The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Dattaprasad M Pore - One of the best experts on this subject based on the ideXlab platform.
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a novel one pot multi component strategy for facile synthesis of 5 aryl 1 2 4 Triazolidine 3 thiones
Tetrahedron Letters, 2014Co-Authors: M M Mane, Dattaprasad M PoreAbstract:Abstract We have disclosed an efficient, one pot, novel multi-component approach for the synthesis of 5-aryl-[1,2,4]Triazolidine-3-thiones from aldehyde, hydrazine hydrate, and trimethylsilyl isothiocyanate (TMSNCS) in the presence of catalytic amount of sulfamic acid. High yields, easy work-up procedure, no chromatographic separation, and novelty in multi-component strategy are the main merits of the present strategy.
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c16mpy alcl3br an efficient novel ionic liquid for synthesis of novel 1 2 4 Triazolidine 3 thiones in water
RSC Advances, 2014Co-Authors: Jayavant D Patil, Dattaprasad M PoreAbstract:An efficient novel ionic liquid, [C16MPy]AlCl3Br has been synthesized and explored as a catalyst for an eco-friendly synthesis of novel 1,2,4-Triazolidine-3-thiones in water at ambient temperature. A variety of aldehydes undergo smooth reaction with thiosemicarbazide and substituted thiosemicarbazides. In the case of substituted thiosemicarbazides the corresponding 1,2,4-Triazolidine-3-thiones are obtained as products instead of 1,3,4-oxadiazoles. A broad variety of functional groups are tolerated and a large number of substrates can be applied with this protocol. Rapid eco-friendly reactions with high yields, use of ambient temperature and water as a solvent, easy work-up procedure as well as isolation of product, excellent catalyst recyclability, high atom economy, novelty of ionic liquid as well as the protocol are the auxiliary advantages of the protocol.
Appaswami Lalitha - One of the best experts on this subject based on the ideXlab platform.
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facile and green chemistry access to 5 aryl 1 2 4 Triazolidine 3 thiones in aqueous medium
ChemistrySelect, 2016Co-Authors: Rathinam Ramesh, Appaswami LalithaAbstract:A clean, cost-effective and very practical approach has been disclosed for the one-pot, cyclo condensation of aromatic aldehydes with different thiosemicarbazides in aqueous ethanol leading to pharmaceutically diverse 5-aryl-1,2,4-Triazolidine-3-thiones in good yields under neutral reaction conditions. Simple operational procedure, high product yield, rapid and use of green solvent system make this protocol economical as well as environmentally benevolent.
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peg assisted two component approach for the facile synthesis of 5 aryl 1 2 4 Triazolidine 3 thiones under catalyst free conditions
RSC Advances, 2015Co-Authors: Rathinam Ramesh, Appaswami LalithaAbstract:A straightforward and greener PEG-assisted protocol has been disclosed for the facile synthesis of 5-aryl-1,2,4-Triazolidine-3-thiones via the two-component reaction of multifarious aromatic aldehydes and thiosemicarbazides using very convenient neutral reaction conditions. This methodology represents a sustainable approach for rapid access to a library of diversity-oriented highly pure Triazolidine scaffolds with broad substrate scope.
Ilknur Dogan - One of the best experts on this subject based on the ideXlab platform.
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axially chiral 2 arylimino 3 aryl thiazolidine 4 one derivatives enantiomeric separation and determination of racemization barriers by chiral hplc
Journal of Organic Chemistry, 2007Co-Authors: Sule Erol, Ilknur DoganAbstract:Axially chiral 2-arylimino-3-aryl-thiazolidine-4-ones have been synthesized as racemic mixtures, and each mixture with the exception of 2-(o-chlorophenyl)imino-3-(o-chlorophenyl)-thiazolidine-4-one has been converted to the corresponding 5-benzylidene-2-arylimino-3-aryl-thiazolidine-4-one racemates by reaction with benzaldehyde. The thermally interconvertible enantiomers of each compound have been obtained by enantioselective HPLC separation on columns Chiralpak AD-H and Chiralcel OD-H, and the barriers to racemization have been found to be 98.1-114.1 kJ/mol. The barriers determined were compared to those of structurally related compounds to provide evidence for the stereochemistry of the aryl imino bond.
Rathinam Ramesh - One of the best experts on this subject based on the ideXlab platform.
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facile and green chemistry access to 5 aryl 1 2 4 Triazolidine 3 thiones in aqueous medium
ChemistrySelect, 2016Co-Authors: Rathinam Ramesh, Appaswami LalithaAbstract:A clean, cost-effective and very practical approach has been disclosed for the one-pot, cyclo condensation of aromatic aldehydes with different thiosemicarbazides in aqueous ethanol leading to pharmaceutically diverse 5-aryl-1,2,4-Triazolidine-3-thiones in good yields under neutral reaction conditions. Simple operational procedure, high product yield, rapid and use of green solvent system make this protocol economical as well as environmentally benevolent.
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peg assisted two component approach for the facile synthesis of 5 aryl 1 2 4 Triazolidine 3 thiones under catalyst free conditions
RSC Advances, 2015Co-Authors: Rathinam Ramesh, Appaswami LalithaAbstract:A straightforward and greener PEG-assisted protocol has been disclosed for the facile synthesis of 5-aryl-1,2,4-Triazolidine-3-thiones via the two-component reaction of multifarious aromatic aldehydes and thiosemicarbazides using very convenient neutral reaction conditions. This methodology represents a sustainable approach for rapid access to a library of diversity-oriented highly pure Triazolidine scaffolds with broad substrate scope.
Hanjie Ying - One of the best experts on this subject based on the ideXlab platform.
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Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones
Bioorganic & medicinal chemistry letters, 2010Co-Authors: Bin Pan, Renzheng Huang, Shiqing Han, Ming-li Zhu, Ping Wei, Hanjie YingAbstract:Abstract A series of novel 2-arylimino-3-aryl-thiazolidine-4-ones was designed, synthesized and tested for in vitro antibiofilm activity against Staphylococcus epidermidis. Among them tested, some compounds with carboxylic acid groups showed good antibiofilm activity. The antibiofilm concentration of 1x was 6.25 μM. The structure–activity relationships revealed that incorporation of 2-phenylfuran moiety could greatly enhance antibiofilm activity of thiazolidine-4-one.
