The Experts below are selected from a list of 267 Experts worldwide ranked by ideXlab platform
T R Bagaeva - One of the best experts on this subject based on the ideXlab platform.
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transforming non Ulcerogenic stress stimuli into gastric Ulcerogenic ones under the circumstances of inhibition of the hypothalamic pituitary adrenocortical axis
The FASEB Journal, 2015Co-Authors: L P Filaretova, Marina Myazina, T R BagaevaAbstract:To investigate contribution of glucocorticoids to the maintenance of gastric mucosal integrity during stress we predominantly used Ulcerogenic stress models. Using these models we demonstrated that glucocorticoids released in response to the Ulcerogenic stimuli attenuated their harmful action on the gastric mucosa.In the present study we hypothesized that mild stressors does not damage the gastric mucosa due to gastroprotective action of glucocorticoids released in response to these stimuli. To verify the hypothesis the effects of normally non-Ulcerogenic mild stimuli (15-30 min cold-restraint) on the gastric mucosa have been studied under the circumstances of inhibition ofthe hypothalamic-pituitary-adrenocortical (HPA) axis in rats. The HPA axis was inhibited by: 1) fast inhibitory action of NBI 27914, the selective antagonist of cortricotropin-releasing factor receptor type 1; 2) fast inhibitory action of metyrapone, inhibitor glucocoricoid synthesis; 3) delayed inhibitory action of a single pharmacolog...
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From gastroprotective to Ulcerogenic effects of glucocorticoids: role of long-term glucocorticoid action.
Current pharmaceutical design, 2014Co-Authors: Ludmila Filaretova, T R Bagaeva, T. T. Podvigina, Olga MorozovaAbstract:Glucocorticoids may have dual action on the gastric mucosa: gastroprotective and Ulcerogenic. In this article, we review the data which suggested that an initial action of endogenous glucocorticoids, including stress-produced ones as well as exogenous glucocorticoids is gastroprotective and consider possible mechanisms of the conversion of physiological gastroprotective action of glucocorticoid hormones to their pathological Ulcerogenic effect.
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High sensitivity of gastric mucosa to Ulcerogenic effect of indomethacin in rats with diabetes.
Bulletin of experimental biology and medicine, 2011Co-Authors: T. T. Podvigina, T R Bagaeva, P. Yu. Bobryshev, Ludmila FilaretovaAbstract:One week after injection of streptozotocin (60 mg/kg intravenously), rats developed diabetes associated with a significant increase of gastric mucosa sensitivity to the Ulcerogenic effect of indomethacin (35 mg/kg subcutaneously). Since potentiation of the Ulcerogenic effect of indomethacin was observed only in rats subjected to fasting before drug injection, we hypothesize that this effect was caused by a drop of high glucose level in the blood after fasting.
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Gastric mucosal susceptibility for Ulcerogenic effect of indometacin at different time points of streptozotocin-induced diabetes development
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2011Co-Authors: T R Bagaeva, Morozova Oiu, Ludmila FilaretovaAbstract:In the study, we examined the gastric mucosal susceptibility for Ulcerogenic effect of indometacin at different time points of streptozotocin-induced diabetes development. Indometacin was injected at Ulcerogenic dose (35 mg/kg, s. c.) on days 3, 7 and 30 after streptozotocin administration (60 mg/kg, i. v.) or its vehicle to fasted rats. Typical diabetic hyperglicaemia was observed as early as in 3 days after streptozotocin administration and accompanied with enhanced mucosal susceptibility for indometacin as compared with that of control group. In 7 and 30 days after streptozotocin administration, when hyperglicaemia was still present, the average areas of indometacin-induced erosion increased 2- and 3-fold, respectively, as compared with those observed in 3 day after streptozotocin administration. The data obtained demonstrate that gastric mucosal susceptibility for the Ulcerogenic effect of indometacin is increased at the early stages of diabetes development and then aggravates along with further development of the pathological condition.
