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George A C Murrell - One of the best experts on this subject based on the ideXlab platform.
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randomised double blind placebo controlled clinical trial of a new topical glyceryl Trinitrate patch for chronic lateral epicondylosis
British Journal of Sports Medicine, 2009Co-Authors: Justin A. Paoloni, George A C Murrell, Ronald BurchAbstract:Objective: This study aimed to determine whether a new glyceryl Trinitrate patch preparation is effective in treating chronic lateral epicondylosis. Design: Randomised double-blind controlled clinical trial. Setting: Private practice patients: 154 adult patients with chronic lateral epicondylosis were recruited, with 136 patients completing the trial. Interventions: 8 weeks of glyceryl Trinitrate patch application (dosages of 72 mg/24 h, 1.44 mg/24 h, and 3.6 mg/24 h), or placebo patch application. Main outcome measures: Subjective global assessment of change in elbow symptoms, patient-rated tennis elbow evaluation, visual analogue pain at rest, visual analogue pain with activity, visual analogue pain intensity, grip strength, and strength testing using the Orthopaedic Research Institute-Tennis Elbow Testing System. Results: At 8 weeks there was a significant decrease in elbow pain with activity in the glyceryl Trinitrate 0.72 mg/24 h group compared with placebo (p = 0.04). There were no other significant differences. Conclusions: Continuous 1.25 mg/24 h topical glyceryl Trinitrate treatment, when combined with daily exercise rehabilitation, has previously demonstrated efficacy in treating chronic lateral epicondylosis. There was significantly decreased elbow pain with activity at 8 weeks in the glyceryl Trinitrate 0.72 mg/24 h group (p = 0.04). This short-term dose-ranging study did not demonstrate a treatment effect of a new topical glyceryl Trinitrate patch in dosages of 1.44 mg/24 h or 3.6 mg/24 h, which conflicts with previous studies on topical glyceryl Trinitrate treatment. Trial registration number: NCT00447928.
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three year followup study of topical glyceryl Trinitrate treatment of chronic noninsertional achilles tendinopathy
Foot & Ankle International, 2007Co-Authors: Justin A. Paoloni, George A C MurrellAbstract:Background: Topical glyceryl Trinitrate treatment has demonstrated short-term efficacy in chronic noninsertional Achilles tendinopathy. No long-term followup is reported. We aimed to assess if the ...
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topical glyceryl Trinitrate application in the treatment of chronic supraspinatus tendinopathy a randomized double blinded placebo controlled clinical trial
American Journal of Sports Medicine, 2005Co-Authors: Justin A. Paoloni, Richard Appleyard, Janis Nelson, George A C MurrellAbstract:Background: Topical glyceryl Trinitrate therapy has previously demonstrated short-term pain reduction in patients with supraspinatus tendinopathy.Hypothesis: Topical glyceryl Trinitrate improves outcome measures in patients with supraspinatus tendinopathy.Study Design: Randomized controlled clinical trial; Level of evidence, 1.Methods: Fifty-three patients (57 shoulders) were recruited, and the authors completed a prospective, randomized, double-blinded, placebo-controlled clinical trial of continuous topical glyceryl Trinitrate treatment (1.25 mg/24-h glyceryl Trinitrate).Results: The glyceryl Trinitrate group had significantly reduced shoulder pain with activity, at night, and at rest at week 24 (P = .03); reduced internal rotation impingement at week 24 (P = .02); increased range of motion in abduction and internal rotation at week 24 (P = .04); and increased force at weeks 12 and 24 with supraspinatus muscle testing (P = .001), external rotation (P = .04), internal rotation (P = .01), adduction (P = ....
