The Experts below are selected from a list of 72 Experts worldwide ranked by ideXlab platform
Shin Aoki - One of the best experts on this subject based on the ideXlab platform.
-
11B NMR Sensing of d-Block Metal Ions in Vitro and in Cells Based on the Carbon–Boron Bond Cleavage of Phenylboronic Acid-Pendant Cyclen (Cyclen = 1,4,7,10-Tetraazacyclododecane)
2016Co-Authors: Masanori Kitamura, Toshihiro Suzuki, Ryo Abe, Takeru Ueno, Shin AokiAbstract:Noninvasive magnetic resonance imaging (MRI) including the “chemical shift imaging (CSI)” technique based on 1H NMR signals is a powerful method for the in vivo imaging of intracellular molecules and for monitoring various biological events. However, it has the drawback of low resolution because of background signals from intrinsic water protons. On the other hand, it is assumed that the 11B NMR signals which can be applied to a CSI technique have certain advantages, since boron is an Ultratrace Element in animal cells and tissues. In this manuscript, we report on the sensing of biologically indispensable d-block metal cations such as zinc, copper, iron, cobalt, manganese, and nickel based on 11B NMR signals of simple phenylboronic acid-pendant cyclen (cyclen = 1,4,7,10-tetraazacyclododecane), L6 and L7, in aqueous solution at physiological pH. The results indicate that the carbon–boron bond of L6 is cleaved upon the addition of Zn2+ and the broad 11B NMR signal of L6 at 31 ppm is shifted upfield to 19 ppm, which corresponds to the signal of B(OH)3. 1H NMR, X-ray single crystal structure analysis, and UV absorption spectra also provide support for the carbon–boron bond cleavage of ZnL6. Because the cellular uptake of L6 was very small, a more cell-membrane permeable ligand containing the boronic acid ester L7 was synthesized and investigated for the sensing of d-block metal ions using 11B NMR. Data on 11B NMR sensing of Zn2+ in Jurkat T cells using L7 is also presented
-
11b nmr sensing of d block metal ions in vitro and in cells based on the carbon boron bond cleavage of phenylboronic acid pendant cyclen cyclen 1 4 7 10 tetraazacyclododecane
Inorganic Chemistry, 2011Co-Authors: Masanori Kitamura, Toshihiro Suzuki, Ryo Abe, Takeru Ueno, Shin AokiAbstract:Noninvasive magnetic resonance imaging (MRI) including the “chemical shift imaging (CSI)” technique based on 1H NMR signals is a powerful method for the in vivo imaging of intracellular molecules and for monitoring various biological events. However, it has the drawback of low resolution because of background signals from intrinsic water protons. On the other hand, it is assumed that the 11B NMR signals which can be applied to a CSI technique have certain advantages, since boron is an Ultratrace Element in animal cells and tissues. In this manuscript, we report on the sensing of biologically indispensable d-block metal cations such as zinc, copper, iron, cobalt, manganese, and nickel based on 11B NMR signals of simple phenylboronic acid-pendant cyclen (cyclen = 1,4,7,10-tetraazacyclododecane), L6 and L7, in aqueous solution at physiological pH. The results indicate that the carbon–boron bond of L6 is cleaved upon the addition of Zn2+ and the broad 11B NMR signal of L6 at 31 ppm is shifted upfield to 19 pp...
Masanori Kitamura - One of the best experts on this subject based on the ideXlab platform.
