The Experts below are selected from a list of 33594 Experts worldwide ranked by ideXlab platform
Peter J. Hotez - One of the best experts on this subject based on the ideXlab platform.
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Neglected Tropical Diseases and HIV / AIDS [letter] [reply]
The Lancet, 2020Co-Authors: Peter J. Hotez, David H. Molyneux, Eileen Stillwaggon, Zvi Bentwich, Jacob KumaresanAbstract:We greatly appreciate The Lancets support of the Global Network for Neglected Tropical Disease Control (GNNTDC). The network will assist in advocacy resource mobilisation and coordination of the public-private partnerships that are committed to the control or elimination of schistosomiasis hookworm lymphatic filariasis onchocerciasis trachoma and other Diseases. By tackling those poverty-promoting disorders in developing countries GNNTDC expects to achieve substantial improvement in the health and wellbeing of the worlds poorest people. The major goals of the conference held at the George Washington University (Oct 26-27 2006) were to (1) highlight the widespread physical economic and social costs of these Diseases on impoverished populations in developing countries; (2) explore opportunities for linking neglected Tropical Disease control with much larger global initiatives for malaria and HIV/AIDS control especially in sub-Saharan Africa; and (3) emphasise the achievability of neglected Tropical Disease control in the context of Millennium Development Goal 6. (excerpt)
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What constitutes a neglected Tropical Disease
PLOS Neglected Tropical Diseases, 2020Co-Authors: Peter J. Hotez, Serap Aksoy, Paul J. Brindley, Shaden KamhawiAbstract:The World Health Organization (WHO) currently classifies 20 Diseases and conditions as neglected Tropical Diseases (NTDs). However, since its inception in 2007, PLOS Neglected Tropical Diseases has considered an expanded list that includes additional Diseases with the chronic and/or debilitating, and poverty-promoting features of NTDs. Described here is an update of our current scope, which attempts to embrace all of the NTDs, and a discussion of the status of some of the more debated medical conditions in terms of whether or not they constitute an NTD.
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Whatever happened to China’s neglected Tropical Diseases?
Infectious Diseases of Poverty, 2019Co-Authors: Peter J. HotezAbstract:Before the founding of the People’s Republic of China 70 years ago, both extreme poverty and parasitic infections and other neglected Tropical Diseases were highly prevalent. Owing to social development, particularly economic reforms since the 1980s, poverty has since been dramatically reduced, and China became increasingly urbanized and industrialized. In parallel, China’s economic transformation translated into similar and remarkable reductions in neglected Tropical Diseases. Qian and colleagues report in their review published in Infectious Diseases of Poverty, the elimination or near elimination as a public health problem of lymphatic filariasis, trachoma, soil-transmitted helminth infections, schistosomiasis and other neglected Tropical Diseases. Of note, neglected Tropical Disease control and poverty reduction each appear to reinforce the other. China’s formula for success in parasitic and neglected Tropical Disease control might translate to other parts of the world, such as in sub-Saharan Africa through China’s new Belt and Road Initiative.
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Whatever happened to China's neglected Tropical Diseases?
Infectious Diseases of Poverty, 2019Co-Authors: Peter J. HotezAbstract:Before the founding of the People’s Republic of China 70 years ago, both extreme poverty and parasitic infections and other neglected Tropical Diseases were highly prevalent. Owing to social development, particularly economic reforms since the 1980s, poverty has since been dramatically reduced, and China became increasingly urbanized and industrialized. In parallel, China’s economic transformation translated into similar and remarkable reductions in neglected Tropical Diseases. Qian and colleagues report in their review published in Infectious Diseases of Poverty, the elimination or near elimination as a public health problem of lymphatic filariasis, trachoma, soil-transmitted helminth infections, schistosomiasis and other neglected Tropical Diseases. Of note, neglected Tropical Disease control and poverty reduction each appear to reinforce the other. China’s formula for success in parasitic and neglected Tropical Disease control might translate to other parts of the world, such as in sub-Saharan Africa through China’s new Belt and Road Initiative.
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ghana accelerating neglected Tropical Disease control in a setting of economic development
PLOS Neglected Tropical Diseases, 2019Co-Authors: Peter J. Hotez, David H. Molyneux, Alan Fenwick, Nanakwadwo Biritwum, Jeffrey D SachsAbstract:Ghana is exhibiting impressive economic gains that may compare with the growth rates expected in India or China. With economic development, there is an expectation that the prevalence and Disease burden of the neglected Tropical Diseases (NTDs) and other poverty-related neglected Diseases will decline. Indeed, guinea worm, human African trypanosomiasis, and trachoma recently have been eliminated in Ghana, and there have been steep declines in the prevalence of onchocerciasis and lymphatic filariasis (as well as oesophogostomiasis and yaws), with the prospect of eliminating these Diseases as well in the not-too-distant future. In contrast, progress toward Disease prevalence reductions for schistosomiasis, hookworm, and other soil-transmitted helminth infections, as well as other NTDs, including cysticercosis, cystic echinococcosis, scabies, Buruli ulcer, and leprosy, have been more modest. Snake bite envenoming, an important regional noninfectious NTD, also requires a different strategic approach. Arbovirus infections are emerging and thus remain a significant and under-recognized public health threat. For some of these NTDs, new technologies, including vaccines, will be required. Health-system strengthening with mobile health-activities are expected to continue furthering NTD Disease reductions, with the hope that Ghana could become the first highly populated Sub-Saharan African nation to achieve its NTD elimination targets.
