The Experts below are selected from a list of 3 Experts worldwide ranked by ideXlab platform
Hava Schneider - One of the best experts on this subject based on the ideXlab platform.
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Influence of Trimedoxime Bromide on degradation of benactyzine in acidic injectable solutions
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 1999Co-Authors: Shai Rubnov, Shai Amisar, Yossef Lomnicky, Hava SchneiderAbstract:Abstract The stability of benactyzine in a multicomponent injectable antidote formulation in deuterium oxide was studied in the presence of various concentrations of Trimedoxime Bromide. Benactyzine was found to be more stable in the absence of Trimedoxime Bromide and its degradation rate accelerated linearly with increasing concentrations of Trimedoxime Bromide. The main reasons for the accelerated decomposition rate of benactyzine were found to be the nucleophilic effect of the Bromide ion and the oxime moiety. For each Trimedoxime concentration studied, t 90 for benactyzine at 25°C was calculated and was found to be 5.3–1.5 years within the concentrations range of 0–120 mg/ml. Rate constants and activation energies for benactyzine degradation were determined for each of the concentrations studied.
Shai Rubnov - One of the best experts on this subject based on the ideXlab platform.
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Influence of Trimedoxime Bromide on degradation of benactyzine in acidic injectable solutions
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 1999Co-Authors: Shai Rubnov, Shai Amisar, Yossef Lomnicky, Hava SchneiderAbstract:Abstract The stability of benactyzine in a multicomponent injectable antidote formulation in deuterium oxide was studied in the presence of various concentrations of Trimedoxime Bromide. Benactyzine was found to be more stable in the absence of Trimedoxime Bromide and its degradation rate accelerated linearly with increasing concentrations of Trimedoxime Bromide. The main reasons for the accelerated decomposition rate of benactyzine were found to be the nucleophilic effect of the Bromide ion and the oxime moiety. For each Trimedoxime concentration studied, t 90 for benactyzine at 25°C was calculated and was found to be 5.3–1.5 years within the concentrations range of 0–120 mg/ml. Rate constants and activation energies for benactyzine degradation were determined for each of the concentrations studied.
Shai Amisar - One of the best experts on this subject based on the ideXlab platform.
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Influence of Trimedoxime Bromide on degradation of benactyzine in acidic injectable solutions
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 1999Co-Authors: Shai Rubnov, Shai Amisar, Yossef Lomnicky, Hava SchneiderAbstract:Abstract The stability of benactyzine in a multicomponent injectable antidote formulation in deuterium oxide was studied in the presence of various concentrations of Trimedoxime Bromide. Benactyzine was found to be more stable in the absence of Trimedoxime Bromide and its degradation rate accelerated linearly with increasing concentrations of Trimedoxime Bromide. The main reasons for the accelerated decomposition rate of benactyzine were found to be the nucleophilic effect of the Bromide ion and the oxime moiety. For each Trimedoxime concentration studied, t 90 for benactyzine at 25°C was calculated and was found to be 5.3–1.5 years within the concentrations range of 0–120 mg/ml. Rate constants and activation energies for benactyzine degradation were determined for each of the concentrations studied.
Yossef Lomnicky - One of the best experts on this subject based on the ideXlab platform.
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Influence of Trimedoxime Bromide on degradation of benactyzine in acidic injectable solutions
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 1999Co-Authors: Shai Rubnov, Shai Amisar, Yossef Lomnicky, Hava SchneiderAbstract:Abstract The stability of benactyzine in a multicomponent injectable antidote formulation in deuterium oxide was studied in the presence of various concentrations of Trimedoxime Bromide. Benactyzine was found to be more stable in the absence of Trimedoxime Bromide and its degradation rate accelerated linearly with increasing concentrations of Trimedoxime Bromide. The main reasons for the accelerated decomposition rate of benactyzine were found to be the nucleophilic effect of the Bromide ion and the oxime moiety. For each Trimedoxime concentration studied, t 90 for benactyzine at 25°C was calculated and was found to be 5.3–1.5 years within the concentrations range of 0–120 mg/ml. Rate constants and activation energies for benactyzine degradation were determined for each of the concentrations studied.
