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Zelaya Araniva, Sindy Margarita - One of the best experts on this subject based on the ideXlab platform.
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“Eosinofilia en sangre periférica como marcador de exacerbación asmática en pacientes mayores de 12 años ingresados en el Hospital San Juan de Dios de San Miguel de enero a diciembre de 2019”.
2021Co-Authors: Cruz Cruz, Ramón Rigoberto, Zelaya Araniva, Sindy MargaritaAbstract:RESUMEN: La crisis de asma es un episodio de progresiva o repentina dificultad para respirar, con disnea, tos o sensación de opresión torácica o una combinación de estos síntomas, en la cual participan células con diferentes implicaciones en el proceso fisiopatológico de la misma, una de estas, y la más estudiada es la eosinofilia, definida como un recuento de eosinófilos en sangre periférica mayor de 400/ microLitro. En El Salvador según las estadísticas del Ministerio de Salud el 10 % de la población salvadoreña padece o ha padecido algún tipo de asma. Sólo el año pasado se produjeron 5,391 egresos hospitalarios por ese padecimiento, de los cuales 2,883 son niños entre las edades de 0 a 9 años, seguidas por 1,253 personas de 20 a 59 años. OBJETIVO GENERAL: Mostrar que la eosinofilia en sangre periférica es un marcador presente de exacerbación asmática en pacientes mayores de 12 años ingresados en el Hospital San Juan de Dios de San Miguel de Enero a diciembre de 2019. METODOLOGIA: Estudio epidemiológico, descriptivo, transversal, retrospectivo en el cual se aplicará criterios de inclusión y exclusión. RESULTADOS ESPERADOS: establecer el perfil clínico y epidemiológico de los pacientes con diagnóstico de asma y la relación entre la eosinofilia y la severidad de las crisis asmàticas. IMPACTO: Mejorar la calidad de atención y seguimiento del paciente asmático tanto a nivel hospitalario y comunitario y redirigir estrategias terapéuticas y de seguimiento. ABSTRACT: The Asthma attack is an episode of progressive or sudden difficulty in breathing, with dyspnea, cough or a sensation of chest tightness or a combination of these symptoms, in which cells participate with different implications in the pathophysiological process of the same, one of these , and the most studied is eosinophilia, defined as a peripheral blood eosinophil count greater than 400 / microLiter. In El Salvador, according to the statistics of the Ministry of Health, 10% of the Salvadoran population suffers or has suffered from some Type of Asthma. Only last year there were 5,391 hospital discharges for this condition, of which 2,883 are children between the ages of 0 to 9 years, followed by 1,253 people between 20 and 59 years old. GENERAL OBJECTIVE: To show that eosinophilia in peripheral blood is a present marker of Asthmatic exacerbation in patients older than 12 years admitted to the San Juan de Dios Hospital in San Miguel from January to December 2019. METHODOLOGY: Epidemiological, descriptive, study cross-sectional, retrospective in which inclusion and exclusion criteria will be applied. EXPECTED RESULTS: establish the clinical and epidemiological profile of patients diagnosed with Asthma and the relationship between eosinophilia and the severity of Asthma attacks. IMPACT: Improve the quality of care and monitoring of Asthmatic patients both at the hospital and community level and redirect therapeutic and monitoring strategie
Cruz Cruz, Ramón Rigoberto - One of the best experts on this subject based on the ideXlab platform.
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“Eosinofilia en sangre periférica como marcador de exacerbación asmática en pacientes mayores de 12 años ingresados en el Hospital San Juan de Dios de San Miguel de enero a diciembre de 2019”.
