The Experts below are selected from a list of 498 Experts worldwide ranked by ideXlab platform
Y Menu - One of the best experts on this subject based on the ideXlab platform.
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mri of unusual lesions in the internal auditory canal
Neuroradiology, 2001Co-Authors: A Krainik, F Cynagorse, D Bouccara, D Cazalshatem, V Vilgrain, Alban Denys, A Rey, O Sterkers, Y MenuAbstract:We report the MRI findings of six unusual lesions of the internal auditory canal: three haemangiomas, one lipoma, one metastasis and one Traumatic Neuroma. We compare the findings to those of 20 intracanalicular schwannomas. We noted the site and size of the tumour, its signal intensity, borders and the homogeneity of enhancement were studied on T1-weighted images before and after intravenous contrast medium and T2-weighted images. Most schwannomas were homogeneous lesions, isointense on T1- and T2-weighted images, and strongly enhancing. Spontaneous high signal on T1-weighted images, heterogeneous contrast enhancement and extranodular enhancement were helpful for recognising lesions other then schwannomas; site, size and signal on T2-weighted images were not. All the haemangiomas had a specific pattern of contrast enhancement, with an anterior core intensely enhancing portion and a posterior portion which enhanced moderately or not at all.
Navapong Anantavorasakul - One of the best experts on this subject based on the ideXlab platform.
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surgery for lower extremity symptomatic Neuroma long term outcomes
Journal of Plastic Reconstructive and Aesthetic Surgery, 2020Co-Authors: Jonathan Lans, Neal C Chen, Navapong Anantavorasakul, Arno A Macken, Ravi F Sood, Kyle R EberlinAbstract:Summary Introduction Traumatic Neuroma caused by injuries or surgery can result in neuropathic pain, functional impairment, and psychological distress, which has an impact on quality of life. The aim of this study was to identify the factors related to successful treatment of symptomatic lower extremity symptomatic Neuromas using patient-reported outcome measures (PROMs). Methods Thirty-two patients with 48 symptomatic Neuromas completed the PROMIS mobility, PROMIS pain interference (PI), Numeric Rating Scale (NRS) for pain (0–10) for both pre- and post-operative pain, and the PROMIS depression at a mean of 8.9±4.5 years following Neuroma surgery. Neuromas were located around the foot and ankle (n=18, 38%), leg (n=14, 29%), around the knee (n=13, 27%), and in the thigh (n=3, 6.3%). Surgical treatment included Neuroma excision and implantation (n=29, 60%) followed by Neuroma excision alone or excision with placement in the subcutaneous tissue (n=12, 25%). We performed multivariable analysis to identify the factors influencing the PROMs. Results Patients reported significant reduction in mean NRS pain after surgery (7.3 vs 4.9, p=0.0013). Higher PROMIS depression scores were independently associated with inferior PROMIS mobility scores (β=–0.38, p=0.001), higher PROMIS PI scores (β=0.68, p Conclusion Surgical treatment of symptomatic Neuromas of the lower extremity provides a long-term improvement in 59% of patients, but 19% of patients still reported severe persistent pain despite surgical treatment. Smoking and negative mood have negative effects on patient-reported outcomes after Neuroma surgery.
Toshiaki Sano - One of the best experts on this subject based on the ideXlab platform.
