The Experts below are selected from a list of 204 Experts worldwide ranked by ideXlab platform
Dirk M Guldi - One of the best experts on this subject based on the ideXlab platform.
-
formation and photophysics of a stable concave convex supramolecular complex of c60 and a substituted s Triazine Derivative
Chemical Communications, 2002Co-Authors: David I Schuster, Joel Rosenthal, Shaun Macmahon, Peter D Jarowski, Christopher A Alabi, Dirk M GuldiAbstract:Spectroscopic, electrochemical and computational data show that C60 and a highly phenylated s-Triazine Derivative form a stable supramolecular complex at micromolar concentrations in solution at ambient temperatures, due to strong van der Waals attraction between their complementary surfaces.
-
Formation and photophysics of a stable concave–convex supramolecular complex of C60 and a substituted s-Triazine Derivative
Chemical Communications, 2002Co-Authors: David I Schuster, Joel Rosenthal, Shaun Macmahon, Peter D Jarowski, Christopher A Alabi, Dirk M GuldiAbstract:Spectroscopic, electrochemical and computational data show that C60 and a highly phenylated s-Triazine Derivative form a stable supramolecular complex at micromolar concentrations in solution at ambient temperatures, due to strong van der Waals attraction between their complementary surfaces.
Hamed Shaykhalishahi - One of the best experts on this subject based on the ideXlab platform.
-
inhibition of h2o2 induced neuroblastoma cell cytotoxicity by a Triazine Derivative aa3e2
European Journal of Pharmacology, 2009Co-Authors: Hamed Shaykhalishahi, Razieh Yazdanparast, Hyungho Ha, Youngtae ChangAbstract:Abstract Alzheimer's disease is the major cause of senile dementia with the hallmark of β-amyloid deposition in neurons. Although the main cause(s) of this deposition is not fully understood, however, the wealth of the present literature data supports the pivotal role of reactive oxygen and nitrogen species in both the initiation and progression of β-amyloid aggregation and deposition. In the present study, we were interested to evaluate the free-radical protecting effect of AA3E2, a Triazine Derivative with a β-amyloid-breaking activity, among SK-N-MC neuroblastoma cells exposed to hydrogen peroxide (H2O2) as an exogenous source of free radicals. Exposure of the cells to different doses of AA3E2 (1–16 µM) for 3 h followed by subsequent exposure to a single dose of H2O2 (mainly 150 µM) attenuated the extent of superoxide dismutase (SOD) and catalase (CAT) inhibition by H2O2, in a dose dependent manner. Furthermore, significant reduction was observed in the extent of cellular lactate dehydrogenase release, intracellular ROS and the extent of apoptosis among the cells pre-treated with AA3E2. Based on these data, an antioxidant mode of action is proposed for AA3E2 besides its previously β-amyloid-breaking activity.
-
protective effect of a Triazine Derivative aa3e2 on β amyloid induced damages in sk n mc cells
Toxicology in Vitro, 2009Co-Authors: Razieh Yazdanparast, Hamed ShaykhalishahiAbstract:Abstract The role of β-amyloid (Aβ) in the pathogenesis of Alzheimer’s disease (AD) is frequently reported in the literature. Though the exact mode of action is not known, it is suggested that Aβ induces cell death through induction of oxidative stress possibly through hydrogen peroxide generation. In that case, antioxidants should be capable of attenuating the Aβ-induced cytotoxicities. In that regard, we evaluated the effect(s) of a Triazine-Derivative, AA3E2, with established antioxidant activity. Pretreatment of SK-N-MC neuroblastoma cells with AA3E2, followed by exposure to Aβ1–42 showed 28.3% higher viability relative to the control cells which has not been treated with AA3E2. In addition, AA3E2 inhibited caspase-3 activation caused by Aβ1–42 and it attenuated Aβ1–42-induced intracellular ROS (reactive oxygen species) accumulation. The lower level of intracellular free radicals was further confirmed by higher and lower activities of intracellular catalase and superoxide dismutase, respectively. These observations, parallel to the literature data, reconfirm the oxidative stress disrupting role of Aβ1–42 peptide. Thus, sequestration of this role by potential antioxidants such as AA3E2 might happen to be a suitable strategy for future treatments of AD.
Prem M S Chauhan - One of the best experts on this subject based on the ideXlab platform.
-
synthesis and biological evaluation of new 1 2 4 triazino 5 6 b indol 3 ylthio 1 3 5 Triazines and 1 2 4 triazino 5 6 b indol 3 ylthio pyrimidines against leishmania donovani
European Journal of Medicinal Chemistry, 2010Co-Authors: Leena Gupta, Naresh Sunduru, Aditya Verma, Saumya Srivastava, Suman Gupta, Neena Goyal, Prem M S ChauhanAbstract:Abstract A series of [1,2,4]triazino[5,6-b]indol-3-ylthio-1,3,5-Triazines and [1,2,4]triazino[5,6-b]indol-3-ylthio-pyrimidines were synthesized and screened for their in vitro antileishmanial activity against Leishmania donovani. Among all, 8 compounds have shown more than 90% inhibition against promastigotes and IC50 in the range of 4.01–57.78 μM against amastigotes. Compound 5, a triazino[5,6-b]indol-3-ylthio-1,3,5-Triazine Derivative was found to be the most active and least toxic with 20- & 10-fold more selectivity (S.I. = 56.61) as compared to that of standard drugs pentamidine and sodium stibogluconate (SSG), respectively.