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Dual action of glucocorticoid hormones on the gastric mucosa: how the gastroprotective action can be transformed to the Ulcerogenic one
Inflammopharmacology, 2009Co-Authors: Ludmila Filaretova, T R Bagaeva, T. T. Podvigina, O. MorozovaAbstract:Glucocorticoid hormones have dual action on the stomach: gastroprotective and Ulcerogenic one. The present study was designed to investigate how physiological gastroprotective action of glucocorticoids can be transformed to pathological Ulcerogenic effect. Dose- and time-dependent effects of single injection of dexamethasone on indomethacin-induced gastric erosions, corticosterone and blood glucose levels, somatic parameters were investigated in rats. Dexamethasone at the doses of 0.1, 1, 10 mg/kg decreased the gastric erosion area dose dependently in the case of its injection 1 h before indomethacin administration. Gastroprotective action of dexamethasone (at a dose of 1 mg/kg) was also observed in the case of its injection 6 and 12 h before indomethacin. However, the further increase in the time interval caused transformation of gastroprotective action of dexamethasone to Ulcerogenic one. Accordingly to the data obtained short-term maintenance of blood glucose level provides the gastroprotective action of dexamethasone, while dexamethasone-induced long-lasting maintenance of blood glucose level accompanied with the signs of catabolic effects may be responsible at least partly for its Ulcerogenic effect.
Miroslav Zavoral - One of the best experts on this subject based on the ideXlab platform.
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a surviving myth corticosteroids are still considered Ulcerogenic by a majority of physicians
Scandinavian Journal of Gastroenterology, 2010Co-Authors: Jan Martinek, Kristyna Hlavova, Filip Zavada, Bohumil Seifert, Stanislav Rejchrt, Ondrej Urban, Miroslav ZavoralAbstract:AbstractObjective. Evidence does not support an association between systemic corticosteroid use and the development of peptic ulcer disease (PUD) and prophylactic anti-ulcer therapy is not routinely indicated. The aim was to find out the opinion of physicians in the Czech Republic on corticosteroid-induced ulcers. Materials and methods. A questionnaire-based study targeting 360 physicians of different specialties (100 from Gastroenterology, 100 from General Practice, 80 from Pneumology/Immunology, and 80 from Neurology/Neurosurgery). Results. Eighty-two percent of the physicians considered corticosteroids Ulcerogenic, 7.5% of the responders considered them Ulcerogenic only in patients with a family history of PUD, and 10.3% of the physicians considered corticosteroids non-Ulcerogenic. Seventy-five percent of the responders would administer concomitant antisecretory treatment. Sixty-seven percent of the physicians thought that PUD was a frequent complication of corticosteroid therapy. If the Ulcerogenic po...
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“A surviving myth” – corticosteroids are still considered Ulcerogenic by a majority of physicians
Scandinavian journal of gastroenterology, 2010Co-Authors: Jan Martinek, Kristyna Hlavova, Filip Zavada, Bohumil Seifert, Stanislav Rejchrt, Ondrej Urban, Miroslav ZavoralAbstract:AbstractObjective. Evidence does not support an association between systemic corticosteroid use and the development of peptic ulcer disease (PUD) and prophylactic anti-ulcer therapy is not routinely indicated. The aim was to find out the opinion of physicians in the Czech Republic on corticosteroid-induced ulcers. Materials and methods. A questionnaire-based study targeting 360 physicians of different specialties (100 from Gastroenterology, 100 from General Practice, 80 from Pneumology/Immunology, and 80 from Neurology/Neurosurgery). Results. Eighty-two percent of the physicians considered corticosteroids Ulcerogenic, 7.5% of the responders considered them Ulcerogenic only in patients with a family history of PUD, and 10.3% of the physicians considered corticosteroids non-Ulcerogenic. Seventy-five percent of the responders would administer concomitant antisecretory treatment. Sixty-seven percent of the physicians thought that PUD was a frequent complication of corticosteroid therapy. If the Ulcerogenic po...
Jan Martinek - One of the best experts on this subject based on the ideXlab platform.