2021Co-Authors: Cruz Cruz, Ramón Rigoberto, Zelaya Araniva, Sindy MargaritaAbstract:RESUMEN: La crisis de asma es un episodio de progresiva o repentina dificultad para respirar, con disnea, tos o sensación de opresión torácica o una combinación de estos síntomas, en la cual participan células con diferentes implicaciones en el proceso fisiopatológico de la misma, una de estas, y la más estudiada es la eosinofilia, definida como un recuento de eosinófilos en sangre periférica mayor de 400/ microLitro. En El Salvador según las estadísticas del Ministerio de Salud el 10 % de la población salvadoreña padece o ha padecido algún tipo de asma. Sólo el año pasado se produjeron 5,391 egresos hospitalarios por ese padecimiento, de los cuales 2,883 son niños entre las edades de 0 a 9 años, seguidas por 1,253 personas de 20 a 59 años. OBJETIVO GENERAL: Mostrar que la eosinofilia en sangre periférica es un marcador presente de exacerbación asmática en pacientes mayores de 12 años ingresados en el Hospital San Juan de Dios de San Miguel de Enero a diciembre de 2019. METODOLOGIA: Estudio epidemiológico, descriptivo, transversal, retrospectivo en el cual se aplicará criterios de inclusión y exclusión. RESULTADOS ESPERADOS: establecer el perfil clínico y epidemiológico de los pacientes con diagnóstico de asma y la relación entre la eosinofilia y la severidad de las crisis asmàticas. IMPACTO: Mejorar la calidad de atención y seguimiento del paciente asmático tanto a nivel hospitalario y comunitario y redirigir estrategias terapéuticas y de seguimiento. ABSTRACT: The Asthma attack is an episode of progressive or sudden difficulty in breathing, with dyspnea, cough or a sensation of chest tightness or a combination of these symptoms, in which cells participate with different implications in the pathophysiological process of the same, one of these , and the most studied is eosinophilia, defined as a peripheral blood eosinophil count greater than 400 / microLiter. In El Salvador, according to the statistics of the Ministry of Health, 10% of the Salvadoran population suffers or has suffered from some Type of Asthma. Only last year there were 5,391 hospital discharges for this condition, of which 2,883 are children between the ages of 0 to 9 years, followed by 1,253 people between 20 and 59 years old. GENERAL OBJECTIVE: To show that eosinophilia in peripheral blood is a present marker of Asthmatic exacerbation in patients older than 12 years admitted to the San Juan de Dios Hospital in San Miguel from January to December 2019. METHODOLOGY: Epidemiological, descriptive, study cross-sectional, retrospective in which inclusion and exclusion criteria will be applied. EXPECTED RESULTS: establish the clinical and epidemiological profile of patients diagnosed with Asthma and the relationship between eosinophilia and the severity of Asthma attacks. IMPACT: Improve the quality of care and monitoring of Asthmatic patients both at the hospital and community level and redirect therapeutic and monitoring strategie
Rasool Choopani* - One of the best experts on this subject based on the ideXlab platform.
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UTERINE Asthma: A Type of Asthma DESCRIBED IN TRADITIONAL PERSIAN MEDICINE
2017Co-Authors: Sohrab Dehghan, Seyyed Shamsadin Athari, Saeed Sadr, Zahra Gorji, Rasool Choopani*Abstract:Background: Asthma is becoming a major health issue globally. Despite a range of short and long acting agents for the management of acute and chronic Asthma, these are not effective on all patients. This encouraged us to find other mechanisms for the treatment of this disease. The aim of this study was to present the uterine conditions which can play a role in development of Asthma. Traditional Persian Medicine (TPM) describes a Type of inter-organ relationship in the form of uterine Asthma, in which the Asthma symptoms are a result of uterine ailments. Hence, the management of uterine Asthma depends on controlling the uterine problem first. Methods: In this review, we searched the major TPM manuscripts and compared our findings with modern studies by searching databases such as PubMed, Scopus, and Google Scholar. Results: Two uterine ailments can show symptoms of Asthma. These are ‘Ehtebase tams’ (amenorrhea, oligomenorrhea, and hypomenorrhea), and ‘Ekhtenaghe rahem’ (uterine strangulation or respiratory and neuropsychiatric symptoms of uterine origin). Each of these has its own set of symptoms. Through the association mechanism described in TPM, they can result in symptoms of Asthma. Conclusion: New medical studies support the relationship between menstrual irregularity and Asthma symptoms. In addition, there is new evidence to suggest that distant organs in the body are connected to each other through a special network, a concept that is mentioned in TPM manuscripts. Further investigations in the near future can help us better understand these relationships, especially in the field of Asthma. Keywords: Asthma, Traditional Persian Medicine, Menstruation, Uteru
Sibila O - One of the best experts on this subject based on the ideXlab platform.
