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Anupam Pathak - One of the best experts on this subject based on the ideXlab platform.
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Effect of Trigonella Foenum-Graecum Linn. (seeds) and Butea monosperma Lam. (flowers) on chemotherapy- induced alopecia Trigonella Foenum-Graecum Linn. (tohum) ve Butea monosperma Lam. (çiçek)'in kemoterapi ile uyarilan alopesi üzerine etkileri
2020Co-Authors: Piyush Gupta, Nagendra Singh Chauhan, Anupam PathakAbstract:SUMMARY AIM: This study aimed to evaluate the hair growth promoting activity of Trigonella Foenum-Graecum Linn. (seeds) and Butea monosperma Lam. (flowers). METHODS: In the present study, it was investigated to prepare herbal hair ointment formulations of Trigonella Foenum-Graecum , Butea monosperma and their polyherbal formulation evaluating the formulations for their hair growth promoting activity, total serum protein level and testosterone level in chemotherapy induced alopecia model. RESULTS: The formulation showed significant increase in hair length and hair count as compared to control group. The polyherbal formulation helped to reduce the dihydro-testosterone (DHT) level. Trigonella Foenum-Graecum contain riched amount of protein which helped in hair growth and Butea monosperma contain riched amount of flavanoid, which has the antioxidant activity by scavenging free radicals and preventing hair fall. CONCLUSION: The results thus corroborate with the traditionally acclaimed hair growth-promoting capabilities of the plants.
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Effect of Trigonella Foenum-Graecum Linn. (seeds) and Butea monosperma Lam. (flowers) on chemotherapy-induced alopecia -
Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery, 2020Co-Authors: Piyush Gupta, Nagendra Singh Chauhan, Anupam PathakAbstract:AIM: This study aimed to evaluate the hair growth promoting activity of Trigonella Foenum-Graecum Linn. (seeds) and Butea monosperma Lam. (flowers). METHODS: In the present study, it was investigated to prepare herbal hair ointment formulations of Trigonella Foenum-Graecum, Butea monosperma and their polyherbal formulation evaluating the formulations for their hair growth promoting activity, total serum protein level and testosterone level in chemotherapy induced alopecia model. RESULTS: The formulation showed significant increase in hair length and hair count as compared to control group. The polyherbal formulation helped to reduce the dihydro-testosterone (DHT) level. Trigonella Foenum-Graecum contain riched amount of protein which helped in hair growth and Butea monosperma contain riched amount of flavanoid, which has the antioxidant activity by scavenging free radicals and preventing hair fall. CONCLUSION: The results thus corroborate with the traditionally acclaimed hair growth-promoting capabilities of the plants.
Piyush Gupta - One of the best experts on this subject based on the ideXlab platform.
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Effect of Trigonella Foenum-Graecum Linn. (seeds) and Butea monosperma Lam. (flowers) on chemotherapy- induced alopecia Trigonella Foenum-Graecum Linn. (tohum) ve Butea monosperma Lam. (çiçek)'in kemoterapi ile uyarilan alopesi üzerine etkileri
2020Co-Authors: Piyush Gupta, Nagendra Singh Chauhan, Anupam PathakAbstract:SUMMARY AIM: This study aimed to evaluate the hair growth promoting activity of Trigonella Foenum-Graecum Linn. (seeds) and Butea monosperma Lam. (flowers). METHODS: In the present study, it was investigated to prepare herbal hair ointment formulations of Trigonella Foenum-Graecum , Butea monosperma and their polyherbal formulation evaluating the formulations for their hair growth promoting activity, total serum protein level and testosterone level in chemotherapy induced alopecia model. RESULTS: The formulation showed significant increase in hair length and hair count as compared to control group. The polyherbal formulation helped to reduce the dihydro-testosterone (DHT) level. Trigonella Foenum-Graecum contain riched amount of protein which helped in hair growth and Butea monosperma contain riched amount of flavanoid, which has the antioxidant activity by scavenging free radicals and preventing hair fall. CONCLUSION: The results thus corroborate with the traditionally acclaimed hair growth-promoting capabilities of the plants.
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Effect of Trigonella Foenum-Graecum Linn. (seeds) and Butea monosperma Lam. (flowers) on chemotherapy-induced alopecia -
Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery, 2020Co-Authors: Piyush Gupta, Nagendra Singh Chauhan, Anupam PathakAbstract:AIM: This study aimed to evaluate the hair growth promoting activity of Trigonella Foenum-Graecum Linn. (seeds) and Butea monosperma Lam. (flowers). METHODS: In the present study, it was investigated to prepare herbal hair ointment formulations of Trigonella Foenum-Graecum, Butea monosperma and their polyherbal formulation evaluating the formulations for their hair growth promoting activity, total serum protein level and testosterone level in chemotherapy induced alopecia model. RESULTS: The formulation showed significant increase in hair length and hair count as compared to control group. The polyherbal formulation helped to reduce the dihydro-testosterone (DHT) level. Trigonella Foenum-Graecum contain riched amount of protein which helped in hair growth and Butea monosperma contain riched amount of flavanoid, which has the antioxidant activity by scavenging free radicals and preventing hair fall. CONCLUSION: The results thus corroborate with the traditionally acclaimed hair growth-promoting capabilities of the plants.
