The Experts below are selected from a list of 7413 Experts worldwide ranked by ideXlab platform
Laiyuan Wang - One of the best experts on this subject based on the ideXlab platform.
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Plasma Trimethylamine N-Oxide as a Novel Biomarker for Plaque Rupture in Patients With ST-Segment-Elevation Myocardial Infarction.
Circulation. Cardiovascular interventions, 2019Co-Authors: Yu Tan, Zhaoxue Sheng, Peng Zhou, Chen Liu, Hanjun Zhao, Li Song, Jinying Zhou, Yi Chen, Laiyuan WangAbstract:Background: Trimethylamine N-Oxide (TMAO) is reported to promote the pathogenesis of atherosclerosis and be associated with cardiovascular events risk. It is unknown whether plasma TMAO is associat...
Stanley L. Hazen - One of the best experts on this subject based on the ideXlab platform.
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Nonlethal Inhibition of Gut Microbial Trimethylamine N‐oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure
Journal of the American Heart Association, 2020Co-Authors: Chelsea L. Organ, W.h. Wilson Tang, Stanley L. Hazen, Thomas E. Sharp, David J. Polhemus, Nilaksh Gupta, Traci T. Goodchild, David J. LeferAbstract:Background Patients at increased risk for coronary artery disease and adverse prognosis during heart failure exhibit increased levels of circulating Trimethylamine N‐oxide (TMAO), a metabolite form...
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Trimethylamine-N-Oxide AND RELATED METABOLITES ARE ASSOCIATED WITH CARDIOVASCULAR EVENTS: RESULTS FROM THE DALLAS HEART STUDY
Journal of the American College of Cardiology, 2019Co-Authors: Yeela Barkan-talmor, Stanley L. Hazen, Colby R. Ayers, Wai Hong, Wilson Tang, Guy Witberg, Alon Eisen, Ashraf Hamdan, James A. De Lemos, Ran KornowskiAbstract:The human microbiota may contribute to atherosclerotic cardiovascular disease (ASCVD) through the production of Trimethylamine-N-Oxide (TMAO), a gut microbiota-dependent metabolite previously implicated in atherosclerosis. Prior studies suggest that TMAO levels predict future ASCVD events in high
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RELATIONSHIP BETWEEN STATIN USE AND Trimethylamine N-Oxide IN CARDIOVASCULAR RISK ASSESSMENT
Journal of the American College of Cardiology, 2018Co-Authors: Zeneng Wang, Stanley L. Hazen, W.h. Wilson TangAbstract:Trimethylamine N-Oxide (TMAO) is a gut microbiota generated metabolite implicated in the development of cardiovascular disease. However, it is unknown how this metabolite responds to statin, a common medication utilized in this patient population. Plasma TMAO and baseline statin use data was
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Microbiome, Trimethylamine N-Oxide, and cardiometabolic disease.
Translational research : the journal of laboratory and clinical medicine, 2016Co-Authors: W.h. Wilson Tang, Stanley L. HazenAbstract:There is increasing appreciation that changes in microbiome composition and function can promote long-term susceptibility for cardiometabolic risk. Gut microbe-derived metabolites that are biologically active, such as Trimethylamine N-Oxide (TMAO), are now recognized as contributors to atherogenesis. This review summarizes our current understanding of the role of TMAO in the pathogenesis of cardiometabolic diseases and will discuss current findings, controversies, and further perspectives in this new area of investigation. Better appreciation of the interactions between dietary nutrient intake with gut microbiota-mediated metabolism may provide clinical insights into defining individuals at risk for disease progression in cardiometabolic diseases, as well as additional potential therapeutic targets for reducing risks for cardiometabolic disease progression.
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Serum Trimethylamine N-Oxide (TMAO), Diet, and Colorectal Cancer Risk
The FASEB Journal, 2016Co-Authors: Kristin A. Guertin, Stanley L. Hazen, Barry I. Graubard, James J. Goedert, Rashmi SinhaAbstract:ObjectiveCholine and carnitine are two compounds that are found in human diets and can be metabolized to Trimethylamine (TMA) and, ultimately, to Trimethylamine N-Oxide (TMAO) by the gut microbiota...
