The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Rajal B Shah - One of the best experts on this subject based on the ideXlab platform.
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An Optimal Immunohistochemical Panel to Distinguish Poorly Differentiated Prostate Adenocarcinoma From Urothelial Carcinoma
2016Co-Authors: Lakshmi P Kunju, Rohit Mehra, Matthew Snyder, Rajal B ShahAbstract:An optimal immunohistochemical panel to distinguish poorly differentiated prostate (PCa) from urothelial (Uca) carcinoma was selected from a panel consisting of prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP), high-molecular-weight cytokeratin (HMWCK) (clone 34βE12), cytokeratin (CK) 7, CK20, p63, and α-methylacyl-coenzyme A racemase. The pilot group was composed of poorly differentiated Uca (n = 36) and PCa (n = 42). PSA and PAP stained 95 % of PCa vs 0 % and 11% of Uca cases, respectively. HMWCK and p63 stained 97 % and 92 % of Uca vs 2 % and 0 % of PCa cases respectively. CK7/CK20 coexpression was noted in 50 % of Uca cases, whereas 86 % of PCa cases were negative with both. A panel of PSA, HMWCK, and p6
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prostate specific antigen high molecular weight cytokeratin clone 34βe12 and or p63 an optimal immunohistochemical panel to distinguish poorly differentiated prostate adenocarcinoma from urothelial carcinoma
American Journal of Clinical Pathology, 2006Co-Authors: Lakshmi P Kunju, Rohit Mehra, Matthew L Snyder, Rajal B ShahAbstract:An optimal immunohistochemical panel to distinguish poorly differentiated prostate (PCa) from urothelial (Uca) carcinoma was selected from a panel consisting of prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP), high-molecular-weight cytokeratin (HMWCK), clone 34betaE12, cytokeratin (CK) 7, CK20, p63, and alpha-methylacyl-coenzyme A racemase. The pilot group was composed of poorly differentiated Uca (n = 36) and PCa (n = 42). PSA and PAP stained 95% of PCa vs 0% and 11% of Uca cases, respectively. HMWCK and p63 stained 97% and 92% of Uca vs 2% and 0% of PCa cases respectively. CK7/CK20 coexpression was noted in 50% of Uca cases, whereas 86% of PCa cases were negative with both. A panel of PSA, HMWCK, and p63 was optimal for separating 95% PCa (PSA+/HMWCK and/or p63-) vs 97% Uca (PSA-/HMWCK and/or p63+). This panel was used on 26 diagnostically challenging cases and resolved 81% of cases as Uca vs PCa. The majority of PCa cases retain PSA. Negative PSA with positive HMWCK and/or p63 establishes a diagnosis of Uca.
Shigehiko Ogoh - One of the best experts on this subject based on the ideXlab platform.
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differential blood flow responses to co2 in human internal and external carotid and vertebral arteries
The Journal of Physiology, 2012Co-Authors: Kohei Sato, Shigehiko Ogoh, Ai Hirasawa, Anna Oue, Tomoko Sadamoto, Andrew W Subudhi, Taiki MiyazawaAbstract:Arterial CO2 serves as a mediator of cerebral blood flow(CBF), and its relative influence on the regulation of CBF is defined as cerebral CO2 reactivity. Our previous studies have demonstrated that there are differences in CBF responses to physiological stimuli (i.e. dynamic exercise and orthostatic stress) between arteries in humans. These findings suggest that dynamic CBF regulation and cerebral CO2 reactivity may be different in the anterior and posterior cerebral circulation. The aim of this study was to identify cerebral CO2 reactivity by measuring blood flow and examine potential differences in CO2 reactivity between the internal carotid artery (ICA), external carotid artery (ECA) and vertebral artery (VA). In 10 healthy young subjects, we evaluated the ICA, ECA, and VA blood flow responses by duplex ultrasonography (Vivid-e, GE Healthcare), and mean blood flow velocity in middle cerebral artery (MCA) and basilar artery (BA) by transcranial Doppler (Vivid-7, GE healthcare) during two levels of hypercapnia (3% and 6% CO2), normocapnia and hypocapnia to estimate CO2 reactivity. To characterize cerebrovascular reactivity to CO2,we used both exponential and linear regression analysis between CBF and estimated partial pressure of arterial CO2, calculated by end-tidal partial pressure of CO2. CO2 reactivity in VA was significantly lower than in ICA (coefficient of exponential regression 0.021 ± 0.008 vs. 0.030 ± 0.008; slope of linear regression 2.11 ± 0.84 vs. 3.18 ± 1.09% mmHg−1: VA vs. ICA, P <0.01). Lower CO2 reactivity in the posterior cerebral circulation was persistent in distal intracranial arteries (exponent 0.023 ± 0.006 vs. 0.037 ± 0.009; linear 2.29 ± 0.56 vs. 3.31 ± 0.87% mmHg−1: BA vs. MCA). In contrast, CO2 reactivity in ECA was markedly lower than in the intra-cerebral circulation (exponent 0.006 ± 0.007; linear 0.63 ± 0.64% mmHg−1, P <0.01). These findings indicate that vertebro-basilar circulation has lower CO2 reactivity than internal carotid circulation, and that CO2 reactivity of the external carotid circulation is markedly diminished compared to that of the cerebral circulation, which may explain different CBF responses to physiological stress.
