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Kullervo Hynynen - One of the best experts on this subject based on the ideXlab platform.
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Focused Ultrasound Surgery in oncology: overview and principles.
Radiology, 2011Co-Authors: Clare M. Tempany, Kullervo Hynynen, Nathan Mcdannold, Ferenc A. JoleszAbstract:Focused Ultrasound Surgery (FUS) is a noninvasive image-guided therapy and an alternative to surgical interventions. It presents an opportunity to revolutionize cancer therapy and to affect or change drug delivery of therapeutic agents in new focally targeted ways. In this article the background, principles, technical devices, and clinical cancer applications of image-guided FUS are reviewed.
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Transcranial magnetic resonance imaging- guided focused Ultrasound Surgery of brain tumors: initial findings in 3 patients.
Neurosurgery, 2010Co-Authors: Nathan Mcdannold, Ferenc A. Jolesz, Greg T. Clement, Peter Mcl. Black, Kullervo HynynenAbstract:Objective This work evaluated the clinical feasibility of transcranial MRI-guided focused Ultrasound Surgery (TcMRgFUS).
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A Simulation Model for Local Harmonic Motion Monitoring of Focused Ultrasound Surgery
2009Co-Authors: Janne Heikkilä, Laura Curiel, Kullervo HynynenAbstract:A computational model for local harmonic motion (LHM) imaging‐based monitoring of high‐intensity focused Ultrasound Surgery (FUS) is presented. LMH technique is based on a focused Ultrasound radiation force excitation, which induces local mechanical vibrations at the focal region. These pulse‐echo imaged vibrations are then used to estimate the mechanical properties of the sonication region. LHM has been proven to be feasible for FUS monitoring because changes in the material properties during the coagulation affect the measured displacements. The presented model includes separate models to simulate acoustic fields, sonication induced temperature elevation and mechanical vibrations, and pulse‐echo imaging of the induced motions. These simulation models are based on Rayleigh integral, finite element, and spatial impulse response methods. Simulated temperature rise and vibration amplitudes have been compared with in vivo rabbit experiments with noninvasive MRI thermometry.
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uterine leiomyomas mr imaging guided focused Ultrasound Surgery imaging predictors of success
Radiology, 2008Co-Authors: Zsuzsanna M. Lénárd, Kullervo Hynynen, Ferenc A. Jolesz, Elizabeth A. Stewart, Nathan Mcdannold, Fiona M. Fennessy, Clare M. TempanyAbstract:Purpose: To retrospectively assess the magnetic resonance (MR) imaging predictors of success at reducing uterine leiomyoma volume and achieving patient symptom relief 12 months after MR imaging–guided focused Ultrasound Surgery. Materials and Methods: This single-center retrospective analysis of 71 symptomatic fibroids in 66 women was approved by the institutional review board and was HIPAA-compliant. Patients were treated with MR imaging–guided focused Ultrasound Surgery. The volume of treated fibroid and nonperfused volume (NPV) were calculated with software, while symptom outcome was assessed with a symptom severity score (SSS). Fibroids were classified as hyperintense or hypointense relative to skeletal muscle on pretreatment T2-weighted MR images. Results: Baseline volume of treated fibroids was 255.5 cm3 ± 201.7 (standard deviation), and baseline SSS was 61.5 ± 14.9. Both pretreatment fibroid signal intensity (SI) and posttreatment NPV predicted 12-month volume reduction independently: Fibroids with...
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Uterine Leiomyomas: MR Imaging–guided Focused Ultrasound Surgery—Imaging Predictors of Success
Radiology, 2008Co-Authors: Zsuzsanna M. Lénárd, Kullervo Hynynen, Ferenc A. Jolesz, Elizabeth A. Stewart, Nathan Mcdannold, Fiona M. Fennessy, Clare M. TempanyAbstract:Purpose: To retrospectively assess the magnetic resonance (MR) imaging predictors of success at reducing uterine leiomyoma volume and achieving patient symptom relief 12 months after MR imaging–guided focused Ultrasound Surgery. Materials and Methods: This single-center retrospective analysis of 71 symptomatic fibroids in 66 women was approved by the institutional review board and was HIPAA-compliant. Patients were treated with MR imaging–guided focused Ultrasound Surgery. The volume of treated fibroid and nonperfused volume (NPV) were calculated with software, while symptom outcome was assessed with a symptom severity score (SSS). Fibroids were classified as hyperintense or hypointense relative to skeletal muscle on pretreatment T2-weighted MR images. Results: Baseline volume of treated fibroids was 255.5 cm3 ± 201.7 (standard deviation), and baseline SSS was 61.5 ± 14.9. Both pretreatment fibroid signal intensity (SI) and posttreatment NPV predicted 12-month volume reduction independently: Fibroids with...