Rumana Afroz - One of the best experts on this subject based on the ideXlab platform.
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Histopathological Evaluation of Gastro Protective Effect of Trigonella Foenum Graecum Seed (Methi) and omeprazole in Experimentally Induced Gastric Ulcer in Rats
Journal of Dhaka Medical College, 2020Co-Authors: Rumana Afroz, Ismail Khan, Kazi Afzalur Rahman, Mahbuba Jahan Lotus, Mir Muhammad Shoyeb Shahabuddin, Tasnin Afrin, Nahid Yeasmin, Kawsar Jahan MoonAbstract:Context: Peptic ulcer is a common disorder of the stomach and duodenum. Bangladesh is a developing country with a very high point prevalence of duodenal ulcer disease (11.9%) and a H. pylori prevalence of more than 90% in asymptomatic adults and 80% in children at the age of 5 years. The multifactorial pathogenesis of peptic ulcers is secretion of gastric acid. The main therapeutic target is the control of this secretion using antacids, H2 receptor blockers (ranitidine, famotidine) or proton pump blockers (omeprazole and lansoprazole). However, nowadays, gastric ulcer therapy faces a major drawback because most of the drugs currently available in the market show limited efficacy against gastric diseases and are often associated with severe side effects. Thus, there is an urgent need to identify more effective and safe antiulcer agents. In this context, the use of medicinal plants for the prevention and treatment of different pathologies is in continuous expansion worldwide. From the ancient time, various plants were used in traditional medicine with reputation as efficacious remedies. The list of plant derived modern medicine is very long now. About 33% of the drugs produced in the developed countries are derived from plants. Trigonella Foenum-Graecum (Fenugreek, Methi) is one of them used in many parts of world. Preliminary study on animal showed that Trigonella Foenum-Graecum seed has significant gastro-protective effect. A study was carried out to demonstrate the gastro-protective effect of aqueous extract and ethanolic extract of Trigonella Foenum-Graecum seed (Fenugreek, Methi) and omeprazole on ethanol induced gastric ulcer in experimental rats. Material and Methods: The present study was performed on 24 (twenty four) rats which were divided randomly into 4 groups each having 6 rats in the Pharmacology Department of Dhaka Medical college, Dhaka. 1 ml of absolute ethanol (5ml/kg body wt.) was orally administered to all groups by gastric intubations to induce gastric ulcer in all groups except normal control. Omeprazole suspension (20mg/kg body wt) was used as synthetic anti ulcer drug in study. Aqueous and ethanolic extract of Trigonella Foenum-Graecum seed(500mg/kg body wt) were used respectively orally. Histopathological analysis was carried out to evaluate the gastroprotective activity of aqueous and ethanolic extract of Trigonella Foenum-Graecum seed and omeprazole on ethanol induced gastric ulcer in experimental rats. Result: Pretreatment with aqueous and ethanolic extract of Trigonella Foenum-Graecum seed (500mg/kg/body wt) showed very significant prevention in ethanol induced gastric ulcer. Results of the study showed that in case of ethanol treated rats gross examination showed a large amount of haemorrhagic lesions confined mostly in the gastric corpus. Histologically lesion involved about two-third of the mucosa layer and exfoliation of the mucosal cells was detected. Meanwhile, red blood cells were present in the gastric mucosa and edematous submucosa was discovered. However aqueous and ethanolic extract of Trigonella Foenum-Graecum seed significantly reduced the haemorrhagic lesions, tissue proliferation, infiltration of cells and sloughing induced by ethanol. This prevention was statistically very significant (P<0.001). Conclusion: The aqueous and ethanol extracts of Trigonella Foenum-Graecum seed and omeprazole possess gastro protective properties. J Dhaka Medical College, Vol. 28, No.1, April, 2019, Page 67-75
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The Gastro Protective Effect of Trigonella Foenum Graecum Seed (Methi) and Omeprazole in Experimentally Induced Gastric illcer in Rats
Journal of Dhaka Medical College, 2018Co-Authors: Rumana Afroz, Kazi Afzalur Rahman, Mahbuba Jahan Lotus, Nahid Yeasmin, Ahm Mostafa Kamal, Yesmin, Kazi Monisur RahmanAbstract:Context : The gastric ulcer is a common gastrointestinal problem in Bangladesh. Gastric epithelium is under constant assault by a series of endogenous noxious factors, including HCl, pepsinogen / pepsin, and bile salts. In addition, a steady flow of exogenous substances such as medications, alcohol, and bacteria encounter the gastric mucosa. A highly intricate biologic system is in place to provide defense from mucosal injury and to repair any injury that may occur. From the ancient time, various plants were used in traditional medicine with reputation as