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Asthma with bronchial hypersecretion: expression of mucins and toll-like receptors in sputum and blood
Dove Medical Press, 2017Co-Authors: Crespo-lessmann A, Mateus E, Torrejón M, Belda A, Giner J, Vidal S, Sibila OAbstract:Astrid Crespo-Lessmann,1 Eder Mateus,1,2 Montserrat Torrejón,1 Alicia Belda,1 Jordi Giner,1 Silvia Vidal,2 Oriol Sibila,1 Vicente Plaza,1 1Service of Pneumology, Hospital de la Santa Ceu i Sant Pau, Institute of Sant Pau Biomedical Research (IBB Sant Pau), Universitat Autònoma de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), 2Department of Immunology, Hospital de la Santa Creu i Sant Pau, Institut d’Investigació Biomédica Sant Pau, Barcelona, Spain Abstract: Asthma with bronchial hypersecretion is a Type of Asthma that is poorly studied. Its pathogenesis is not well understood, but is probably related to innate impaired immunity, particularly with toll-like receptors (TLRs) and secretory mucins (MUC). Objectives: 1) Define the clinical and inflammatory phenoType of Asthma with bronchial hypersecretion of mucus. 2) Compare the Type of mucin present in induced sputum (IS) of patients with and without bronchial hypersecretion. 3) Determine the expression of TLRs in IS and blood of Asthmatics with and without bronchial hypersecretion. Materials and methods: Cross-sectional study which included 43 non-smoking Asthmatic patients without bronchiectasis, 19 with bronchiectasis, and 24 without bronchial hypersecretion. All patients underwent the following: IS, spirometry, fractional exhaled nitric oxide, prick test, total immunoglobulin E (IgE), and blood albumin. Analysis of mucins was determined by ELISA and expression of TLR2 and TLR4 by flow cytometry. The level of Asthma control was determined by the Asthma Control Test (ACT) questionnaire and quality of life was assessed by the reduced version of the Asthma Quality of Life Questionnaire (mini-AQLQ). Results: Asthmatics with bronchial hypersecretion were significantly older (62.6 years vs 48.5 years; p=0.02); had greater severity (persistent severe Asthma 94.7% vs 29.2%; p=0.000); a higher proportion of nasal polyposis (36.8% vs 8.3%; p=0.022); less control of Asthma (73.7% vs 8.3%; p=0,000); a higher proportion of Asthma with negative prick test (68.4% vs 16.6%; p=0.001), and lower levels of IgE (113.4 IU/mL vs 448 IU/mL; p=0.007), compared with Asthmatics without bronchial hypersecretion. Significant differences were observed neither in the expression of TLRs 2 and 4 in inflammatory cells of IS or peripheral blood, nor in the expression of mucins between both groups. Conclusion: Asthma patients with bronchial hypersecretion have more severe and uncontrolled disease, with poor quality of life as well as a non-allergic inflammatory phenoType. Within the mechanisms involving these differences, it does not appear that mucins and TLRs play an important role. Keywords: Asthma, mucins, inflammation, induced sputum, toll-like recepto
Sohrab Dehghan - One of the best experts on this subject based on the ideXlab platform.
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UTERINE Asthma: A Type of Asthma DESCRIBED IN TRADITIONAL PERSIAN MEDICINE
2017Co-Authors: Sohrab Dehghan, Seyyed Shamsadin Athari, Saeed Sadr, Zahra Gorji, Rasool Choopani*Abstract:Background: Asthma is becoming a major health issue globally. Despite a range of short and long acting agents for the management of acute and chronic Asthma, these are not effective on all patients. This encouraged us to find other mechanisms for the treatment of this disease. The aim of this study was to present the uterine conditions which can play a role in development of Asthma. Traditional Persian Medicine (TPM) describes a Type of inter-organ relationship in the form of uterine Asthma, in which the Asthma symptoms are a result of uterine ailments. Hence, the management of uterine Asthma depends on controlling the uterine problem first. Methods: In this review, we searched the major TPM manuscripts and compared our findings with modern studies by searching databases such as PubMed, Scopus, and Google Scholar. Results: Two uterine ailments can show symptoms of Asthma. These are ‘Ehtebase tams’ (amenorrhea, oligomenorrhea, and hypomenorrhea), and ‘Ekhtenaghe rahem’ (uterine strangulation or respiratory and neuropsychiatric symptoms of uterine origin). Each of these has its own set of symptoms. Through the association mechanism described in TPM, they can result in symptoms of Asthma. Conclusion: New medical studies support the relationship between menstrual irregularity and Asthma symptoms. In addition, there is new evidence to suggest that distant organs in the body are connected to each other through a special network, a concept that is mentioned in TPM manuscripts. Further investigations in the near future can help us better understand these relationships, especially in the field of Asthma. Keywords: Asthma, Traditional Persian Medicine, Menstruation, Uteru
