The Experts below are selected from a list of 1422 Experts worldwide ranked by ideXlab platform
Paul A. Demers - One of the best experts on this subject based on the ideXlab platform.
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Prostate cancer surveillance by occupation and industry: the Canadian Census Health and Environment Cohort (CanCHEC).
Cancer medicine, 2018Co-Authors: Jeavana Sritharan, Jill S. Macleod, Shelley A. Harris, Donald C. Cole, Anne Harris, Michael Tjepkema, Paul A. Peters, Paul A. DemersAbstract:As there are no well-established modifiable risk factors for prostate cancer, further evidence is needed on possible factors such as occupation. Our study uses one of the largest Canadian worker cohorts to examine occupation, industry, and prostate cancer and to assess patterns of prostate cancer rates. The Canadian Census Health and Environment Cohort (CanCHEC) was established by linking the 1991 Canadian Census Cohort to the Canadian Cancer Database (1969-2010), Canadian Mortality Database (1991-2011), and Tax Summary Files (1981-2011). A total of 37,695 prostate cancer cases were identified in men aged 25-74 based on age at diagnosis. Cox proportional hazards models were used to estimate hazards ratios and 95% confidence intervals. In men aged 25-74 years, elevated risks were observed in the following Occupations: senior management (HR = 1.12, 95% CI: 1.04-1.20); office and administration (HR = 1.19, 95% CI: 1.11-1.27); finance services (HR = 1.09, 95% CI: 1.04-1.14); education (HR = 1.05, 95% CI: 1.00-1.11); agriculture and farm management (HR = 1.12, 95% CI: 1.06-1.17); farm work (HR = 1.11, 95% CI: 1.01-1.21); construction managers (HR = 1.07, 95% CI: 1.01-1.14); firefighting (HR = 1.17, 95% CI: 1.01-1.36); and police work (HR = 1.22, 95% CI: 1.09-1.36). Decreased risks were observed across other construction and Transportation Occupations. Results by industry were consistent with occupation results. Associations were identified for white-collar, agriculture, protective services, construction, and Transportation Occupations. These findings emphasize the need for further study of job-related exposures and the potential influence of nonoccupational factors such as screening practices.
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0456 Initial results from a new canadian occupational disease surveillance system
Oral Presentation, 2017Co-Authors: Paul A. Demers, Jill S. Macleod, Alice Peter, Saul G Feinstein, Luis Palma Lazgare, Christopher B. McleodAbstract:Large scale occupational disease surveillance has been challenging in many countries, with a few notable exceptions, such as the Nordic countries with their substantial record linkage abilities. We present initial results for lung cancer from a new Canadian Occupational Disease Surveillance System. The surveillance cohort was created using data from Ontario, Canada time-loss workers’ compensation claims 1983–2016 (96% for injuries) linked to cancer registry records. Follow-up was from first claim date until diagnosis, death, loss-to-follow-up or 2016. Hazard ratios (HRs) were calculated for each industry/occupation using Cox Proportional Hazard models, adjusted for year of birth and stratified on gender. The study population was 7 40 000 women and 1,430,000 men. Significant excess risks were observed in many of the a priori suspected Occupations and industries, particularly in construction, mining, and Transportation Occupations. In addition, other relevant associations were observed among both women and men, such as for janitors and cleaners (men: HR=1.22, 95% CI=1.16–1.29, women: HR=1.22, 95% CI=1.13–1.32) and primary metals industry (men: HR=1.18, 95% CI=1.11–1.25, women: HR=1.20, 95% CI=0.89–1.60). Many sex-specific associations were also observed, particularly in women (such as printing and publishing industries: HR=1.42, 95% CI=1.23–1.65 and chemical, rubber and plastic processing Occupations HR=1.31, 95% CI=1.15–1.51), which will need further investigation. The excess risks observed in many a priori suspected groups provides a good confirmation that this study can produce valid results and identify new associations. Triage methods are being developed to target new associations in need of further investigation. Future analyses will use hospital discharge data and outpatient visits.