Clare M. Tempany - One of the best experts on this subject based on the ideXlab platform.
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An Update on Magnetic Resonance Guided Focused Ultrasound Surgery (MRgFUS) of Uterine Fibroids
Current Radiology Reports, 2013Co-Authors: Fiona M. Fennessy, Clare M. TempanyAbstract:Magnetic resonance-guided high focused Ultrasound Surgery (MRgFUS) is a non-invasive treatment option for uterine fibroids. In addition to offering excellent anatomical depiction of the uterine fibroids and uterus, magnetic resonance imaging offers functional imaging and thermal guidance for safe delivery of the focused Ultrasound beam. Once appropriately selected for treatment, this out patient treatment option is well tolerated by patients and results in sustained symptom relief. More recent advances in this technology allows for quicker treatment times, allowing for greater nonperfused volumes to be attainable within the allotted scanner time. Also, upon review of fibroid and patient characteristics, the optimal candidates for successful MRgFUS are becoming more established.
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Focused Ultrasound Surgery in oncology: overview and principles.
Radiology, 2011Co-Authors: Clare M. Tempany, Kullervo Hynynen, Nathan Mcdannold, Ferenc A. JoleszAbstract:Focused Ultrasound Surgery (FUS) is a noninvasive image-guided therapy and an alternative to surgical interventions. It presents an opportunity to revolutionize cancer therapy and to affect or change drug delivery of therapeutic agents in new focally targeted ways. In this article the background, principles, technical devices, and clinical cancer applications of image-guided FUS are reviewed.
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uterine leiomyomas mr imaging guided focused Ultrasound Surgery imaging predictors of success
Radiology, 2008Co-Authors: Zsuzsanna M. Lénárd, Kullervo Hynynen, Ferenc A. Jolesz, Elizabeth A. Stewart, Nathan Mcdannold, Fiona M. Fennessy, Clare M. TempanyAbstract:Purpose: To retrospectively assess the magnetic resonance (MR) imaging predictors of success at reducing uterine leiomyoma volume and achieving patient symptom relief 12 months after MR imaging–guided focused Ultrasound Surgery. Materials and Methods: This single-center retrospective analysis of 71 symptomatic fibroids in 66 women was approved by the institutional review board and was HIPAA-compliant. Patients were treated with MR imaging–guided focused Ultrasound Surgery. The volume of treated fibroid and nonperfused volume (NPV) were calculated with software, while symptom outcome was assessed with a symptom severity score (SSS). Fibroids were classified as hyperintense or hypointense relative to skeletal muscle on pretreatment T2-weighted MR images. Results: Baseline volume of treated fibroids was 255.5 cm3 ± 201.7 (standard deviation), and baseline SSS was 61.5 ± 14.9. Both pretreatment fibroid signal intensity (SI) and posttreatment NPV predicted 12-month volume reduction independently: Fibroids with...