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immunohistochemical demonstration of ema glut1 positive perineurial cells and cd34 positive fibroblastic cells in peripheral nerve sheath tumors
Modern Pathology, 2003Co-Authors: Takanori Hirose, Takayuki Tani, Tetsuya Shimada, Keisuke Ishizawa, Shio Shimada, Toshiaki SanoAbstract:To clarify the cellular composition of various peripheral nerve tumorous lesions (Traumatic Neuroma, 5 cases; schwannoma, 10 cases; neurofibroma, 14 cases; perineurioma, 3 cases; conventional malignant peripheral nerve sheath tumor (MPNST), 7 cases; perineurial MPNST, 4 cases), expression of several markers specific to nerve sheath cells, including glucose transporter protein 1 (Glut1) and CD34, were immunohistochemically investigated with highly sensitive detection methods. In normal nerves and Neuromas, perineuriums were positive for Glut1 as well as for epithelial membrane antigen (EMA), and there were some CD34-positive fibroblast-like cells in the endoneurium. Schwannomas consisted principally of S-100 protein–positive Schwann cells, whereas a few CD34-positive fibroblastic cells were present in Antoni B areas. Neurofibromas and conventional MPNST exhibited a mixed proliferation of S-100 protein-, EMA/Glut1-, and CD34-positive cells, indicating a heterogeneous composition of the constituents. The catalyzed signal amplification (CSA) system demonstrated more numerous EMA-positive perineurial cells in neurofibromas than did the ENVISION+ method. Perineurial cell tumors (benign and malignant) were composed of EMA/Glut1-positive and S-100 protein–negative tumor cells. The present study confirmed the characteristic cellular composition to each nerve sheath tumor immunohistochemically and showed the usefulness of the nerve sheath cell markers. Glut1 as well as EMA are specific to perineurial cells, and CD34 seems to be immunoreactive to endoneurial fibroblasts.
A Krainik - One of the best experts on this subject based on the ideXlab platform.
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mri of unusual lesions in the internal auditory canal
Neuroradiology, 2001Co-Authors: A Krainik, F Cynagorse, D Bouccara, D Cazalshatem, V Vilgrain, Alban Denys, A Rey, O Sterkers, Y MenuAbstract:We report the MRI findings of six unusual lesions of the internal auditory canal: three haemangiomas, one lipoma, one metastasis and one Traumatic Neuroma. We compare the findings to those of 20 intracanalicular schwannomas. We noted the site and size of the tumour, its signal intensity, borders and the homogeneity of enhancement were studied on T1-weighted images before and after intravenous contrast medium and T2-weighted images. Most schwannomas were homogeneous lesions, isointense on T1- and T2-weighted images, and strongly enhancing. Spontaneous high signal on T1-weighted images, heterogeneous contrast enhancement and extranodular enhancement were helpful for recognising lesions other then schwannomas; site, size and signal on T2-weighted images were not. All the haemangiomas had a specific pattern of contrast enhancement, with an anterior core intensely enhancing portion and a posterior portion which enhanced moderately or not at all.
Anne Cotten - One of the best experts on this subject based on the ideXlab platform.
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peripheral tumor and tumor like neurogenic lesions
European Journal of Radiology, 2013Co-Authors: Evandro Abreu, Sebastien Aubert, Guillaume Wavreille, Ramon Gheno, Clarissa Canella, Anne CottenAbstract:Neoplasms of neurogenic origin account for about 12% of all benign and 8% of all malignant soft tissue neoplasms. Traumatic Neuroma, Morton Neuroma, lipomatosis of a nerve, nerve sheath ganglion, perineurioma, benign and malignant peripheral nerve sheath tumors (PNST) are included in this group of pathologies. Clinical and radiologic evaluation of patients with neurogenic tumors and pseudotumors often reveals distinctive features. In this context, advanced imaging techniques, especially ultrasound (US) and magnetic resonance (MR) play an important role in the characterization of these lesions. Imaging findings such as location of a soft tissue mass in the region of a major nerve, nerve entering or exiting the mass, fusiform shape, abnormalities of the muscle supplied by the nerve, split-fat sign, target sign and fascicular appearance should always evoke a peripheric nerve sheath neoplasm. Although no single imaging finding or combination of findings allows definitive differentiation between benign from malign peripheric neurogenic tumors, both US and MR imaging may show useful features that can lead us to a correct diagnosis and improve patient treatment. Traumatic Neuromas and Morton Neuromas are commonly associated to an amputation stump or are located in the intermetatarsal space. Lipomatosis of a nerve usually appears as a nerve enlargement, with thickened nerve fascicles, embedded in evenly distributed fat. Nerve sheath ganglion has a cystic appearance and commonly occurs at the level of the knee. Intraneural periNeuroma usually affects young people and manifests as a focal and fusiform nerve enlargement. In this article, we review clinical characteristics and radiologic appearances of these neurogenic lesions, observing pathologic correlation, when possible.
