The Experts below are selected from a list of 258 Experts worldwide ranked by ideXlab platform
Andries E. Budding - One of the best experts on this subject based on the ideXlab platform.
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Ulcerative Gastritis and Esophagitis in Two Children with Sarcina ventriculi Infection.
Frontiers in Medicine, 2017Co-Authors: Tim G. J. De Meij, Michiel P. Van Wijk, Aart Mookhoek, Andries E. BuddingAbstract:Sarcina ventriculi is a Gram-positive, obligate anaerobic coccus, with a characteristic morphology. Only 22 cases of human infections by this micro-organism, including seven in children, have been reported in literature so far. Affected subjects usually present with abdominal pain, nausea, vomiting and delayed gastric emptying. However, life-threatening complications, like emphysematous gastritis and gastric perforation have also been described. Gastroparesis and gastric outlet obstruction have been considered as a potential etiologic factor. All paediatric cases described thus far presented with concomitant gastro-intestinal pathology, such as Helicobacter pylori gastritis, celiac disease, infection with Giardia lamblia or Candida spp. Here, we report two children with Sarcina ventriculi infection, in whom the diagnosis was established by typical histological findings in mucosal biopsies. The first child presented with hematemesis due to Ulcerative Esophagitis and gastritis, the second child with a history of esophageal stricture had Ulcerative gastritis. Confirmation of Sarcina ventriculi infection is feasible by molecular microbiota detection methods, since this microorganism cannot be detected by classical culture techniques. Prompt treatment with antibiotics could prevent life-threatening complications.
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Ulcerative Gastritis and Esophagitis in Two Children with Sarcina ventriculi Infection.
Frontiers in medicine, 2017Co-Authors: Tim G. J. De Meij, Michiel P. Van Wijk, Aart Mookhoek, Andries E. BuddingAbstract:Sarcina ventriculi is a Gram-positive, obligate anaerobic coccus, with a characteristic morphology. Only 22 cases of human infections by this microorganism, including 7 in children, have been reported in literature so far. Affected subjects usually present with abdominal pain, nausea, vomiting, and delayed gastric emptying. However, life-threatening complications, like emphysematous gastritis and gastric perforation have also been described. Gastroparesis and gastric outlet obstruction have been considered as a potential etiologic factor. All pediatric cases described thus far presented with concomitant gastrointestinal pathology, such as Helicobacter pylori gastritis, celiac disease, infection with Giardia lamblia or Candida spp. Here, we report two children with S. ventriculi infection, in whom the diagnosis was established by typical histological findings in mucosal biopsies. The first child presented with hematemesis due to Ulcerative Esophagitis and gastritis, the second child with a history of esophageal stricture had Ulcerative gastritis. Confirmation of S. ventriculi infection is feasible by molecular microbiota detection methods, since this microorganism cannot be detected by classical culture techniques. Prompt treatment with antibiotics could prevent life-threatening complications.
Charles M. Wilcox - One of the best experts on this subject based on the ideXlab platform.
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esophageal strictures complicating Ulcerative Esophagitis in patients with aids
The American Journal of Gastroenterology, 1999Co-Authors: Charles M. WilcoxAbstract:Abstract Objective: Esophageal strictures have been reported to complicate opportunistic esophageal infections in human immunodeficiency virus (HIV)-infected patients, although the etiology, prevalence, and incidence of strictures after these infections have not been studied. Methods: HIV-infected patients undergoing upper endoscopy for clinical indications over a 7.5-yr period were prospectively identified. The cause of esophageal ulceration was defined by previously proposed criteria. Endoscopic re-examination was performed in most patients after treatment, and long term clinical follow-up was obtained. An esophageal stricture was defined as circumferential luminal narrowing of ≥30% at endoscopy and/or barium esophagography. Results: A total of 160 HIV-infected patients were identified with esophageal ulcer. Of these patients, 13 (8%; 95% CI 4–12%) developed esophageal strictures. Strictures were identified at the time of initial endoscopy in three patients (cytomegalovirus [CMV] in one patient and gastroesophageal reflux disease in two), and at the site of ulcer healing or persistence in the other patients (four, CMV; four, idiopathic; one, herpes simplex virus [HSV]; one, CMV/HSV). Long term follow-up did not identify any additional patients who developed an esophageal stricture. Conclusion: Esophageal strictures infrequently complicate Ulcerative Esophagitis caused by opportunistic infections in HIV-infected patients.
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Esophageal strictures complicating Ulcerative Esophagitis in patients with AIDS.