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the distribution of blood flow in the carotid and vertebral arteries during dynamic exercise in humans
The Journal of Physiology, 2011Co-Authors: Kohei Sato, Shigehiko Ogoh, Ai Hirasawa, Anna Oue, Tomoko SadamotoAbstract:The mechanism underlying the plateau or relative decrease in cerebral blood flow (CBF) during maximal incremental dynamic exercise remains unclear. We hypothesized that cerebral perfusion is limited during high-intensity dynamic exercise due to a redistribution of carotid artery blood flow. To identify the distribution of blood flow among the arteries supplying the head and brain, we evaluated common carotid artery (CCA), internal carotid artery (ICA), external carotid artery (ECA) and vertebral artery (VA) blood flow during dynamic exercise using Doppler ultrasound. Ten subjects performed graded cycling exercise in a semi-supine position at 40, 60 and 80% of peak oxygen uptake (VO2 peak) for 5 min at each workload. The ICA blood flow increased by 23.0 ± 4.6% (mean ± SE) from rest to exercise at 60% (VO2 peak). However, at 80% (VO2 peak), ICA blood flow returned towards near resting levels (9.6 ± 4.7% vs. rest). In contrast, ECA, CCA and VA blood flow increased proportionally with workload. The change in ICA blood flow during graded exercise was correlated with end-tidal partial pressure of CO2 (r = 0.72). The change in ICA blood flow from 60% (VO2 peak) to 80% (VO2 peak) was negatively correlated with the change in ECA blood flow (r = −0.77). Moreover, there was a significant correlation between forehead cutaneous vascular conductance and ECA blood flow during exercise (r = 0.79). These results suggest that during high-intensity dynamic exercise the plateau or decrease in ICA blood flow is partly due to a large increase in ECA blood flow, which is selectively increased to prioritize thermoregulation.
Lakshmi P Kunju - One of the best experts on this subject based on the ideXlab platform.
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An Optimal Immunohistochemical Panel to Distinguish Poorly Differentiated Prostate Adenocarcinoma From Urothelial Carcinoma
2016Co-Authors: Lakshmi P Kunju, Rohit Mehra, Matthew Snyder, Rajal B ShahAbstract:An optimal immunohistochemical panel to distinguish poorly differentiated prostate (PCa) from urothelial (Uca) carcinoma was selected from a panel consisting of prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP), high-molecular-weight cytokeratin (HMWCK) (clone 34βE12), cytokeratin (CK) 7, CK20, p63, and α-methylacyl-coenzyme A racemase. The pilot group was composed of poorly differentiated Uca (n = 36) and PCa (n = 42). PSA and PAP stained 95 % of PCa vs 0 % and 11% of Uca cases, respectively. HMWCK and p63 stained 97 % and 92 % of Uca vs 2 % and 0 % of PCa cases respectively. CK7/CK20 coexpression was noted in 50 % of Uca cases, whereas 86 % of PCa cases were negative with both. A panel of PSA, HMWCK, and p6
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prostate specific antigen high molecular weight cytokeratin clone 34βe12 and or p63 an optimal immunohistochemical panel to distinguish poorly differentiated prostate adenocarcinoma from urothelial carcinoma
American Journal of Clinical Pathology, 2006Co-Authors: Lakshmi P Kunju, Rohit Mehra, Matthew L Snyder, Rajal B ShahAbstract:An optimal immunohistochemical panel to distinguish poorly differentiated prostate (PCa) from urothelial (Uca) carcinoma was selected from a panel consisting of prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP), high-molecular-weight cytokeratin (HMWCK), clone 34betaE12, cytokeratin (CK) 7, CK20, p63, and alpha-methylacyl-coenzyme A racemase. The pilot group was composed of poorly differentiated Uca (n = 36) and PCa (n = 42). PSA and PAP stained 95% of PCa vs 0% and 11% of Uca cases, respectively. HMWCK and p63 stained 97% and 92% of Uca vs 2% and 0% of PCa cases respectively. CK7/CK20 coexpression was noted in 50% of Uca cases, whereas 86% of PCa cases were negative with both. A panel of PSA, HMWCK, and p63 was optimal for separating 95% PCa (PSA+/HMWCK and/or p63-) vs 97% Uca (PSA-/HMWCK and/or p63+). This panel was used on 26 diagnostically challenging cases and resolved 81% of cases as Uca vs PCa. The majority of PCa cases retain PSA. Negative PSA with positive HMWCK and/or p63 establishes a diagnosis of Uca.
Meselech Ambaw Dessie - One of the best experts on this subject based on the ideXlab platform.