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a surviving myth corticosteroids are still considered Ulcerogenic by a majority of physicians
Scandinavian Journal of Gastroenterology, 2010Co-Authors: Jan Martinek, Kristyna Hlavova, Filip Zavada, Bohumil Seifert, Stanislav Rejchrt, Ondrej Urban, Miroslav ZavoralAbstract:AbstractObjective. Evidence does not support an association between systemic corticosteroid use and the development of peptic ulcer disease (PUD) and prophylactic anti-ulcer therapy is not routinely indicated. The aim was to find out the opinion of physicians in the Czech Republic on corticosteroid-induced ulcers. Materials and methods. A questionnaire-based study targeting 360 physicians of different specialties (100 from Gastroenterology, 100 from General Practice, 80 from Pneumology/Immunology, and 80 from Neurology/Neurosurgery). Results. Eighty-two percent of the physicians considered corticosteroids Ulcerogenic, 7.5% of the responders considered them Ulcerogenic only in patients with a family history of PUD, and 10.3% of the physicians considered corticosteroids non-Ulcerogenic. Seventy-five percent of the responders would administer concomitant antisecretory treatment. Sixty-seven percent of the physicians thought that PUD was a frequent complication of corticosteroid therapy. If the Ulcerogenic po...
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“A surviving myth” – corticosteroids are still considered Ulcerogenic by a majority of physicians
Scandinavian journal of gastroenterology, 2010Co-Authors: Jan Martinek, Kristyna Hlavova, Filip Zavada, Bohumil Seifert, Stanislav Rejchrt, Ondrej Urban, Miroslav ZavoralAbstract:AbstractObjective. Evidence does not support an association between systemic corticosteroid use and the development of peptic ulcer disease (PUD) and prophylactic anti-ulcer therapy is not routinely indicated. The aim was to find out the opinion of physicians in the Czech Republic on corticosteroid-induced ulcers. Materials and methods. A questionnaire-based study targeting 360 physicians of different specialties (100 from Gastroenterology, 100 from General Practice, 80 from Pneumology/Immunology, and 80 from Neurology/Neurosurgery). Results. Eighty-two percent of the physicians considered corticosteroids Ulcerogenic, 7.5% of the responders considered them Ulcerogenic only in patients with a family history of PUD, and 10.3% of the physicians considered corticosteroids non-Ulcerogenic. Seventy-five percent of the responders would administer concomitant antisecretory treatment. Sixty-seven percent of the physicians thought that PUD was a frequent complication of corticosteroid therapy. If the Ulcerogenic po...
Marian G. William - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of modified steroids as a novel class of non-Ulcerogenic, anti-inflammatory and anti-nociceptive agents.
Steroids, 2011Co-Authors: Rafat M. Mohareb, Gamal A. Elmegeed, Omar M.e. Abdel-salam, Senot H. Doss, Marian G. WilliamAbstract:The identification of compounds able to treat both pain and inflammation with limited side effects is one of the prominent goals in biomedical research. This study aimed at the synthesis of new modified steroids with structures justifying non-Ulcerogenic, anti-inflammatory and anti-nociceptive activities. The steroid derivatives were synthesized via straightforward and efficient methods and their structures were established based on the analytical and spectral data. The in vivo anti-inflammatory, anti-nociceptive and anti-Ulcerogenic activities of some of these compounds were studied. The newly synthesized compounds 8b, 19b, 24 and 31a showed anti-inflammatory, anti-nociceptive and anti-Ulcerogenic activity with various intensities. Oedema was significantly reduced by either dose 25 or 50 mg/kg of all tested compounds at 3 and 4 h post-carrageenan. Compound 19b was the most effective in alleviating thermal pain. The analgesic activity of either dose of the compounds 8b, 24, 31a as well as the high dose 19b was significantly higher than that for indomethacin (IND). Gastric mucosal lesions caused in the rats by the administration of 96% EtOH and IND were inhibited by all tested compounds administered at (50 mg/kg) dose in the study.
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Non-Ulcerogenic New Anti-Inflammatory Drugs
2011Co-Authors: Gamal A. Elmegeed, Emad F. Eskander, Marian G. WilliamAbstract:Inflammatory diseases are widely prevalent throughout the world. The identification of compounds able to treat both pain and inflammation with limited side effects is one of the prominent goals in biomedical research. Developing new therapeutic agents that can overcome gastrointestinal injury and at the same time could lead to an enhanced anti-inflammatory effect becomes an urgent need for inflammation patients. This book provides new insights for developing new modified steroids with structures justifying non-Ulcerogenic, anti-inflammatory and anti-nociceptive activities. The steroid derivatives were synthesized via straightforward and efficient methods and their structures were established based on the analytical and spectral data. The in vivo anti-inflammatory, anti-nociceptive and anti-Ulcerogenic activities of these compounds were studied. Our finding provides a unique opportunity to develop new anti-inflammatory drugs which devoid the Ulcerogenic liabilities associated with currently marketed drugs.
