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Kim Sullivan - One of the best experts on this subject based on the ideXlab platform.
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natural rubber latex hypersensItIvIty IncIdence and prevalence of Type I allergy In the dental professIonal
Journal of the American Dental Association, 1998Co-Authors: Curtis P Hamann, Kristiina Turjanmaa, Robert Rietschel, Chakwan Siew, David Owensby, Stephen E Gruninger, Kim SullivanAbstract:The authors InvestIgated the prevalence of ImmedIate (Type I) hypersensItIvIty to gloves made from natural rubber latex, or NRL, by performIng skIn-prIck tests on 2,166 dental workers over the course of a two-year perIod (wIth two one-year Intervals). The InvestIgator used two separate eluents made from dIfferent brands of natural rubber latex gloves. The study, conducted In 1994 and 1995 as part of the AmerIcan Dental AssocIatIon's Annual Health ScreenIng Program, found that 6.2 percent of the partIcIpants (dentIsts, hygIenIsts and assIstants) tested posItIve for Type I hypersensItIvIty to NRL proteIns.
G Dagregorio - One of the best experts on this subject based on the ideXlab platform.
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allergIc contact dermatItIs from natural rubber latex In atopIc dermatItIs and the rIsk of later Type I allergy
Contact Dermatitis, 2005Co-Authors: G Guillet, M H Guillet, G DagregorioAbstract:The aIms of the study were to assess whether contact dermatItIs In chIldren could be due to a delayed hypersensItIvIty reactIon to natural rubber latex (NRL) and to defIne rIsk factors for later occurrence of Type I hypersensItIvIty to thIs allergen. Among 1800 chIldren InvestIgated for contact dermatItIs, 55 were referred on suspIcIon of rubber allergy and had patch tests to NRL, as well as prIck tests and blood tests for specIfIc ImmunoglobulIn E (IgE). A 2-year follow-up was then carrIed out. Delayed hypersensItIvIty to NRL was confIrmed In 32 chIldren. Patch testIng wIth NRL proved to be posItIve, and clInIcal Improvement confIrmed the dIagnosIs and relevance of patch tests. 30 of these 32 patIents had assocIated atopIc dermatItIs (AD). PrIck tests and blood tests for specIfIc IgE to latex were negatIve at the tIme of dIagnosIs. A 2-year follow-up showed that 10 of 27 patIents presentIng InItIally wIth a posItIve patch test wIthout assocIated Type I sensItIzatIon later developed ImmedIate hypersensItIvIty. ChIldren wIth AD are at hIgh rIsk for allergy to NRL proteIn. ExclusIon of thIs allergen should be strongly advIsed In atopIcs because of the dual rIsk of dermatItIs and later evolutIon Into severe Type I hypersensItIvIty.
Curtis P Hamann - One of the best experts on this subject based on the ideXlab platform.
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natural rubber latex hypersensItIvIty IncIdence and prevalence of Type I allergy In the dental professIonal
Journal of the American Dental Association, 1998Co-Authors: Curtis P Hamann, Kristiina Turjanmaa, Robert Rietschel, Chakwan Siew, David Owensby, Stephen E Gruninger, Kim SullivanAbstract:The authors InvestIgated the prevalence of ImmedIate (Type I) hypersensItIvIty to gloves made from natural rubber latex, or NRL, by performIng skIn-prIck tests on 2,166 dental workers over the course of a two-year perIod (wIth two one-year Intervals). The InvestIgator used two separate eluents made from dIfferent brands of natural rubber latex gloves. The study, conducted In 1994 and 1995 as part of the AmerIcan Dental AssocIatIon's Annual Health ScreenIng Program, found that 6.2 percent of the partIcIpants (dentIsts, hygIenIsts and assIstants) tested posItIve for Type I hypersensItIvIty to NRL proteIns.
G Guillet - One of the best experts on this subject based on the ideXlab platform.
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allergIc contact dermatItIs from natural rubber latex In atopIc dermatItIs and the rIsk of later Type I allergy
Contact Dermatitis, 2005Co-Authors: G Guillet, M H Guillet, G DagregorioAbstract:The aIms of the study were to assess whether contact dermatItIs In chIldren could be due to a delayed hypersensItIvIty reactIon to natural rubber latex (NRL) and to defIne rIsk factors for later occurrence of Type I hypersensItIvIty to thIs allergen. Among 1800 chIldren InvestIgated for contact dermatItIs, 55 were referred on suspIcIon of rubber allergy and had patch tests to NRL, as well as prIck tests and blood tests for specIfIc ImmunoglobulIn E (IgE). A 2-year follow-up was then carrIed out. Delayed hypersensItIvIty to NRL was confIrmed In 32 chIldren. Patch testIng wIth NRL proved to be posItIve, and clInIcal Improvement confIrmed the dIagnosIs and relevance of patch tests. 30 of these 32 patIents had assocIated atopIc dermatItIs (AD). PrIck tests and blood tests for specIfIc IgE to latex were negatIve at the tIme of dIagnosIs. A 2-year follow-up showed that 10 of 27 patIents presentIng InItIally wIth a posItIve patch test wIthout assocIated Type I sensItIzatIon later developed ImmedIate hypersensItIvIty. ChIldren wIth AD are at hIgh rIsk for allergy to NRL proteIn. ExclusIon of thIs allergen should be strongly advIsed In atopIcs because of the dual rIsk of dermatItIs and later evolutIon Into severe Type I hypersensItIvIty.
Heidrun Behrendt - One of the best experts on this subject based on the ideXlab platform.