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0339 Occupation and risk of prostate cancer in a national population-based cohort study: the canadian census health and environment cohort
Oral Presentation, 2017Co-Authors: Jeavana Sritharan, Jill S. Macleod, Shelley A. Harris, Donald C. Cole, Michael Tjepkema, Paul A. Peters, M. Anne Harris, Paul A. DemersAbstract:Prostate cancer is one of the most commonly diagnosed cancers in men and further evidence is needed on preventable risk factors. This study investigated the relationship between prostate cancer risk and occupation using a large Canadian cohort. The Canadian Census Health and Environment Cohort was established by linking the 1991 Canadian Census Cohort to the Canadian Cancer Database (1969–2010), Canadian Mortality Database (1991–2011) and the Tax Summary Files (1981–2011). A total of 37 695 prostate cancer cases were identified based on age at diagnosis. Cox proportional hazards models were used to estimate hazards ratios (HR) and 95% confidence intervals (CI). Overall, age standardised prostate cancer rates were observed to be highest in white collar workers and lowest in construction/Transportation workers. In men aged 50–74 years, elevated risks were observed in agriculture management (HR=1.11, 95% CI 1.06–1.17), farm work (HR=1.12, 95% CI 1.02–1.23), firefighting (HR=1.16, 95% CI 1.00–1.35), military (HR=1.14, 95% CI 1.00–1.32), police (HR=1.28, 95% CI 1.14–1.42), senior management (HR=1.09, 95% CI 1.02–1.17), office (HR=1.16, 95% CI 1.08–1.24), and finance (HR=1.08, 95% CI 1.03–1.13). Similar findings were observed in men aged 25–49 years, with additional elevated risks in office management (HR=1.19, 95% CI 1.11–1.27) and education (HR=1.05, 95% CI 1.00–1.11). Decreased risks were observed in construction and Transportation Occupations in both age groups. Findings across agriculture and protective services were consistent with previous studies. Some findings, particularly among management Occupations, may be due to screening. Further investigation is needed on job-specific exposures with better understanding on differences in rates across Occupations.
Jeavana Sritharan - One of the best experts on this subject based on the ideXlab platform.
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Prostate cancer surveillance by occupation and industry: the Canadian Census Health and Environment Cohort (CanCHEC).
Cancer medicine, 2018Co-Authors: Jeavana Sritharan, Jill S. Macleod, Shelley A. Harris, Donald C. Cole, Anne Harris, Michael Tjepkema, Paul A. Peters, Paul A. DemersAbstract:As there are no well-established modifiable risk factors for prostate cancer, further evidence is needed on possible factors such as occupation. Our study uses one of the largest Canadian worker cohorts to examine occupation, industry, and prostate cancer and to assess patterns of prostate cancer rates. The Canadian Census Health and Environment Cohort (CanCHEC) was established by linking the 1991 Canadian Census Cohort to the Canadian Cancer Database (1969-2010), Canadian Mortality Database (1991-2011), and Tax Summary Files (1981-2011). A total of 37,695 prostate cancer cases were identified in men aged 25-74 based on age at diagnosis. Cox proportional hazards models were used to estimate hazards ratios and 95% confidence intervals. In men aged 25-74 years, elevated risks were observed in the following Occupations: senior management (HR = 1.12, 95% CI: 1.04-1.20); office and administration (HR = 1.19, 95% CI: 1.11-1.27); finance services (HR = 1.09, 95% CI: 1.04-1.14); education (HR = 1.05, 95% CI: 1.00-1.11); agriculture and farm management (HR = 1.12, 95% CI: 1.06-1.17); farm work (HR = 1.11, 95% CI: 1.01-1.21); construction managers (HR = 1.07, 95% CI: 1.01-1.14); firefighting (HR = 1.17, 95% CI: 1.01-1.36); and police work (HR = 1.22, 95% CI: 1.09-1.36). Decreased risks were observed across other construction and Transportation Occupations. Results by industry were consistent with occupation results. Associations were identified for white-collar, agriculture, protective services, construction, and Transportation Occupations. These findings emphasize the need for further study of job-related exposures and the potential influence of nonoccupational factors such as screening practices.