efficacious remedies. The incidence of duodenal ulcer disease has been declining dramatically for the past 30 years, but the incidence of gastric ulcers appears to be increasing as a result of the widespread use of NSAIDs and low-dose aspirin. The list of plant derived modern medicine is very long now. About 33% of the drugs produced in the developed countries are derived from plants. Trigonella foenumgraecum (Fenugreek, Methi) is a herbal medicine used in many parts of world. Preliminary study on animal showed that Trigonella Foenum-Graecum seed has significant gastro-protective effect. A study was carried out to see the gastro-protective effect of Trigonella Foenum-Graecum (Fenugreek, Methi) and omeprazole in ethanol induced gastric ulcer in an experimental rats.Material and Methods: The present study was performed on 24 (twenty four) rats which were divided randomly into 4 groups each having 6 rats in the Pharmacology Department of Dhaka Medical college, Dhaka. The rats were aged between 8-10 weeks of both sexes and weighing between 180-200 gm. The study was carried out to demonstrate the gastro-protective effect of aqueous extract and ethanolic extract of Trigonella Foenum-Graecum seed and omeprazole on ethanol induced gastric ulcer in experimental rats.Result : Pretreatment with aqueous extract and ethanolic of Trigonella Foenum-Graecum seed (500mg/kg/body wt) showed very significant prevention in ethanol induced gastric ulcer in number of lesion, lesion length, lesion breadth, lesion area and lesion index. This prevention was statistically very significant (P<0.001). In this study there was no statistical significant difference was observed between aqueous and ethanolic extracts of Trigonella foenumgraecum seed in gastro-protective effects.Conclusion: The aqueous and ethanol extracts of Trigonella Foenum-Graecum seed and omeprazole possess gastro protective properties.J Dhaka Medical College, Vol. 26, No.2, October, 2017, Page 126-131
A. Mohamed Sadiq - One of the best experts on this subject based on the ideXlab platform.
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INFLUENCE OF Trigonella FOENUM GRAECUM (FENUGREEK) IN ALLOXAN INDUCED DIABETIC RATS
2020Co-Authors: A. Rajarajeswari, P. Vijayalakshmi, A. Mohamed SadiqAbstract:The present study was used to investigate the antidiabetic activity of Trigonella foenum graecum in alloxan induced diabetic rats. The effect observed were compared with a known antidiabetic agent glibenclamide. In active pancreatic damage induced by alloxan (i.p.75mg/kg b.w), fenugreek seed aqueous extract (1300 mg/kg b.w) and ethanol extract (1g/kg b.w) adminstration significantly reduced the elevated level of blood glucose and increased the levels of serum insulin. It decreases the elevated levels of cholesterol, triglycerides, urea, uric acid, creatinine, glycosylated Hb, and increases the decreased levels of liver glycogen and protein. Also the histological examination of pancreas supported the antidiabetic effect of fenugreek.It is concluded that the aqueous and ethanol extract of fenugreek could act and possess good antidiabetic activity. Further Trigonella foenum graecum aqueous extract shows more significant results than Trigonella foenum graecum ethanol extract.
Fathima Mary - One of the best experts on this subject based on the ideXlab platform.
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A comparative study on the antidiabetic effects of Trigonella foenum graecum and Caesalpinia bonducella in alloxan induced diabetic rats.
BioChemistry: An Indian Journal, 2020Co-Authors: Karpagam T, B.varalakshmi, George Margret Rosal, Fathima MaryAbstract:Diabetes mellitus is a metabolic disease characterized by defects in insulin secretion. Allopathic medicines decrease the glucose level by acting on pancreatic beta cells. Indigenous medicines are used to treat diabetes mellitus because, the side effect are less, easy availability and less expensiveness. Trigonella foenum graecum seeds and Caesalpinia bonducella can increase glucose induced insulin release in human and rat pancreatic islets. The studywas carried out to compare the antidiabetic potential of Trigonella foenum graecum seeds and Caesalpinia bonducella in alloxan induced diabetic rats. In our present study group I rats were treated with saline, group II rats with alloxan, group III rats with methanolic extract of Caesalpinia bonducella leaves along with alloxan and group IV rats with Trigonella foenum graecum seeds powder along with alloxan and group V ratswithGlibenclamide alongwith alloxan for 21 days. The objective of the study was to analyze the diabetic profile, lipid profile, toxicity studies, changes in the levels of Homocysteine, (marker of cardiovascular disease), Folic acid (enhancer of endothelial function) and to compare the antidiabetic effects of Trigonella foenum graecum and Caesalpinia bonducella in alloxan induced diabetic rats.
