The Experts below are selected from a list of 23958 Experts worldwide ranked by ideXlab platform
Bharat B. Aggarwal - One of the best experts on this subject based on the ideXlab platform.
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curcumin free Turmeric exhibits anti inflammatory and anticancer activities identification of novel components of Turmeric
Molecular Nutrition & Food Research, 2013Co-Authors: Bharat B. Aggarwal, Shiyou Li, Wei Yuan, Subash C GuptaAbstract:: Turmeric, a dried powder derived from the rhizome of Curcuma longa, has been used for centuries in certain parts of the world and has been linked to numerous biological activities including antioxidant, anti-inflammatory, anticancer, antigrowth, anti-arthritic, anti-atherosclerotic, antidepressant, anti-aging, antidiabetic, antimicrobial, wound healing, and memory-enhancing activities. One component of Turmeric is curcumin, which has been extensively studied, as indicated by more than 5600 citations, most of which have appeared within the past decade. Recent research has identified numerous chemical entities from Turmeric other than curcumin. It is unclear whether all of the activities ascribed to Turmeric are due to curcumin or whether other compounds in Turmeric can manifest these activities uniquely, additively, or synergistically with curcumin. However, studies have indicated that Turmeric oil, present in Turmeric, can enhance the bioavailability of curcumin. Studies over the past decade have indicated that curcumin-free Turmeric (CFT) components possess numerous biological activities including anti-inflammatory, anticancer, and antidiabetic activities. Elemene derived from Turmeric is approved in China for the treatment of cancer. The current review focuses on the anticancer and anti-inflammatory activities exhibited by CFT and by some individual components of Turmeric, including turmerin, turmerone, elemene, furanodiene, curdione, bisacurone, cyclocurcumin, calebin A, and germacrone.
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Multitargeting by Turmeric, the golden spice: From kitchen to clinic
Molecular Nutrition and Food Research, 2013Co-Authors: Subash C Gupta, Ji-hye Kim, Bokyung Sung, Shiyou Li, Sahdeo Prasad, Bharat B. AggarwalAbstract:Although much has been published about curcumin, which is obtained from Turmeric, comparatively little is known about Turmeric itself. Turmeric, a golden spice obtained from the rhizome of the plant Curcuma longa, has been used to give color and taste to food preparations since ancient times. Traditionally, this spice has been used in Ayurveda and folk medicine for the treatment of such ailments as gynecological problems, gastric problems, hepatic disorders, infectious diseases, and blood disorders. Modern science has provided the scientific basis for the use of Turmeric against such disorders. Various chemical constituents have been isolated from this spice, including polyphenols, sesquiterpenes, diterpenes, triterpenoids, sterols, and alkaloids. Curcumin, which constitutes 2-5% of Turmeric, is perhaps the most-studied component. Although some of the activities of Turmeric can be mimicked by curcumin, other activities are curcumin-independent. Cell-based studies have demonstrated the potential of Turmeric as an antimicrobial, insecticidal, larvicidal, antimutagenic, radioprotector, and anticancer agent. Numerous animal studies have shown the potential of this spice against proinflammatory diseases, cancer, neurodegenerative diseases, depression, diabetes, obesity, and atherosclerosis. At the molecular level, this spice has been shown to modulate numerous cell-signaling pathways. In clinical trials, Turmeric has shown efficacy against numerous human ailments including lupus nephritis, cancer, diabetes, irritable bowel syndrome, acne, and fibrosis. Thus, a spice originally common in the kitchen is now exhibiting activities in the clinic. In this review, we discuss the chemical constituents of Turmeric, its biological activities, its molecular targets, and its potential in the clinic.
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Turmeric curcuma longa inhibits inflammatory nuclear factor nf κb and nf κb regulated gene products and induces death receptors leading to suppressed proliferation induced chemosensitization and suppressed osteoclastogenesis
Molecular Nutrition & Food Research, 2012Co-Authors: Subash C Gupta, Byoungduck Park, Vivek R Yadav, Bharat B. AggarwalAbstract:Scope The incidence of cancer is significantly lower in regions where Turmeric is heavily consumed. Whether lower cancer incidence is due to Turmeric was investigated by examining its effects on tumor cell proliferation, on pro-inflammatory transcription factors NF-κB and STAT3, and on associated gene products Methods and results Cell proliferation and cell cytotoxicity were measured by the MTT method, NF-κB activity by EMSA, protein expression by Western blot analysis, ROS generation by FACS analysis, and osteoclastogenesis by TRAP assay. Turmeric inhibited NF-κB activation and down-regulated NF-κB-regulated gene products linked to survival (Bcl-2, cFLIP, XIAP, and cIAP1), proliferation (cyclin D1 and c-Myc), and metastasis (CXCR4) of cancer cells. The spice suppressed the activation of STAT3, and induced the death receptors (DR)4 and DR5. Turmeric enhanced the production of ROS, and suppressed the growth of tumor cell lines. Furthermore, Turmeric sensitized the tumor cells to chemotherapeutic agents capecitabine and taxol. Turmeric was found to be more potent than pure curcumin for cell growth inhibition. Turmeric also inhibited NF-κB activation induced by RANKL that correlated with the suppression of osteoclastogenesis Conclusion Our results indicate that Turmeric can effectively block the proliferation of tumor cells through the suppression of NF-κB and STAT3 pathways.