The American journal of gastroenterology, 1999Co-Authors: Charles M. WilcoxAbstract:Esophageal strictures have been reported to complicate opportunistic esophageal infections in human immunodeficiency virus (HIV)-infected patients, although the etiology, prevalence, and incidence of strictures after these infections have not been studied. HIV-infected patients undergoing upper endoscopy for clinical indications over a 7.5-yr period were prospectively identified. The cause of esophageal ulceration was defined by previously proposed criteria. Endoscopic re-examination was performed in most patients after treatment, and long term clinical follow-up was obtained. An esophageal stricture was defined as circumferential luminal narrowing of > or = 30% at endoscopy and/or barium esophagography. A total of 160 HIV-infected patients were identified with esophageal ulcer. Of these patients, 13 (8%; 95% CI 4-12%) developed esophageal strictures. Strictures were identified at the time of initial endoscopy in three patients (cytomegalovirus [CMV] in one patient and gastroesophageal reflux disease in two), and at the site of ulcer healing or persistence in the other patients (four, CMV; four, idiopathic; one, herpes simplex virus [HSV]; one, CMV/HSV). Long term follow-up did not identify any additional patients who developed an esophageal stricture. Esophageal strictures infrequently complicate Ulcerative Esophagitis caused by opportunistic infections in HIV-infected patients.
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Fluconazole compared with endoscopy for human immunodeficiency virus- infected patients with esophageal symptoms
Gastroenterology, 1996Co-Authors: Charles M. Wilcox, Lorraine N. Alexander, Ws Clark, ThompsonAbstract:The best initial treatment of human immunodeficiency virus (HIV)-infected patients with esophageal symptoms is unknown. The outcome, including safety and cost-effectiveness, of fluconazole compared with endoscopy as a treatment strategy for HIV-infected patients with new-onset esophageal symptoms was evaluated. During a 53-month period, 134 HIV-infected patients with esophageal symptoms were randomized prospectively to groups receiving either standard doses of fluconazole or endoscopy. Among the 68 patients in the fluconazole group, a complete symptomatic response was observed in 56 patients (82%), usually within 1 week. The most common endoscopic findings in the 66 patients in the endoscopy group included Candida Esophagitis alone in 42 patients (64%) and Ulcerative Esophagitis in 10 patients (15%). Patients responding to empirical antifungal therapy or who had Candida Esophagitis alone at endoscopy were less like to have severe symptoms (P = 0.027) or odynophagia as the only symptom (P < 0.001) but more frequently had odynophagia and dysphagia (P = 0.007) and thrush (P = 0.002). Empirical fluconazole was cost-effective, saving $738.16 per patient. Empirical oral antifungal therapy with fluconazole is highly efficacious, safe, and cost-effective for HIV-infected patients with new-onset esophageal symptoms.
Tim G. J. De Meij - One of the best experts on this subject based on the ideXlab platform.
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Ulcerative Gastritis and Esophagitis in Two Children with Sarcina ventriculi Infection.
Frontiers in Medicine, 2017Co-Authors: Tim G. J. De Meij, Michiel P. Van Wijk, Aart Mookhoek, Andries E. BuddingAbstract:Sarcina ventriculi is a Gram-positive, obligate anaerobic coccus, with a characteristic morphology. Only 22 cases of human infections by this micro-organism, including seven in children, have been reported in literature so far. Affected subjects usually present with abdominal pain, nausea, vomiting and delayed gastric emptying. However, life-threatening complications, like emphysematous gastritis and gastric perforation have also been described. Gastroparesis and gastric outlet obstruction have been considered as a potential etiologic factor. All paediatric cases described thus far presented with concomitant gastro-intestinal pathology, such as Helicobacter pylori gastritis, celiac disease, infection with Giardia lamblia or Candida spp. Here, we report two children with Sarcina ventriculi infection, in whom the diagnosis was established by typical histological findings in mucosal biopsies. The first child presented with hematemesis due to Ulcerative Esophagitis and gastritis, the second child with a history of esophageal stricture had Ulcerative gastritis. Confirmation of Sarcina ventriculi infection is feasible by molecular microbiota detection methods, since this microorganism cannot be detected by classical culture techniques. Prompt treatment with antibiotics could prevent life-threatening complications.
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Ulcerative Gastritis and Esophagitis in Two Children with Sarcina ventriculi Infection.
