Transport Delay

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Lucile Godillon - One of the best experts on this subject based on the ideXlab platform.

Val C Sheffield - One of the best experts on this subject based on the ideXlab platform.

  • The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome.
    PLoS genetics, 2014
    Co-Authors: Xitiz Chamling, Charles Searby, Diane C Slusarski, Seongjin Seo, Gunhee Kim, Val C Sheffield
    Abstract:

    Bardet-Biedl syndrome (BBS) is a well-known ciliopathy with mutations reported in 18 different genes. Most of the protein products of the BBS genes localize at or near the primary cilium and the centrosome. Near the centrosome, BBS proteins interact with centriolar satellite proteins, and the BBSome (a complex of seven BBS proteins) is believed to play a role in Transporting ciliary membrane proteins. However, the precise mechanism by which BBSome ciliary trafficking activity is regulated is not fully understood. Here, we show that a centriolar satellite protein, AZI1 (also known as CEP131), interacts with the BBSome and regulates BBSome ciliary trafficking activity. Furthermore, we show that AZI1 interacts with the BBSome through BBS4. AZI1 is not involved in BBSome assembly, but accumulation of the BBSome in cilia is enhanced upon AZI1 depletion. Under conditions in which the BBSome does not normally enter cilia, such as in BBS3 or BBS5 depleted cells, knock down of AZI1 with siRNA restores BBSome trafficking to cilia. Finally, we show that azi1 knockdown in zebrafish embryos results in typical BBS phenotypes including Kupffer's vesicle abnormalities and melanosome Transport Delay. These findings associate AZI1 with the BBS pathway. Our findings provide further insight into the regulation of BBSome ciliary trafficking and identify AZI1 as a novel BBS candidate gene.

  • The Centriolar Satellite Protein AZI1 Interacts with BBS4 and Regulates Ciliary Trafficking of the BBSome
    2014
    Co-Authors: Xitiz Chamling, Charles Searby, Diane C Slusarski, Seongjin Seo, Gunhee Kim, Val C Sheffield
    Abstract:

    Bardet-Biedl syndrome (BBS) is a well-known ciliopathy with mutations reported in 18 different genes. Most of the protein products of the BBS genes localize at or near the primary cilium and the centrosome. Near the centrosome, BBS proteins interact with centriolar satellite proteins, and the BBSome (a complex of seven BBS proteins) is believed to play a role in Transporting ciliary membrane proteins. However, the precise mechanism by which BBSome ciliary trafficking activity is regulated is not fully understood. Here, we show that a centriolar satellite protein, AZI1 (also known as CEP131), interacts with the BBSome and regulates BBSome ciliary trafficking activity. Furthermore, we show that AZI1 interacts with the BBSome through BBS4. AZI1 is not involved in BBSome assembly, but accumulation of the BBSome in cilia is enhanced upon AZI1 depletion. Under conditions in which the BBSome does not normally enter cilia, such as in BBS3 or BBS5 depleted cells, knock down of AZI1 with siRNA restores BBSome trafficking to cilia. Finally, we show that azi1 knockdown in zebrafish embryos results in typical BBS phenotypes including Kupffer’s vesicle abnormalities and melanosome Transport Delay. These findings associate AZI1 with the BBS pathway. Our findings provide further insight into the regulation of BBSome ciliar

R Hakim - One of the best experts on this subject based on the ideXlab platform.

N Chakraborty - One of the best experts on this subject based on the ideXlab platform.

  • daily combined economic emission scheduling of hydrothermal systems with cascaded reservoirs using self organizing hierarchical particle swarm optimization technique
    Expert Systems With Applications, 2012
    Co-Authors: K K Mandal, N Chakraborty
    Abstract:

    Daily optimum economic emission scheduling of hydrothermal systems is an important task in the operation of power systems. Many heuristic techniques such as differential evolution, and particle swarm optimization have been applied to solve this problem and found to perform better in comparison with classical techniques. But a very common problem with these methods is that they often converge to sub-optimal solution prematurely. A reliable and efficient method termed as self-organizing hierarchical particle swarm optimization technique with time-varying acceleration coefficients (SOHPSO_TVAC) is presented in this paper to avoid premature convergence. A multi-chain cascaded hydrothermal system with non-linear relationship between water discharge rate, power generation and net head is considered in this paper. The water Transport Delay between connected reservoirs is also taken into consideration. The problem is formulated considering both cost and emission as competing objectives. The effect of valve point loading is also taken into account in the present problem formulation. The feasibility of the proposed method is demonstrated on a sample test system. The results of the proposed technique are compared with other heuristic techniques. It is found that the results obtained by the proposed technique are superior in terms of fuel cost, emission output etc.

