instrument for Risk Acceptance • Patients' understanding of risk • Face versus hand Transplantation • Rejection rates/risks • Patient compliance • Exit strategy • Functional recovery • Societietal implications • Psychological implications • Conclusion: Uncertainty likely to persist
-
on the ethics of facial Transplantation Research
American Journal of Bioethics, 2004Co-Authors: Osborne P. Wiggins, Michael R Cunningham, Claudio Maldonado, Marieke Vossen, Cedric Francois, Gustavo Perezabadia, Serge A. Martinez, John H Barker, Federico Grossi, Moshe KonAbstract:Transplantation continues to push the frontiers of medicine into domains that summon forth troublesome ethical questions. Looming on the frontier today is human facial Transplantation. We develop criteria that, we maintain, must be satisfied in order to ethically undertake this as-yet-untried transplant procedure. We draw on the criteria advanced by Dr. Francis Moore in the late 1980s for introducing innovative procedures in transplant surgery. In addition to these we also insist that human face Transplantation must meet all the ethical requirements usually applied to health care Research. We summarize the achievements of transplant surgery to date, focusing in particular on the safety and efficacy of immunosuppressive medications. We also emphasize the importance of risk/benefit assessments that take into account the physical, aesthetic, psychological, and social dimensions of facial disfiguration, reconstruction, and Transplantation. Finally, we maintain that the time has come to move facial Transplantation Research into the clinical phase.
Joseph C. Banis - One of the best experts on this subject based on the ideXlab platform.
-
on the ethics of facial Transplantation Research
American Journal of Bioethics, 2004Co-Authors: Osborne P. Wiggins, Michael R Cunningham, Claudio Maldonado, Marieke Vossen, Cedric Francois, Gustavo Perezabadia, Federico V Grossi, Serge A. Martinez, John H Barker, Joseph C. BanisAbstract:Transplantation continues to push the frontiers of medicine into domains that summon forth troublesome ethical questions. Looming on the frontier today is human facial Transplantation. We develop criteria that, we maintain, must be satisfied in order to ethically undertake this as-yet-untried transplant procedure. We draw on the criteria advanced by Dr. Francis Moore in the late 1980s for introducing innovative procedures in transplant surgery. In addition to these we also insist that human face Transplantation must meet all the ethical requirements usually applied to health care Research. We summarize the achievements of transplant surgery to date, focusing in particular on the safety and efficacy of immunosuppressive medications. We also emphasize the importance of risk/benefit assessments that take into account the physical, aesthetic, psychological, and social dimensions of facial disfiguration, reconstruction, and Transplantation. Finally, we maintain that the time has come to move facial transplanta...
-
response to selected commentaries on the ajob target article on the ethics of facial Transplantation Research
American Journal of Bioethics, 2004Co-Authors: Joseph C. Banis, Michael R Cunningham, Claudio Maldonado, Cedric Francois, Gustavo Perezabadia, Federico V Grossi, Serge A. Martinez, John H Barker, Allen Furr, Marieke VossenAbstract:Main Response Topics • Introduction • Open display and public evaluation • Publicity versus patient privacy • Facial tissue donation • Validity of Louisville Instrument for Risk Acceptance • Patients' understanding of risk • Face versus hand Transplantation • Rejection rates/risks • Patient compliance • Exit strategy • Functional recovery • Societietal implications • Psychological implications • Conclusion: Uncertainty likely to persist
Sonia Montanari - One of the best experts on this subject based on the ideXlab platform.
-
development and characterization of a new inbred transgenic rat strain expressing dsred monomeric fluorescent protein
Transgenic Research, 2014Co-Authors: Eiji Kobayashi, Sonia Montanari, Xinghua Wang, Gustavo Yannarelli, Victor Dayan, Thorsten Berger, Larissa Zocche, Sowmya ViswanathanAbstract:The inbred rat is a suitable model for studying human disease and because of its larger size is more amenable to complex surgical manipulation than the mouse. While the rodent fulfills many of the criteria for Transplantation Research, an important requirement is the ability to mark and track donors cells and assess organ viability. However, tracking ability is limited by the availability of transgenic (Tg) rats that express suitable luminescent or fluorescent proteins. Red fluorescent protein cloned from Discosoma coral (DsRed) has several advantages over other fluorescent proteins, including in vivo detection in the whole animal and ex vivo visualization in organs as there is no interference with autofluorescence. We generated and characterized a novel inbred Tg Lewis rat strain expressing DsRed monomeric (DsRed mono) fluorescent protein under the control of a ubiquitously expressed ROSA26 promoter. DsRed mono Tg rats ubiquitously expressed the marker gene as detected by RT-PCR but the protein was expressed at varying levels in different organs. Conventional skin grafting experiments showed acceptance of DsRed monomeric Tg rat skin on wild-type rats for more than 30 days. Cardiac Transplantation of DsRed monomeric Tg rat hearts into wild-type recipients further showed graft acceptance and long-term organ viability (>6 months). The DsRed monomeric Tg rat provides marked cells and/or organs that can be followed for long periods without immune rejection and therefore is a suitable model to investigate cell tracking and organ Transplantation.