Frontiers in medicine, 2017Co-Authors: Tim G. J. De Meij, Michiel P. Van Wijk, Aart Mookhoek, Andries E. BuddingAbstract:Sarcina ventriculi is a Gram-positive, obligate anaerobic coccus, with a characteristic morphology. Only 22 cases of human infections by this microorganism, including 7 in children, have been reported in literature so far. Affected subjects usually present with abdominal pain, nausea, vomiting, and delayed gastric emptying. However, life-threatening complications, like emphysematous gastritis and gastric perforation have also been described. Gastroparesis and gastric outlet obstruction have been considered as a potential etiologic factor. All pediatric cases described thus far presented with concomitant gastrointestinal pathology, such as Helicobacter pylori gastritis, celiac disease, infection with Giardia lamblia or Candida spp. Here, we report two children with S. ventriculi infection, in whom the diagnosis was established by typical histological findings in mucosal biopsies. The first child presented with hematemesis due to Ulcerative Esophagitis and gastritis, the second child with a history of esophageal stricture had Ulcerative gastritis. Confirmation of S. ventriculi infection is feasible by molecular microbiota detection methods, since this microorganism cannot be detected by classical culture techniques. Prompt treatment with antibiotics could prevent life-threatening complications.
Agostinho Pinto Gouvêa - One of the best experts on this subject based on the ideXlab platform.
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Esofagite ulcerativa associada ao uso de alendronato de sódio: achados histopatológicos e endoscópicos Ulcerative Esophagitis associated with the use of alendronate sodium: histopathological and endoscopic features
Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE), 2002Co-Authors: Paula Ávila Fernandes, Marcelo Soares Pires, Agostinho Pinto GouvêaAbstract:RACIONAL: A esofagite induzida por drogas pode ser decorrente do contato prolongado do medicamento com a mucosa ou de alterações das condições locais da mucosa esofágica. O uso de alendronato de sódio, um inibidor da reabsorção óssea utilizado na prevenção e tratamento da osteoporose, tem sido recentemente citado como causa de lesões no trato gastrointestinal superior. OBJETIVO: Descrever os achados clínicos, endoscópicos e histopatológicos de pacientes com esofagite ulcerativa associada ao uso de alendronato de sódio. PACIENTES: Quatro pacientes do sexo feminino e um do sexo masculino, em tratamento de osteoporose com alendronato de sódio, submetidos a endoscopia digestiva alta seguida de biopsia esofágica. RESULTADOS: Os pacientes apresentavam idade entre 64 e 84 anos e sintomatologia dispéptica após um período de 2 a 12 meses de uso de alendronato de sódio. A endoscopia digestiva mostrou área de mucosa friável, com erosão e/ou ulceração recobertas por fibrina, localizadas no terço distal do esôfago. O exame histopatológico mostrou esofagite ulcerativa caracterizada por material necrofibrinopurulento e tecido de granulação, além de material amarelado e refringente à luz polarizada. Os pacientes evoluíram com remissão completa dos sintomas após suspensão da droga. CONCLUSÕES: As lesões esofágicas associadas ao uso de alendronato de sódio não são freqüentes e parecem estar relacionadas ao uso incorreto da medicação. Os endoscopistas e patologistas devem ficar atentos à possibilidade do uso de alendronato de sódio diante do diagnóstico de úlceras esofágicas em pacientes idosos, principalmente do sexo feminino. Esta identificação implicaria em melhor tratamento dos pacientes.BACKGROUND: Drug-induced or "pill-induced" Esophagitis may be secondary to the prolonged contact of the drug with the esophageal mucosa or secondary to the drug ability to alter the local conditions. The alendronate sodium, a bone resorption inhibitor used in the treatment and prevention of osteoporosis, has been cited, recently, as one of the causes of adverse upper gastrointestinal tract injury. AIM: To describe the clinical, endoscopic and histopathological features of patients with Ulcerative Esophagitis associated with alendronate sodium. PATIENTS: Four women and one man with osteoporosis were treated with alendronate sodium and submitted to endoscopy followed esophageal biopsy. RESULTS: The age range of the patients was from 64 to 84 years old. The patients showed dyspeptic symptoms after taking alendronate sodium during a period of 2-12 months. At endoscopic evaluation, the mucosa was friable, with erosion and/or ulceration covered by fibrin in the distal esophagus. The pathological examination of the esophageal biopsies revealed Ulcerative Esophagitis characterized by necrofibrinpurulent material, granulation tissue, and yellow refractile polarizable crystal. The patients' symptoms resolved after stopping alendronate sodium use. CONCLUSIONS: The esophagus injuries associated with alendronate sodium are not frequent and seem to be associated with the incorrect use of medication. The endoscopists and pathologists should be alert to the possibility of alendronate sodium therapy in cases of diagnosis of Ulcerative Esophagitis in ancient patients, particularly in women. The recognition of this condition would improve the patient care
