The Experts below are selected from a list of 2652 Experts worldwide ranked by ideXlab platform
Gino Tripodi - One of the best experts on this subject based on the ideXlab platform.
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Blood transfusions with high levels of contaminating soluble HLA-I correlate with levels of soluble CD8 in recipients’ plasma; a new control factor in soluble HLA-I-mediated transfusion-modulated immunomodulation?
Blood Transfusion, 2012Co-Authors: Massimo Ghio, Paola Contini, Gianluca Ubezio, Filippo Ansaldi, Maurizio Setti, Gino TripodiAbstract:BACKGROUND: The cause of transfusion-related immunomodulation (Trim) has proved tantalisingly elusive. An ever-growing body of evidence indicates that the infusion of large amounts of soluble and cell-associated antigens into a recipient can somehow induce Trim. One soluble molecule that has been implicated in Trim is soluble human leucocyte antigen I (sHLA-I). However, patients infused with large amounts of sHLA-I do not always and unambiguously experience Trim. As soluble CD8 (sCD8) molecules have been shown to capable of binding membrane and soluble HLA-I molecules, we focused on sCD8 as a possible modulator of sHLA-I-mediated Trim. Material AND METHODS: To this aim we compared the up-regulation of circulating sCD8 in plasma from patients suffering from the same pathology, but chronically transfused with two different blood derivatives: pre- and post-storage leucodepleted red blood cells which contain low and high levels of contaminating sHLA-I, respectively. RESULTS: Significantly larger amounts of sCD8 circulating molecules were detectable in the plasma of patients transfused with post-storage leucodepleted red blood cells whose supernatants contained significantly larger amounts of sHLA-I contaminating molecules. CONCLUSION: With the limitation of indirect evidence, this report introduces a new facet of the bioactivity of sCD8 as a possible modulator of sHLA-I-mediated Trim.
Massimo Ghio - One of the best experts on this subject based on the ideXlab platform.
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Blood transfusions with high levels of contaminating soluble HLA-I correlate with levels of soluble CD8 in recipients’ plasma; a new control factor in soluble HLA-I-mediated transfusion-modulated immunomodulation?
Blood Transfusion, 2012Co-Authors: Massimo Ghio, Paola Contini, Gianluca Ubezio, Filippo Ansaldi, Maurizio Setti, Gino TripodiAbstract:BACKGROUND: The cause of transfusion-related immunomodulation (Trim) has proved tantalisingly elusive. An ever-growing body of evidence indicates that the infusion of large amounts of soluble and cell-associated antigens into a recipient can somehow induce Trim. One soluble molecule that has been implicated in Trim is soluble human leucocyte antigen I (sHLA-I). However, patients infused with large amounts of sHLA-I do not always and unambiguously experience Trim. As soluble CD8 (sCD8) molecules have been shown to capable of binding membrane and soluble HLA-I molecules, we focused on sCD8 as a possible modulator of sHLA-I-mediated Trim. Material AND METHODS: To this aim we compared the up-regulation of circulating sCD8 in plasma from patients suffering from the same pathology, but chronically transfused with two different blood derivatives: pre- and post-storage leucodepleted red blood cells which contain low and high levels of contaminating sHLA-I, respectively. RESULTS: Significantly larger amounts of sCD8 circulating molecules were detectable in the plasma of patients transfused with post-storage leucodepleted red blood cells whose supernatants contained significantly larger amounts of sHLA-I contaminating molecules. CONCLUSION: With the limitation of indirect evidence, this report introduces a new facet of the bioactivity of sCD8 as a possible modulator of sHLA-I-mediated Trim.
Maurizio Setti - One of the best experts on this subject based on the ideXlab platform.
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Blood transfusions with high levels of contaminating soluble HLA-I correlate with levels of soluble CD8 in recipients’ plasma; a new control factor in soluble HLA-I-mediated transfusion-modulated immunomodulation?