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0339 Occupation and risk of prostate cancer in a national population-based cohort study: the canadian census health and environment cohort
Oral Presentation, 2017Co-Authors: Jeavana Sritharan, Jill S. Macleod, Shelley A. Harris, Donald C. Cole, Michael Tjepkema, Paul A. Peters, M. Anne Harris, Paul A. DemersAbstract:Prostate cancer is one of the most commonly diagnosed cancers in men and further evidence is needed on preventable risk factors. This study investigated the relationship between prostate cancer risk and occupation using a large Canadian cohort. The Canadian Census Health and Environment Cohort was established by linking the 1991 Canadian Census Cohort to the Canadian Cancer Database (1969–2010), Canadian Mortality Database (1991–2011) and the Tax Summary Files (1981–2011). A total of 37 695 prostate cancer cases were identified based on age at diagnosis. Cox proportional hazards models were used to estimate hazards ratios (HR) and 95% confidence intervals (CI). Overall, age standardised prostate cancer rates were observed to be highest in white collar workers and lowest in construction/Transportation workers. In men aged 50–74 years, elevated risks were observed in agriculture management (HR=1.11, 95% CI 1.06–1.17), farm work (HR=1.12, 95% CI 1.02–1.23), firefighting (HR=1.16, 95% CI 1.00–1.35), military (HR=1.14, 95% CI 1.00–1.32), police (HR=1.28, 95% CI 1.14–1.42), senior management (HR=1.09, 95% CI 1.02–1.17), office (HR=1.16, 95% CI 1.08–1.24), and finance (HR=1.08, 95% CI 1.03–1.13). Similar findings were observed in men aged 25–49 years, with additional elevated risks in office management (HR=1.19, 95% CI 1.11–1.27) and education (HR=1.05, 95% CI 1.00–1.11). Decreased risks were observed in construction and Transportation Occupations in both age groups. Findings across agriculture and protective services were consistent with previous studies. Some findings, particularly among management Occupations, may be due to screening. Further investigation is needed on job-specific exposures with better understanding on differences in rates across Occupations.
Jill S. Macleod - One of the best experts on this subject based on the ideXlab platform.
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Prostate cancer surveillance by occupation and industry: the Canadian Census Health and Environment Cohort (CanCHEC).
Cancer medicine, 2018Co-Authors: Jeavana Sritharan, Jill S. Macleod, Shelley A. Harris, Donald C. Cole, Anne Harris, Michael Tjepkema, Paul A. Peters, Paul A. DemersAbstract:As there are no well-established modifiable risk factors for prostate cancer, further evidence is needed on possible factors such as occupation. Our study uses one of the largest Canadian worker cohorts to examine occupation, industry, and prostate cancer and to assess patterns of prostate cancer rates. The Canadian Census Health and Environment Cohort (CanCHEC) was established by linking the 1991 Canadian Census Cohort to the Canadian Cancer Database (1969-2010), Canadian Mortality Database (1991-2011), and Tax Summary Files (1981-2011). A total of 37,695 prostate cancer cases were identified in men aged 25-74 based on age at diagnosis. Cox proportional hazards models were used to estimate hazards ratios and 95% confidence intervals. In men aged 25-74 years, elevated risks were observed in the following Occupations: senior management (HR = 1.12, 95% CI: 1.04-1.20); office and administration (HR = 1.19, 95% CI: 1.11-1.27); finance services (HR = 1.09, 95% CI: 1.04-1.14); education (HR = 1.05, 95% CI: 1.00-1.11); agriculture and farm management (HR = 1.12, 95% CI: 1.06-1.17); farm work (HR = 1.11, 95% CI: 1.01-1.21); construction managers (HR = 1.07, 95% CI: 1.01-1.14); firefighting (HR = 1.17, 95% CI: 1.01-1.36); and police work (HR = 1.22, 95% CI: 1.09-1.36). Decreased risks were observed across other construction and Transportation Occupations. Results by industry were consistent with occupation results. Associations were identified for white-collar, agriculture, protective services, construction, and Transportation Occupations. These findings emphasize the need for further study of job-related exposures and the potential influence of nonoccupational factors such as screening practices.