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Esofagite ulcerativa associada ao uso de alendronato de sódio: achados histopatológicos e endoscópicos
Arquivos de gastroenterologia, 2002Co-Authors: Paula Ávila Fernandes, Marcelo Soares Pires, Agostinho Pinto GouvêaAbstract:BACKGROUND: Drug-induced or "pill-induced" Esophagitis may be secondary to the prolonged contact of the drug with the esophageal mucosa or secondary to the drug ability to alter the local conditions. The alendronate sodium, a bone resorption inhibitor used in the treatment and prevention of osteoporosis, has been cited, recently, as one of the causes of adverse upper gastrointestinal tract injury. AIM: To describe the clinical, endoscopic and histopathological features of patients with Ulcerative Esophagitis associated with alendronate sodium. PATIENTS: Four women and one man with osteoporosis were treated with alendronate sodium and submitted to endoscopy followed esophageal biopsy. RESULTS: The age range of the patients was from 64 to 84 years old. The patients showed dyspeptic symptoms after taking alendronate sodium during a period of 2-12 months. At endoscopic evaluation, the mucosa was friable, with erosion and/or ulceration covered by fibrin in the distal esophagus. The pathological examination of the esophageal biopsies revealed Ulcerative Esophagitis characterized by necrofibrinpurulent material, granulation tissue, and yellow refractile polarizable crystal. The patients' symptoms resolved after stopping alendronate sodium use. CONCLUSIONS: The esophagus injuries associated with alendronate sodium are not frequent and seem to be associated with the incorrect use of medication. The endoscopists and pathologists should be alert to the possibility of alendronate sodium therapy in cases of diagnosis of Ulcerative Esophagitis in ancient patients, particularly in women. The recognition of this condition would improve the patient care.
Aart Mookhoek - One of the best experts on this subject based on the ideXlab platform.
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Ulcerative Gastritis and Esophagitis in Two Children with Sarcina ventriculi Infection.
Frontiers in Medicine, 2017Co-Authors: Tim G. J. De Meij, Michiel P. Van Wijk, Aart Mookhoek, Andries E. BuddingAbstract:Sarcina ventriculi is a Gram-positive, obligate anaerobic coccus, with a characteristic morphology. Only 22 cases of human infections by this micro-organism, including seven in children, have been reported in literature so far. Affected subjects usually present with abdominal pain, nausea, vomiting and delayed gastric emptying. However, life-threatening complications, like emphysematous gastritis and gastric perforation have also been described. Gastroparesis and gastric outlet obstruction have been considered as a potential etiologic factor. All paediatric cases described thus far presented with concomitant gastro-intestinal pathology, such as Helicobacter pylori gastritis, celiac disease, infection with Giardia lamblia or Candida spp. Here, we report two children with Sarcina ventriculi infection, in whom the diagnosis was established by typical histological findings in mucosal biopsies. The first child presented with hematemesis due to Ulcerative Esophagitis and gastritis, the second child with a history of esophageal stricture had Ulcerative gastritis. Confirmation of Sarcina ventriculi infection is feasible by molecular microbiota detection methods, since this microorganism cannot be detected by classical culture techniques. Prompt treatment with antibiotics could prevent life-threatening complications.
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Ulcerative Gastritis and Esophagitis in Two Children with Sarcina ventriculi Infection.
Frontiers in medicine, 2017Co-Authors: Tim G. J. De Meij, Michiel P. Van Wijk, Aart Mookhoek, Andries E. BuddingAbstract:Sarcina ventriculi is a Gram-positive, obligate anaerobic coccus, with a characteristic morphology. Only 22 cases of human infections by this microorganism, including 7 in children, have been reported in literature so far. Affected subjects usually present with abdominal pain, nausea, vomiting, and delayed gastric emptying. However, life-threatening complications, like emphysematous gastritis and gastric perforation have also been described. Gastroparesis and gastric outlet obstruction have been considered as a potential etiologic factor. All pediatric cases described thus far presented with concomitant gastrointestinal pathology, such as Helicobacter pylori gastritis, celiac disease, infection with Giardia lamblia or Candida spp. Here, we report two children with S. ventriculi infection, in whom the diagnosis was established by typical histological findings in mucosal biopsies. The first child presented with hematemesis due to Ulcerative Esophagitis and gastritis, the second child with a history of esophageal stricture had Ulcerative gastritis. Confirmation of S. ventriculi infection is feasible by molecular microbiota detection methods, since this microorganism cannot be detected by classical culture techniques. Prompt treatment with antibiotics could prevent life-threatening complications.
