The Experts below are selected from a list of 261 Experts worldwide ranked by ideXlab platform
Neha Jindal - One of the best experts on this subject based on the ideXlab platform.
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Tyloxapol niosomes as prospective drug delivery module for antiretroviral drug nevirapine
Aaps Pharmscitech, 2015Co-Authors: S K Mehta, Neha JindalAbstract:With the aim of assuring more patient compliant pharmacotherapy for acquired immuno deficiency syndrome, a formulation of the first line anti-retroviral drug, nevirapine (NVP), has been developed by encapsulating it within niosomes. Biocompatible niosomes were fabricated using a biological surfactant, Tyloxapol, with variable cholesterol concentrations. Formulation with surfactant/cholesterol molar ratio 1:0.1 exhibits maximum stability and optimum hydrophobicity. Thus, it is most suitable for the entrapment of NVP and has high entrapment efficiency of 94.3%. FTIR and DSC results indicate that NVP has sufficient compatibility with the excipients of the formulation. Photoluminescence quenching measurements were employed to elucidate the position of drug molecules in niosome bilayer along with the partition coefficient. Dissolution results indicate that the efflux of drug is sustained which creates a depot effect and decreases the fluctuations in drug release. Such a versatile and improved formulation of NVP is expected to increase its therapeutic index and alleviate toxic systemic side effects while improving the quality of life and duration of survival of the patients.
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mixed micelles of lecithin Tyloxapol as pharmaceutical nanocarriers for anti tubercular drug delivery
Colloids and Surfaces B: Biointerfaces, 2013Co-Authors: S K Mehta, Neha JindalAbstract:The equimolar mixed micellar system of Lecithin-Tyloxapol has been explored using physicochemical and spectroscopic measurements. Thermodynamic parameters have been computed for the prepared mixed micellar system. Interaction parameter, β, suggests synergistic interactions in the mixed systems. This has been further examined for the solubilization of anti-tuberculosis drugs (ATDs). In addition, the entrapment efficiency of the formulation has been evaluated for three ATDs. Micropolarity measurements indicate location of all the three drugs inside the mixed micellar systems. Fourier transform infrared spectroscopic and differential scanning calorimetric studies infer that the drugs are in harmony with the excipients since no visible interactions between the drugs and mixed micelles have been detected. In vitro release analyses exhibit sustained release of drugs from the formulation. Comparison of regression coefficients of different kinetic models reveal that release of ATDs from mixed micellar system follows first order exponential decay.
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formulation of Tyloxapol niosomes for encapsulation stabilization and dissolution of anti tubercular drugs
Colloids and Surfaces B: Biointerfaces, 2013Co-Authors: S K Mehta, Neha JindalAbstract:Abstract The present study delineates the formulation of niosomes from biocompatible surfactant Tyloxapol and their potential as drug delivery system for anti-tuberculosis drugs. Drug loaded niosomes have a size of 150 nm with a loading efficiency of 97.95 ± 0.2, 98.89 ± 0.2 and 99.50 ± 0.2% for rifampicin (RIF), isoniazid (INH), pyrazinamide (PZA), respectively. Fourier transform infrared spectroscopic studies infer that the drugs are in harmony with the fabricated niosomes since no visible interactions between the drug and niosomes have been detected. The prepared formulations are quite stable as assessed using absorption spectroscopy. TEM images and photoluminescence results reveal that RIF and INH are located in the film bilayer whereas PZA is adsorbed mainly on the surface head groups. In vitro dissolution studies at physiological conditions have been undertaken to compare the release behavior of drugs from the prepared niosomes. Sustained release has been achieved for hydrophilic drugs and an acceptable release in case of RIF. Comparison of regression coefficients of different kinetic models reveal that INH release follows Fickian diffusion mechanism whereas RIF and PZA, a non-Fickian release mechanism. Such a versatile system is expected to reduce dose-related drug toxicity and reach the atelectatic areas.