-
11B NMR Sensing of d-Block Metal Ions in Vitro and in Cells Based on the Carbon–Boron Bond Cleavage of Phenylboronic Acid-Pendant Cyclen (Cyclen = 1,4,7,10-Tetraazacyclododecane)
2016Co-Authors: Masanori Kitamura, Toshihiro Suzuki, Ryo Abe, Takeru Ueno, Shin AokiAbstract:Noninvasive magnetic resonance imaging (MRI) including the “chemical shift imaging (CSI)” technique based on 1H NMR signals is a powerful method for the in vivo imaging of intracellular molecules and for monitoring various biological events. However, it has the drawback of low resolution because of background signals from intrinsic water protons. On the other hand, it is assumed that the 11B NMR signals which can be applied to a CSI technique have certain advantages, since boron is an Ultratrace Element in animal cells and tissues. In this manuscript, we report on the sensing of biologically indispensable d-block metal cations such as zinc, copper, iron, cobalt, manganese, and nickel based on 11B NMR signals of simple phenylboronic acid-pendant cyclen (cyclen = 1,4,7,10-tetraazacyclododecane), L6 and L7, in aqueous solution at physiological pH. The results indicate that the carbon–boron bond of L6 is cleaved upon the addition of Zn2+ and the broad 11B NMR signal of L6 at 31 ppm is shifted upfield to 19 ppm, which corresponds to the signal of B(OH)3. 1H NMR, X-ray single crystal structure analysis, and UV absorption spectra also provide support for the carbon–boron bond cleavage of ZnL6. Because the cellular uptake of L6 was very small, a more cell-membrane permeable ligand containing the boronic acid ester L7 was synthesized and investigated for the sensing of d-block metal ions using 11B NMR. Data on 11B NMR sensing of Zn2+ in Jurkat T cells using L7 is also presented
-
11b nmr sensing of d block metal ions in vitro and in cells based on the carbon boron bond cleavage of phenylboronic acid pendant cyclen cyclen 1 4 7 10 tetraazacyclododecane
Inorganic Chemistry, 2011Co-Authors: Masanori Kitamura, Toshihiro Suzuki, Ryo Abe, Takeru Ueno, Shin AokiAbstract:Noninvasive magnetic resonance imaging (MRI) including the “chemical shift imaging (CSI)” technique based on 1H NMR signals is a powerful method for the in vivo imaging of intracellular molecules and for monitoring various biological events. However, it has the drawback of low resolution because of background signals from intrinsic water protons. On the other hand, it is assumed that the 11B NMR signals which can be applied to a CSI technique have certain advantages, since boron is an Ultratrace Element in animal cells and tissues. In this manuscript, we report on the sensing of biologically indispensable d-block metal cations such as zinc, copper, iron, cobalt, manganese, and nickel based on 11B NMR signals of simple phenylboronic acid-pendant cyclen (cyclen = 1,4,7,10-tetraazacyclododecane), L6 and L7, in aqueous solution at physiological pH. The results indicate that the carbon–boron bond of L6 is cleaved upon the addition of Zn2+ and the broad 11B NMR signal of L6 at 31 ppm is shifted upfield to 19 pp...
Takeru Ueno - One of the best experts on this subject based on the ideXlab platform.
-
11B NMR Sensing of d-Block Metal Ions in Vitro and in Cells Based on the Carbon–Boron Bond Cleavage of Phenylboronic Acid-Pendant Cyclen (Cyclen = 1,4,7,10-Tetraazacyclododecane)
2016Co-Authors: Masanori Kitamura, Toshihiro Suzuki, Ryo Abe, Takeru Ueno, Shin AokiAbstract:Noninvasive magnetic resonance imaging (MRI) including the “chemical shift imaging (CSI)” technique based on 1H NMR signals is a powerful method for the in vivo imaging of intracellular molecules and for monitoring various biological events. However, it has the drawback of low resolution because of background signals from intrinsic water protons. On the other hand, it is assumed that the 11B NMR signals which can be applied to a CSI technique have certain advantages, since boron is an Ultratrace Element in animal cells and tissues. In this manuscript, we report on the sensing of biologically indispensable d-block metal cations such as zinc, copper, iron, cobalt, manganese, and nickel based on 11B NMR signals of simple phenylboronic acid-pendant cyclen (cyclen = 1,4,7,10-tetraazacyclododecane), L6 and L7, in aqueous solution at physiological pH. The results indicate that the carbon–boron bond of L6 is cleaved upon the addition of Zn2+ and the broad 11B NMR signal of L6 at 31 ppm is shifted upfield to 19 ppm, which corresponds to the signal of B(OH)3. 1H NMR, X-ray single crystal structure analysis, and UV absorption spectra also provide support for the carbon–boron bond cleavage of ZnL6. Because the cellular uptake of L6 was very small, a more cell-membrane permeable ligand containing the boronic acid ester L7 was synthesized and investigated for the sensing of d-block metal ions using 11B NMR. Data on 11B NMR sensing of Zn2+ in Jurkat T cells using L7 is also presented