Ilhan Gurbuz - One of the best experts on this subject based on the ideXlab platform.
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Investigations on the anti-Ulcerogenic activity of Sideritis caesarea H. Duman, Aytaç & Başer
Journal of ethnopharmacology, 2020Co-Authors: Tuğba Günbatan, Ilhan Gurbuz, Erdal Bedir, Ayşe Mine Gençler Özkan, Özge ÖzçınarAbstract:Aerial parts of Sideritis caesarea H. Duman, Aytaç & Başer are used for complaints such as stomach-aches, and intestinal spasms as traditional medicine in Kayseri, Turkey. To investigate the anti-Ulcerogenic activity by using bioassay guided fractionation technique (BAGF) and to identify the compound(s) that are responsible for anti-Ulcerogenic activity through ethanol-induced anti-Ulcerogenic activity model in vivo. Liquid-liquid partition and then different chromatographic techniques were utilized for the BAGF of the ethanol (80%) extract of the aerial parts of Sideritis caesarea. Ethanol-induced gastric ulcer method on rats was employed for the determination of the anti-Ulcerogenic activity, and the ulcer index was also calculated for anti-Ulcerogenic activity detection. The ethanol (80%) extract of S. caesarea showed statistically potent anti-Ulcerogenic activity (95.9% ulcer inhibition, p < 0.001). Among the liquid-liquid fractions, strongest anti-Ulcerogenic activity was observed with the ethyl acetate fraction (91.4% inhibition, p < 0.001) and therefore BAGF studies were proceeded with the ethyl acetate fraction. Two anti-Ulcerogenic flavonoids {4'-O-methylhypolaetin-7-O-[6‴-O-acetyl-β-D-allopyranosyl-(1→2)]-6″-O-acetyl-β-D-glucopyranoside and isoscutellarein-7-O-[6‴-O-acetyl-β-D-allopyranosyl-(1→2)]-6″-O-acetyl-β-D-glucopyranoside} were isolated from this fraction together with a sesquiterpene glycoside [(2E,6E)-2,6,10-trimethyl-2,6,11-dodecatriene-1,10-diol-1-O-β-D-glucopyranoside] and two additional flavonoids {4'-O-methylhypolaetin-7-O-[6‴-O-acetyl-β-D-allopyranosyl-(1→2)]-β-D-glucopyranoside and isoscutellarein-7-O-[6‴-O-acetyl-β-D-allopyranosyl-(1→2)]-β-D-glucopyranoside}. Traditional use of S. caesarea in the treatment of stomach-aches was supported by this study and four flavonoids were isolated by using BAGF method and two of them were determined to have significant anti-Ulcerogenic activity. Additionally, (2E,6E)-2,6,10-trimethyl-2,6,11-dodecatriene-1,10-diol-1-O-β-D-glucopyranoside was obtained from a Sideritis genus for the first time. Copyright © 2020 Elsevier B.V. All rights reserved.
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characterization of volatiles and anti Ulcerogenic effect of turkish sweetgum balsam styrax liquidus
Journal of Ethnopharmacology, 2013Co-Authors: Ilhan Gurbuz, Ekrem Sezik, Erdem Yesilada, Betül Demirci, Fatih Demirci, K. Hüsnü Can BaşerAbstract:Abstract Ethnopharmacological relevance Sweetgum, Styrax liquidus (Turkish sweetgum) is a resinous exudate obtained from the wounded barks of Liquidambar orientalis Miller tree which belongs to Altingiaceae (Hamamelidaceae). The plant material has been used for the treatment of peptic ulcer symptoms in Turkish folk medicine since centuries. In order to evaluate the claimed activity, we studied the anti-Ulcerogenic effect of Styrax liquidus by using an in vivo anti-Ulcerogenic activity model and to determine the chemical composition of the balsam. Materials and methods Anti-Ulcerogenic effects of the balsam “Styrax liquidus” itself and its fractions obtained by successive solvent extractions with chloroform and n-butanol, were investigated against the ethanol-induced peptic ulcer model in rats. The chloroform extract demonstrated a statistically significant gastroprotective effect. In addition, the chemical characterization of the volatiles obtained by microdistillation technique from the balsam and the sub-extracts were analyzed by gas chromatography (GC) and gas chromatography–mass spectrometry (GC–MS), respectively. Results Pharmacological experiments have clearly demonstrated that 150 and 300 mg/kg doses of Styrax liquidus given orally to rats showed significant gastric protection. On GC–MS analysis of the resin, overall, 31 compounds representing 99.8% of the total oil were identified where styrene (81.9%), cinnamyl alcohol (6.9%) and α-pinene (3.5%) were identified as the major components. Conclusion Present study confirmed the anti-Ulcerogenic activity of the local ethnobotanical usage of Styrax liquidus in Turkey.