S K Mehta - One of the best experts on this subject based on the ideXlab platform.
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Tyloxapol niosomes as prospective drug delivery module for antiretroviral drug nevirapine
Aaps Pharmscitech, 2015Co-Authors: S K Mehta, Neha JindalAbstract:With the aim of assuring more patient compliant pharmacotherapy for acquired immuno deficiency syndrome, a formulation of the first line anti-retroviral drug, nevirapine (NVP), has been developed by encapsulating it within niosomes. Biocompatible niosomes were fabricated using a biological surfactant, Tyloxapol, with variable cholesterol concentrations. Formulation with surfactant/cholesterol molar ratio 1:0.1 exhibits maximum stability and optimum hydrophobicity. Thus, it is most suitable for the entrapment of NVP and has high entrapment efficiency of 94.3%. FTIR and DSC results indicate that NVP has sufficient compatibility with the excipients of the formulation. Photoluminescence quenching measurements were employed to elucidate the position of drug molecules in niosome bilayer along with the partition coefficient. Dissolution results indicate that the efflux of drug is sustained which creates a depot effect and decreases the fluctuations in drug release. Such a versatile and improved formulation of NVP is expected to increase its therapeutic index and alleviate toxic systemic side effects while improving the quality of life and duration of survival of the patients.
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mixed micelles of lecithin Tyloxapol as pharmaceutical nanocarriers for anti tubercular drug delivery
Colloids and Surfaces B: Biointerfaces, 2013Co-Authors: S K Mehta, Neha JindalAbstract:The equimolar mixed micellar system of Lecithin-Tyloxapol has been explored using physicochemical and spectroscopic measurements. Thermodynamic parameters have been computed for the prepared mixed micellar system. Interaction parameter, β, suggests synergistic interactions in the mixed systems. This has been further examined for the solubilization of anti-tuberculosis drugs (ATDs). In addition, the entrapment efficiency of the formulation has been evaluated for three ATDs. Micropolarity measurements indicate location of all the three drugs inside the mixed micellar systems. Fourier transform infrared spectroscopic and differential scanning calorimetric studies infer that the drugs are in harmony with the excipients since no visible interactions between the drugs and mixed micelles have been detected. In vitro release analyses exhibit sustained release of drugs from the formulation. Comparison of regression coefficients of different kinetic models reveal that release of ATDs from mixed micellar system follows first order exponential decay.
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formulation of Tyloxapol niosomes for encapsulation stabilization and dissolution of anti tubercular drugs
Colloids and Surfaces B: Biointerfaces, 2013Co-Authors: S K Mehta, Neha JindalAbstract:Abstract The present study delineates the formulation of niosomes from biocompatible surfactant Tyloxapol and their potential as drug delivery system for anti-tuberculosis drugs. Drug loaded niosomes have a size of 150 nm with a loading efficiency of 97.95 ± 0.2, 98.89 ± 0.2 and 99.50 ± 0.2% for rifampicin (RIF), isoniazid (INH), pyrazinamide (PZA), respectively. Fourier transform infrared spectroscopic studies infer that the drugs are in harmony with the fabricated niosomes since no visible interactions between the drug and niosomes have been detected. The prepared formulations are quite stable as assessed using absorption spectroscopy. TEM images and photoluminescence results reveal that RIF and INH are located in the film bilayer whereas PZA is adsorbed mainly on the surface head groups. In vitro dissolution studies at physiological conditions have been undertaken to compare the release behavior of drugs from the prepared niosomes. Sustained release has been achieved for hydrophilic drugs and an acceptable release in case of RIF. Comparison of regression coefficients of different kinetic models reveal that INH release follows Fickian diffusion mechanism whereas RIF and PZA, a non-Fickian release mechanism. Such a versatile system is expected to reduce dose-related drug toxicity and reach the atelectatic areas.
V S N Rao - One of the best experts on this subject based on the ideXlab platform.