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Uterine Leiomyomas: MR Imaging–guided Focused Ultrasound Surgery—Imaging Predictors of Success
Radiology, 2008Co-Authors: Zsuzsanna M. Lénárd, Kullervo Hynynen, Ferenc A. Jolesz, Elizabeth A. Stewart, Nathan Mcdannold, Fiona M. Fennessy, Clare M. TempanyAbstract:Purpose: To retrospectively assess the magnetic resonance (MR) imaging predictors of success at reducing uterine leiomyoma volume and achieving patient symptom relief 12 months after MR imaging–guided focused Ultrasound Surgery. Materials and Methods: This single-center retrospective analysis of 71 symptomatic fibroids in 66 women was approved by the institutional review board and was HIPAA-compliant. Patients were treated with MR imaging–guided focused Ultrasound Surgery. The volume of treated fibroid and nonperfused volume (NPV) were calculated with software, while symptom outcome was assessed with a symptom severity score (SSS). Fibroids were classified as hyperintense or hypointense relative to skeletal muscle on pretreatment T2-weighted MR images. Results: Baseline volume of treated fibroids was 255.5 cm3 ± 201.7 (standard deviation), and baseline SSS was 61.5 ± 14.9. Both pretreatment fibroid signal intensity (SI) and posttreatment NPV predicted 12-month volume reduction independently: Fibroids with...
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sustained relief of leiomyoma symptoms by using focused Ultrasound Surgery
Obstetrics & Gynecology, 2007Co-Authors: Elizabeth A. Stewart, Bobbie Gostout, Jaron Rabinovici, Hyun S Kim, Lesley Regan, Clare M. TempanyAbstract:used to assess outcome based on completeness of leiomyoma ablation. RESULTS: Women undergoing magnetic resonance– guided focused Ultrasound Surgery for symptomatic uterine leiomyomata have durable symptom relief, as measured by the symptom severity score at 24 months, with significantly greater improvement with more complete ablation (P<.001). Survival analysis demonstrates a significant reduction in the percentage of women undergoing additional leiomyoma treatment (P.001) in women in the high nonperfused volume group. The mean shrinkage and mean residual nonperfused volume ratio are both significantly above zero at 6 months in the high nonperfused volume group (P<.001). The incidence of adverse events is low. However, for women with minimal treatment, the risk of additional procedures is high.
Elizabeth A. Stewart - One of the best experts on this subject based on the ideXlab platform.
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Updated Costs of Uterine Fibroid Treatments Including Focused Ultrasound Surgery
2018Co-Authors: Bijan J. Borah, Elizabeth A. StewartAbstract:Uterine leiomyomas (fibroids) affect 20–40% of reproductive age women and are the major indication for hysterectomy. Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) is a new, potentially disruptive, non-invasive and uterine-sparing treatment option that has been shown to yield similar or better clinical outcomes than other uterine-sparing interventions. However, the costs of MRgFUS and other minimally-invasive treatment options have not been studied using US practice data. This study attempts to fill this void. And since uterine fibroids are the first FDA-approved indication for MRgFUS treatment, this study may also have implications for other indications which are now investigational.
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Magnetic resonance-guided focused Ultrasound Surgery for leiomyoma-associated infertility
Fertility and sterility, 2011Co-Authors: Esther V.a. Bouwsma, Gina K. Hesley, Krzysztof R. Gorny, Jani R. Jensen, Lisa G. Peterson, Elizabeth A. StewartAbstract:Objective To describe magnetic resonance-guided focused Ultrasound Surgery (FUS) as a treatment for a case of leiomyoma-associated infertility. Design Case report from a randomized clinical trial. Setting Academic medical center. Patient(s) A 37-year-old woman with known leiomyomas and a history of 18 months of home-inseminations from a known donor. Intervention(s) Magnetic resonance-guided FUS treatment of uterine fibroids, where the dominant fibroid distorted the uterine cavity. Main Outcome Measure(s) Pregnancy. Result(s) A viable intrauterine pregnancy, with a full-term vaginal delivery, was conceived after a single clomiphene citrate and intrauterine insemination cycle. Conclusion(s) The role of FUS for enhancement of fertility in women with nonhysteroscopically resectable uterine fibroids distorting the uterine cavity should be investigated further.
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Magnetic resonance-guided focused Ultrasound Surgery.
