The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform
Lejla Burnazović-ristić - One of the best experts on this subject based on the ideXlab platform.
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Cytogenetic effects of combination of Tridecactide and met-enkephalin on lymphocytes of patients with multiple sclerosis
Journal of Health Sciences, 2015Co-Authors: Maida Rakanović-todić, Lejla Burnazović-ristić, Slavka Ibrulj, Amra Ćatović, Izeta Aganovic-musinovic, Jasna KusturicaAbstract:Introduction: The met-enkephalin (1-5 Adrenorphin) and Tridecactide (alpha-corticotropin 1-13) combination is used in the multiple sclerosis (MS) immuno-modulatory treatment. A testing of cytogenetic effects of met-enkephalin resulted in reductions of lymphocytic aberrations in the in the lymphocytes of the peripheral blood (PBL) of patients with immune-mediated diseases. The aim of this research is to evaluate the in vitro effects of the combination of the met-enkephalin and Tridecactide on the number and the type of chromosome aberrations in PBL of the MS patients. Methods: We used blood samples from seven female patients with the diagnosis multiple sclerosis based on a McDonald Diagnostic Criteria. The tested combination, met-enkephalin and alpha-ACTH 1-13 was added at three different concentrations and constant volume. Results: Results showed that the combination of tested substances did not reduce the number of structural aberrations, although the treatment did not result in severe aberrations such as ring, fragmented, and dicentric chromosomes. Furthermore, it elicited an increase in the number of numerical aberrations and aneuploidy after the treatment with the test combo. Conclusion: As the changes in ploidy significantly change the DNA as well as the biochemical cell phenotype, we concluded that more research in this field should be conducted, including both toxicological as well as the pharmacodynamic considerations.
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Enkorten – A Potential Drug for the Treatment of Rheumatoid Arthritis
Rheumatoid Arthritis - Treatment, 2012Co-Authors: Nedzad Mulabegović, Jasna Kusturica, Maida Todić-rakanović, Mirjana Mijanović, Fahir Bečić, Asija Zaciragic, Selma Skrbo, Lejla Burnazović-ristić, Aida Kulo, Svjetlana Loga-zecAbstract:Enkorten is a new potential drug for the treatment of rheumatoid arthritis, with an immunomodulatory and anti-inflammatory effect. It is a combination of two peptide components of endogenous origin: methionine-enkephalin of 5 mg and Tridecactide of 1 mg (Picture 1 and 2). According to the chemical structures, these components correspond to amino acid sequences of the neuropeptide precursor proopiomelanocortin.
Jasna Kusturica - One of the best experts on this subject based on the ideXlab platform.
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Cytogenetic effects of combination of Tridecactide and met-enkephalin on lymphocytes of patients with multiple sclerosis
Journal of Health Sciences, 2015Co-Authors: Maida Rakanović-todić, Lejla Burnazović-ristić, Slavka Ibrulj, Amra Ćatović, Izeta Aganovic-musinovic, Jasna KusturicaAbstract:Introduction: The met-enkephalin (1-5 Adrenorphin) and Tridecactide (alpha-corticotropin 1-13) combination is used in the multiple sclerosis (MS) immuno-modulatory treatment. A testing of cytogenetic effects of met-enkephalin resulted in reductions of lymphocytic aberrations in the in the lymphocytes of the peripheral blood (PBL) of patients with immune-mediated diseases. The aim of this research is to evaluate the in vitro effects of the combination of the met-enkephalin and Tridecactide on the number and the type of chromosome aberrations in PBL of the MS patients. Methods: We used blood samples from seven female patients with the diagnosis multiple sclerosis based on a McDonald Diagnostic Criteria. The tested combination, met-enkephalin and alpha-ACTH 1-13 was added at three different concentrations and constant volume. Results: Results showed that the combination of tested substances did not reduce the number of structural aberrations, although the treatment did not result in severe aberrations such as ring, fragmented, and dicentric chromosomes. Furthermore, it elicited an increase in the number of numerical aberrations and aneuploidy after the treatment with the test combo. Conclusion: As the changes in ploidy significantly change the DNA as well as the biochemical cell phenotype, we concluded that more research in this field should be conducted, including both toxicological as well as the pharmacodynamic considerations.
