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A. Shahi - One of the best experts on this subject based on the ideXlab platform.
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Romifidine–Ketamine Anaesthesia in Atropine and Triflupromazine Pre-medicated Buffalo Calves
Journal of Veterinary Medicine Series A-physiology Pathology Clinical Medicine, 2004Co-Authors: A. K. Sharma, Naveen Kumar, Umesh Dimri, M. Hoque, Swapan Kumar Maiti, O. P. Gupta, A. ShahiAbstract:The study was conducted on 10 buffalo calves with a weight of 98.5 +/- 3.9 kg and age 9.7 +/- 1.3 months. Ten trials of two treatments were carried out using a randomized block design. Atropine at the dose of 0.02 mg/kg bodyweight was administered in both the groups. The animals of group I received romifidine at the dose of 10 microg/kg i.v., 10 min after atropine administration, whereas, animals of group II received Triflupromazine at the dose of 0.3 mg/kg i.m. and 10 min later romifidine at the dose of 10 microg/kg i.v. immediately followed by ketamine at the dose of 5 mg/kg i.v. The onset of action of romifidine in group I occurred within 2 min and the animals remained under mild sedation for 31 +/- 4.8 min. In group II, the Triflupromazine-romifidine-ketamine combination induced anaesthesia for 14 +/- 2.3 min. Hypothermia, significant bradycardia and respiratory depression was noticed in both groups at different time intervals.
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romifidine ketamine anaesthesia in atropine and Triflupromazine pre medicated buffalo calves
Journal of Veterinary Medicine Series A-physiology Pathology Clinical Medicine, 2004Co-Authors: A. K. Sharma, Naveen Kumar, Umesh Dimri, M. Hoque, Swapan Kumar Maiti, O. P. Gupta, A. ShahiAbstract:The study was conducted on 10 buffalo calves with a weight of 98.5 +/- 3.9 kg and age 9.7 +/- 1.3 months. Ten trials of two treatments were carried out using a randomized block design. Atropine at the dose of 0.02 mg/kg bodyweight was administered in both the groups. The animals of group I received romifidine at the dose of 10 microg/kg i.v., 10 min after atropine administration, whereas, animals of group II received Triflupromazine at the dose of 0.3 mg/kg i.m. and 10 min later romifidine at the dose of 10 microg/kg i.v. immediately followed by ketamine at the dose of 5 mg/kg i.v. The onset of action of romifidine in group I occurred within 2 min and the animals remained under mild sedation for 31 +/- 4.8 min. In group II, the Triflupromazine-romifidine-ketamine combination induced anaesthesia for 14 +/- 2.3 min. Hypothermia, significant bradycardia and respiratory depression was noticed in both groups at different time intervals.
L. Ranganath - One of the best experts on this subject based on the ideXlab platform.
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Veterinary World, 2010, Vol.3(11):513-514 CLINICAL Tension band wiring for avulsion fracture of Olecranon in a Dog
2014Co-Authors: K. Srinivasa M. Murthy, Md. Arif, Basha K, V. Mahesh, Manjunatha D. R, L. RanganathAbstract:Labs) and Triflupromazine hydrochloride @ 1mg/kg body wt. i/v (Siquil, Zydus AHL). Anesthesia was Olecranon fractures get distracted by the pull of induced and maintained with Thiopentone sodiu
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diazepam premedication for propofol anaesthesia in dogs
2013Co-Authors: L. Suresha, B. N. Ranganath, M. S. Vasanth, L. RanganathAbstract:Haemato-biochemical studies on Triflupromazine HCL an
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Haemato-biochemical studies on Triflupromazine HCL and diazepam premedication for propofol anaesthesia in dogs -
Veterinary World, 2012Co-Authors: L. Suresha, B. N. Ranganath, M. S. Vasanth, L. RanganathAbstract:Aim: To study the effect of Triflupromazine Hcl and diazepam in combination with propofol as preanaesthetic on haematobiochemical parameters in dogs was carried out. Materials and Methods: 16 clinical cases of dogs undergoing different surgical interventions irrespective of age, sex and breed were allotted randomly in to two groups viz., Group A (Triflupromazine Hcl – propofol) and Group B (diazepam – propofol) consisting eight dogs each. Blood samples were collected at different intervals from both the Groups in heparinised syringes as follows: Prior to premedication, fifteen minutes after premedication, fifteen minutes, one hour, six hour, 24 hour and 48 hour after induction with Propofol. The samples were subjected for various hematological and biochemical analysis. Results: Hematology revealed a significant (P 0.05) fall in total erythrocyte count (TEC), packed cell volume (PCV) and haemoglobin (Hb), whereas TLC showed a non significant decrease in both the groups throughout the observation period of 48 hours. In the present study blood glucose level was significantly increased between 15 min to one hour in Group A and 15 min to 6 hours of observation period of the study in Group B. The total plasma protein (TPP), alanine amino transferase (ALT),alkaline phosphatase (AP) and creatinine levels did not differ significantly in both the groups throughout the observation period of 48 hours. Conclusion: Both the anaesthetic combinations were found to be safe and effective with smooth and stress free recovery. However Triflupromazine Hcl premedication proved to be better with quick sedative effect, long duration of anaesthesia with less induction dose of propofol and shorter recovery time than diazepam.