Subash C Gupta - One of the best experts on this subject based on the ideXlab platform.
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curcumin free Turmeric exhibits anti inflammatory and anticancer activities identification of novel components of Turmeric
Molecular Nutrition & Food Research, 2013Co-Authors: Bharat B. Aggarwal, Shiyou Li, Wei Yuan, Subash C GuptaAbstract:: Turmeric, a dried powder derived from the rhizome of Curcuma longa, has been used for centuries in certain parts of the world and has been linked to numerous biological activities including antioxidant, anti-inflammatory, anticancer, antigrowth, anti-arthritic, anti-atherosclerotic, antidepressant, anti-aging, antidiabetic, antimicrobial, wound healing, and memory-enhancing activities. One component of Turmeric is curcumin, which has been extensively studied, as indicated by more than 5600 citations, most of which have appeared within the past decade. Recent research has identified numerous chemical entities from Turmeric other than curcumin. It is unclear whether all of the activities ascribed to Turmeric are due to curcumin or whether other compounds in Turmeric can manifest these activities uniquely, additively, or synergistically with curcumin. However, studies have indicated that Turmeric oil, present in Turmeric, can enhance the bioavailability of curcumin. Studies over the past decade have indicated that curcumin-free Turmeric (CFT) components possess numerous biological activities including anti-inflammatory, anticancer, and antidiabetic activities. Elemene derived from Turmeric is approved in China for the treatment of cancer. The current review focuses on the anticancer and anti-inflammatory activities exhibited by CFT and by some individual components of Turmeric, including turmerin, turmerone, elemene, furanodiene, curdione, bisacurone, cyclocurcumin, calebin A, and germacrone.
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Multitargeting by Turmeric, the golden spice: From kitchen to clinic
Molecular Nutrition and Food Research, 2013Co-Authors: Subash C Gupta, Ji-hye Kim, Bokyung Sung, Shiyou Li, Sahdeo Prasad, Bharat B. AggarwalAbstract:Although much has been published about curcumin, which is obtained from Turmeric, comparatively little is known about Turmeric itself. Turmeric, a golden spice obtained from the rhizome of the plant Curcuma longa, has been used to give color and taste to food preparations since ancient times. Traditionally, this spice has been used in Ayurveda and folk medicine for the treatment of such ailments as gynecological problems, gastric problems, hepatic disorders, infectious diseases, and blood disorders. Modern science has provided the scientific basis for the use of Turmeric against such disorders. Various chemical constituents have been isolated from this spice, including polyphenols, sesquiterpenes, diterpenes, triterpenoids, sterols, and alkaloids. Curcumin, which constitutes 2-5% of Turmeric, is perhaps the most-studied component. Although some of the activities of Turmeric can be mimicked by curcumin, other activities are curcumin-independent. Cell-based studies have demonstrated the potential of Turmeric as an antimicrobial, insecticidal, larvicidal, antimutagenic, radioprotector, and anticancer agent. Numerous animal studies have shown the potential of this spice against proinflammatory diseases, cancer, neurodegenerative diseases, depression, diabetes, obesity, and atherosclerosis. At the molecular level, this spice has been shown to modulate numerous cell-signaling pathways. In clinical trials, Turmeric has shown efficacy against numerous human ailments including lupus nephritis, cancer, diabetes, irritable bowel syndrome, acne, and fibrosis. Thus, a spice originally common in the kitchen is now exhibiting activities in the clinic. In this review, we discuss the chemical constituents of Turmeric, its biological activities, its molecular targets, and its potential in the clinic.
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Turmeric curcuma longa inhibits inflammatory nuclear factor nf κb and nf κb regulated gene products and induces death receptors leading to suppressed proliferation induced chemosensitization and suppressed osteoclastogenesis
Molecular Nutrition & Food Research, 2012Co-Authors: Subash C Gupta, Byoungduck Park, Vivek R Yadav, Bharat B. AggarwalAbstract:Scope The incidence of cancer is significantly lower in regions where Turmeric is heavily consumed. Whether lower cancer incidence is due to Turmeric was investigated by examining its effects on tumor cell proliferation, on pro-inflammatory transcription factors NF-κB and STAT3, and on associated gene products Methods and results Cell proliferation and cell cytotoxicity were measured by the MTT method, NF-κB activity by EMSA, protein expression by Western blot analysis, ROS generation by FACS analysis, and osteoclastogenesis by TRAP assay. Turmeric inhibited NF-κB activation and down-regulated NF-κB-regulated gene products linked to survival (Bcl-2, cFLIP, XIAP, and cIAP1), proliferation (cyclin D1 and c-Myc), and metastasis (CXCR4) of cancer cells. The spice suppressed the activation of STAT3, and induced the death receptors (DR)4 and DR5. Turmeric enhanced the production of ROS, and suppressed the growth of tumor cell lines. Furthermore, Turmeric sensitized the tumor cells to chemotherapeutic agents capecitabine and taxol. Turmeric was found to be more potent than pure curcumin for cell growth inhibition. Turmeric also inhibited NF-κB activation induced by RANKL that correlated with the suppression of osteoclastogenesis Conclusion Our results indicate that Turmeric can effectively block the proliferation of tumor cells through the suppression of NF-κB and STAT3 pathways.