-
11b nmr sensing of d block metal ions in vitro and in cells based on the carbon boron bond cleavage of phenylboronic acid pendant cyclen cyclen 1 4 7 10 tetraazacyclododecane
Inorganic Chemistry, 2011Co-Authors: Masanori Kitamura, Toshihiro Suzuki, Ryo Abe, Takeru Ueno, Shin AokiAbstract:Noninvasive magnetic resonance imaging (MRI) including the “chemical shift imaging (CSI)” technique based on 1H NMR signals is a powerful method for the in vivo imaging of intracellular molecules and for monitoring various biological events. However, it has the drawback of low resolution because of background signals from intrinsic water protons. On the other hand, it is assumed that the 11B NMR signals which can be applied to a CSI technique have certain advantages, since boron is an Ultratrace Element in animal cells and tissues. In this manuscript, we report on the sensing of biologically indispensable d-block metal cations such as zinc, copper, iron, cobalt, manganese, and nickel based on 11B NMR signals of simple phenylboronic acid-pendant cyclen (cyclen = 1,4,7,10-tetraazacyclododecane), L6 and L7, in aqueous solution at physiological pH. The results indicate that the carbon–boron bond of L6 is cleaved upon the addition of Zn2+ and the broad 11B NMR signal of L6 at 31 ppm is shifted upfield to 19 pp...
Toshihiro Suzuki - One of the best experts on this subject based on the ideXlab platform.
-
11B NMR Sensing of d-Block Metal Ions in Vitro and in Cells Based on the Carbon–Boron Bond Cleavage of Phenylboronic Acid-Pendant Cyclen (Cyclen = 1,4,7,10-Tetraazacyclododecane)
2016Co-Authors: Masanori Kitamura, Toshihiro Suzuki, Ryo Abe, Takeru Ueno, Shin AokiAbstract:Noninvasive magnetic resonance imaging (MRI) including the “chemical shift imaging (CSI)” technique based on 1H NMR signals is a powerful method for the in vivo imaging of intracellular molecules and for monitoring various biological events. However, it has the drawback of low resolution because of background signals from intrinsic water protons. On the other hand, it is assumed that the 11B NMR signals which can be applied to a CSI technique have certain advantages, since boron is an Ultratrace Element in animal cells and tissues. In this manuscript, we report on the sensing of biologically indispensable d-block metal cations such as zinc, copper, iron, cobalt, manganese, and nickel based on 11B NMR signals of simple phenylboronic acid-pendant cyclen (cyclen = 1,4,7,10-tetraazacyclododecane), L6 and L7, in aqueous solution at physiological pH. The results indicate that the carbon–boron bond of L6 is cleaved upon the addition of Zn2+ and the broad 11B NMR signal of L6 at 31 ppm is shifted upfield to 19 ppm, which corresponds to the signal of B(OH)3. 1H NMR, X-ray single crystal structure analysis, and UV absorption spectra also provide support for the carbon–boron bond cleavage of ZnL6. Because the cellular uptake of L6 was very small, a more cell-membrane permeable ligand containing the boronic acid ester L7 was synthesized and investigated for the sensing of d-block metal ions using 11B NMR. Data on 11B NMR sensing of Zn2+ in Jurkat T cells using L7 is also presented
-
11b nmr sensing of d block metal ions in vitro and in cells based on the carbon boron bond cleavage of phenylboronic acid pendant cyclen cyclen 1 4 7 10 tetraazacyclododecane
Inorganic Chemistry, 2011Co-Authors: Masanori Kitamura, Toshihiro Suzuki, Ryo Abe, Takeru Ueno, Shin AokiAbstract:Noninvasive magnetic resonance imaging (MRI) including the “chemical shift imaging (CSI)” technique based on 1H NMR signals is a powerful method for the in vivo imaging of intracellular molecules and for monitoring various biological events. However, it has the drawback of low resolution because of background signals from intrinsic water protons. On the other hand, it is assumed that the 11B NMR signals which can be applied to a CSI technique have certain advantages, since boron is an Ultratrace Element in animal cells and tissues. In this manuscript, we report on the sensing of biologically indispensable d-block metal cations such as zinc, copper, iron, cobalt, manganese, and nickel based on 11B NMR signals of simple phenylboronic acid-pendant cyclen (cyclen = 1,4,7,10-tetraazacyclododecane), L6 and L7, in aqueous solution at physiological pH. The results indicate that the carbon–boron bond of L6 is cleaved upon the addition of Zn2+ and the broad 11B NMR signal of L6 at 31 ppm is shifted upfield to 19 pp...