Scott G Franzblau - One of the best experts on this subject based on the ideXlab platform.
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Structural requirements for the antitubercular quaternized Triflupromazine pharmacophore.
Bioorganic & Medicinal Chemistry Letters, 2012Co-Authors: Dominique L. Kunciw, Miguel O Mitchell, Jacob J. Liechty, Baojie Wan, Scott G FranzblauAbstract:Abstract Quaternized Triflupromazine derivatives (QTDs) must possess benzyl groups attached to the quaternary nitrogen in order to have significant antitubercular potency. Replacing the quaternary amine with a triazole abolishes antitubercular activity. A modest halogen substitution effect exists, with the 4-bromophenyl QTD 3 having the best selectivity index (>21). All N-benzyl QTDs 1 – 4 similarly inhibit non-replicating, persistent Mycobacterium tuberculosis with MIC 1 – 3 were all nontoxic to mammalian cells in vitro (IC 50 >128 μM).
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synthesis and antitubercular activity of quaternized promazine and promethazine derivatives
Bioorganic & Medicinal Chemistry Letters, 2007Co-Authors: Aaron B Bate, Jay H Kalin, Eric M Fooksman, Erica L Amorose, Cristofer M Price, Heather M Williams, Michael John Rodig, Miguel O Mitchell, Yuehong Wang, Scott G FranzblauAbstract:Abstract Quaternized chlorpromazine, Triflupromazine, and promethazine derivatives were synthesized and examined as antitubercular agents against both actively growing and non-replicating Mycobacterium tuberculosis H37Rv. Impressively, several compounds inhibited non-replicating M. tuberculosis at concentrations equal to or double their MICs against the actively growing strain. All active compounds were non-toxic toward Vero cells (IC 50 > 128 μM). N -Allylchlorpromazinium bromide was only weakly antitubercular, but replacing allyl with benzyl or substituted benzyl improved potency. An electron-withdrawing substituent on the phenothiazine ring was also essential. Branching at the carbon chain decreased antitubercular activity. The optimum antitubercular structures possessed N -(4- or 3-chlorobenzyl) substitution on Triflupromazine.
A. K. Sharma - One of the best experts on this subject based on the ideXlab platform.
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Romifidine–Ketamine Anaesthesia in Atropine and Triflupromazine Pre-medicated Buffalo Calves
Journal of Veterinary Medicine Series A-physiology Pathology Clinical Medicine, 2004Co-Authors: A. K. Sharma, Naveen Kumar, Umesh Dimri, M. Hoque, Swapan Kumar Maiti, O. P. Gupta, A. ShahiAbstract:The study was conducted on 10 buffalo calves with a weight of 98.5 +/- 3.9 kg and age 9.7 +/- 1.3 months. Ten trials of two treatments were carried out using a randomized block design. Atropine at the dose of 0.02 mg/kg bodyweight was administered in both the groups. The animals of group I received romifidine at the dose of 10 microg/kg i.v., 10 min after atropine administration, whereas, animals of group II received Triflupromazine at the dose of 0.3 mg/kg i.m. and 10 min later romifidine at the dose of 10 microg/kg i.v. immediately followed by ketamine at the dose of 5 mg/kg i.v. The onset of action of romifidine in group I occurred within 2 min and the animals remained under mild sedation for 31 +/- 4.8 min. In group II, the Triflupromazine-romifidine-ketamine combination induced anaesthesia for 14 +/- 2.3 min. Hypothermia, significant bradycardia and respiratory depression was noticed in both groups at different time intervals.