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topical glyceryl Trinitrate treatment of chronic noninsertional achilles tendinopathy a randomized double blind placebo controlled trial
Journal of Bone and Joint Surgery American Volume, 2004Co-Authors: Justin A. Paoloni, Richard Appleyard, Janis Nelson, George A C MurrellAbstract:Background: Noninsertional Achilles tendinopathy is a degenerative overuse disorder. No method has been universally successful in treating this condition. Topically applied nitric oxide has been shown, in animal models, to be effective for the treatment of fractures and cutaneous wounds through mechanisms that may include stimulation of collagen synthesis in fibroblasts. The goal of the present study was to determine if topical glyceryl Trinitrate improves clinical outcome measures in patients with Achilles tendinopathy. Methods: A prospective, randomized, double-blind, placebo-controlled trial involving a total of sixty-five patients (eighty-four Achilles tendons) was performed to compare continuous application of topical glyceryl Trinitrate (at a dosage of 1.25 mg per twenty-four hours) with rehabilitation alone for the treatment of noninsertional Achilles tendinopathy. Results: Compared with the control group, the glyceryl Trinitrate group showed reduced pain with activity at twelve weeks (p = 0.02) and twenty-four weeks (p = 0.03), reduced night pain at twelve weeks (p = 0.04), reduced tenderness at twelve weeks (p = 0.02), decreased pain scores after the hop test at twenty-four weeks (p = 0.005), and increased ankle plantar flexor mean total work compared with the baseline level at twenty-four weeks (p = 0.04). Twenty-eight (78%) of thirty-six tendons in the glyceryl Trinitrate group were asymptomatic with activities of daily living at six months, compared with twenty (49%) of forty-one tendons in the placebo group (p = 0.001, chi-square analysis). The mean effect size for all outcome measures was 0.14. Conculsions: Topical glyceryl Trinitrate significantly reduced pain with activity and at night, improved functional measures, and improved outcomes in patients with Achilles tendinopathy. Level of Evidence: Therapeutic study, Level I-1a (randomized controlled trial [significant difference]). See Instructions to Authors for a complete description of levels of evidence.
Justin A. Paoloni - One of the best experts on this subject based on the ideXlab platform.
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a New Topical Glyceryl Trinitrate Patch for Chronic Lateral
2011Co-Authors: Justin A. PaoloniAbstract:Abstract Objective: This study aimed to determine if a new glyceryl Trinitrate patch preparation is effective in treating chronic lateral epicondylosis. Design: Randomised double blind controlled clinical trial. Setting: Private practice Patients: 154 adult patients with chronic lateral epicondylosis were recruited, with 136 patients completing the trial. Interventions: Eight weeks of glyceryl Trinitrate patch application (dosages of 0.72 mg/ 24 hour, 1.44 mg/ 24 hour, and 3.6 mg/ 24 hour), or placebo patch application. Main outcome measures: Subjective global assessment of change in elbow symptoms, patient rated tennis elbow evaluation, visual analogue pain at rest, visual analogue pain with activity, visual analogue pain intensity, grip strength, and strength testing using the Orthopaedic Research Institute-Tennis Elbow Testing System. Results: At eight weeks there was a significant decrease in elbow pain with activity in the glyceryl Trinitrate 0.72 mg/ 24 hour group compared with placebo (p=0.04). There were no other significant differences. Conclusions: Continuous 1.25mg/ 24 hour topical glyceryl Trinitrate treatment, when combined with daily exercise rehabilitation, has previously demonstrated efficacy in treating chronic lateral epicondylosis. There was significantly decreased elbow pain with activity at eight weeks in the glyceryl Trinitrate 0.72 mg/ 24 hour group (p=0.04). This short-term dose-ranging study did not demonstrate a treatment effect of a new topical glyceryl Trinitrate patch in dosages of 1.44 mg/ 24 hour, and 3.6 mg/ 24 hour, and conflicts with previous studies on topical glyceryl Trinitrate treatment. US Food and Drug Administration Clinical Trial Registration Number: IND 72,568 Downloaded from bjsm.bmj.com on May 22, 2011 - Published by group.bmj.com
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randomised double blind placebo controlled clinical trial of a new topical glyceryl Trinitrate patch for chronic lateral epicondylosis
British Journal of Sports Medicine, 2009Co-Authors: Justin A. Paoloni, George A C Murrell, Ronald BurchAbstract:Objective: This study aimed to determine whether a new glyceryl Trinitrate patch preparation is effective in treating chronic lateral epicondylosis. Design: Randomised double-blind controlled clinical trial. Setting: Private practice patients: 154 adult patients with chronic lateral epicondylosis were recruited, with 136 patients completing the trial. Interventions: 8 weeks of glyceryl Trinitrate patch application (dosages of 72 mg/24 h, 1.44 mg/24 h, and 3.6 mg/24 h), or placebo patch application. Main outcome measures: Subjective global assessment of change in elbow symptoms, patient-rated tennis elbow evaluation, visual analogue pain at rest, visual analogue pain with activity, visual analogue pain intensity, grip strength, and strength testing using the Orthopaedic Research Institute-Tennis Elbow Testing System. Results: At 8 weeks there was a significant decrease in elbow pain with activity in the glyceryl Trinitrate 0.72 mg/24 h group compared with placebo (p = 0.04). There were no other significant differences. Conclusions: Continuous 1.25 mg/24 h topical glyceryl Trinitrate treatment, when combined with daily exercise rehabilitation, has previously demonstrated efficacy in treating chronic lateral epicondylosis. There was significantly decreased elbow pain with activity at 8 weeks in the glyceryl Trinitrate 0.72 mg/24 h group (p = 0.04). This short-term dose-ranging study did not demonstrate a treatment effect of a new topical glyceryl Trinitrate patch in dosages of 1.44 mg/24 h or 3.6 mg/24 h, which conflicts with previous studies on topical glyceryl Trinitrate treatment. Trial registration number: NCT00447928.