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effect of trans dehydrocrotonin a 19 nor clerodane diterpene from croton cajucara on experimental hypertriglyceridaemia and hypercholesterolaemia induced by triton wr 1339 Tyloxapol in mice
Planta Medica, 2001Co-Authors: Regilane M Silva, F A Santos, Maria Aparecida Medeiros Maciel, Angelo C Pinto, V S N RaoAbstract:The effect of trans-dehydrocrotonin (t-DCTN) from Croton cajucara Benth. was investigated in mice on Triton WR 1339 (Tyloxapol)-induced hypercholesterolaemia and hypertriglyceridaemia. Mice treated with single application of Tyloxapol (400 mg/kg, i.p.) demonstrated significantly increased blood levels of total cholesterol and triglycerides at 24 h and 48 h after its injection, compared to normal controls. These increases were found to be markedly suppressed in animals treated orally with 25 and 50 mg/kg t-DCTN or 100 mg/kg gemfibrozil, an established antihypercholesterolaemic drug. These results suggest that t-DCTN may be a suitable candidate for combating pathologies associated with hyperlipaemia.
Olukayode Adeayo Lawal - One of the best experts on this subject based on the ideXlab platform.
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evaluation of antioxidant and hypolipidaemic effects of fermented parkia biglobosa jacq seeds in Tyloxapol induced hyperlipidaemic rats
African Journal of Food Science, 2014Co-Authors: Rachael Aderonke Ayolawal, Omolaja Osoniyi, Akindele J Famurewa, Olukayode Adeayo LawalAbstract:Globally, fermented foods form an intricate part of the staple diet of people. This study investigated the hypolipidaemic potential of fermented seeds of Parkia biglobosa (African locust bean/iru), a popular condiment by supplementing (20% w/w) in animal feed. Animals (n=5) in six treatment groups received; standard rat diet (control); iru-supplemented feed; standard rat feed with Tyloxapol administered at the end of the experimental period (Tyloxapol control); iru supplemented feed and triton at the end of the experimental period; standard feed with administration of fluvastatin sodium (40 and 80 mg/kg body weight) accordingly. Hyperlipidaemia was induced and ascertained by single intraperitoneal injection of 250 mg/kg triton WR 1339 (Tyloxapol) constituted in normal saline. It was administered after six weeks experimental period to respective groups. The results revealed that addition of the fermented condiment into animals’ feed mitigated increased lipid levels [total cholesterol (TC) and Low-density lipoprotein-cholesterol (LDL-C); triglyceride (TG)] triggered by injection of Tyloxapol. On the other hand, iru caused a significant decrease in plasma and liver total cholesterol (TC), triglyceride (TG), LDL-C (p< 0.05) and increased high-density lipoprotein-cholesterol (HDL)-C levels (p< 0.05). The condiment showed a competitive hypotriglyceridaemic and greater hypocholesterolemic activity in the plasma when compared with fluvastatin at both concentrations. The condiment showed reasonable activities for the entire in vitro antioxidant assays done. Histopathologic examination revealed its hepatoprotective capability. Regular consumption of this condiment may represent a good dietary alternative for control of hyperlipidaemia and associated conditions. Key words: Parkia biglobosa, hyperlipidaemia, total cholesterol, high density lipoproteins-cholesterol, low density lipoproteins-cholesterol, triglyceride, fluvastatin, Tyloxapol.
Xia Xin - One of the best experts on this subject based on the ideXlab platform.