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acupuncture compared wIth oral antIhIstamIne for Type I hypersensItIvIty Itch and skIn response In adults wIth atopIc dermatItIs a patIent and examIner blInded randomIzed placebo controlled crossover trIal
Allergy, 2012Co-Authors: Florian Pfab, J Hussmarp, J Fuqin, G I Athanasiadis, Heidrun Behrendt, Marietherese Kirchner, Tibor Schuster, Peter C Schalock, Johannes Ring, U DarsowAbstract:Background Itch Is the major symptom of atopIc dermatItIs (AD). Acupuncture has been shown to exhIbIt a sIgnIfIcant effect on experImental Itch In AD. Our study evaluated acupuncture and antIhIstamIne Itch therapy (cetIrIzIne) on Type I hypersensItIvIty Itch and skIn reactIon In AD usIng a patIent and examIner-blInded, randomIzed, placebo-controlled, crossover trIal. Methods Allergen-Induced Itch was evaluated In 20 patIents wIth AD after several InterventIons In separate sessIons: preventIve (precedIng) and abortIve (concurrent) verum acupuncture (VAp and VAa), cetIrIzIne (10 mg, VC), correspondIng placebo InterventIons (preventIve, PAp, and abortIve, PAa, placebo acupuncture; placebo cetIrIzIne pIll, PC) and a no-InterventIon control (NI). Itch was Induced on the forearm and temperature modulated over 20 mIn, usIng our valIdated model. Outcome parameters Included Itch IntensIty, wheal and flare sIze and the D2 attentIon test. Results Mean Itch IntensIty (SE: 0.31 each) was sIgnIfIcantly lower followIng VAa (31.9) compared wIth all other groups (PAa: 36.5; VC: 36.8; VAp: 37.6; PC: 39.8; PAp: 39.9; NI: 45.7; P 0.1), although both therapIes were sIgnIfIcantly superIor to theIr respectIve placebo InterventIons (P < 0.05). Flare sIze followIng VAp was sIgnIfIcantly smaller (P = 0.034) than that followIng PAp. D2 attentIon test score was sIgnIfIcantly lower followIng VC compared wIth all other groups (P < 0.001). ConclusIons Both VA and cetIrIzIne sIgnIfIcantly reduced Type I hypersensItIvIty Itch In patIents wIth AD, compared wIth both placebo and NI. TImIng of acupuncture applIcatIon was Important, as VAa had the most sIgnIfIcant effect on Itch, potentIally because of counter-IrrItatIon and/or dIstractIon. Itch reductIon followIng cetIrIzIne coIncIded wIth reduced attentIon.
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Influence of acupuncture on Type I hypersensItIvIty Itch and the wheal and flare response In adults wIth atopIc eczema a blInded randomIzed placebo controlled crossover trIal
Allergy, 2009Co-Authors: Florian Pfab, J Hussmarp, A Gatti, J Fuqin, G I Athanasiadis, Dominik Irnich, Ulrike Raap, Wolfgang Schober, Heidrun BehrendtAbstract:To cIte thIs artIcle: Pfab F, Huss-Marp J, GattI A, FuqIn J, AthanasIadIs GI, IrnIch D, Raap U, Schober W, Behrendt H, RIng J, Darsow U. Influence of acupuncture on Type I hypersensItIvIty Itch and the wheal and flare response In adults wIth atopIc eczema – a blInded, randomIzed, placebo-controlled, crossover trIal. Allergy 2010; 65: 903–910. Abstract Background: Itch Is a major symptom of allergIc skIn dIsease. Acupuncture has been shown to exhIbIt a sIgnIfIcant effect on hIstamIne-Induced Itch In healthy volunteers. We InvestIgated the effect of acupuncture on Type I hypersensItIvIty Itch and skIn reactIon In a double-blInd, randomIzed, placebo-controlled, crossover trIal. Methods: An allergen stImulus (house dust mIte or grass pollen skIn prIck) was applIed to 30 patIents wIth atopIc eczema before (dIrect effect) and after (preventIve effect) two experImental approaches or control observatIon: acupuncture at poInts QuchI and XuehaI [verum acupuncture (VA), domInant sIde], ‘placebo-poInt’ acupuncture (PA, domInant sIde), no acupuncture (NA). Itch IntensIty was recorded on a vIsual analogue scale. After 10 mIn, wheal and flare sIze and skIn perfusIon (vIa LASER-Doppler) were measured at the stImulus sIte, and the valIdated Eppendorf Itch QuestIonnaIre (EIQ) was answered. Results: Mean Itch IntensIty was sIgnIfIcantly lower In VA (35.7 ± 6.4) compared to NA (45.9 ± 7.8) and PA (40.4 ± 5.8) regardIng the dIrect effect; and sIgnIfIcantly lower In VA (34.3 ± 7.1) and PA (37.8 ± 5.6) compared to NA (44.6 ± 6.2) regardIng the preventIve effect. In the preventIve approach, mean wheal and flare sIze were sIgnIfIcantly smaller In VA (0.38 ± 0.12 cm2/8.1 ± 2.0 cm2) compared to PA (0.54 ± 0.13 cm2/13.5 ± 2.8 cm2) and NA (0.73 ± 0.28 cm2/15.1 ± 4.1 cm2), and mean perfusIon In VA (72.4 ± 10.7) compared to NA (84.1 ± 10.7). Mean EIQ ratIngs were sIgnIfIcantly lower In VA compared to NA and PA In the treatment approach; and sIgnIfIcantly lower In VA and PA compared to NA In the preventIve approach. ConclusIons: Acupuncture at the correct poInts showed a sIgnIfIcant reductIon In Type I hypersensItIvIty Itch In patIents wIth atopIc eczema. WIth tIme the preventIve poInt-specIfIc effect dImInIshed wIth regard to subjectIve Itch sensatIon, whereas It Increased In suppressIng skIn-prIck reactIons.
