The Experts below are selected from a list of 51 Experts worldwide ranked by ideXlab platform
Hyun Yong Jeong - One of the best experts on this subject based on the ideXlab platform.
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a case of gastric lymphoepithelioma like carcinoma presenting as panperitonitis by Perforation of stomach
The Korean Journal of Gastroenterology, 2011Co-Authors: Hee Seok Moon, Hyun Yong JeongAbstract:Gastric lymphoepithelioma-like carcinoma is a rare carcinoma among gastric malignant Tumor but has a good prognosis. The carcinoma has histologic feature characterized by small nest of cancer cells mixed with lymphoid stroma. We report a case with lymphoepithelioma-like carcinoma of stomach initially presenting as panperitonitis because of spontaneous Tumor Perforation. A 56-year-old man visited our emergency room because of epigastric pain. A preoperative abdominal CT scan showed a massive pneumoperitoneum in the upper abdomen, and the presence of gastric cancer in the lesser curvature of the stomach. An emergent laparotomy was performed followed by radical subtotal gastrectomy. Pathologic examination revealed that the Tumor was a lymphoepithelioma-like gastric carcinoma. (Korean J Gastroenterol 2011;58:208-211)
J J Gonzalezaguilera - One of the best experts on this subject based on the ideXlab platform.
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clinicopathological analysis of factors related to colorectal Tumor Perforation influence of angiogenesis
Medicine, 2015Co-Authors: Vicente Medinaarana, Antonio Martinezriera, Luciano Delgadoplasencia, Diana Rodriguezgonzalez, Alberto Bravogutierrez, Hugo Alvarezarguelles, Antonio Alarcohernandez, Eduardo Salidoruiz, Antonia M Fernandezperalta, J J GonzalezaguileraAbstract:AbstractColorectal Tumor Perforation is a life-threatening complication of this disease. However, little is known about the anatomopathological factors or pathophysiologic mechanisms involved.Pathological and immunohistochemical analysis of factors related with Tumoral neo-angiogenesis, which could
Hee Seok Moon - One of the best experts on this subject based on the ideXlab platform.
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a case of gastric lymphoepithelioma like carcinoma presenting as panperitonitis by Perforation of stomach
The Korean Journal of Gastroenterology, 2011Co-Authors: Hee Seok Moon, Hyun Yong JeongAbstract:Gastric lymphoepithelioma-like carcinoma is a rare carcinoma among gastric malignant Tumor but has a good prognosis. The carcinoma has histologic feature characterized by small nest of cancer cells mixed with lymphoid stroma. We report a case with lymphoepithelioma-like carcinoma of stomach initially presenting as panperitonitis because of spontaneous Tumor Perforation. A 56-year-old man visited our emergency room because of epigastric pain. A preoperative abdominal CT scan showed a massive pneumoperitoneum in the upper abdomen, and the presence of gastric cancer in the lesser curvature of the stomach. An emergent laparotomy was performed followed by radical subtotal gastrectomy. Pathologic examination revealed that the Tumor was a lymphoepithelioma-like gastric carcinoma. (Korean J Gastroenterol 2011;58:208-211)
Donald C Mcmillan - One of the best experts on this subject based on the ideXlab platform.