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0456 Initial results from a new canadian occupational disease surveillance system
Oral Presentation, 2017Co-Authors: Paul A. Demers, Jill S. Macleod, Alice Peter, Saul G Feinstein, Luis Palma Lazgare, Christopher B. McleodAbstract:Large scale occupational disease surveillance has been challenging in many countries, with a few notable exceptions, such as the Nordic countries with their substantial record linkage abilities. We present initial results for lung cancer from a new Canadian Occupational Disease Surveillance System. The surveillance cohort was created using data from Ontario, Canada time-loss workers’ compensation claims 1983–2016 (96% for injuries) linked to cancer registry records. Follow-up was from first claim date until diagnosis, death, loss-to-follow-up or 2016. Hazard ratios (HRs) were calculated for each industry/occupation using Cox Proportional Hazard models, adjusted for year of birth and stratified on gender. The study population was 7 40 000 women and 1,430,000 men. Significant excess risks were observed in many of the a priori suspected Occupations and industries, particularly in construction, mining, and Transportation Occupations. In addition, other relevant associations were observed among both women and men, such as for janitors and cleaners (men: HR=1.22, 95% CI=1.16–1.29, women: HR=1.22, 95% CI=1.13–1.32) and primary metals industry (men: HR=1.18, 95% CI=1.11–1.25, women: HR=1.20, 95% CI=0.89–1.60). Many sex-specific associations were also observed, particularly in women (such as printing and publishing industries: HR=1.42, 95% CI=1.23–1.65 and chemical, rubber and plastic processing Occupations HR=1.31, 95% CI=1.15–1.51), which will need further investigation. The excess risks observed in many a priori suspected groups provides a good confirmation that this study can produce valid results and identify new associations. Triage methods are being developed to target new associations in need of further investigation. Future analyses will use hospital discharge data and outpatient visits.
-
0339 Occupation and risk of prostate cancer in a national population-based cohort study: the canadian census health and environment cohort
Oral Presentation, 2017Co-Authors: Jeavana Sritharan, Jill S. Macleod, Shelley A. Harris, Donald C. Cole, Michael Tjepkema, Paul A. Peters, M. Anne Harris, Paul A. DemersAbstract:Prostate cancer is one of the most commonly diagnosed cancers in men and further evidence is needed on preventable risk factors. This study investigated the relationship between prostate cancer risk and occupation using a large Canadian cohort. The Canadian Census Health and Environment Cohort was established by linking the 1991 Canadian Census Cohort to the Canadian Cancer Database (1969–2010), Canadian Mortality Database (1991–2011) and the Tax Summary Files (1981–2011). A total of 37 695 prostate cancer cases were identified based on age at diagnosis. Cox proportional hazards models were used to estimate hazards ratios (HR) and 95% confidence intervals (CI). Overall, age standardised prostate cancer rates were observed to be highest in white collar workers and lowest in construction/Transportation workers. In men aged 50–74 years, elevated risks were observed in agriculture management (HR=1.11, 95% CI 1.06–1.17), farm work (HR=1.12, 95% CI 1.02–1.23), firefighting (HR=1.16, 95% CI 1.00–1.35), military (HR=1.14, 95% CI 1.00–1.32), police (HR=1.28, 95% CI 1.14–1.42), senior management (HR=1.09, 95% CI 1.02–1.17), office (HR=1.16, 95% CI 1.08–1.24), and finance (HR=1.08, 95% CI 1.03–1.13). Similar findings were observed in men aged 25–49 years, with additional elevated risks in office management (HR=1.19, 95% CI 1.11–1.27) and education (HR=1.05, 95% CI 1.00–1.11). Decreased risks were observed in construction and Transportation Occupations in both age groups. Findings across agriculture and protective services were consistent with previous studies. Some findings, particularly among management Occupations, may be due to screening. Further investigation is needed on job-specific exposures with better understanding on differences in rates across Occupations.
Paul A. Peters - One of the best experts on this subject based on the ideXlab platform.