David I Schuster - One of the best experts on this subject based on the ideXlab platform.
-
formation and photophysics of a stable concave convex supramolecular complex of c60 and a substituted s Triazine Derivative
Chemical Communications, 2002Co-Authors: David I Schuster, Joel Rosenthal, Shaun Macmahon, Peter D Jarowski, Christopher A Alabi, Dirk M GuldiAbstract:Spectroscopic, electrochemical and computational data show that C60 and a highly phenylated s-Triazine Derivative form a stable supramolecular complex at micromolar concentrations in solution at ambient temperatures, due to strong van der Waals attraction between their complementary surfaces.
-
Formation and photophysics of a stable concave–convex supramolecular complex of C60 and a substituted s-Triazine Derivative
Chemical Communications, 2002Co-Authors: David I Schuster, Joel Rosenthal, Shaun Macmahon, Peter D Jarowski, Christopher A Alabi, Dirk M GuldiAbstract:Spectroscopic, electrochemical and computational data show that C60 and a highly phenylated s-Triazine Derivative form a stable supramolecular complex at micromolar concentrations in solution at ambient temperatures, due to strong van der Waals attraction between their complementary surfaces.
Bertold Hock - One of the best experts on this subject based on the ideXlab platform.
-
Improvement of a Monoclonal Antibody‐based Immunoassay for the Determination of Terbutryn Verbesserung eines Immunassays mit monoklonalen Antikörpern zur Bestimmung von Terbutryn
Acta Hydrochimica Et Hydrobiologica, 1993Co-Authors: Thomas Giersch, K Kramer, M. G. Weller, Bertold HockAbstract:The performance of an existing enzyme immunoassay (EIA) with monoclonal antibodies (mAb) for the determination of terbutryn was improved by the application of a new enzyme tracer. For this purpose the Triazine Derivative 6-chloro-2-(tert-butylamino)-1,3,5-Triazine-4-(6-aminohexane carboxylic acid) was coupled to horseradish peroxidase (HRP). The competitive EIA on microwell plates made it possible to determine terbutryn in the range from 0.05 to 1 μg/L with a 50% B/B0 value of the test at 0.2 μg/L. The application of the EIA to determine terbutryn in spiked surface waters provided good recoveries of terbutryn without matrix effects. Die Leistungsfahigkeit eines Enzymimmunassays (EIA) zur Bestimmung von Terbutryn wurde durch den Einsatz eines neuen Enzymtracers verbessert. Zu diesem Zweck wurde das Triazinderivat 6-Chlor-2-(tert-butylamino)-1,3,5-triazin-4-(6-aminohexansaure) an Meerrettichperoxidase gekoppelt. Der daraus resultierende Enzymimmunassay erlaubte die Bestimmung von Terbutryn im Bereich von 0.05 bis 1 μg/L mit einem Testmittelpunkt bei 0.2 μg/L. Die Anwendung des Tests mit aufgestocktem Oberflachenwasser zeigte hohe Wiederfindungsraten ohne storende Matrixeffekte.
-
improvement of a monoclonal antibody based immunoassay for the determination of terbutryn verbesserung eines immunassays mit monoklonalen antikorpern zur bestimmung von terbutryn
Acta Hydrochimica Et Hydrobiologica, 1993Co-Authors: Thomas Giersch, K Kramer, M. G. Weller, Bertold HockAbstract:The performance of an existing enzyme immunoassay (EIA) with monoclonal antibodies (mAb) for the determination of terbutryn was improved by the application of a new enzyme tracer. For this purpose the Triazine Derivative 6-chloro-2-(tert-butylamino)-1,3,5-Triazine-4-(6-aminohexane carboxylic acid) was coupled to horseradish peroxidase (HRP). The competitive EIA on microwell plates made it possible to determine terbutryn in the range from 0.05 to 1 μg/L with a 50% B/B0 value of the test at 0.2 μg/L. The application of the EIA to determine terbutryn in spiked surface waters provided good recoveries of terbutryn without matrix effects. Die Leistungsfahigkeit eines Enzymimmunassays (EIA) zur Bestimmung von Terbutryn wurde durch den Einsatz eines neuen Enzymtracers verbessert. Zu diesem Zweck wurde das Triazinderivat 6-Chlor-2-(tert-butylamino)-1,3,5-triazin-4-(6-aminohexansaure) an Meerrettichperoxidase gekoppelt. Der daraus resultierende Enzymimmunassay erlaubte die Bestimmung von Terbutryn im Bereich von 0.05 bis 1 μg/L mit einem Testmittelpunkt bei 0.2 μg/L. Die Anwendung des Tests mit aufgestocktem Oberflachenwasser zeigte hohe Wiederfindungsraten ohne storende Matrixeffekte.