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signal transduction and activator of transcription 3 stat3 in patients with colorectal cancer associations with the phenotypic features of the Tumor and host
Clinical Cancer Research, 2017Co-Authors: Paul G Horgan, Donald C Mcmillan, James H Park, Hester C Van Wyk, Jean A Quinn, Jennifer Clark, Campbell S D Roxburgh, Joanne EdwardsAbstract:Purpose: In patients with colorectal cancer, a high-density local inflammatory infiltrate response is associated with improved survival, whereas elevated systemic inflammatory responses are associated with poor survival. One potential unifying mechanism is the IL6/JAK/STAT3 pathway. The present study examines the relationship between Tumor total STAT3 and phosphorylated STAT3Tyr705 (pSTAT3) expression, host inflammatory responses, and survival in patients undergoing resection of stage I-III colorectal cancer.Experimental Design: Immunohistochemical assessment of STAT3/pSTAT3 expression was performed using a tissue microarray and Tumor cell expression divided into tertiles using the weighted histoscore. The relationship between STAT3/pSTAT3 expression and local inflammatory (CD3+, CD8+, CD45R0+, FOXP3+ T-cell density, and Klintrup-Makinen grade) and systemic inflammatory responses and cancer-specific survival were examined.Results: A total of 196 patients were included in the analysis. Cytoplasmic and nuclear STAT3 expression strongly correlated (r = 0.363; P < 0.001); nuclear STAT3 and pSTAT3 expression weakly correlated (r = 0.130; P = 0.068). Cytoplasmic STAT3 was inversely associated with the density of CD3+ (P = 0.012), CD8+ (P = 0.003), and FOXP3+ T lymphocytes (P = 0.002) within the cancer cell nests and was associated with an elevated systemic inflammatory response as measured by modified Glasgow Prognostic Score (mGPS2: 19% vs. 4%, P = 0.004).The combination of nuclear STAT3/pSTAT3 stratified 5-year survival from 81% to 62% (P = 0.012), however, was not associated with survival independent of venous invasion, Tumor Perforation, or Tumor budding.Conclusions: In patients undergoing colorectal cancer resection, STAT3 expression was associated with adverse host inflammatory responses and reduced survival. Upregulation of Tumor STAT3 may be an important mechanism whereby the Tumor deregulates local and systemic inflammatory responses. Clin Cancer Res; 23(7); 1698-709. ©2016 AACR.
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neutrophil count is the most important prognostic component of the differential white cell count in patients undergoing elective surgery for colorectal cancer
American Journal of Surgery, 2015Co-Authors: David G Watt, John C Martin, James Park, Paul G Horgan, Donald C McmillanAbstract:Abstract Background Systemic inflammatory scoring systems such as the NLR have been reported to have prognostic value in many solid organ cancers. The aim of this study was to examine the relationships between the components of the white cell count (WCC) and survival in patients undergoing elective surgery for colorectal cancer. Methods Patients undergoing elective resection at a single center (1997 to 2008) were identified from a prospective database (n = 508). Patient demographics and preoperative laboratory measurements including the differential WCC and their association with cancer-specific survival (CSS) and overall survival were examined. Results There were 172 cancer deaths and 120 noncancer deaths. On Kaplan–Meier analysis of the whole cohort, age, Tumor, Nodal, and Metastasis stage, venous invasion, margin involvement, peritoneal involvement and Tumor Perforation, and white cell and neutrophil count (all P P Conclusion Of the components of a differential WCC, only the neutrophil count was independently associated with survival, particularly in node-negative colon cancer.
I Gogenur - One of the best experts on this subject based on the ideXlab platform.
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extralevatory abdominoperineal excision elape does not result in reduced rate of Tumor Perforation or rate of positive circumferential resection margin a nationwide database study
Annals of Surgery, 2015Co-Authors: Mads Klein, Anders Fischer, Jacob Rosenberg, I GogenurAbstract:Objective To evaluate the oncological results and possible benefits associated with extralevatory abdominoperineal excision (ELAPE) when compared with conventional abdominoperineal excision (APE). Background ELAPE was introduced in 2007 with the purpose of reducing the rate of positive resection margins after resection of low rectal cancers. Preliminary studies have shown promising results. No large-scale or nationwide data have been presented. Methods Database study based on data from the Danish Colorectal Cancer Group's prospective database. Data on all ELAPEs and APEs performed in Denmark in the period January 1, 2009, through August 2012 were retrieved and evaluated for differences in demography, Tumor characteristics, and oncological results. Uni- and multivariate logistic regression analyses were performed to identify risk factors for resection with a positive circumferential resection margin (CRM+). Results A total of 554 patients were included, 301(54%) were operated by ELAPE; 253(46%) by APE. Sixty-three percent were men, median (interquartile range) age was 69 (61-76 years) years, and Tumors removed had predominantly T-stages T2 and T3 (32% and 45%, respectively). Overall, CRM+ was found in 13% of patients. When divided according to type of procedure, we found no significant differences in demography and Tumor T- and N-stages. Resections with a CRM+ were more common after ELAPE (16% vs 7%; P = 0.006). After uni- and multivariate logistic regression analyses, surgery by ELAPE remained a risk factor for a CRM+ [odds ratio, 2.59 (95% confidence interval, 1.31-5.12); P = 0.006). Conclusions In this nationwide study, resection of low rectal cancers by ELAPE did not improve short-term oncological results, when compared with conventional APE.
