The Experts below are selected from a list of 3 Experts worldwide ranked by ideXlab platform
Kohsuke Ohmatsu - One of the best experts on this subject based on the ideXlab platform.
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In Situ Electrophilic Activation of Hydrogen Peroxide for Catalytic Asymmetric α-Hydroxylation of 3-Substituted Oxindoles
Synlett, 2017Co-Authors: Kohsuke Ohmatsu, Yuichiro Ando, Takashi OoiAbstract:Peroxy Trichloroacetimidic Acid, in situ generated from aqueous hydrogen peroxide and trichloroacetonitrile, was found to act as a competent electrophilic oxygenating agent for the direct α-hydroxylation of oxindoles. The use of chiral 1,2,3-triazolium salt as a phase-transfer catalyst enabled rigorous absolute stereocontrol in the carbon–oxygen bond-forming reaction. The present study provides a new, yet practical method for straightforward access to optically active α-hydroxycarbonyl compounds.
Yuichiro Ando - One of the best experts on this subject based on the ideXlab platform.
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In Situ Electrophilic Activation of Hydrogen Peroxide for Catalytic Asymmetric α-Hydroxylation of 3-Substituted Oxindoles
Synlett, 2017Co-Authors: Kohsuke Ohmatsu, Yuichiro Ando, Takashi OoiAbstract:Peroxy Trichloroacetimidic Acid, in situ generated from aqueous hydrogen peroxide and trichloroacetonitrile, was found to act as a competent electrophilic oxygenating agent for the direct α-hydroxylation of oxindoles. The use of chiral 1,2,3-triazolium salt as a phase-transfer catalyst enabled rigorous absolute stereocontrol in the carbon–oxygen bond-forming reaction. The present study provides a new, yet practical method for straightforward access to optically active α-hydroxycarbonyl compounds.
Takashi Ooi - One of the best experts on this subject based on the ideXlab platform.
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In Situ Electrophilic Activation of Hydrogen Peroxide for Catalytic Asymmetric α-Hydroxylation of 3-Substituted Oxindoles
Synlett, 2017Co-Authors: Kohsuke Ohmatsu, Yuichiro Ando, Takashi OoiAbstract:Peroxy Trichloroacetimidic Acid, in situ generated from aqueous hydrogen peroxide and trichloroacetonitrile, was found to act as a competent electrophilic oxygenating agent for the direct α-hydroxylation of oxindoles. The use of chiral 1,2,3-triazolium salt as a phase-transfer catalyst enabled rigorous absolute stereocontrol in the carbon–oxygen bond-forming reaction. The present study provides a new, yet practical method for straightforward access to optically active α-hydroxycarbonyl compounds.