Seminars in reproductive medicine, 2010Co-Authors: Mariam M Al Hilli, Elizabeth A. StewartAbstract:Magnetic resonance guided focused Ultrasound Surgery (MRgFUS) is a noninvasive thermoablative therapy that was approved by the Food and Drug Administration in 2004 for the treatment of uterine fibroids (leiomyomas). Data on safety and long-term efficacy are accumulating to establish the unique usefulness of this therapy in targeting and treating leiomyomas through the integration of MR imaging. This article describes the established thermoablative therapies in the treatment of uterine fibroids, emphasizing their role in the genesis of MRgFUS. Treatment specifications are highlighted, and an overview of the procedure is given. Data from both clinical trials and commercial treatments are detailed for multiple efficacy outcomes, including symptom improvement, leiomyoma shrinkage, and use of alternative procedures. The concept of nonperfused volume as a surrogate marker for treatment success is discussed. Importantly, favorable pregnancy outcomes following MRgFUS have been reported. Applications of MRgFUS have recently expanded into the realm of adenomyosis treatment. MRgFUS has been deemed a safe and effective method of fibroid treatment and offers the advantages of no incisions or blood loss, speedy recovery, and a cost-effective means of treatment.
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uterine leiomyomas mr imaging guided focused Ultrasound Surgery imaging predictors of success
Radiology, 2008Co-Authors: Zsuzsanna M. Lénárd, Kullervo Hynynen, Ferenc A. Jolesz, Elizabeth A. Stewart, Nathan Mcdannold, Fiona M. Fennessy, Clare M. TempanyAbstract:Purpose: To retrospectively assess the magnetic resonance (MR) imaging predictors of success at reducing uterine leiomyoma volume and achieving patient symptom relief 12 months after MR imaging–guided focused Ultrasound Surgery. Materials and Methods: This single-center retrospective analysis of 71 symptomatic fibroids in 66 women was approved by the institutional review board and was HIPAA-compliant. Patients were treated with MR imaging–guided focused Ultrasound Surgery. The volume of treated fibroid and nonperfused volume (NPV) were calculated with software, while symptom outcome was assessed with a symptom severity score (SSS). Fibroids were classified as hyperintense or hypointense relative to skeletal muscle on pretreatment T2-weighted MR images. Results: Baseline volume of treated fibroids was 255.5 cm3 ± 201.7 (standard deviation), and baseline SSS was 61.5 ± 14.9. Both pretreatment fibroid signal intensity (SI) and posttreatment NPV predicted 12-month volume reduction independently: Fibroids with...
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Uterine Leiomyomas: MR Imaging–guided Focused Ultrasound Surgery—Imaging Predictors of Success
Radiology, 2008Co-Authors: Zsuzsanna M. Lénárd, Kullervo Hynynen, Ferenc A. Jolesz, Elizabeth A. Stewart, Nathan Mcdannold, Fiona M. Fennessy, Clare M. TempanyAbstract:Purpose: To retrospectively assess the magnetic resonance (MR) imaging predictors of success at reducing uterine leiomyoma volume and achieving patient symptom relief 12 months after MR imaging–guided focused Ultrasound Surgery. Materials and Methods: This single-center retrospective analysis of 71 symptomatic fibroids in 66 women was approved by the institutional review board and was HIPAA-compliant. Patients were treated with MR imaging–guided focused Ultrasound Surgery. The volume of treated fibroid and nonperfused volume (NPV) were calculated with software, while symptom outcome was assessed with a symptom severity score (SSS). Fibroids were classified as hyperintense or hypointense relative to skeletal muscle on pretreatment T2-weighted MR images. Results: Baseline volume of treated fibroids was 255.5 cm3 ± 201.7 (standard deviation), and baseline SSS was 61.5 ± 14.9. Both pretreatment fibroid signal intensity (SI) and posttreatment NPV predicted 12-month volume reduction independently: Fibroids with...
Nathan Mcdannold - One of the best experts on this subject based on the ideXlab platform.
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Focused Ultrasound Surgery in oncology: overview and principles.
Radiology, 2011Co-Authors: Clare M. Tempany, Kullervo Hynynen, Nathan Mcdannold, Ferenc A. JoleszAbstract:Focused Ultrasound Surgery (FUS) is a noninvasive image-guided therapy and an alternative to surgical interventions. It presents an opportunity to revolutionize cancer therapy and to affect or change drug delivery of therapeutic agents in new focally targeted ways. In this article the background, principles, technical devices, and clinical cancer applications of image-guided FUS are reviewed.
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Transcranial magnetic resonance imaging- guided focused Ultrasound Surgery of brain tumors: initial findings in 3 patients.