L.a. Knapp - One of the best experts on this subject based on the ideXlab platform.
-
Molecular study of Mhc-DRB in wild chacma baboons reveals high variability and evidence for transspecies inheritance
Immunogenetics, 2006Co-Authors: Elise Huchard, Michel Raymond, Guy Colishaw, Mylène Weill, L.a. KnappAbstract:The MHC class II genes of many primate species were investigated extensively in recent years. However, while Mhc-DRB genes were studied in Old World monkeys such as rhesus macaques, the Mhc-DRB of baboons was only studied in a limited way. Because of their close anatomical and physiological relationship to humans, baboons are often used as models for reproduction and Transplantation Research. Baboons are also studied as a model species in behavioural ecology. Thus, identification of MHC genes would provide a foundation for studies of Mhc, biology and behaviour. Here, we describe the use of PCR, cloning, denaturing gradient gel electrophoresis (DGGE) and sequencing to identify Mhc-DRB sequences in wild chacma baboons (Papio ursinus). We amplified the highly variable second exon of baboon Mhc-DRB sequences using generic DRB primers. To validate and optimize the DGGE protocol, four DNA samples were initially studied using cloning and sequencing. Clones were screened using a novel RFLP approach to increase the number of clones identified for each individual. Results from cloning and sequencing were used to optimise DGGE conditions for Mhc-DRB genotyping of the remaining study subjects. Using these techniques, we identified 16 Paur-DRB sequences from 30 chacma baboons. On the basis of phylogenetic tree analyses, representatives of the Mhc- DRB1 and Mhc-DRB5 loci, and 13 different DRB lineages were identified. Evidence for trans-species inheritance of some Mhc-DRB sequences comes from high identity between the new Paur-DRB sequences and sequences from Papio cynocephalus, Macaca mulatta and possibly Galago moholi.
John H Barker - One of the best experts on this subject based on the ideXlab platform.
-
on the ethics of facial Transplantation Research
American Journal of Bioethics, 2004Co-Authors: Osborne P. Wiggins, Michael R Cunningham, Claudio Maldonado, Marieke Vossen, Cedric Francois, Gustavo Perezabadia, Federico V Grossi, Serge A. Martinez, John H Barker, Joseph C. BanisAbstract:Transplantation continues to push the frontiers of medicine into domains that summon forth troublesome ethical questions. Looming on the frontier today is human facial Transplantation. We develop criteria that, we maintain, must be satisfied in order to ethically undertake this as-yet-untried transplant procedure. We draw on the criteria advanced by Dr. Francis Moore in the late 1980s for introducing innovative procedures in transplant surgery. In addition to these we also insist that human face Transplantation must meet all the ethical requirements usually applied to health care Research. We summarize the achievements of transplant surgery to date, focusing in particular on the safety and efficacy of immunosuppressive medications. We also emphasize the importance of risk/benefit assessments that take into account the physical, aesthetic, psychological, and social dimensions of facial disfiguration, reconstruction, and Transplantation. Finally, we maintain that the time has come to move facial transplanta...
-
response to selected commentaries on the ajob target article on the ethics of facial Transplantation Research
American Journal of Bioethics, 2004Co-Authors: Joseph C. Banis, Michael R Cunningham, Claudio Maldonado, Cedric Francois, Gustavo Perezabadia, Federico V Grossi, Serge A. Martinez, John H Barker, Allen Furr, Marieke VossenAbstract:Main Response Topics • Introduction • Open display and public evaluation • Publicity versus patient privacy • Facial tissue donation • Validity of Louisville Instrument for Risk Acceptance • Patients' understanding of risk • Face versus hand Transplantation • Rejection rates/risks • Patient compliance • Exit strategy • Functional recovery • Societietal implications • Psychological implications • Conclusion: Uncertainty likely to persist
-
on the ethics of facial Transplantation Research
American Journal of Bioethics, 2004Co-Authors: Osborne P. Wiggins, Michael R Cunningham, Claudio Maldonado, Marieke Vossen, Cedric Francois, Gustavo Perezabadia, Serge A. Martinez, John H Barker, Federico Grossi, Moshe KonAbstract:Transplantation continues to push the frontiers of medicine into domains that summon forth troublesome ethical questions. Looming on the frontier today is human facial Transplantation. We develop criteria that, we maintain, must be satisfied in order to ethically undertake this as-yet-untried transplant procedure. We draw on the criteria advanced by Dr. Francis Moore in the late 1980s for introducing innovative procedures in transplant surgery. In addition to these we also insist that human face Transplantation must meet all the ethical requirements usually applied to health care Research. We summarize the achievements of transplant surgery to date, focusing in particular on the safety and efficacy of immunosuppressive medications. We also emphasize the importance of risk/benefit assessments that take into account the physical, aesthetic, psychological, and social dimensions of facial disfiguration, reconstruction, and Transplantation. Finally, we maintain that the time has come to move facial Transplantation Research into the clinical phase.