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Prostate cancer surveillance by occupation and industry: the Canadian Census Health and Environment Cohort (CanCHEC).
Cancer medicine, 2018Co-Authors: Jeavana Sritharan, Jill S. Macleod, Shelley A. Harris, Donald C. Cole, Anne Harris, Michael Tjepkema, Paul A. Peters, Paul A. DemersAbstract:As there are no well-established modifiable risk factors for prostate cancer, further evidence is needed on possible factors such as occupation. Our study uses one of the largest Canadian worker cohorts to examine occupation, industry, and prostate cancer and to assess patterns of prostate cancer rates. The Canadian Census Health and Environment Cohort (CanCHEC) was established by linking the 1991 Canadian Census Cohort to the Canadian Cancer Database (1969-2010), Canadian Mortality Database (1991-2011), and Tax Summary Files (1981-2011). A total of 37,695 prostate cancer cases were identified in men aged 25-74 based on age at diagnosis. Cox proportional hazards models were used to estimate hazards ratios and 95% confidence intervals. In men aged 25-74 years, elevated risks were observed in the following Occupations: senior management (HR = 1.12, 95% CI: 1.04-1.20); office and administration (HR = 1.19, 95% CI: 1.11-1.27); finance services (HR = 1.09, 95% CI: 1.04-1.14); education (HR = 1.05, 95% CI: 1.00-1.11); agriculture and farm management (HR = 1.12, 95% CI: 1.06-1.17); farm work (HR = 1.11, 95% CI: 1.01-1.21); construction managers (HR = 1.07, 95% CI: 1.01-1.14); firefighting (HR = 1.17, 95% CI: 1.01-1.36); and police work (HR = 1.22, 95% CI: 1.09-1.36). Decreased risks were observed across other construction and Transportation Occupations. Results by industry were consistent with occupation results. Associations were identified for white-collar, agriculture, protective services, construction, and Transportation Occupations. These findings emphasize the need for further study of job-related exposures and the potential influence of nonoccupational factors such as screening practices.
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0339 Occupation and risk of prostate cancer in a national population-based cohort study: the canadian census health and environment cohort
Oral Presentation, 2017Co-Authors: Jeavana Sritharan, Jill S. Macleod, Shelley A. Harris, Donald C. Cole, Michael Tjepkema, Paul A. Peters, M. Anne Harris, Paul A. DemersAbstract:Prostate cancer is one of the most commonly diagnosed cancers in men and further evidence is needed on preventable risk factors. This study investigated the relationship between prostate cancer risk and occupation using a large Canadian cohort. The Canadian Census Health and Environment Cohort was established by linking the 1991 Canadian Census Cohort to the Canadian Cancer Database (1969–2010), Canadian Mortality Database (1991–2011) and the Tax Summary Files (1981–2011). A total of 37 695 prostate cancer cases were identified based on age at diagnosis. Cox proportional hazards models were used to estimate hazards ratios (HR) and 95% confidence intervals (CI). Overall, age standardised prostate cancer rates were observed to be highest in white collar workers and lowest in construction/Transportation workers. In men aged 50–74 years, elevated risks were observed in agriculture management (HR=1.11, 95% CI 1.06–1.17), farm work (HR=1.12, 95% CI 1.02–1.23), firefighting (HR=1.16, 95% CI 1.00–1.35), military (HR=1.14, 95% CI 1.00–1.32), police (HR=1.28, 95% CI 1.14–1.42), senior management (HR=1.09, 95% CI 1.02–1.17), office (HR=1.16, 95% CI 1.08–1.24), and finance (HR=1.08, 95% CI 1.03–1.13). Similar findings were observed in men aged 25–49 years, with additional elevated risks in office management (HR=1.19, 95% CI 1.11–1.27) and education (HR=1.05, 95% CI 1.00–1.11). Decreased risks were observed in construction and Transportation Occupations in both age groups. Findings across agriculture and protective services were consistent with previous studies. Some findings, particularly among management Occupations, may be due to screening. Further investigation is needed on job-specific exposures with better understanding on differences in rates across Occupations.
Shelley A. Harris - One of the best experts on this subject based on the ideXlab platform.