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Enkorten – A Potential Drug for the Treatment of Rheumatoid Arthritis
Rheumatoid Arthritis - Treatment, 2012Co-Authors: Nedzad Mulabegović, Jasna Kusturica, Maida Todić-rakanović, Mirjana Mijanović, Fahir Bečić, Asija Zaciragic, Selma Skrbo, Lejla Burnazović-ristić, Aida Kulo, Svjetlana Loga-zecAbstract:Enkorten is a new potential drug for the treatment of rheumatoid arthritis, with an immunomodulatory and anti-inflammatory effect. It is a combination of two peptide components of endogenous origin: methionine-enkephalin of 5 mg and Tridecactide of 1 mg (Picture 1 and 2). According to the chemical structures, these components correspond to amino acid sequences of the neuropeptide precursor proopiomelanocortin.
Svjetlana Loga-zec - One of the best experts on this subject based on the ideXlab platform.
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Enkorten – A Potential Drug for the Treatment of Rheumatoid Arthritis
Rheumatoid Arthritis - Treatment, 2012Co-Authors: Nedzad Mulabegović, Jasna Kusturica, Maida Todić-rakanović, Mirjana Mijanović, Fahir Bečić, Asija Zaciragic, Selma Skrbo, Lejla Burnazović-ristić, Aida Kulo, Svjetlana Loga-zecAbstract:Enkorten is a new potential drug for the treatment of rheumatoid arthritis, with an immunomodulatory and anti-inflammatory effect. It is a combination of two peptide components of endogenous origin: methionine-enkephalin of 5 mg and Tridecactide of 1 mg (Picture 1 and 2). According to the chemical structures, these components correspond to amino acid sequences of the neuropeptide precursor proopiomelanocortin.
Nedzad Mulabegović - One of the best experts on this subject based on the ideXlab platform.
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Enkorten – A Potential Drug for the Treatment of Rheumatoid Arthritis
Rheumatoid Arthritis - Treatment, 2012Co-Authors: Nedzad Mulabegović, Jasna Kusturica, Maida Todić-rakanović, Mirjana Mijanović, Fahir Bečić, Asija Zaciragic, Selma Skrbo, Lejla Burnazović-ristić, Aida Kulo, Svjetlana Loga-zecAbstract:Enkorten is a new potential drug for the treatment of rheumatoid arthritis, with an immunomodulatory and anti-inflammatory effect. It is a combination of two peptide components of endogenous origin: methionine-enkephalin of 5 mg and Tridecactide of 1 mg (Picture 1 and 2). According to the chemical structures, these components correspond to amino acid sequences of the neuropeptide precursor proopiomelanocortin.
Maida Todić-rakanović - One of the best experts on this subject based on the ideXlab platform.
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Enkorten – A Potential Drug for the Treatment of Rheumatoid Arthritis
Rheumatoid Arthritis - Treatment, 2012Co-Authors: Nedzad Mulabegović, Jasna Kusturica, Maida Todić-rakanović, Mirjana Mijanović, Fahir Bečić, Asija Zaciragic, Selma Skrbo, Lejla Burnazović-ristić, Aida Kulo, Svjetlana Loga-zecAbstract:Enkorten is a new potential drug for the treatment of rheumatoid arthritis, with an immunomodulatory and anti-inflammatory effect. It is a combination of two peptide components of endogenous origin: methionine-enkephalin of 5 mg and Tridecactide of 1 mg (Picture 1 and 2). According to the chemical structures, these components correspond to amino acid sequences of the neuropeptide precursor proopiomelanocortin.