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three year followup study of topical glyceryl Trinitrate treatment of chronic noninsertional achilles tendinopathy
Foot & Ankle International, 2007Co-Authors: Justin A. Paoloni, George A C MurrellAbstract:Background: Topical glyceryl Trinitrate treatment has demonstrated short-term efficacy in chronic noninsertional Achilles tendinopathy. No long-term followup is reported. We aimed to assess if the ...
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Topical glyceryl Trinitrate treatment in chronic tendinopathies : review article
International Sportmed Journal, 2006Co-Authors: Justin A. PaoloniAbstract:lIgObjective:l/Ig Literature review of topical glyceryl Trinitrate treatment for chronic tendinopathy. Data sources:l/Ig MEDLINE, PubMed, and EMBASE searches were performed in April, 2006 on all studies from 1966 onwards using the terms: nitric oxide, nitroglycerin, glyceryl Trinitrate, tendon, tendonitis, tendinosis, tendinopathy, tendonopathy, elbow, tennis elbow, epicondylitis, epicondylosis, Achilles, patella, patellar, supraspinatus, impingement, and rotator cuff. Study section:l/Ig Only randomised controlled trials were included in the analysis. Four studies were identified using topical glyceryl Trinitrate treatment in tendinopathy. Data extraction:l/Ig Relevant literature was identified, sourced, and reviewed. Data synthesis:l/Ig Topical glyceryl Trinitrate treatment of chronic tendinopathy has recently been investigated with several published clinical trials. Randomised, double-blind, placebo controlled clinical trials investigating topical glyceryl Trinitrate treatment (1.25mg/24-hours) for chronic tendinopathies in adults (Achilles tendinopathy, N=84: extensor tendinopathy at the elbow, N=95: and supraspinatus tendinopathy, N=57) have demonstrated improved patient outcomes when compared with rehabilitation alone. Topical glyceryl Trinitrate treatment results in significant improvements in patient rated pain, increased tendon force measures, improved functional measures, and improved patient outcomes relative to tendon rehabilitation. Outcomes at 6 months demonstrate that 22-29% more patients were completely asymptomatic when treated with topical glyceryl Trinitrate. Effect size estimates ranged from 12-26%. lbrglIgConclusions:l/Ig Topical glyceryl Trinitrate treatment is a well-tested medication with no irreversible side effects and use of this therapy is warranted to treat chronic tendinopathies to improve patient outcomes. Topical glyceryl Trinitrate treatment requires further investigation to: define the mechanism of action of glyceryl Trinitrate in tendinopathy, and delineate the most effective dosage regime to maximize effect and limit side effects.
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topical glyceryl Trinitrate application in the treatment of chronic supraspinatus tendinopathy a randomized double blinded placebo controlled clinical trial
American Journal of Sports Medicine, 2005Co-Authors: Justin A. Paoloni, Richard Appleyard, Janis Nelson, George A C MurrellAbstract:Background: Topical glyceryl Trinitrate therapy has previously demonstrated short-term pain reduction in patients with supraspinatus tendinopathy.Hypothesis: Topical glyceryl Trinitrate improves outcome measures in patients with supraspinatus tendinopathy.Study Design: Randomized controlled clinical trial; Level of evidence, 1.Methods: Fifty-three patients (57 shoulders) were recruited, and the authors completed a prospective, randomized, double-blinded, placebo-controlled clinical trial of continuous topical glyceryl Trinitrate treatment (1.25 mg/24-h glyceryl Trinitrate).Results: The glyceryl Trinitrate group had significantly reduced shoulder pain with activity, at night, and at rest at week 24 (P = .03); reduced internal rotation impingement at week 24 (P = .02); increased range of motion in abduction and internal rotation at week 24 (P = .04); and increased force at weeks 12 and 24 with supraspinatus muscle testing (P = .001), external rotation (P = .04), internal rotation (P = .01), adduction (P = ....