Ryo Abe - One of the best experts on this subject based on the ideXlab platform.
-
11B NMR Sensing of d-Block Metal Ions in Vitro and in Cells Based on the Carbon–Boron Bond Cleavage of Phenylboronic Acid-Pendant Cyclen (Cyclen = 1,4,7,10-Tetraazacyclododecane)
2016Co-Authors: Masanori Kitamura, Toshihiro Suzuki, Ryo Abe, Takeru Ueno, Shin AokiAbstract:Noninvasive magnetic resonance imaging (MRI) including the “chemical shift imaging (CSI)” technique based on 1H NMR signals is a powerful method for the in vivo imaging of intracellular molecules and for monitoring various biological events. However, it has the drawback of low resolution because of background signals from intrinsic water protons. On the other hand, it is assumed that the 11B NMR signals which can be applied to a CSI technique have certain advantages, since boron is an Ultratrace Element in animal cells and tissues. In this manuscript, we report on the sensing of biologically indispensable d-block metal cations such as zinc, copper, iron, cobalt, manganese, and nickel based on 11B NMR signals of simple phenylboronic acid-pendant cyclen (cyclen = 1,4,7,10-tetraazacyclododecane), L6 and L7, in aqueous solution at physiological pH. The results indicate that the carbon–boron bond of L6 is cleaved upon the addition of Zn2+ and the broad 11B NMR signal of L6 at 31 ppm is shifted upfield to 19 ppm, which corresponds to the signal of B(OH)3. 1H NMR, X-ray single crystal structure analysis, and UV absorption spectra also provide support for the carbon–boron bond cleavage of ZnL6. Because the cellular uptake of L6 was very small, a more cell-membrane permeable ligand containing the boronic acid ester L7 was synthesized and investigated for the sensing of d-block metal ions using 11B NMR. Data on 11B NMR sensing of Zn2+ in Jurkat T cells using L7 is also presented
-
11b nmr sensing of d block metal ions in vitro and in cells based on the carbon boron bond cleavage of phenylboronic acid pendant cyclen cyclen 1 4 7 10 tetraazacyclododecane
Inorganic Chemistry, 2011Co-Authors: Masanori Kitamura, Toshihiro Suzuki, Ryo Abe, Takeru Ueno, Shin AokiAbstract:Noninvasive magnetic resonance imaging (MRI) including the “chemical shift imaging (CSI)” technique based on 1H NMR signals is a powerful method for the in vivo imaging of intracellular molecules and for monitoring various biological events. However, it has the drawback of low resolution because of background signals from intrinsic water protons. On the other hand, it is assumed that the 11B NMR signals which can be applied to a CSI technique have certain advantages, since boron is an Ultratrace Element in animal cells and tissues. In this manuscript, we report on the sensing of biologically indispensable d-block metal cations such as zinc, copper, iron, cobalt, manganese, and nickel based on 11B NMR signals of simple phenylboronic acid-pendant cyclen (cyclen = 1,4,7,10-tetraazacyclododecane), L6 and L7, in aqueous solution at physiological pH. The results indicate that the carbon–boron bond of L6 is cleaved upon the addition of Zn2+ and the broad 11B NMR signal of L6 at 31 ppm is shifted upfield to 19 pp...