Raja K Sivamani - One of the best experts on this subject based on the ideXlab platform.
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effects of Turmeric curcuma longa on skin health a systematic review of the clinical evidence
Phytotherapy Research, 2016Co-Authors: Alexandra R Vaughn, Amy Branum, Raja K SivamaniAbstract:Turmeric (Curcuma longa), a commonly used spice throughout the world, has been shown to exhibit antiinflammatory, antimicrobial, antioxidant, and anti-neoplastic properties. Growing evidence shows that an active component of Turmeric, curcumin, may be used medically to treat a variety of dermatologic diseases. This systematic review was conducted to examine the evidence for the use of both topical and ingested Turmeric/curcumin to modulate skin health and function. The PubMed and Embase databases were systematically searched for clinical studies involving humans that examined the relationship between products containing Turmeric, curcumin, and skin health. A total of 234 articles were uncovered, and a total of 18 studies met inclusion criteria. Nine studies evaluated the effects of ingestion, eight studies evaluated the effects of topical, and one study evaluated the effects of both ingested and topical application of Turmeric/curcumin. Skin conditions examined include acne, alopecia, atopic dermatitis, facial photoaging, oral lichen planus, pruritus, psoriasis, radiodermatitis, and vitiligo. Ten studies noted statistically significant improvement in skin disease severity in the Turmeric/curcumin treatment groups compared with control groups. Overall, there is early evidence that Turmeric/curcumin products and supplements, both oral and topical, may provide therapeutic benefits for skin health. However, currently published studies are limited and further studies will be essential to better evaluate efficacy and the mechanisms involved. Copyright © 2016 John Wiley & Sons, Ltd.
Samrithi Yuvaraj - One of the best experts on this subject based on the ideXlab platform.
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Effects of Turmeric on oral submucous fibrosis: A Systematic Review
Research Journal of Pharmacy and Technology, 2015Co-Authors: Nirisha Sriram, Gheena. S, Samrithi YuvarajAbstract:Oral submucous fibrosis is a chronic, complex potentially malignant disorder with a high risk of malignant transformation. As the disease progresses, the jaws become rigid to the point that the sufferers are unable to open their mouth. The major cause of this condition is arecanut or betel quid chewing. This systematic review explores and discusses the researches done in the effectiveness of Turmeric in oral submucous fibrosis. The name Turmeric is derived from the Latin word terra merita or turmeryte. The most active component present in Turmeric is curcumin. It is a safe, non-toxic and an effective herb that can act as an alternative for many conventional drugs due to its enormous therapeutic properties on various systems of our body. Since age old times Turmeric has been used in households with the belief that it can destroy harmful agents. Now has come the era where Turmeric finds its use out of households and into clinics. Through various studies it has been found that Turmeric has anti oxidants and anti allergic activities. This makes Turmeric a better choice for clinicians to use it to cure precancerous lesions like oral submucous fibrosis. Researches that are done on human beings have almost shown positive results in curing oral submucous fibrosis. However to implement the use of Turmeric in oral submucous fibrosis clinically more trials on a large scale are yet to be conducted.
Alexandra R Vaughn - One of the best experts on this subject based on the ideXlab platform.
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effects of Turmeric curcuma longa on skin health a systematic review of the clinical evidence
Phytotherapy Research, 2016Co-Authors: Alexandra R Vaughn, Amy Branum, Raja K SivamaniAbstract:Turmeric (Curcuma longa), a commonly used spice throughout the world, has been shown to exhibit antiinflammatory, antimicrobial, antioxidant, and anti-neoplastic properties. Growing evidence shows that an active component of Turmeric, curcumin, may be used medically to treat a variety of dermatologic diseases. This systematic review was conducted to examine the evidence for the use of both topical and ingested Turmeric/curcumin to modulate skin health and function. The PubMed and Embase databases were systematically searched for clinical studies involving humans that examined the relationship between products containing Turmeric, curcumin, and skin health. A total of 234 articles were uncovered, and a total of 18 studies met inclusion criteria. Nine studies evaluated the effects of ingestion, eight studies evaluated the effects of topical, and one study evaluated the effects of both ingested and topical application of Turmeric/curcumin. Skin conditions examined include acne, alopecia, atopic dermatitis, facial photoaging, oral lichen planus, pruritus, psoriasis, radiodermatitis, and vitiligo. Ten studies noted statistically significant improvement in skin disease severity in the Turmeric/curcumin treatment groups compared with control groups. Overall, there is early evidence that Turmeric/curcumin products and supplements, both oral and topical, may provide therapeutic benefits for skin health. However, currently published studies are limited and further studies will be essential to better evaluate efficacy and the mechanisms involved. Copyright © 2016 John Wiley & Sons, Ltd.