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photoluminescent lyotropic liquid crystals formed by Tyloxapol and n dodecyl tetraethylene monoether
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2018Co-Authors: Xingang Wang, Xia Xin, Han Zhang, Congxin Xia, Liupeng Zhao, Yanji Yin, Yiqiang Zhang, Wei PanAbstract:Abstract Photoluminescent lytropic liquid crystals (LLCs) were prepared in aqueous solutions from n-dodecyl tetraethylene monoether (C12E4) and Tyloxapol, which is an oligomer of polyoxyethylene tert-octylphenyl ether (TX-100) with a polymerization degree below 7. The close packing of the seven benzene rings in Tyloxapol induces a strong π–π interaction, which makes Tyloxapol fluorescent. The Tyloxapol/C12E4 mixed system were characterized by polarized optical microscopy (POM) observations, small-angle X-ray scattering (SAXS), rheological and fluorescence measurements with close comparison to the TX-100/C12E4 mixture. It was found that the type of LLCs transfered gradually from lamellar phase to hexagonal phase with increasing mass ratio of Tyloxapol to C12E4, during which an enhanced photoluminescence was observed. Our results showed that encapsulation of fluorescent molecules into the matrix of traditional surfactants could be an effective way for the preparation of photoluminescent LLCs.
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fluorescent oligomer as a chemosensor for the label free detection of fe 3 and dopamine with selectivity and sensitivity
Analytica Chimica Acta, 2016Co-Authors: Lingli Zhao, Xia Xin, Peng Ding, Aixin Song, Zengchun Xie, Jinglin ShenAbstract:In this article, a sensitive and selective turn-off fluorescence chemosensor, Tyloxapol (one kind of water soluble oligomer), was developed for the label-free detection of Fe(3+) ions in aqueous solution. Fluorescence (FL) experiments demonstrated that Tyloxapol was a sensitive and selective fluorescence sensor for the detection of Fe(3+) directly in water over a wide range of metal cations including Na(+), K(+), Ag(+), Hg(2+), Cd(2+), Co(2+), Cu(2+), Cr(3+), Mn(2+), Ba(2+), Zn(2+), Ni(2+), Mg(2+), Ca(2+), and Pb(2+). Moreover, the fluorescence intensity of Tyloxapol has shown a linear response to Fe(3+) in the concentration range of 0-100 μmol L(-1) with a detection limit of 2.2 μmol L(-1) in aqueous solution. Next, based on a competition mechanism, another turn-on sensing application of the Tyloxapol/Fe(3+) platform to probe dopamine (DA) against various other biological molecules such as other neurotransmitters or amino acids (norepinephrine bitartrate, acetylcholine chloride, alanine, valine, phenylalanine, tyrosine, leucine, glycine, histidine) were also investigated. It is expected that our strategy may offer a new approach for developing simple, cost-effective, rapid and sensitive sensors in biological and environmental applications.
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manipulation the properties of supramolecular hydrogels of α cyclodextrin Tyloxapol carbon based nanomaterials
Journal of Colloid and Interface Science, 2016Co-Authors: Jinglin Shen, Xia Xin, Teng Liu, Lu Tong, Shiling YuanAbstract:Supermolecular hydrogels were prepared by α-cyclodeatrin (α-CD) and Tyloxapol, which can be considered as an oligomer of the nonionic surfactant polyoxyethylene tert-octylphenyl ether (TX-100) with a polymerization degree below 7. Two carbon materials, graphene oxide (GO) and graphene, were mixed into the α-CD/Tyloxapol hydrogel to adjust the physicochemical properties of hydrogel. In order to get stable graphene dispersion and then mix it with α-CD/Tyloxapol hydrogel, both TX-100 and Tyloxapol were used to disperse graphene for comparison. Interestingly, it can be found that TX-100 could disperse graphene better than Tyloxapol owing to smaller molecular size of TX-100 compared with Tyloxapol. Then, both the α-CD/Tyloxapol/GO and α-CD/Tyloxapol/graphene hydrogels were characterized by transmission electron microscopy (TEM), field emission scanning electron microscopy (FE-SEM), Fourier transform infrared (FT-IR) spectroscopy, small angle X-ray scattering (SAXS), X-ray diffraction (XRD) and rheological measurements. The results revealed that the addition of carbon materials into α-CD/Tyloxapol hydrogel can change their microstructures and the rheological properties. Furthermore, it can be confirmed that a little amount of carbon materials could induce fluorescence quenching sharply which could be a promising candidate for optical sensor.