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Prostate cancer surveillance by occupation and industry: the Canadian Census Health and Environment Cohort (CanCHEC).
Cancer medicine, 2018Co-Authors: Jeavana Sritharan, Jill S. Macleod, Shelley A. Harris, Donald C. Cole, Anne Harris, Michael Tjepkema, Paul A. Peters, Paul A. DemersAbstract:As there are no well-established modifiable risk factors for prostate cancer, further evidence is needed on possible factors such as occupation. Our study uses one of the largest Canadian worker cohorts to examine occupation, industry, and prostate cancer and to assess patterns of prostate cancer rates. The Canadian Census Health and Environment Cohort (CanCHEC) was established by linking the 1991 Canadian Census Cohort to the Canadian Cancer Database (1969-2010), Canadian Mortality Database (1991-2011), and Tax Summary Files (1981-2011). A total of 37,695 prostate cancer cases were identified in men aged 25-74 based on age at diagnosis. Cox proportional hazards models were used to estimate hazards ratios and 95% confidence intervals. In men aged 25-74 years, elevated risks were observed in the following Occupations: senior management (HR = 1.12, 95% CI: 1.04-1.20); office and administration (HR = 1.19, 95% CI: 1.11-1.27); finance services (HR = 1.09, 95% CI: 1.04-1.14); education (HR = 1.05, 95% CI: 1.00-1.11); agriculture and farm management (HR = 1.12, 95% CI: 1.06-1.17); farm work (HR = 1.11, 95% CI: 1.01-1.21); construction managers (HR = 1.07, 95% CI: 1.01-1.14); firefighting (HR = 1.17, 95% CI: 1.01-1.36); and police work (HR = 1.22, 95% CI: 1.09-1.36). Decreased risks were observed across other construction and Transportation Occupations. Results by industry were consistent with occupation results. Associations were identified for white-collar, agriculture, protective services, construction, and Transportation Occupations. These findings emphasize the need for further study of job-related exposures and the potential influence of nonoccupational factors such as screening practices.
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0339 Occupation and risk of prostate cancer in a national population-based cohort study: the canadian census health and environment cohort
Oral Presentation, 2017Co-Authors: Jeavana Sritharan, Jill S. Macleod, Shelley A. Harris, Donald C. Cole, Michael Tjepkema, Paul A. Peters, M. Anne Harris, Paul A. DemersAbstract:Prostate cancer is one of the most commonly diagnosed cancers in men and further evidence is needed on preventable risk factors. This study investigated the relationship between prostate cancer risk and occupation using a large Canadian cohort. The Canadian Census Health and Environment Cohort was established by linking the 1991 Canadian Census Cohort to the Canadian Cancer Database (1969–2010), Canadian Mortality Database (1991–2011) and the Tax Summary Files (1981–2011). A total of 37 695 prostate cancer cases were identified based on age at diagnosis. Cox proportional hazards models were used to estimate hazards ratios (HR) and 95% confidence intervals (CI). Overall, age standardised prostate cancer rates were observed to be highest in white collar workers and lowest in construction/Transportation workers. In men aged 50–74 years, elevated risks were observed in agriculture management (HR=1.11, 95% CI 1.06–1.17), farm work (HR=1.12, 95% CI 1.02–1.23), firefighting (HR=1.16, 95% CI 1.00–1.35), military (HR=1.14, 95% CI 1.00–1.32), police (HR=1.28, 95% CI 1.14–1.42), senior management (HR=1.09, 95% CI 1.02–1.17), office (HR=1.16, 95% CI 1.08–1.24), and finance (HR=1.08, 95% CI 1.03–1.13). Similar findings were observed in men aged 25–49 years, with additional elevated risks in office management (HR=1.19, 95% CI 1.11–1.27) and education (HR=1.05, 95% CI 1.00–1.11). Decreased risks were observed in construction and Transportation Occupations in both age groups. Findings across agriculture and protective services were consistent with previous studies. Some findings, particularly among management Occupations, may be due to screening. Further investigation is needed on job-specific exposures with better understanding on differences in rates across Occupations.