Sandip Paul - One of the best experts on this subject based on the ideXlab platform.
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Hydrophobic interactions in water-Trimethylamine-N-Oxide solutions: the effects of pressure.
The journal of physical chemistry. B, 2009Co-Authors: Nikhil Biyani, Sandip PaulAbstract:Molecular dynamics simulations were performed to obtain the effects of pressure on the potentials of mean force between a pair of neopentane molecules immersed in water as well as in aqueous solutions containing Trimethylamine-N-Oxide (TMAO). It was found that the hydrophobic attraction acting between a neopentane pair in pure water increases with increasing pressure. However, the hydrophobic attraction diminishes by the addition of TMAO even at high pressure. This strongly suggests that TMAO does not counter the pressure induced protein denaturation by enhancing hydrophobic attraction among nonpolar groups.
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Hydrophobic interactions in urea-Trimethylamine-N-Oxide solutions.
The journal of physical chemistry. B, 2008Co-Authors: Sandip Paul, G. N. PateyAbstract:The influence of osmolytes urea and Trimethylamine-N-Oxide (TMAO) on hydrophobic interactions is investigated employing molecular dynamics simulations. These osmolytes are of interest because of their opposing influence on proteins in solution; the denaturing effect of urea can be countered with TMAO. A neopentane pair is used to model typical nonpolar entities. Binary water−urea and water−TMAO as well as ternary water−urea−TMAO systems are considered. Neopentane−neopentane potentials of mean force, neopentane−water, and neopentane−osmolyte distribution functions are reported. Urea is found to have only modest influence on the neopentane−neopentane potential of mean force, but the hydrophobic attraction is completely destroyed by the presence of TMAO. It is shown that TMAO tends to act as a simple “surfactant” displacing water and urea (if it is present) from the first solvation shell of neopentane. It is likely the surfactant-like influence of TMAO that accounts for the elimination of the hydrophobic att...
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The influence of urea and Trimethylamine-N-Oxide on hydrophobic interactions.
The journal of physical chemistry. B, 2007Co-Authors: Sandip Paul, G. N. PateyAbstract:Molecular dynamics simulations are used to obtain potentials of mean force for pairs of neopentane molecules immersed in aqueous solutions containing urea, Trimethylamine-N-Oxide (TMAO), or both solutes at once. It is shown that the hydrophobic attraction acting between neopentane pairs in pure water and in water-urea solution is completely destroyed by the addition of TMAO. This strongly suggests that TMAO does not counter the protein denaturing effect of urea by enhancing hydrophobic attraction amongst nonpolar groups.
Yan Hong-bing - One of the best experts on this subject based on the ideXlab platform.
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ASSOCIATION OF CIRCULATING Trimethylamine N-Oxide WITH CORONARY ATHEROSCLEROTIC BURDEN IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
Journal of the American College of Cardiology, 2019Co-Authors: Sheng Zhaoxue, Yan Hong-bingAbstract:The gut microbial metabolite Trimethylamine N-Oxide (TMAO) can promote atherosclerosis and cardiovascular diseases. A previous study demonstrated that TMAO levels are associated with coronary atherosclerotic burden in patients with stable coronary artery disease. However, the relationship between
Yu Tan - One of the best experts on this subject based on the ideXlab platform.
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Plasma Trimethylamine N-Oxide as a Novel Biomarker for Plaque Rupture in Patients With ST-Segment-Elevation Myocardial Infarction.
Circulation. Cardiovascular interventions, 2019Co-Authors: Yu Tan, Zhaoxue Sheng, Peng Zhou, Chen Liu, Hanjun Zhao, Li Song, Jinying Zhou, Yi Chen, Laiyuan WangAbstract:Background: Trimethylamine N-Oxide (TMAO) is reported to promote the pathogenesis of atherosclerosis and be associated with cardiovascular events risk. It is unknown whether plasma TMAO is associat...
