The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
Robert B. Innis - One of the best experts on this subject based on the ideXlab platform.
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evaluation of Ultrafiltration for the free fraction determination of single photon emission computed tomography spect radiotracers β cit ibf and iomazenil
Journal of Pharmaceutical Sciences, 1994Co-Authors: Mitchell S Gandelman, Sami S Zoghbi, Ronald M Baldwin, Yolanda Zeaponce, Robert B. InnisAbstract:An Ultrafiltration system was evaluated for the free‐fraction measurement of SPECT radiotracers (β‐CIT, IBF, and iomazenil) used in functional brain imaging. The effect of temperature, storage, centrifugal force, tracer concentration, and percentage filtered demonstrated a relative error of < 9%. As a result of the minimal temperature effect, 25 °C was employed for all measurements. A comparison of the Ultrafiltration system with equilibrium dialysis revealed < 5% difference for β‐CIT and iomazenil, but 16% for IBF. Additionally, the time and ease of operation considerably favored the Ultrafiltration system. The precision quantitated by repetition was < 6% for between‐run and within‐run variability. In conclusion, Ultrafiltration provided rapid results, demonstrated minor analytical errors, revealed generally good correlation with equilibrium dialysis, and allowed excellent precision.
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Evaluation of Ultrafiltration for the Free‐Fraction Determination of Single Photon Emission Computed Tomography (SPECT) Radiotracers: β‐CIT, IBF, and Iomazenil
Journal of Pharmaceutical Sciences, 1994Co-Authors: Mitchell S Gandelman, Sami S Zoghbi, Ronald M Baldwin, Yolanda Zea-ponce, Robert B. InnisAbstract:An Ultrafiltration system was evaluated for the free‐fraction measurement of SPECT radiotracers (β‐CIT, IBF, and iomazenil) used in functional brain imaging. The effect of temperature, storage, centrifugal force, tracer concentration, and percentage filtered demonstrated a relative error of < 9%. As a result of the minimal temperature effect, 25 °C was employed for all measurements. A comparison of the Ultrafiltration system with equilibrium dialysis revealed < 5% difference for β‐CIT and iomazenil, but 16% for IBF. Additionally, the time and ease of operation considerably favored the Ultrafiltration system. The precision quantitated by repetition was < 6% for between‐run and within‐run variability. In conclusion, Ultrafiltration provided rapid results, demonstrated minor analytical errors, revealed generally good correlation with equilibrium dialysis, and allowed excellent precision.
Mitchell S Gandelman - One of the best experts on this subject based on the ideXlab platform.
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evaluation of Ultrafiltration for the free fraction determination of single photon emission computed tomography spect radiotracers β cit ibf and iomazenil
Journal of Pharmaceutical Sciences, 1994Co-Authors: Mitchell S Gandelman, Sami S Zoghbi, Ronald M Baldwin, Yolanda Zeaponce, Robert B. InnisAbstract:An Ultrafiltration system was evaluated for the free‐fraction measurement of SPECT radiotracers (β‐CIT, IBF, and iomazenil) used in functional brain imaging. The effect of temperature, storage, centrifugal force, tracer concentration, and percentage filtered demonstrated a relative error of < 9%. As a result of the minimal temperature effect, 25 °C was employed for all measurements. A comparison of the Ultrafiltration system with equilibrium dialysis revealed < 5% difference for β‐CIT and iomazenil, but 16% for IBF. Additionally, the time and ease of operation considerably favored the Ultrafiltration system. The precision quantitated by repetition was < 6% for between‐run and within‐run variability. In conclusion, Ultrafiltration provided rapid results, demonstrated minor analytical errors, revealed generally good correlation with equilibrium dialysis, and allowed excellent precision.
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Evaluation of Ultrafiltration for the Free‐Fraction Determination of Single Photon Emission Computed Tomography (SPECT) Radiotracers: β‐CIT, IBF, and Iomazenil
Journal of Pharmaceutical Sciences, 1994Co-Authors: Mitchell S Gandelman, Sami S Zoghbi, Ronald M Baldwin, Yolanda Zea-ponce, Robert B. InnisAbstract:An Ultrafiltration system was evaluated for the free‐fraction measurement of SPECT radiotracers (β‐CIT, IBF, and iomazenil) used in functional brain imaging. The effect of temperature, storage, centrifugal force, tracer concentration, and percentage filtered demonstrated a relative error of < 9%. As a result of the minimal temperature effect, 25 °C was employed for all measurements. A comparison of the Ultrafiltration system with equilibrium dialysis revealed < 5% difference for β‐CIT and iomazenil, but 16% for IBF. Additionally, the time and ease of operation considerably favored the Ultrafiltration system. The precision quantitated by repetition was < 6% for between‐run and within‐run variability. In conclusion, Ultrafiltration provided rapid results, demonstrated minor analytical errors, revealed generally good correlation with equilibrium dialysis, and allowed excellent precision.
Ronald M Baldwin - One of the best experts on this subject based on the ideXlab platform.