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isolation of anti Ulcerogenic sesquiterpene lactones from centaurea solstitialis l ssp solstitialis through bioassay guided fractionation procedures in rats
Journal of Ethnopharmacology, 2004Co-Authors: Erdem Yesilada, Ilhan Gurbuz, Irem I Tatli, Erdal Bedir, Ikhlas A. KhanAbstract:Abstract The fresh spiny flowers of Centaurea solstitialis ssp. solstitialis (CSS) are used for the treatment of peptic ulcers in Turkey. Ethanol (80%) extract of CSS exhibited significant anti-Ulcerogenic effect on the ethanol-induced ulcerogenesis model in rats. The ethanol extract was further fractionated by successive solvent extractions with n-hexane, chloroform, ethyl acetate and n-butanol. All fractions showed significant anti-Ulcerogenic activity, however, the effect of the chloroform fraction was found to be more prominent with 99.5% ulcer inhibition. Bioassay-guided fractionation yielded sesquiterpene lactones as the active components. The main components responsible for the activity of the chloroform fraction were determined as chlorojanerin and 13-acetyl solstitialin A which were elucidated by HR-ESI and 1H, 13C and 2D NMR spectroscopic techniques.
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Anti-Ulcerogenic lignans from Taxus baccata L.
Zeitschrift fur Naturforschung. C Journal of biosciences, 2004Co-Authors: Ilhan Gurbuz, Erdem Yesilada, Nurgun Erdemoglu, Bilge SenerAbstract:Four lignan type compounds, lariciresinol, taxiresinol, isolariciresinol and 3-demethyl-iso-lariciresinol, were isolated from the heartwood of Taxus baccata L. (Taxaceae) growing in Turkey through chromatographic techniques. In vivo anti-Ulcerogenic potency of these compounds was investigated on ethanol-induced ulcerogenesis model in rats at two different doses, 50 and 100 mg/kg. All compounds were shown to possess significant anti-Ulcerogenic activity at both doses. However, the effect of taxiresinol was the most prominent.
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Anti-Ulcerogenic activity of some plants used as folk remedy in Turkey.
Journal of ethnopharmacology, 2003Co-Authors: Ilhan Gurbuz, Ekrem Sezik, Erdem Yesilada, Osman Üstün, Osman KutsalAbstract:Five herbal remedies used as gastroprotective crude drugs in Turkey were assessed for anti-Ulcerogenic activity using the EtOH-induced ulcerogenesis model in rat. The crude drugs investigated comprises fruits of Elaeagnus angustifolia L. (Elaeagnaceae), fresh fruits of Hibiscus esculentus L. (Malvaceae), fresh roots of Papaver rhoeas L. (Papaveraceae), leaves of Phlomis grandiflora H.S. Thomson (Lamiaceae) and fresh fruits of Rosa canina L. (Rosaceae). Extracts were prepared according to the traditional indications of use. Under our experimental conditions, all extracts exhibited statistically significant gastroprotective effect with better results for Phlomis grandiflora and Rosa canina (100%). At the concentration under study, both crude drugs were more effective than the reference compound misoprostol at 0.4 mg/kg. Even the weakest anti-Ulcerogenic effect observed for Papaver rhoeas roots was found statistically potent (95.6%). Histopathological studies confirmed the results of the in vivo test.