Mingwei Wang - One of the best experts on this subject based on the ideXlab platform.
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innovation in neglected Tropical Disease drug discovery and development
Infectious Diseases of Poverty, 2018Co-Authors: Hongbo Weng, Haixia Chen, Mingwei WangAbstract:Background Neglected Tropical Diseases (NTDs) are closely related to poverty and affect over a billion people in developing countries. The unmet treatment needs cause high mortality and disability thereby imposing a huge burden with severe social and economic consequences. Although coordinated by the World Health Organization, various philanthropic organizations, national governments and the pharmaceutical industry have been making efforts in improving the situation, the control of NTDs is still inadequate and extremely difficult today. The lack of safe, effective and affordable medicines is a key contributing factor. This paper reviews the recent advances and some of the challenges that we are facing in the fight against NTDs.
David J Williams - One of the best experts on this subject based on the ideXlab platform.
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strategy for a globally coordinated response to a priority neglected Tropical Disease snakebite envenoming
PLOS Neglected Tropical Diseases, 2019Co-Authors: David J Williams, Mohd Abul Faiz, Bernadette Abelaridder, Stuart Ainsworth, Tommaso C Bulfone, Andrea D Nickerson, Abdulrazaq G Habib, Thomas Junghanss, Michael TurnerAbstract:In one of his final essays, statesman and former United Nations secretary general Kofi Annan said, ‘Snakebite is the most important Tropical Disease you’ve never heard of’ [1]. Mr. Annan firmly believed that victims of snakebite envenoming should be recognised and afforded greater efforts at improved prevention, treatment, and rehabilitation. During the last years of his life, he advocated strongly for the World Health Organisation (WHO) and the global community to give greater priority to this Disease of poverty and its victims.
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Snakebite envenoming
Nature Reviews Disease Primers, 2017Co-Authors: José María Gutiérrez, David J Williams, Abdulrazaq G Habib, Juan J. Calvete, Robert A. Harrison, David A. WarrellAbstract:Snakebite envenoming is a neglected Tropical Disease that particularly affects impoverished populations in the rural tropics. This Primer describes the efforts toward reducing the burden of snakebites, which require input from private, public and non-profit stakeholders worldwide. Snakebite envenoming is a neglected Tropical Disease that kills >100,000 people and maims >400,000 people every year. Impoverished populations living in the rural tropics are particularly vulnerable; snakebite envenoming perpetuates the cycle of poverty. Snake venoms are complex mixtures of proteins that exert a wide range of toxic actions. The high variability in snake venom composition is responsible for the various clinical manifestations in envenomings, ranging from local tissue damage to potentially life-threatening systemic effects. Intravenous administration of antivenom is the only specific treatment to counteract envenoming. Analgesics, ventilator support, fluid therapy, haemodialysis and antibiotic therapy are also used. Novel therapeutic alternatives based on recombinant antibody technologies and new toxin inhibitors are being explored. Confronting snakebite envenoming at a global level demands the implementation of an integrated intervention strategy involving the WHO, the research community, antivenom manufacturers, regulatory agencies, national and regional health authorities, professional health organizations, international funding agencies, advocacy groups and civil society institutions.
Simon Brooker - One of the best experts on this subject based on the ideXlab platform.
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the global atlas of helminth infection mapping the way forward in neglected Tropical Disease control
PLOS Neglected Tropical Diseases, 2010Co-Authors: Peter J. Hotez, Simon Brooker, Donald A P BundyAbstract:The recent commitment of the Obama administration to establish the Global Health Initiative, which is expected to increase to over US$100 million annually for neglected Tropical Disease (NTD) control, provides the most significant investment and opportunity for the global control of NTDs to date [1], [2]. These investments, together with commitments by the British Department for International Development, the World Bank, and several key private philanthropies, including the Bill & Melinda Gates Foundation, must be guided by a strong evidence-based approach. First, the problem, and the resources required to tackle it, need to be clearly quantified. Second, mass drug administration (MDA) should be optimally targeted to communities with the highest prevalence of infection and presumed greatest morbidity [3], [4]. Furthermore, for Diseases targeted for elimination, including lymphatic filariasis (LF) and onchocerciasis, it will become increasingly important to determine whether MDA can be stopped, and, if so, when and where. In the case of schistosomiasis, as control is scaled up, there is the additional requirement of determining when and where to shift praziquantel treatment from once per year to less frequent intervals.
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spatial co distribution of neglected Tropical Diseases in the east african great lakes region revisiting the justification for integrated control
Tropical Medicine & International Health, 2010Co-Authors: Simon Brooker, Archie C A Clements, Mariealice Deville, Ona Sime Ndayishimiye, Alan FenwickAbstract:OBJECTIVE To determine spatial patterns of co-endemicity of schistosomiasis mansoni and the soil-transmitted helminths (STHs) Ascaris lumbricoides, Trichuris trichiura and hookworm in the Great Lakes region of East Africa, to help plan integrated neglected Tropical Disease programmes in this region.
John H Adams - One of the best experts on this subject based on the ideXlab platform.
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why is plasmodium vivax a neglected Tropical Disease
PLOS Neglected Tropical Diseases, 2011Co-Authors: Jane M Carlton, Barbara Sina, John H AdamsAbstract:Summary Plasmodium vivax malaria is a debilitating, sometimes life-threatening, and economically repressive Disease of many Tropical and temperate countries outside Africa, and yet it is perceived as relatively benign. The estimated cost of the