Neurosurgery, 2010Co-Authors: Nathan Mcdannold, Ferenc A. Jolesz, Greg T. Clement, Peter Mcl. Black, Kullervo HynynenAbstract:Objective This work evaluated the clinical feasibility of transcranial MRI-guided focused Ultrasound Surgery (TcMRgFUS).
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uterine leiomyomas mr imaging guided focused Ultrasound Surgery imaging predictors of success
Radiology, 2008Co-Authors: Zsuzsanna M. Lénárd, Kullervo Hynynen, Ferenc A. Jolesz, Elizabeth A. Stewart, Nathan Mcdannold, Fiona M. Fennessy, Clare M. TempanyAbstract:Purpose: To retrospectively assess the magnetic resonance (MR) imaging predictors of success at reducing uterine leiomyoma volume and achieving patient symptom relief 12 months after MR imaging–guided focused Ultrasound Surgery. Materials and Methods: This single-center retrospective analysis of 71 symptomatic fibroids in 66 women was approved by the institutional review board and was HIPAA-compliant. Patients were treated with MR imaging–guided focused Ultrasound Surgery. The volume of treated fibroid and nonperfused volume (NPV) were calculated with software, while symptom outcome was assessed with a symptom severity score (SSS). Fibroids were classified as hyperintense or hypointense relative to skeletal muscle on pretreatment T2-weighted MR images. Results: Baseline volume of treated fibroids was 255.5 cm3 ± 201.7 (standard deviation), and baseline SSS was 61.5 ± 14.9. Both pretreatment fibroid signal intensity (SI) and posttreatment NPV predicted 12-month volume reduction independently: Fibroids with...
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Uterine Leiomyomas: MR Imaging–guided Focused Ultrasound Surgery—Imaging Predictors of Success
Radiology, 2008Co-Authors: Zsuzsanna M. Lénárd, Kullervo Hynynen, Ferenc A. Jolesz, Elizabeth A. Stewart, Nathan Mcdannold, Fiona M. Fennessy, Clare M. TempanyAbstract:Purpose: To retrospectively assess the magnetic resonance (MR) imaging predictors of success at reducing uterine leiomyoma volume and achieving patient symptom relief 12 months after MR imaging–guided focused Ultrasound Surgery. Materials and Methods: This single-center retrospective analysis of 71 symptomatic fibroids in 66 women was approved by the institutional review board and was HIPAA-compliant. Patients were treated with MR imaging–guided focused Ultrasound Surgery. The volume of treated fibroid and nonperfused volume (NPV) were calculated with software, while symptom outcome was assessed with a symptom severity score (SSS). Fibroids were classified as hyperintense or hypointense relative to skeletal muscle on pretreatment T2-weighted MR images. Results: Baseline volume of treated fibroids was 255.5 cm3 ± 201.7 (standard deviation), and baseline SSS was 61.5 ± 14.9. Both pretreatment fibroid signal intensity (SI) and posttreatment NPV predicted 12-month volume reduction independently: Fibroids with...
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Focal Beam Distortion and Treatment Planning in Abdominal Focused Ultrasound Surgery
AIP Conference Proceedings, 2006Co-Authors: Hao-li Liu, Nathan Mcdannold, Kullervo HynynenAbstract:The purpose of this study was to numerically demonstrate the focal‐beam distortion in abdominal focused Ultrasound Surgery, and to present a phase correction procedure to restore the focal beam patterns. Abdominal MR data from four uterine fibroid patients were obtained to reconstruct the 3‐D meshes of interfaces used in simulations, and one patient was selected to perform the analysis of key parameters in focused Ultrasound Surgery. Results show that, without phase correction, the focused beam can be severely distorted while using a frequency above 1 MHz or delivering ring‐shape focal patterns. Different focal positions at the same depth may require a different power to induce the same ultrasonic intensity level (up to 179% among the different focal patterns). After adding a phase correction procedure, the distorted focal beams can be restored, and the peak intensity can be largely recovered (up to 85% among the different focal patterns). This study may offer important implications and information for tr...
Ferenc A. Jolesz - One of the best experts on this subject based on the ideXlab platform.