Seogue Yoon - One of the best experts on this subject based on the ideXlab platform.
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effect of 0 2 percent glyceryl Trinitrate ointment on wound healing after a hemorrhoidectomy results of a randomized prospective double blind placebo controlled trial
Diseases of The Colon & Rectum, 2003Co-Authors: Do Yeon Hwang, Seogue YoonAbstract:PURPOSE: Glyceryl Trinitrate ointment acts as a dilator of the internal anal sphincter. It has been used as a treatment modality that replaces the lateral sphincterotomy in chronic anal fissures. When glyceryl Trinitrate ointment is applied to the wound from a hemorrhoidectomy, it is thought that it will shorten the healing time and decrease postoperative pain. Our study focused on the efficacy of using 0.2 percent glyceryl Trinitrate ointment to shorten the healing time after a hemorrhoidectomy. METHODS: A randomized, prospective, double-blind, and placebo-controlled study was designed. The power test indicated that 55 patients should be in each group to give a 90 percent chance of finding a 30 percent difference in healing time. The selection criteria for inclusion in this study were patients with third-degree or fourth-degree hemorrhoids and patients undergoing hemorrhoidectomies for three or more piles. From November 2000 to July 2001, the first 110 patients to meet our criteria were selected, 55 in the nitroglycerin group and 55 in the placebo group. The same physician performed all of the hemorrhoidectomies, and intravenous patient-controlled analgesia was not used. Cases involving other procedures for fissures or fistulas were excluded. The patients randomly received glyceryl Trinitrate and placebo ointments from the pharmacologist. The pain score was checked using a visual analog scale (minimum 0, maximum 10) during the hospital stay, and complete wound healing was checked at three weeks after the operation. Demands for analgesics and the frequency of postoperative complications were recorded. RESULTS: When the trial was completed, 49 patients remained in the nitroglycerin group and 53 patients in the placebo group. No significant differences in the gender and the age distributions, the number of excised piles, the time for the procedures, the length of hospital stay, and the consumed amounts of analgesics existed between the two groups. The pain score in the nitroglycerin group showed a significant difference with the repeated measures analysis (P 0.001). The wound healing rates at three weeks postoperative were 74.5 percent in the nitroglycerin group and 42 percent in the placebo group (P 0.002). There was no significant increase in complications in the nitroglycerin group. CONCLUSION: More rapid healing of hemorrhoidectomy wounds without any specific complications was effected by 0.2 percent glyceryl Trinitrate ointment. [Key words: Glyceryl Trinitrate ointment; Hemorrhoidectomy; Wound healing; Postoperative pain] Hwang DY, Yoon S-G, Kim HS, Lee JK, Kim KY. Effect of 0.2 percent glyceryl Trinitrate ointment on wound healing after a hemorrhoidectomy: results of a randomized, prospective, double-blind, placebo-controlled trial. Dis Colon Rectum 2003;46:950–954.
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effect of 0 2 percent glyceryl Trinitrate ointment on wound healing after a hemorrhoidectomy
Diseases of The Colon & Rectum, 2003Co-Authors: Do Yeon Hwang, Seogue YoonAbstract:PURPOSE: Glyceryl Trinitrate ointment acts as a dilator of the internal anal sphincter. It has been used as a treatment modality that replaces the lateral sphincterotomy in chronic anal fissures. When glyceryl Trinitrate ointment is applied to the wound from a hemorrhoidectomy, it is thought that it will shorten the healing time and decrease postoperative pain. Our study focused on the efficacy of using 0.2 percent glyceryl Trinitrate ointment to shorten the healing time after a hemorrhoidectomy. METHODS: A randomized, prospective, double-blind, and placebo-controlled study was designed. The power test indicated that 55 patients should be in each group to give a 90 percent chance of finding a 30 percent difference in healing time. The selection criteria for inclusion in this study were patients with third-degree or fourth-degree hemorrhoids and patients undergoing hemorrhoidectomies for three or more piles. From November 2000 to July 2001, the first 110 patients to meet our criteria were selected, 55 in the nitroglycerin group and 55 in the placebo group. The same physician performed all of the hemorrhoidectomies, and intravenous patient-controlled analgesia was not used. Cases involving other procedures for fissures or fistulas were excluded. The patients randomly received glyceryl Trinitrate and placebo ointments from the pharmacologist. The pain score was checked using a visual analog scale (minimum = 0, maximum = 10) during the hospital stay, and complete wound healing was checked at three weeks after the operation. Demands for analgesics and the frequency of postoperative complications were recorded. RESULTS: When the trial was completed, 49 patients remained in the nitroglycerin group and 53 patients in the placebo group. No significant differences in the gender and the age distributions, the number of excised piles, the time for the procedures, the length of hospital stay, and the consumed amounts of analgesics existed between the two groups. The pain score in the nitroglycerin group showed a significant difference with the repeated measures analysis (P < 0.001). The wound healing rates at three weeks postoperative were 74.5 percent in the nitroglycerin group and 42 percent in the placebo group (P = 0.002). There was no significant increase in complications in the nitroglycerin group. CONCLUSION: More rapid healing of hemorrhoidectomy wounds without any specific complications was effected by 0.2 percent glyceryl Trinitrate ointment.