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evaluation of Ultrafiltration for the free fraction determination of single photon emission computed tomography spect radiotracers β cit ibf and iomazenil
Journal of Pharmaceutical Sciences, 1994Co-Authors: Mitchell S Gandelman, Sami S Zoghbi, Ronald M Baldwin, Yolanda Zeaponce, Robert B. InnisAbstract:An Ultrafiltration system was evaluated for the free‐fraction measurement of SPECT radiotracers (β‐CIT, IBF, and iomazenil) used in functional brain imaging. The effect of temperature, storage, centrifugal force, tracer concentration, and percentage filtered demonstrated a relative error of < 9%. As a result of the minimal temperature effect, 25 °C was employed for all measurements. A comparison of the Ultrafiltration system with equilibrium dialysis revealed < 5% difference for β‐CIT and iomazenil, but 16% for IBF. Additionally, the time and ease of operation considerably favored the Ultrafiltration system. The precision quantitated by repetition was < 6% for between‐run and within‐run variability. In conclusion, Ultrafiltration provided rapid results, demonstrated minor analytical errors, revealed generally good correlation with equilibrium dialysis, and allowed excellent precision.
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Evaluation of Ultrafiltration for the Free‐Fraction Determination of Single Photon Emission Computed Tomography (SPECT) Radiotracers: β‐CIT, IBF, and Iomazenil
Journal of Pharmaceutical Sciences, 1994Co-Authors: Mitchell S Gandelman, Sami S Zoghbi, Ronald M Baldwin, Yolanda Zea-ponce, Robert B. InnisAbstract:An Ultrafiltration system was evaluated for the free‐fraction measurement of SPECT radiotracers (β‐CIT, IBF, and iomazenil) used in functional brain imaging. The effect of temperature, storage, centrifugal force, tracer concentration, and percentage filtered demonstrated a relative error of < 9%. As a result of the minimal temperature effect, 25 °C was employed for all measurements. A comparison of the Ultrafiltration system with equilibrium dialysis revealed < 5% difference for β‐CIT and iomazenil, but 16% for IBF. Additionally, the time and ease of operation considerably favored the Ultrafiltration system. The precision quantitated by repetition was < 6% for between‐run and within‐run variability. In conclusion, Ultrafiltration provided rapid results, demonstrated minor analytical errors, revealed generally good correlation with equilibrium dialysis, and allowed excellent precision.
Sami S Zoghbi - One of the best experts on this subject based on the ideXlab platform.
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evaluation of Ultrafiltration for the free fraction determination of single photon emission computed tomography spect radiotracers β cit ibf and iomazenil
Journal of Pharmaceutical Sciences, 1994Co-Authors: Mitchell S Gandelman, Sami S Zoghbi, Ronald M Baldwin, Yolanda Zeaponce, Robert B. InnisAbstract:An Ultrafiltration system was evaluated for the free‐fraction measurement of SPECT radiotracers (β‐CIT, IBF, and iomazenil) used in functional brain imaging. The effect of temperature, storage, centrifugal force, tracer concentration, and percentage filtered demonstrated a relative error of < 9%. As a result of the minimal temperature effect, 25 °C was employed for all measurements. A comparison of the Ultrafiltration system with equilibrium dialysis revealed < 5% difference for β‐CIT and iomazenil, but 16% for IBF. Additionally, the time and ease of operation considerably favored the Ultrafiltration system. The precision quantitated by repetition was < 6% for between‐run and within‐run variability. In conclusion, Ultrafiltration provided rapid results, demonstrated minor analytical errors, revealed generally good correlation with equilibrium dialysis, and allowed excellent precision.
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Evaluation of Ultrafiltration for the Free‐Fraction Determination of Single Photon Emission Computed Tomography (SPECT) Radiotracers: β‐CIT, IBF, and Iomazenil
Journal of Pharmaceutical Sciences, 1994Co-Authors: Mitchell S Gandelman, Sami S Zoghbi, Ronald M Baldwin, Yolanda Zea-ponce, Robert B. InnisAbstract:An Ultrafiltration system was evaluated for the free‐fraction measurement of SPECT radiotracers (β‐CIT, IBF, and iomazenil) used in functional brain imaging. The effect of temperature, storage, centrifugal force, tracer concentration, and percentage filtered demonstrated a relative error of < 9%. As a result of the minimal temperature effect, 25 °C was employed for all measurements. A comparison of the Ultrafiltration system with equilibrium dialysis revealed < 5% difference for β‐CIT and iomazenil, but 16% for IBF. Additionally, the time and ease of operation considerably favored the Ultrafiltration system. The precision quantitated by repetition was < 6% for between‐run and within‐run variability. In conclusion, Ultrafiltration provided rapid results, demonstrated minor analytical errors, revealed generally good correlation with equilibrium dialysis, and allowed excellent precision.
Yolanda Zeaponce - One of the best experts on this subject based on the ideXlab platform.
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evaluation of Ultrafiltration for the free fraction determination of single photon emission computed tomography spect radiotracers β cit ibf and iomazenil
Journal of Pharmaceutical Sciences, 1994Co-Authors: Mitchell S Gandelman, Sami S Zoghbi, Ronald M Baldwin, Yolanda Zeaponce, Robert B. InnisAbstract:An Ultrafiltration system was evaluated for the free‐fraction measurement of SPECT radiotracers (β‐CIT, IBF, and iomazenil) used in functional brain imaging. The effect of temperature, storage, centrifugal force, tracer concentration, and percentage filtered demonstrated a relative error of < 9%. As a result of the minimal temperature effect, 25 °C was employed for all measurements. A comparison of the Ultrafiltration system with equilibrium dialysis revealed < 5% difference for β‐CIT and iomazenil, but 16% for IBF. Additionally, the time and ease of operation considerably favored the Ultrafiltration system. The precision quantitated by repetition was < 6% for between‐run and within‐run variability. In conclusion, Ultrafiltration provided rapid results, demonstrated minor analytical errors, revealed generally good correlation with equilibrium dialysis, and allowed excellent precision.