Blood Transfusion, 2012Co-Authors: Massimo Ghio, Paola Contini, Gianluca Ubezio, Filippo Ansaldi, Maurizio Setti, Gino TripodiAbstract:BACKGROUND: The cause of transfusion-related immunomodulation (Trim) has proved tantalisingly elusive. An ever-growing body of evidence indicates that the infusion of large amounts of soluble and cell-associated antigens into a recipient can somehow induce Trim. One soluble molecule that has been implicated in Trim is soluble human leucocyte antigen I (sHLA-I). However, patients infused with large amounts of sHLA-I do not always and unambiguously experience Trim. As soluble CD8 (sCD8) molecules have been shown to capable of binding membrane and soluble HLA-I molecules, we focused on sCD8 as a possible modulator of sHLA-I-mediated Trim. Material AND METHODS: To this aim we compared the up-regulation of circulating sCD8 in plasma from patients suffering from the same pathology, but chronically transfused with two different blood derivatives: pre- and post-storage leucodepleted red blood cells which contain low and high levels of contaminating sHLA-I, respectively. RESULTS: Significantly larger amounts of sCD8 circulating molecules were detectable in the plasma of patients transfused with post-storage leucodepleted red blood cells whose supernatants contained significantly larger amounts of sHLA-I contaminating molecules. CONCLUSION: With the limitation of indirect evidence, this report introduces a new facet of the bioactivity of sCD8 as a possible modulator of sHLA-I-mediated Trim.
Filippo Ansaldi - One of the best experts on this subject based on the ideXlab platform.
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Blood transfusions with high levels of contaminating soluble HLA-I correlate with levels of soluble CD8 in recipients’ plasma; a new control factor in soluble HLA-I-mediated transfusion-modulated immunomodulation?
Blood Transfusion, 2012Co-Authors: Massimo Ghio, Paola Contini, Gianluca Ubezio, Filippo Ansaldi, Maurizio Setti, Gino TripodiAbstract:BACKGROUND: The cause of transfusion-related immunomodulation (Trim) has proved tantalisingly elusive. An ever-growing body of evidence indicates that the infusion of large amounts of soluble and cell-associated antigens into a recipient can somehow induce Trim. One soluble molecule that has been implicated in Trim is soluble human leucocyte antigen I (sHLA-I). However, patients infused with large amounts of sHLA-I do not always and unambiguously experience Trim. As soluble CD8 (sCD8) molecules have been shown to capable of binding membrane and soluble HLA-I molecules, we focused on sCD8 as a possible modulator of sHLA-I-mediated Trim. Material AND METHODS: To this aim we compared the up-regulation of circulating sCD8 in plasma from patients suffering from the same pathology, but chronically transfused with two different blood derivatives: pre- and post-storage leucodepleted red blood cells which contain low and high levels of contaminating sHLA-I, respectively. RESULTS: Significantly larger amounts of sCD8 circulating molecules were detectable in the plasma of patients transfused with post-storage leucodepleted red blood cells whose supernatants contained significantly larger amounts of sHLA-I contaminating molecules. CONCLUSION: With the limitation of indirect evidence, this report introduces a new facet of the bioactivity of sCD8 as a possible modulator of sHLA-I-mediated Trim.
Gianluca Ubezio - One of the best experts on this subject based on the ideXlab platform.
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Blood transfusions with high levels of contaminating soluble HLA-I correlate with levels of soluble CD8 in recipients’ plasma; a new control factor in soluble HLA-I-mediated transfusion-modulated immunomodulation?
Blood Transfusion, 2012Co-Authors: Massimo Ghio, Paola Contini, Gianluca Ubezio, Filippo Ansaldi, Maurizio Setti, Gino TripodiAbstract:BACKGROUND: The cause of transfusion-related immunomodulation (Trim) has proved tantalisingly elusive. An ever-growing body of evidence indicates that the infusion of large amounts of soluble and cell-associated antigens into a recipient can somehow induce Trim. One soluble molecule that has been implicated in Trim is soluble human leucocyte antigen I (sHLA-I). However, patients infused with large amounts of sHLA-I do not always and unambiguously experience Trim. As soluble CD8 (sCD8) molecules have been shown to capable of binding membrane and soluble HLA-I molecules, we focused on sCD8 as a possible modulator of sHLA-I-mediated Trim. Material AND METHODS: To this aim we compared the up-regulation of circulating sCD8 in plasma from patients suffering from the same pathology, but chronically transfused with two different blood derivatives: pre- and post-storage leucodepleted red blood cells which contain low and high levels of contaminating sHLA-I, respectively. RESULTS: Significantly larger amounts of sCD8 circulating molecules were detectable in the plasma of patients transfused with post-storage leucodepleted red blood cells whose supernatants contained significantly larger amounts of sHLA-I contaminating molecules. CONCLUSION: With the limitation of indirect evidence, this report introduces a new facet of the bioactivity of sCD8 as a possible modulator of sHLA-I-mediated Trim.