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The superior thyroid artery arising from common carotid artery bifurcation at the level of the lamina of thyroid cartilage; CCA = Common carotid artery, ECA = External carotid artery, ICA = Internal carotid artery, STA = Superior thyroid artery, STV
2018Co-Authors: Meselech Ambaw DessieAbstract:The superior thyroid artery arising from common carotid artery bifurcation at the level of the lamina of thyroid cartilage; CCA = Common carotid artery, ECA = External carotid artery, ICA = Internal carotid artery, STA = Superior thyroid artery, STV = Superior thyroid vein, EBSLN = External branch of the superior laryngeal nerve.
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The superior thyroid artery arising from the external carotid artery and EBSLN near the upper pole of the thyroid gland; CCA = Common carotid artery, ECA = External carotid artery, ICA = Internal carotid artery, IJV = Internal jugular vein, SLA = Sup
2018Co-Authors: Meselech Ambaw DessieAbstract:The superior thyroid artery arising from the external carotid artery and EBSLN near the upper pole of the thyroid gland; CCA = Common carotid artery, ECA = External carotid artery, ICA = Internal carotid artery, IJV = Internal jugular vein, SLA = Superior laryngeal artery, EBSLN = External branch of the superior laryngeal nerve.
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The superior thyroid artery arising from the common carotid artery at the level of the lamina of thyroid cartilage; CCA = Common carotid artery, ECA = External carotid artery, ICA = Internal carotid artery, STA = Superior thyroid artery, EBSLN = Exte
2018Co-Authors: Meselech Ambaw DessieAbstract:The superior thyroid artery arising from the common carotid artery at the level of the lamina of thyroid cartilage; CCA = Common carotid artery, ECA = External carotid artery, ICA = Internal carotid artery, STA = Superior thyroid artery, EBSLN = External branch of the superior laryngeal nerve.
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STA arising from the lingual artery and EBSLN passing posterior to it after removal of posterior belly of digastric and hypoglossal nerve; CCA = Common carotid artery, ECA = External carotid artery, ICA = Internal carotid artery, STA = Superior thyro
2018Co-Authors: Meselech Ambaw DessieAbstract:STA arising from the lingual artery and EBSLN passing posterior to it after removal of posterior belly of digastric and hypoglossal nerve; CCA = Common carotid artery, ECA = External carotid artery, ICA = Internal carotid artery, STA = Superior thyroid artery, EBSLN = External branch of superior laryngeal nerve.
Rohit Mehra - One of the best experts on this subject based on the ideXlab platform.
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An Optimal Immunohistochemical Panel to Distinguish Poorly Differentiated Prostate Adenocarcinoma From Urothelial Carcinoma
2016Co-Authors: Lakshmi P Kunju, Rohit Mehra, Matthew Snyder, Rajal B ShahAbstract:An optimal immunohistochemical panel to distinguish poorly differentiated prostate (PCa) from urothelial (Uca) carcinoma was selected from a panel consisting of prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP), high-molecular-weight cytokeratin (HMWCK) (clone 34βE12), cytokeratin (CK) 7, CK20, p63, and α-methylacyl-coenzyme A racemase. The pilot group was composed of poorly differentiated Uca (n = 36) and PCa (n = 42). PSA and PAP stained 95 % of PCa vs 0 % and 11% of Uca cases, respectively. HMWCK and p63 stained 97 % and 92 % of Uca vs 2 % and 0 % of PCa cases respectively. CK7/CK20 coexpression was noted in 50 % of Uca cases, whereas 86 % of PCa cases were negative with both. A panel of PSA, HMWCK, and p6
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prostate specific antigen high molecular weight cytokeratin clone 34βe12 and or p63 an optimal immunohistochemical panel to distinguish poorly differentiated prostate adenocarcinoma from urothelial carcinoma
American Journal of Clinical Pathology, 2006Co-Authors: Lakshmi P Kunju, Rohit Mehra, Matthew L Snyder, Rajal B ShahAbstract:An optimal immunohistochemical panel to distinguish poorly differentiated prostate (PCa) from urothelial (Uca) carcinoma was selected from a panel consisting of prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP), high-molecular-weight cytokeratin (HMWCK), clone 34betaE12, cytokeratin (CK) 7, CK20, p63, and alpha-methylacyl-coenzyme A racemase. The pilot group was composed of poorly differentiated Uca (n = 36) and PCa (n = 42). PSA and PAP stained 95% of PCa vs 0% and 11% of Uca cases, respectively. HMWCK and p63 stained 97% and 92% of Uca vs 2% and 0% of PCa cases respectively. CK7/CK20 coexpression was noted in 50% of Uca cases, whereas 86% of PCa cases were negative with both. A panel of PSA, HMWCK, and p63 was optimal for separating 95% PCa (PSA+/HMWCK and/or p63-) vs 97% Uca (PSA-/HMWCK and/or p63+). This panel was used on 26 diagnostically challenging cases and resolved 81% of cases as Uca vs PCa. The majority of PCa cases retain PSA. Negative PSA with positive HMWCK and/or p63 establishes a diagnosis of Uca.