Amaia Baranda - One of the best experts on this subject based on the ideXlab platform.
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Transdermal glyceryl Trinitrate for prevention of post-ERCP pancreatitis: A randomized double-blind trial.
Gastrointestinal endoscopy, 2020Co-Authors: Manuel Moretó, Manuel Zaballa, Ignacio Casado, Olga Merino, Miguel Rueda, Kléber Ramírez, Raquel Urcelay, Amaia BarandaAbstract:Pancreatic sphincter hypertension increases the risk of pancreatitis in patients undergoing ERCP. Glyceryl Trinitrate reduces sphincter of Oddi pressure. This study tested the hypothesis that transdermal glyceryl Trinitrate could be effective in the prevention of post-ERCP pancreatitis. One hundred forty-four patients undergoing ERCP were randomized: 71 received a 15-mg glyceryl Trinitrate patch (glyceryl Trinitrate group) and 73 a placebo patch (control group). In the control group, post-ERCP pancreatitis developed in 11 patients versus 3 in the glyceryl Trinitrate group (p < 0.05). Twenty-four hour to baseline serum amylase and lipase ratios were lower in the glyceryl Trinitrate group (respectively, 3.6 vs. 7.5, p < 0.05; and 5.3 vs. 27.7, p < 0.05). In a multivariate analysis, glyceryl Trinitrate patch and the number of pancreatic injections, but not endoscopic sphincterotomy, were independent risk factors for post-ERCP pancreatitis. The results of this study suggest that use of a transdermal glyceryl Trinitrate patch protects against post-ERCP pancreatitis.
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transdermal glyceryl Trinitrate for prevention of post ercp pancreatitis a randomized double blind trial
Gastrointestinal Endoscopy, 2003Co-Authors: Manuel Moretó, Manuel Zaballa, Ignacio Casado, Olga Merino, Miguel Rueda, Kléber Ramírez, Raquel Urcelay, Amaia BarandaAbstract:Abstract Background: Pancreatic sphincter hypertension increases the risk of pancreatitis in patients undergoing ERCP. Glyceryl Trinitrate reduces sphincter of Oddi pressure. This study tested the hypothesis that transdermal glyceryl Trinitrate could be effective in the prevention of post-ERCP pancreatitis. Methods: One hundred forty-four patients undergoing ERCP were randomized: 71 received a 15-mg glyceryl Trinitrate patch (glyceryl Trinitrate group) and 73 a placebo patch (control group). Results: In the control group, post-ERCP pancreatitis developed in 11 patients versus 3 in the glyceryl Trinitrate group ( p p p Conclusions: The results of this study suggest that use of a transdermal glyceryl Trinitrate patch protects against post-ERCP pancreatitis. (Gastrointest Endosc 2003;57:1-7.)
Do Yeon Hwang - One of the best experts on this subject based on the ideXlab platform.