  • short term combined economic emission scheduling of hydrothermal power systems with cascaded reservoirs using differential evolution
    Energy Conversion and Management, 2009
    Co-Authors: K K Mandal, N Chakraborty
    Abstract:

    A reliable algorithm based on differential evolution (DE) for solving short-term combined economic emission scheduling of hydrothermal systems with several equality and non-equality constraints is presented in this paper. The water Transport Delay between connected reservoirs is also considered. The problem is formulated considering both cost and emission as competing objectives. Combined economic emission scheduling (CEES) is a bi-objective problem. A price penalty factor approach is utilized here to convert this bi-objective CEES problem into a single objective one. The effect of valve point loading is also taken into account in the present problem formulation. The effectiveness of the proposed method is tested on a sample test system consisting of four cascaded hydro units and three thermal units. The results of the proposed technique based on DE are compared with other population based method. It is found that the results obtained by the proposed technique are superior in terms of fuel cost, emission output. It is also observed that the computation time is considerably reduced by the application of the proposed technique based on differential evolution.

Xitiz Chamling - One of the best experts on this subject based on the ideXlab platform.

  • The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome.
    PLoS genetics, 2014
    Co-Authors: Xitiz Chamling, Charles Searby, Diane C Slusarski, Seongjin Seo, Gunhee Kim, Val C Sheffield
    Abstract:

    Bardet-Biedl syndrome (BBS) is a well-known ciliopathy with mutations reported in 18 different genes. Most of the protein products of the BBS genes localize at or near the primary cilium and the centrosome. Near the centrosome, BBS proteins interact with centriolar satellite proteins, and the BBSome (a complex of seven BBS proteins) is believed to play a role in Transporting ciliary membrane proteins. However, the precise mechanism by which BBSome ciliary trafficking activity is regulated is not fully understood. Here, we show that a centriolar satellite protein, AZI1 (also known as CEP131), interacts with the BBSome and regulates BBSome ciliary trafficking activity. Furthermore, we show that AZI1 interacts with the BBSome through BBS4. AZI1 is not involved in BBSome assembly, but accumulation of the BBSome in cilia is enhanced upon AZI1 depletion. Under conditions in which the BBSome does not normally enter cilia, such as in BBS3 or BBS5 depleted cells, knock down of AZI1 with siRNA restores BBSome trafficking to cilia. Finally, we show that azi1 knockdown in zebrafish embryos results in typical BBS phenotypes including Kupffer's vesicle abnormalities and melanosome Transport Delay. These findings associate AZI1 with the BBS pathway. Our findings provide further insight into the regulation of BBSome ciliary trafficking and identify AZI1 as a novel BBS candidate gene.

  • The Centriolar Satellite Protein AZI1 Interacts with BBS4 and Regulates Ciliary Trafficking of the BBSome
    2014
    Co-Authors: Xitiz Chamling, Charles Searby, Diane C Slusarski, Seongjin Seo, Gunhee Kim, Val C Sheffield
    Abstract:

    Bardet-Biedl syndrome (BBS) is a well-known ciliopathy with mutations reported in 18 different genes. Most of the protein products of the BBS genes localize at or near the primary cilium and the centrosome. Near the centrosome, BBS proteins interact with centriolar satellite proteins, and the BBSome (a complex of seven BBS proteins) is believed to play a role in Transporting ciliary membrane proteins. However, the precise mechanism by which BBSome ciliary trafficking activity is regulated is not fully understood. Here, we show that a centriolar satellite protein, AZI1 (also known as CEP131), interacts with the BBSome and regulates BBSome ciliary trafficking activity. Furthermore, we show that AZI1 interacts with the BBSome through BBS4. AZI1 is not involved in BBSome assembly, but accumulation of the BBSome in cilia is enhanced upon AZI1 depletion. Under conditions in which the BBSome does not normally enter cilia, such as in BBS3 or BBS5 depleted cells, knock down of AZI1 with siRNA restores BBSome trafficking to cilia. Finally, we show that azi1 knockdown in zebrafish embryos results in typical BBS phenotypes including Kupffer’s vesicle abnormalities and melanosome Transport Delay. These findings associate AZI1 with the BBS pathway. Our findings provide further insight into the regulation of BBSome ciliar

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