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Focused Ultrasound Surgery in oncology: overview and principles.
Radiology, 2011Co-Authors: Clare M. Tempany, Kullervo Hynynen, Nathan Mcdannold, Ferenc A. JoleszAbstract:Focused Ultrasound Surgery (FUS) is a noninvasive image-guided therapy and an alternative to surgical interventions. It presents an opportunity to revolutionize cancer therapy and to affect or change drug delivery of therapeutic agents in new focally targeted ways. In this article the background, principles, technical devices, and clinical cancer applications of image-guided FUS are reviewed.
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Transcranial magnetic resonance imaging- guided focused Ultrasound Surgery of brain tumors: initial findings in 3 patients.
Neurosurgery, 2010Co-Authors: Nathan Mcdannold, Ferenc A. Jolesz, Greg T. Clement, Peter Mcl. Black, Kullervo HynynenAbstract:Objective This work evaluated the clinical feasibility of transcranial MRI-guided focused Ultrasound Surgery (TcMRgFUS).
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uterine leiomyomas mr imaging guided focused Ultrasound Surgery imaging predictors of success
Radiology, 2008Co-Authors: Zsuzsanna M. Lénárd, Kullervo Hynynen, Ferenc A. Jolesz, Elizabeth A. Stewart, Nathan Mcdannold, Fiona M. Fennessy, Clare M. TempanyAbstract:Purpose: To retrospectively assess the magnetic resonance (MR) imaging predictors of success at reducing uterine leiomyoma volume and achieving patient symptom relief 12 months after MR imaging–guided focused Ultrasound Surgery. Materials and Methods: This single-center retrospective analysis of 71 symptomatic fibroids in 66 women was approved by the institutional review board and was HIPAA-compliant. Patients were treated with MR imaging–guided focused Ultrasound Surgery. The volume of treated fibroid and nonperfused volume (NPV) were calculated with software, while symptom outcome was assessed with a symptom severity score (SSS). Fibroids were classified as hyperintense or hypointense relative to skeletal muscle on pretreatment T2-weighted MR images. Results: Baseline volume of treated fibroids was 255.5 cm3 ± 201.7 (standard deviation), and baseline SSS was 61.5 ± 14.9. Both pretreatment fibroid signal intensity (SI) and posttreatment NPV predicted 12-month volume reduction independently: Fibroids with...
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Uterine Leiomyomas: MR Imaging–guided Focused Ultrasound Surgery—Imaging Predictors of Success
Radiology, 2008Co-Authors: Zsuzsanna M. Lénárd, Kullervo Hynynen, Ferenc A. Jolesz, Elizabeth A. Stewart, Nathan Mcdannold, Fiona M. Fennessy, Clare M. TempanyAbstract:Purpose: To retrospectively assess the magnetic resonance (MR) imaging predictors of success at reducing uterine leiomyoma volume and achieving patient symptom relief 12 months after MR imaging–guided focused Ultrasound Surgery. Materials and Methods: This single-center retrospective analysis of 71 symptomatic fibroids in 66 women was approved by the institutional review board and was HIPAA-compliant. Patients were treated with MR imaging–guided focused Ultrasound Surgery. The volume of treated fibroid and nonperfused volume (NPV) were calculated with software, while symptom outcome was assessed with a symptom severity score (SSS). Fibroids were classified as hyperintense or hypointense relative to skeletal muscle on pretreatment T2-weighted MR images. Results: Baseline volume of treated fibroids was 255.5 cm3 ± 201.7 (standard deviation), and baseline SSS was 61.5 ± 14.9. Both pretreatment fibroid signal intensity (SI) and posttreatment NPV predicted 12-month volume reduction independently: Fibroids with...
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Comprar MRI-Guided Focused Ultrasound Surgery | Kullervo H. Hynynen | 9780849373701 | Informa Healthcare
2007Co-Authors: Kullervo Hynynen, Ferenc A. JoleszAbstract:Tienda online donde Comprar MRI-Guided Focused Ultrasound Surgery al precio 133,41 € de Kullervo H. Hynynen | Ferenc A. Jolesz, tienda de Libros de Medicina, Libros de Oncologia - Oncologia clinica
