The Experts below are selected from a list of 1848 Experts worldwide ranked by ideXlab platform
Jie Chen - One of the best experts on this subject based on the ideXlab platform.
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intraductal Tubular Adenomas pyloric gland type of the pancreas clinicopathologic features are similar to gastric type intraductal papillary mucinous neoplasms and different from intraductal tubulopapillary neoplasms
Diagnostic Pathology, 2014Co-Authors: Xiaoyan Chang, Ying Jiang, Jie ChenAbstract:Background Intraductal Tubular Adenoma of the pancreas, pyloric gland type (ITA), is an infrequent intraductal benign lesion located in the main duct and large branch duct of the pancreas. The purpose of this report is to introduce seven new cases and to compare their clinicopathologic features and KRAS mutations to gastric-type intraductal papillary mucinous neoplasms (IPMNs) and intraductal tubulopapillary neoplasms (ITPNs).
Teiichi Motoyama - One of the best experts on this subject based on the ideXlab platform.
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pyloric gland type Tubular Adenoma superimposed on intraductal papillary mucinous tumor of the pancreas pyloric gland Adenoma of the pancreas
Virchows Archiv, 2002Co-Authors: Noriko Kato, Sunao Akiyama, Teiichi MotoyamaAbstract:We report a rare case of pyloric gland-type Tubular Adenoma of the main pancreatic duct. It was a grossly visible polypoid nodule and was composed of closely packed pyloric-type glands. This Adenoma was present within an intraductal papillary mucinous Adenoma (IPMA). In this IPMA lesion, aggregations of pyloric-type glands were occasionally observed, and most of the cells including ductal lining cells expressed pyloric gland-type mucin. The IPMA of the present case showed more extensive pyloric gland metaplasia or differentiation than commonly noted in IPMAs. We consider this pyloric gland-type Tubular Adenoma to be derived from a selective growth of IPMA cells showing pyloric gland metaplasia.
Stefano Serra - One of the best experts on this subject based on the ideXlab platform.
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intraductal Tubular Adenoma pyloric gland type of the pancreas a reappraisal and possible relationship with gastric type intraductal papillary mucinous neoplasm
Histopathology, 2009Co-Authors: Runjan Chetty, Stefano SerraAbstract:Aims: Intraductal Tubular Adenoma (ITA) is an uncommon intraluminal polypoid lesion that occurs in the main pancreatic duct and involves the main pancreatic duct in the region of head or body. Three cases of ITA are presented, the literature reviewed and their association with intraductal papillary mucinous neoplasm (IPMN) is postulated. Methods and results: ITA is composed of tightly packed Tubular structures with focal cystic dilation and papillary areas lined by gastric/pyloric epithelium showing minimal to mild cytological atypia. Pancreatic intraepithelial neoplasia (PanIN) 1A and B was present in smaller ducts of all cases. In addition, in the cases in this report and 50% of cases reported in the literature, an associated gastric-type IPMN was present in the same duct as the ITA or in adjacent ducts. The coexistence of ITA and IPMN and the similarities of their epithelial lining (gastric/pyloric mucosa) suggest a possible pathogenic link. Conclusions: ITA can occur without (type A) or with (type B) an associated gastric-type IPMN. ITA could represent a localized, polypoid form of gastric-type IPMN.It is a benign lesion with no evidence of invasion and no direct tumour-related deaths. Its relationship to intraductal Tubular carcinoma remains to be elucidated.
Deepti Shukla - One of the best experts on this subject based on the ideXlab platform.
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intraductal Tubular Adenoma pyloric type of the pancreas additional observations on a new type of pancreatic neoplasm
The American Journal of Surgical Pathology, 2004Co-Authors: Jorge Alboressaavedra, Kieran Sheahan, Ciaran Oriain, Deepti ShuklaAbstract:Three cases of a distinctive intraductal Tubular Adenoma, pyloric type, of the main pancreatic duct are reported. The patients, two women and a man, whose ages ranged from 63 to 70 years, complained of abdominal pain attributed to chronic pancreatitis in two patients. The patient with the largest tumor also had symptoms of gastric outlet obstruction. The tumors, two of which arose in the head and one in the tail of the pancreas, led to occlusion and cystic dilatation of the main pancreatic duct. Two Adenomas were sessile and one was attached to the wall of the pancreatic duct by a thin fibrous stalk. Microscopically, they were composed of lobules of closely packed Tubular glands similar to pyloric glands. In one tumor, nearly all glands were lined by columnar mucin-secreting cells with abundant clear cytoplasm and basally oriented nuclei. In addition to pyloric glands, two Adenomas contained glands lined by cells with little or no mucin as well as by pink oncocytic cells. Focal intestinal differentiation was identified in one tumor. Both intracellular and extracellular mucin was detected with the mucicarmine, periodic acid-Schiff, and alcian blue stains. All three Adenomas were CK7 positive and CK20 negative. Focal carcinoembryonic antigen linear reactivity along the apical cytoplasm was seen in many cells, but few cells expressed cytoplasmic carcinoembryonic antigen. All three Adenomas showed low proliferative activity as measured by the MIB-1 labeling index. The three Adenomas were p53 negative and showed loss of DPC4 expression. No endocrine cells were identified in any of the tumors. All patients are alive and symptom free from 4 months to 5 years following surgical treatment.
Yohichi Yasunami - One of the best experts on this subject based on the ideXlab platform.
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intraductal Tubular Adenoma of the pancreas pyloric gland type a clinicopathologic and immunohistochemical study of 6 cases
The American Journal of Surgical Pathology, 2005Co-Authors: Yoshifuku Nakayama, Hiroshi Inoue, Yoshihiro Hamada, Morishige Takeshita, Hiroshi Iwasaki, Kensei Maeshiro, Shinichi Iwanaga, Hiroki Tani, Shinichirou Ryu, Yohichi YasunamiAbstract:The intraductal Tubular Adenoma (ITA), pyloric gland type, of the pancreas is an uncommon benign tumor, akin to the pyloric gland type Adenoma of the gallbladder. We report 6 cases of ITA of the pancreas: 3 male and 3 female aged 50 to 79 years (mean, 63.5 years; median, 65 years); all were examined clinicopathologically. Four patients showed no symptoms, but appetite loss and/or general fatigue presented in two. Grossly, all tumors formed a localized polypoid mass protruding into the lumen of the dilated pancreatic duct. Five of the six tumors were found within the main duct, and the other arose within the branch duct of the pancreas. Microscopically, the tumors were composed of closely packed Tubular glands resembling pyloric type glands. They were lined by columnar or cuboidal epithelial cells with foci of mild to moderate dysplastic change. In 2 cases, the adjacent pancreas showed foci of intraductal papillary-mucinous Adenoma. Histochemically, the tumors largely showed neutral mucin with a lesser amount of acidic mucin made up mainly of sialomucin. Endocrine cells were found in five tumors. Immunohistochemically, all tumors were labeled with M-GGMC-1 and MUC6, whereas MUC1 and MUC2 stains were negative. Pepsinogen II was positive in 5 tumors; thus, the results displayed a pattern of differentiation similar to those of ordinary gastric pyloric or metaplastic pyloric glands. DPC4 expression was maintained in all tumors and p53-positive nuclei were hardly encountered. All patients are alive with no evidence of disease 3 to 10.5 years after surgical resection.