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smart stimuli responsive fluorescent vesicular sensor based on inclusion complexation of cyclodextrins with Tyloxapol
RSC Advances, 2016Co-Authors: Jinglin Shen, Xia Xin, Jinyu Pang, Yingjie Yang, Xiaoyu Luan, Shiling YuanAbstract:Novel fluorescent vesicles based on inclusion complexes of β-cyclodextrins (β-CD) with Tyloxapol were constructed. For comparison, α-cyclodextrins (α-CD) were also selected to form inclusion complexes with Tyloxapol. The vesicles formed by β-CD/Tyloxapol were characterized thoroughly using various techniques including phase behavior observation, transmission electron microscopy (TEM), freeze fracture transmission electron microscopy (FF-TEM), field emission scanning electron microscopy (FE-SEM), atomic force microscopy (AFM), 2D 1H–1H ROESY NMR, fluorescence spectra, Fourier transform infrared (FT-IR) spectroscopy, and X-ray diffraction (XRD). The results of TEM, SEM, FF-TEM, AFM indicated the formation of vesicles of β-CD/Tyloxapol; they presented aggregation-induced emission enhancement properties because the alkyl chain of Tyloxapol molecules enters the cavity of β-CD and forms inclusion complexes, while α-CD/Tyloxapol showed aggregation-induced quenching fluorescence emission properties owing to the interaction between PEO chain of Tyloxapol molecules and α-CD. Moreover, the vesicles of β-CD/Tyloxapol were responsive to external stimuli and their fluorescent intensities were changed by various environmental conditions such as urea, phenylalanine, α-amylase and NaOH. These properties made our vesicle a promising candidate as novel, smart, stimuli-responsive, fluorescent vesicular sensors.
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manipulation of multiple responsive fluorescent supramolecular materials based on the inclusion complexation of cyclodextrins with Tyloxapol
Journal of Materials Chemistry C, 2015Co-Authors: Jinglin Shen, Xia Xin, Jinyu Pang, Xiaoyu Luan, Tomasz Kalwarczyk, Robert Holyst, Yingjie YangAbstract:A fluorescent supramolecular hydrogel was prepared by α-cyclodextrin (α-CD) and Tyloxapol, which can be considered as an oligomer of the nonionic surfactant polyoxyethylene tert-octylphenyl ether (Triton X-100, TX-100) with a polymerization degree below 7. For comparison, both Tyloxapol and TX-100 were selected to form hydrogels with α-CD to get more information about the interaction between different types of surfactants and cyclodextrin. These hydrogels have been thoroughly characterized using various techniques including phase behavior observation, transmission electron microscopy (TEM), field emission scanning electron microscopy (FE-SEM), fluorescence spectra, fluorescence microscopy observations, Fourier transform infrared (FT-IR) spectroscopy, 1H NMR, 2D 1H-1H ROESY NMR, small-angle X-ray scattering (SAXS), X-ray diffraction (XRD) and rheological measurements. The hydrogels of α-CD/Tyloxapol are responsive to external stimuli including temperature, pH and guest molecules, and present gelation-induced quenching fluorescence emission properties. The reason for this phenomenon may be that Tyloxapol molecules come into the cavity of α-CD and form the inclusion complexes. Due to the high electron density of the narrow cavity of α-CD, it induces the shift of the electron on the benzene ring which can weaken the π–π interaction and lead to the fluorescence quenching. Moreover, the hydrogel formed by α-CD/Tyloxapol is highly responsive to the formaldehyde (HCHO). The addition of a small amount of HCHO can induce a gel-to-sol transition. Interestingly, once the gel transforms into solution, it becomes fluorescent. This makes the α-CD/Tyloxapol hydrogel a promising candidate for HCHO detection and removal in home furnishings to reduce indoor environmental pollutants.
