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Neena Singla - One of the best experts on this subject based on the ideXlab platform.
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histomorphological and biochemical changes induced by triptolide Treatment in male lesser bandicoot rat bandicota bengalensis
Pesticide Biochemistry and Physiology, 2014Co-Authors: Parul Dhar, Neena SinglaAbstract:Mature and healthy male lesser bandicoot rats, Bandicota bengalensis (n = 40) were fed on bait (mixture of cracked wheat and powdered sugar in 98:2) containing different concentrations of triptolide (0, 0.15, 0.20 and 0.25% w/w) for 15 days in two-choice trials. Results revealed no significant effect of triptolide Treatment on weights of vital organs after 30 and 60 days of Treatment Withdrawal. A significant (P ≤ 0.05) increase in plasma levels of TP, ALP, ACP, ALT and AST in response to stress induced in groups of rats treated with 0.20 and 0.25% triptolide was observed after 30 days of Treatment Withdrawal. No significant effect of Treatment was observed on histomorphology of liver. A significant (P ≤ 0.05) effect of triptolide Treatment was, however, observed on testicular function in the form of reduced diameter of seminiferous tubules and number of various spermatogenic cells indicating effect on spermatogenesis and spermiogenesis. The cell stages affected did not recover fully within 60 days period following Treatment Withdrawal. The present study suggests the potential of triptolide in the reproductive management of B. bengalensis by way of affecting testicular function.
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research article effect of triptolide on reproductive output of male bandicota bengalensis
2013Co-Authors: Parul Dhar, Neena SinglaAbstract:Manuscript History: Present study was aimed to evaluate the effect of triptolide on reproductive output of wild male rodent pest species, Bandicota bengalensis for its further use in integration with chemical control for management of this pest species under field conditions. One group of rats (n =15) was kept as vehicle control and other three groups (n = 15 each) were fed on bait containing different concentrations of triptolide. Feeding of bait containing 0.15, 0.2 and 0.25% triptolide for a period of 15 days in choice with plain bait resulted in per day ingestion of 19.99 ± 2.41, 19.28 ± 2.01 and 11.42 ± 1.30 mg/kg bw of triptolide, respectively. No pregnancy was observed in female rats paired with male rats treated with 0.2 and 0.25% triptolide immediately after Treatment Withdrawal. No pregnancy was observed in female rats paired with male rats treated with 0.25% triptolide even after 30 days of Treatment Withdrawal. Autopsy of rats immediately and after 30 and 60 days of termination of Treatment revealed significant effect of triptolide Treatment on weights reproductive organs, sperm motility, viability, density and sperm morphology. No effect of Treatment was observed on plasma levels of testosterone. The present study suggests triptolide to be a strong candidate for reducing the reproductive output of male B. bengalensis.
Jim Howe - One of the best experts on this subject based on the ideXlab platform.
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the persistent vegetative state Treatment Withdrawal and the hillsborough disaster airedale nhs trust v bland
Practical Neurology, 2006Co-Authors: Jim HoweAbstract:Liverpool fans desperately trying to escape the crush in the terraces. “Dr Venables from Sheffield on the phone for you, he says you are old friends”. My secretary Jane transferred the call to me, and so it began. Graham asked if I could take a young man from Keighley, who had been injured at the Hillsborough football stadium in Sheffield on 15 April 1989. The Football Association Cup semi-final that afternoon, between Liverpool and Nottingham Forrest, had been abandoned soon after kick off, when hundreds of Liverpool fans were crushed in fenced pens at one end of the ground. The disaster had been seen unfolding live on TV. Airedale General is Keighley’s hospital, and at that time I was responsible for the physical rehabilitation service. The young man’s name was Anthony Bland, he was 18 years old, and he had suffered severe anoxic brain damage when his chest was crushed. Graham said that after a few days ventilation he had been able to breathe unaided, and once extubated, appeared to be in a vegetative state. Tony Bland was transferred to us in May. He was unresponsive, with open eyes and all the features of the vegetative state.1 His parents, older sister, and other family members came to hear what was planned. After outlining what we would do to try to prevent complications and encourage recovery, I explained that because he had suffered severe brain damage it did not look hopeful, but we would do our best. Graham had already begun breaking the bad news. The police liaison officer assigned to the family came to see me, and asked to be kept informed of Tony’s progress. Soon afterwards, the local and national press heard that a “Hillsborough victim” was at Airedale and asked for information. Despite the rehabilitation team’s best …
Parul Dhar - One of the best experts on this subject based on the ideXlab platform.