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romifidine ketamine anaesthesia in atropine and Triflupromazine pre medicated buffalo calves
Journal of Veterinary Medicine Series A-physiology Pathology Clinical Medicine, 2004Co-Authors: A. K. Sharma, Naveen Kumar, Umesh Dimri, M. Hoque, Swapan Kumar Maiti, O. P. Gupta, A. ShahiAbstract:The study was conducted on 10 buffalo calves with a weight of 98.5 +/- 3.9 kg and age 9.7 +/- 1.3 months. Ten trials of two treatments were carried out using a randomized block design. Atropine at the dose of 0.02 mg/kg bodyweight was administered in both the groups. The animals of group I received romifidine at the dose of 10 microg/kg i.v., 10 min after atropine administration, whereas, animals of group II received Triflupromazine at the dose of 0.3 mg/kg i.m. and 10 min later romifidine at the dose of 10 microg/kg i.v. immediately followed by ketamine at the dose of 5 mg/kg i.v. The onset of action of romifidine in group I occurred within 2 min and the animals remained under mild sedation for 31 +/- 4.8 min. In group II, the Triflupromazine-romifidine-ketamine combination induced anaesthesia for 14 +/- 2.3 min. Hypothermia, significant bradycardia and respiratory depression was noticed in both groups at different time intervals.
B. N. Ranganath - One of the best experts on this subject based on the ideXlab platform.
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diazepam premedication for propofol anaesthesia in dogs
2013Co-Authors: L. Suresha, B. N. Ranganath, M. S. Vasanth, L. RanganathAbstract:Haemato-biochemical studies on Triflupromazine HCL an
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Haemato-biochemical studies on Triflupromazine HCL and diazepam premedication for propofol anaesthesia in dogs -
Veterinary World, 2012Co-Authors: L. Suresha, B. N. Ranganath, M. S. Vasanth, L. RanganathAbstract:Aim: To study the effect of Triflupromazine Hcl and diazepam in combination with propofol as preanaesthetic on haematobiochemical parameters in dogs was carried out. Materials and Methods: 16 clinical cases of dogs undergoing different surgical interventions irrespective of age, sex and breed were allotted randomly in to two groups viz., Group A (Triflupromazine Hcl – propofol) and Group B (diazepam – propofol) consisting eight dogs each. Blood samples were collected at different intervals from both the Groups in heparinised syringes as follows: Prior to premedication, fifteen minutes after premedication, fifteen minutes, one hour, six hour, 24 hour and 48 hour after induction with Propofol. The samples were subjected for various hematological and biochemical analysis. Results: Hematology revealed a significant (P 0.05) fall in total erythrocyte count (TEC), packed cell volume (PCV) and haemoglobin (Hb), whereas TLC showed a non significant decrease in both the groups throughout the observation period of 48 hours. In the present study blood glucose level was significantly increased between 15 min to one hour in Group A and 15 min to 6 hours of observation period of the study in Group B. The total plasma protein (TPP), alanine amino transferase (ALT),alkaline phosphatase (AP) and creatinine levels did not differ significantly in both the groups throughout the observation period of 48 hours. Conclusion: Both the anaesthetic combinations were found to be safe and effective with smooth and stress free recovery. However Triflupromazine Hcl premedication proved to be better with quick sedative effect, long duration of anaesthesia with less induction dose of propofol and shorter recovery time than diazepam.
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Haemato-biochemical studies on Triflupromazine HCL and diazepam premedication for propofol anaesthesia in dogs
Veterinary World, 1Co-Authors: L. Suresha, B. N. RanganathAbstract:Aim: To study the effect of Triflupromazine Hcl and diazepam in combination with propofol as preanaesthetic on haematobiochemical parameters in dogs was carried out. Materials and Methods: 16 clinical cases of dogs undergoing different surgical interventions irrespective of age, sex and breed were allotted randomly in to two groups viz., Group A (Triflupromazine Hcl – propofol) and Group B (diazepam – propofol) consisting eight dogs each. Blood samples were collected at different intervals from both the Groups in heparinised syringes as follows: Prior to premedication, fifteen minutes after premedication, fifteen minutes, one hour, six hour, 24 hour and 48 hour after induction with Propofol. The samples were subjected for various hematological and biochemical analysis. Results: Hematology revealed a significant (P 0.05) fall in total erythrocyte count (TEC), packed cell volume (PCV) and haemoglobin (Hb), whereas TLC showed a non significant decrease in both the groups throughout the observation period of 48 hours. In the present study blood glucose level was significantly increased between 15 min to one hour in Group A and 15 min to 6 hours of observation period of the study in Group B. The total plasma protein (TPP), alanine amino transferase (ALT),alkaline phosphatase (AP) and creatinine levels did not differ significantly in both the groups throughout the observation period of 48 hours. Conclusion: Both the anaesthetic combinations were found to be safe and effective with smooth and stress free recovery. However Triflupromazine Hcl premedication proved to be better with quick sedative effect, long duration of anaesthesia with less induction dose of propofol and shorter recovery time than diazepam. [Vet World 2012; 5(11.000): 672-675