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effect of 0 2 percent glyceryl Trinitrate ointment on wound healing after a hemorrhoidectomy results of a randomized prospective double blind placebo controlled trial
Diseases of The Colon & Rectum, 2003Co-Authors: Do Yeon Hwang, Seogue YoonAbstract:PURPOSE: Glyceryl Trinitrate ointment acts as a dilator of the internal anal sphincter. It has been used as a treatment modality that replaces the lateral sphincterotomy in chronic anal fissures. When glyceryl Trinitrate ointment is applied to the wound from a hemorrhoidectomy, it is thought that it will shorten the healing time and decrease postoperative pain. Our study focused on the efficacy of using 0.2 percent glyceryl Trinitrate ointment to shorten the healing time after a hemorrhoidectomy. METHODS: A randomized, prospective, double-blind, and placebo-controlled study was designed. The power test indicated that 55 patients should be in each group to give a 90 percent chance of finding a 30 percent difference in healing time. The selection criteria for inclusion in this study were patients with third-degree or fourth-degree hemorrhoids and patients undergoing hemorrhoidectomies for three or more piles. From November 2000 to July 2001, the first 110 patients to meet our criteria were selected, 55 in the nitroglycerin group and 55 in the placebo group. The same physician performed all of the hemorrhoidectomies, and intravenous patient-controlled analgesia was not used. Cases involving other procedures for fissures or fistulas were excluded. The patients randomly received glyceryl Trinitrate and placebo ointments from the pharmacologist. The pain score was checked using a visual analog scale (minimum 0, maximum 10) during the hospital stay, and complete wound healing was checked at three weeks after the operation. Demands for analgesics and the frequency of postoperative complications were recorded. RESULTS: When the trial was completed, 49 patients remained in the nitroglycerin group and 53 patients in the placebo group. No significant differences in the gender and the age distributions, the number of excised piles, the time for the procedures, the length of hospital stay, and the consumed amounts of analgesics existed between the two groups. The pain score in the nitroglycerin group showed a significant difference with the repeated measures analysis (P 0.001). The wound healing rates at three weeks postoperative were 74.5 percent in the nitroglycerin group and 42 percent in the placebo group (P 0.002). There was no significant increase in complications in the nitroglycerin group. CONCLUSION: More rapid healing of hemorrhoidectomy wounds without any specific complications was effected by 0.2 percent glyceryl Trinitrate ointment. [Key words: Glyceryl Trinitrate ointment; Hemorrhoidectomy; Wound healing; Postoperative pain] Hwang DY, Yoon S-G, Kim HS, Lee JK, Kim KY. Effect of 0.2 percent glyceryl Trinitrate ointment on wound healing after a hemorrhoidectomy: results of a randomized, prospective, double-blind, placebo-controlled trial. Dis Colon Rectum 2003;46:950–954.
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effect of 0 2 percent glyceryl Trinitrate ointment on wound healing after a hemorrhoidectomy
Diseases of The Colon & Rectum, 2003Co-Authors: Do Yeon Hwang, Seogue YoonAbstract:PURPOSE: Glyceryl Trinitrate ointment acts as a dilator of the internal anal sphincter. It has been used as a treatment modality that replaces the lateral sphincterotomy in chronic anal fissures. When glyceryl Trinitrate ointment is applied to the wound from a hemorrhoidectomy, it is thought that it will shorten the healing time and decrease postoperative pain. Our study focused on the efficacy of using 0.2 percent glyceryl Trinitrate ointment to shorten the healing time after a hemorrhoidectomy. METHODS: A randomized, prospective, double-blind, and placebo-controlled study was designed. The power test indicated that 55 patients should be in each group to give a 90 percent chance of finding a 30 percent difference in healing time. The selection criteria for inclusion in this study were patients with third-degree or fourth-degree hemorrhoids and patients undergoing hemorrhoidectomies for three or more piles. From November 2000 to July 2001, the first 110 patients to meet our criteria were selected, 55 in the nitroglycerin group and 55 in the placebo group. The same physician performed all of the hemorrhoidectomies, and intravenous patient-controlled analgesia was not used. Cases involving other procedures for fissures or fistulas were excluded. The patients randomly received glyceryl Trinitrate and placebo ointments from the pharmacologist. The pain score was checked using a visual analog scale (minimum = 0, maximum = 10) during the hospital stay, and complete wound healing was checked at three weeks after the operation. Demands for analgesics and the frequency of postoperative complications were recorded. RESULTS: When the trial was completed, 49 patients remained in the nitroglycerin group and 53 patients in the placebo group. No significant differences in the gender and the age distributions, the number of excised piles, the time for the procedures, the length of hospital stay, and the consumed amounts of analgesics existed between the two groups. The pain score in the nitroglycerin group showed a significant difference with the repeated measures analysis (P < 0.001). The wound healing rates at three weeks postoperative were 74.5 percent in the nitroglycerin group and 42 percent in the placebo group (P = 0.002). There was no significant increase in complications in the nitroglycerin group. CONCLUSION: More rapid healing of hemorrhoidectomy wounds without any specific complications was effected by 0.2 percent glyceryl Trinitrate ointment.