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histomorphological and biochemical changes induced by triptolide Treatment in male lesser bandicoot rat bandicota bengalensis
Pesticide Biochemistry and Physiology, 2014Co-Authors: Parul Dhar, Neena SinglaAbstract:Mature and healthy male lesser bandicoot rats, Bandicota bengalensis (n = 40) were fed on bait (mixture of cracked wheat and powdered sugar in 98:2) containing different concentrations of triptolide (0, 0.15, 0.20 and 0.25% w/w) for 15 days in two-choice trials. Results revealed no significant effect of triptolide Treatment on weights of vital organs after 30 and 60 days of Treatment Withdrawal. A significant (P ≤ 0.05) increase in plasma levels of TP, ALP, ACP, ALT and AST in response to stress induced in groups of rats treated with 0.20 and 0.25% triptolide was observed after 30 days of Treatment Withdrawal. No significant effect of Treatment was observed on histomorphology of liver. A significant (P ≤ 0.05) effect of triptolide Treatment was, however, observed on testicular function in the form of reduced diameter of seminiferous tubules and number of various spermatogenic cells indicating effect on spermatogenesis and spermiogenesis. The cell stages affected did not recover fully within 60 days period following Treatment Withdrawal. The present study suggests the potential of triptolide in the reproductive management of B. bengalensis by way of affecting testicular function.
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research article effect of triptolide on reproductive output of male bandicota bengalensis
2013Co-Authors: Parul Dhar, Neena SinglaAbstract:Manuscript History: Present study was aimed to evaluate the effect of triptolide on reproductive output of wild male rodent pest species, Bandicota bengalensis for its further use in integration with chemical control for management of this pest species under field conditions. One group of rats (n =15) was kept as vehicle control and other three groups (n = 15 each) were fed on bait containing different concentrations of triptolide. Feeding of bait containing 0.15, 0.2 and 0.25% triptolide for a period of 15 days in choice with plain bait resulted in per day ingestion of 19.99 ± 2.41, 19.28 ± 2.01 and 11.42 ± 1.30 mg/kg bw of triptolide, respectively. No pregnancy was observed in female rats paired with male rats treated with 0.2 and 0.25% triptolide immediately after Treatment Withdrawal. No pregnancy was observed in female rats paired with male rats treated with 0.25% triptolide even after 30 days of Treatment Withdrawal. Autopsy of rats immediately and after 30 and 60 days of termination of Treatment revealed significant effect of triptolide Treatment on weights reproductive organs, sperm motility, viability, density and sperm morphology. No effect of Treatment was observed on plasma levels of testosterone. The present study suggests triptolide to be a strong candidate for reducing the reproductive output of male B. bengalensis.
Pascal De Tullio - One of the best experts on this subject based on the ideXlab platform.
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blocking lipid synthesis overcomes tumor regrowth and metastasis after antiangiogenic therapy Withdrawal
Cell Metabolism, 2014Co-Authors: Nor Eddine Sounni, Jonathan Cimino, Silvia Blacher, Irina Primac, Alice Truong, Gabriel Mazzucchelli, Alexandra Paye, David Calligaris, Delphine Debois, Pascal De TullioAbstract:Summary The molecular mechanisms responsible for the failure of antiangiogenic therapies and how tumors adapt to these therapies are unclear. Here, we applied transcriptomic, proteomic, and metabolomic approaches to preclinical models and provide evidence for tumor adaptation to vascular endothelial growth factor blockade through a metabolic shift toward carbohydrate and lipid metabolism in tumors. During sunitinib or sorafenib Treatment, tumor growth was inhibited and tumors were hypoxic and glycolytic. In sharp contrast, Treatment Withdrawal led to tumor regrowth, angiogenesis restoration, moderate lactate production, and enhanced lipid synthesis. This metabolic shift was associated with a drastic increase in metastatic dissemination. Interestingly, pharmacological lipogenesis inhibition with orlistat or fatty acid synthase downregulation with shRNA inhibited tumor regrowth and metastases after sunitinib Treatment Withdrawal. Our data shed light on metabolic alterations that result in cancer adaptation to antiangiogenic Treatments and identify key molecules involved in lipid metabolism as putative therapeutic targets.
Pascal Renard - One of the best experts on this subject based on the ideXlab platform.
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Sustained Remission After Treatment Withdrawal in Autoimmune Hepatitis: A Multicenter Retrospective Study
Digestive Diseases and Sciences, 2020Co-Authors: Yasmina Ben Merabet, Coralie Barbe, Alexandra Heurgue-berlot, Thierry Thévenot, Anne Minello, François Habersetzer, Didier Samuel, Brigitte Bernard-chabert, Delphine Weil-verhoeven, Pascal RenardAbstract:Background In patients with autoimmune hepatitis (AIH), relapse rates between 25 and 100% after Treatment Withdrawal have been reported. The optimal strategy for immunosuppressive Treatment Withdrawal is controversial. Aim To identify the predictive factors of histological remission and to assess the relapse rate after Treatment Withdrawal in AIH patients with prolonged biochemical response. Methods Patients with AIH and sustained biochemical remission on first-line Treatment were retrospectively included. Histological response was defined as complete regression of interface hepatitis and lobular necrosis and no or minimal portal inflammation and relapse as any elevation of serum aminotransferase or gammaglobulin/IgG levels. Results Sixty-two patients were included. Forty-seven had a biopsy after a median biochemical response of 49.7 months. Twenty-five of them were histological responders. Independent predictors of histological remission were older age (OR = 1.1; CI 95%: 1.0; 1.2), mild-to-moderate fibrosis at diagnosis (OR = 8; CI: 1.4; 47.6) and aspartate aminotransferases
